21 results on '"Huang-Hsi Chen"'
Search Results
2. Risk of primary Sjogren’s Syndrome following human papillomavirus infections: a nationwide population-based cohort study
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Huang-Hsi Chen, Kevin Sheng-Kai Ma, Chen Dong, Wen-Jung Chang, Kuan-Rong Gao, Wuu-Tsun Perng, Jing-Yang Huang, and James Cheng-Chung Wei
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Human papillomavirus ,infection ,autoimmunity ,primary Sjogren's Syndrome ,cohort study ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionViral infection is an exogeneous factor for primary Sjogren’s syndrome (pSS). This study investigated the association between human papillomavirus (HPV) infections and pSS through a nationwide population based cohort study.MethodsPatients with HPV infections between January, 1999 and December, 2013 were included. The incidence of new-onset pSS in patients with HPV infections and non-HPV controls were derived. The multiple Cox regression model derived the risk of pSS in patients with HPV infections. Subgroup analysis and sensitivity analysis were performed to validate the association.ResultsDuring a follow-up period of 12 years, the adjusted hazard ratio (aHR) of pSS in patients with HPV infections was significantly higher than that in non-HPV controls (aHR=1.64, 95% CI=1.47-1.83, P
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- 2022
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3. Traditional Chinese Medicine in Patients With Primary Sjogren's Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
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Huang-Hsi Chen, Jung-Nien Lai, Min-Chien Yu, Chia-Yin Chen, Yi-Ting Hsieh, Yi-Fan Hsu, and James Cheng-Chung Wei
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Sjogren's syndrome ,Jia-Wei-Xiao-Yao-San ,Gan-Lu-Yin ,randomized clinical trial ,efficacy ,safety ,Medicine (General) ,R5-920 - Abstract
Background: Sjogren's syndrome (SS) is a chronic inflammatory autoimmune disease mainly characterized by dryness, fatigue, and pain. Current therapies for SS in Western medicine are limited. The purpose of this clinical study was to explore the efficacy and safety of using a traditional Chinese medicine (TCM) formula on patients with primary SS.Methods: We performed a 12-week, randomized, double-blinded, placebo-controlled clinical trial at Chung Shan Medical University Hospital. We included 42 patients with SS between the ages of 20 and 80 years who met the classification criteria of the American and European Consensus Group (AECG). Patients who had other severe systemic manifestations or diseases were excluded from this trial. After screening, patients were randomly assigned to the TCM treatment group or placebo group (ratio of 2:1). We treated the TCM group with 6 g of Gan-Lu-Yin granules after breakfast and 6 g of Jia-Wei-Xiao-Yao-San combined with 1 g of Suan-Zao-Ren-Tang and 1 g of Ye-Jiao-Teng every night after dinner. Patients in the control group were treated with a placebo with the same appearance and flavor but only one-tenth the dosage of that received by the treatment group. The European League Against Rheumatism Sjogren's Syndrome Patient-Reported Index (ESSPRI) was used as the primary endpoint at week 12. Secondary endpoints were the Sjogren's Syndrome Disease Activity Index (SSDAI), physician global assessment (PGA), visual analogue scale (VAS), Multidimensional Fatigue Inventory, Medical Outcomes Survey Short Form-36, and the Pittsburgh Sleep Quality Score (PSQI). Adverse events were also recorded.Results: Of the 42 randomized patients, 28 patients were assigned to the TCM treatment group and 14 patients were assigned to the controlled group. During the study period, 5 patients withdrew from the TCM group and 7 withdrew from the control group. At week 12, the ESSPRI scores of both groups had improved. The ESSPRI score of the treatment group decreased by 0.62 (95% CI P = 0.557) and that of the placebo group decreased by 0.91 (P = 0.557). However, no significant difference was observed between the two groups. Sleep duration in the PSQI was −0.61, which exhibited an improvement of more than the −0.21 compared with the placebo group (P = 0.914).Conclusion: At week 12, the ESSPRI scores did not reveal that the use of the TCM formula was efficacious for treating patients with Sjogren's syndrome. However, the PSQI scores indicated that this formula could prolong patient sleep duration. We also found that this formula could decrease the blood pressure of patients.
