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Background Gefitinib is a first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). It was approved by the U.S. Food and Drug Administration (FDA) for clinical use in 2003. However, gefitinib has only come to China in recent years. Previous studies have not compared the efficacy and safety of domestic and imported gefitinib. Therefore, we conducted this study. Methods This study included 227 patients with advanced non-small cell lung cancer (NSCLC) who received gefitinib treatment in four medical institutions: The First Affiliated Hospital of USTC, Division of life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Cancer Hospital, Fudan University Shanghai Cancer Center, Shandong Provincial Institute of Cancer Prevention and Jiangsu Cancer Hospital, from January 2017 to July 2018. The patients were divided into a Yiruike group (55 patients treated with domestic gefitinib, Yiruike) and an Iressa group (172 patients treated with imported gefitinib, Iressa). Because gefitinib resistance usually occurs within 8-10 months of gefitinib administration, the patients were followed up for one year to observe their conditions and compare the occurrence of adverse reactions between the two groups. Results The two groups had no significant difference in baseline data. The median progression-free survival (PFS) of Yiruike group and that of Iressa group were 10.270±2.036 and 12.970±1.634 months, respectively. The mean PFS of Yiruike group and that of Iressa group were 12.598±1.083 and 15.958±0.987 months, respectively. The one-year disease control rate (DCR) of Yiruike group and that of Iressa group were 61.8% and 59.3%, respectively. The differences were all insignificant (P>0.05). The incidence of adverse reactions in these two groups were not significantly different. Conclusions Yiruike was slightly superior to Iressa in terms of DCR. However, comparisons of bioequivalence and DCR were not sufficient for evaluating a drug. Other comparisons require long-term follow-up studies with a large sample size.

Opioid-tolerant patients are more likely to deviate from recommended treatments and to experience inadequate analgesia than opioid-naive ones. The aim of this study was to examine whether pharmacist-led management could help improve treatment adherence and quality of life.Eligible patients were randomized in a 1:1 ratio to control group and intervention group. The control group received routine education and support, while the intervention group received additional individualized pharmacist-led care. The primary endpoint was treatment adherence in the per-protocol analysis, as evaluated by blinded assessors. An interim analysis was planned when 30% patients completed the study. Alpha was divided into the interim analysis (0.015) and the final analysis (0.035).In the interim analysis (97 and 87 patients in the control and intervention groups, respectively), the primary endpoint was met. Pharmacist-led intervention significantly increased treatment adherence (93.3 vs. 79.8%; OR: 2.25; 95% CI 1.02, 4.94; P = 0.013), quality of life (0.81 ± 0.17 vs. 0.72 ± 0.25; P = 0.008), and reporting of adverse events (82.7 vs. 61.9%; OR: 1.88; 95% CI 1.16, 3.07; P = 0.004). The two groups did not differ in pain control rate (66.7 vs. 57.1%; OR: 1.25; 95% CI 0.87, 1.78; P = 0.218), breakthrough pain-free rate (66.7 vs. 61.9%; OR: 1.12; 95% CI 0.78, 1.59; P = 0.532) and pain score (1.97 ± 1.04 vs. 2.15 ± 1.24; P = 0.522).Pharmacist-led management improved treatment adherence, quality of life, and the reporting of adverse events in opioid-tolerant patients with cancer pain.ClinicalTrials.gov, NCT03455023.

With the deepening of reform and opening-up and the establishment of the socialist of market economic system, plenty of rural surplus labor forces have moved from countryside to city. Rural floating population makes a great contribution to the construction of cities and the development of economy, and they are becoming an indispensable group of city life and construction. But, this kind of group has not been integrated into cities in reality and at the edge of the cities. Therefore, in order to change the living condition of rural floating population, improve their social status, make them integrated into the city society quickly, it is with great significance to establish a social support system which include government, community, non- governmental organizations and rural floating population themselves. I. THE PROBLEM In China, since the middle of 1980s, with the deepening of reform and opening-up and the establishment of the socialist of market economic system, the original and rigid dual social and economic system is breaking. The rural population goes out and find non-farm jobs, this has become a significant social economic phenomenon. It not only changed urban and rural dual structure widely, but also caused the change of the social class structure. The statistic shows that, as of 2003, the number of rural floating population who come into cities to find jobs has been 160 million. Rural floating population is a group of powerhouse in city development; they undertake the most of construction of infrastructure, manufacture and service industry, some dirty, heavy and tired work, they make a great contribution to instruction of cities and development of economy, and they are becoming an indispensable group. The appearances of great number of rural floating population cause to the problem of it have more and more attention in the society. The reality shows that, rural floating population is being in an awkward state in common. Though they live in cities, in other aspects, rural floating population cannot integrate into cities smoothly and in the edge of cities, not being real "citizen" and show apparent shortcomings in social integration. While lack of social integration may bring direct social risk as for social safety and stabilization. Therefore, it is with great significance in eliminating rejection, realizing fairness, improving the social integration of rural floating population as for themselves or social harmony and stability of our country. In this practical background, the social integration of rural floating population and social support come into the view of academic research gradually, and obtain the attention of government and general public day by day. Based on this, changing the present state of rural floating population, enhancing their social status, making them integrated into the society rapidly, these not only influence the problem of fairness of rural floating population, but also The inevitable requirement of modernization development in our country, so that, establishing network which aims at rural floating population is particularly important and urgent.

Alzheimer's disease (AD) is a devastating neurodegenerative disease and there is no effective therapy for it. Peroxisome proliferators activated receptor-gamma (PPAR-γ) agonists is a promising therapeutic approach for AD and has been widely studied recently, but no consensus was available up to now. To clarify this point, a meta-analysis was performed. We searched MEDLINE, EMBASE, Cochrane Central database, PUBMED, Springer Link database, SDOS database, CBM, CNKI and Wan fang database by December 2014. Standardized mean difference (SMD), relative risk (RR) and 95% confidence interval (CI) were calculated to assess the strength of the novel therapeutics for AD and mild-to-moderate AD. A total of nine studies comprising 1314 patients and 1311 controls were included in the final meta-analysis. We found the effect of PPAR-γ agonists on Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-cog) scores by using STATA software. There was no evidence for obvious publication bias in the overall meta-analysis. There is insufficient evidence of statistically incognition of AD and mild-to-moderate AD patients have been improved who were treated with PPAR-γ agonists in our research. However, PPAR-γ agonists may be a promising therapeutic approach in future, especially pioglitazone, with large-scale randomized controlled trials to confirm.

In order to improve the information literature of young migrant workers and to speed up the urban social integration, this paper adopts literature review and data analysis method, to make the research. Results showed that the information quality of young workers were generally not high, mainly for the lack of awareness of the initiative to use information, lack the skills and knowledge of modern information platform, lack of awareness to resist the adverse information, and can't use library and other public information service resources. Therefore, information service support system should be established by the government, communities, non- governmental and organization composed, give full play to library public role to improve young migrant workers cultural quality and moral quality, accelerate the process of urbanization, and really realize the integration of urban society. I. DESCRIPTION OF THE PROBLEM "Migrant workers" is a new social group in the process of economic and social transformation in China. The latest statistics from the National Bureau of statistics showed that by the end of 2013, the total number of migrant workers in China is about 0.26 billion, and about 0.125 billion young farmers was born in the eighties of the twentieth century, accounting for 46.6% of the total number of migrant workers. Young migrant workers have a relatively higher cultural, high school and higher education level accounted for 1/3, which was 19.2% higher than the old generation of migrant workers (1) . This shows that half of the migrant workers are young. Compared with the older generation of migrant workers, young migrant workers have a higher cultural level, most of them had not engaged in agricultural production before, they were influence by urban life and peer group and came to the city, so they are more eager to really integrate into city life. But due to China's long-term implementation of the binary division of the household registration system, the real situation of young migrant workers showed that the young migrant workers could not really integrate into the city in employment, social security, political participation, social interaction, and was in the city's edge. The city's informatization, efficient, scientific and technological influence the young migrant workers all the time. Especially with the increase of the degree of urban informatization, the demand of the young migrant workers for information is becoming urgent more and more. Information literacy has been regarded as a necessary condition for people to enter the digital age. The information quality of young migrant workers will affect their city living conditions directly. Therefore to improve the information literacy of young migrant workers continuously, improve their ability to understanding, using and identification information is very important to change their life state at the edge of city, accelerate their pace to integration into the urban life.

The Tibetan population, long a resident on the Qinghai-Tibetan Plateau, has lower hemoglobin concentrations than Han Chinese migrants, but it is incompletely known how gender affects the hemoglobin concentrations in the two populations at various altitudes. Measurements of hemoglobin concentration were obtained in 5,887 healthy male and female Tibetan and Han residents aged 5–60 yr, at altitudes of 2,664, 3,813, 4,525, and 5,200 m. Multiple regression equations showed the β-coefficients for altitude and for age were higher ( P < 0.05) in Han men than in Tibetan men and in Han women than in Tibetan women. Analysis indicated a significant three-way interaction between altitude, gender, and ethnicity (χ2 = 3.72, P = 0.05). With increasing altitude, men progressively had more hemoglobin than women in the Han, but not the Tibetan, population. Above 2,664 m, this gender-related difference in hemoglobin concentration increased from childhood to young adulthood more in Han than in Tibetans. We suggest that the Han-Tibetan ethnic difference in the effect of altitude on hemoglobin concentration depends to a large extent on gender.

Alzheimer's disease (AD) is a chronic degenerative disorder. It is caused by both genetic and environmental factors. The association of Insulin Degrading Enzyme (IDE) genotypes rs4646953, rs2251101 and rs1544210 with AD has been detected, but the findings were conflicted, however, Apolipoprotein-E (APOE)-e4 allele has been observed as a genetic risk factor for AD. To investigate the issue, a meta-analysis was performed. We searched PubMed, Springer Link, AlzGene and CNKI for relevant literatures published by June 2013. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to explore the significant association. A total of 11 studies comprising 5771 cases and 5474 controls were considered in final meta-analysis. We found that weak connections existed between rs4646953 (TT vs. CC: z = 2.24, p = 0.025, OR = 1.536) and AD, but no significant associations have been found between other IDE gene single nucleotide polymorphisms of rs4646953, rs2251101 and rs1544210 with AD. We certified that APOE-e4 allele was still be a suspected factor to AD. There was no evidence for obvious publication bias in overall meta-analysis. Furthermore, larger-scale randomized controlled trials are necessary to validate the association between IDE gene polymorphisms with AD.

Background Recent studies of Toxoplasma gondii isolates from animals in different regions of China have shown a limited genetic diversity and type China 1 was the dominant genotype of T. gondii prevalent in Chinese animals. However, little has been known concerning the isolation and genotyping of T. gondii circulating in chickens, pigs and rodents in China. The aim of the study was to characterize samples of T. gondii isolates obtained from naturally infected cats, pigs and free-range chickens slaughtered for human consumption in China. Methods In the present study, brain tissues of 77 animals collected from different areas of China, including 24 free-range chickens (Gallus domesticus) , 13 voles (Rattus flavipectus), 23 pigs and 17 cats, were bioassayed in mice and viable T. gondii were isolated from the brains of eleven. These eleven T. gondii isolates were maintained in Kunming (KM) outbred mice and DNA isolated from tissues of infected mice was characterized using 11 PCR-restriction fragment length polymorphism (PCR-RFLP) markers: SAG1, SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1, Apico, and CS3. Moreover, to determine mouse virulence of China 1 lineage of parasites, a TgCtgy5 genotype isolate was selected randomly and assessed in KM mice with different inoculation doses. Results Results of genotyping revealed that ten isolates were type China 1 (ToxoDB PCR-RFLP genotype #9), and TgCksz1 was a new genotype that was reported for the first time designated here as ToxoDB PCR-RFLP #225. No clonal types I, II and III lineages were found. DNA sequencing of four introns (EF1, HP2, UPRT1 and UPRT7) and two genes (GRA6 and GRA7) from representative isolates confirmed the results of PCR-RFLP genotyping. The TgCtgy5 isolate was highly virulent in KM mice; all infected mice died of acute toxoplasmosis, irrespective of the inoculation dose. The results indicate that mouse virulent isolates of T. gondii are predominantly circulating in cats in China. Conclusions T. gondii isolated from chickens, pigs, cats and rodents in different locations in China were genotyped and the results reconfirmed the limited diversity of T. gondii in China and showed that type China 1 lineage was dominant in this country.