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- 2021
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4. Methotrexate at middle and high accumulative doses might be associated with lower risk of new-onset cancers in patients with rheumatoid arthritis: a nationwide population-based cohort study
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Wuu-Tsun Perng, Yao-Min Hung, Renin Chang, Cheng-Li Lin, Jeng-Yuan Chiou, Huang-Hsi Chen, Chia-Hung Kao, and James Cheng-Chung Wei
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Diseases of the musculoskeletal system ,RC925-935 - Abstract
Background: We investigated whether taking methotrexate (MTX) is associated with a lower risk of new-onset cancers in patients with rheumatoid arthritis (RA). Methods: We conducted a 12-year retrospective cohort study from a population-based National Health Insurance Research Database in Taiwan. A total of 21,699 patients with newly diagnosed RA were enrolled during 2000–2009. The overall cancer rate was compared between 10,352 new users of MTX and 11,347 non-users. We used the WHO Defined Daily Dose (DDD) as a tool to assess drug exposure. Cox proportional hazard regression models were used to estimate the hazard ratio (HR) of disease after controlling for demographics and other comorbidities. Results: After adjusting for age, sex, cancer-related comorbidities, and RA-combined medication, the HR of cancer risk was 0.87 (95% CI = 0.74–1.02) for the MTX user group compared with the MTX non-user group. The cumulative incidence of cancer in the MTX non-user group was significantly higher than that of the MTX user group (log-rank test p
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- 2020
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5. Increased Risk of Systemic Lupus Erythematosus in Patients With Helicobacter pylori Infection: A Nationwide Population-Based Cohort Study
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Meng-Che Wu, Pui-Ying Leong, Jeng-Yuan Chiou, Huang-Hsi Chen, Jing-Yang Huang, and James Cheng-Chung Wei
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Helicobacter pylori ,systemic lupus erythematosus ,cohort study ,population based ,longitudinal health insurance research database ,Medicine (General) ,R5-920 - Abstract
Helicobacter pylori (HP) infection is associated with systemic lupus erythematosus (SLE), but the related results have been controversial. Therefore, this study investigated the association between HP infection and SLE by using a nationwide longitudinal population-based cohort. We identified 41,651 patients with HP infection and 83,302 matched controls between 2000 and 2013 from the Longitudinal Health Insurance Research Database of the National Taiwan Insurance Research Database. Age, gender, comorbidities, and medical visits were matched at a 1:2 ratio by using propensity score analysis. The adjusted hazard ratio (aHR) of SLE was calculated by multiple Cox regression. Furthermore, sensitivity test and stratified analysis were performed. The SLE incidence rate was 1.17 [95% confidence interval (CI): 0.89–1.54] per 100,000 person-months in the HP cohort, and the hazard ratio was 1.63 (95% CI: 1.12–2.37) in comparison with the propensity score-matched control cohort. After multivariate adjustment, patients with HP infection had a significantly high overall aHR (1.58; 95% CI: 1.08–2.30) of SLE. Stratified analysis revealed the aHR of 8.23 (95% CI: 1.77–38.32) in patients
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- 2020
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6. Impact of mycoplasma pneumonia infection on urticaria: A nationwide, population-based retrospective cohort study in Taiwan.
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Su-Boon Yong, Wei-Chu Yeh, Hsing-Ju Wu, Huang-Hsi Chen, Jing-Yang Huang, Tung-Ming Chang, and James Cheng-Chung Wei
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Medicine ,Science - Abstract
Mycoplasma pneumonia (MP) infection might be pathogenically closely related to urticaria. This study is a nationwide population-based cohort study from 1997 to 2013, which investigated the association between MP infection and urticaria in Taiwan. A total of 1,175 patients were included for the study group, and 2,350 for the control group. Multivariate Cox regression analysis was performed to estimate the adjusted hazard ratio (aHR) for urticaria. Result showed that 254 patients with new-onset urticaria were involved in the study group and 465 incident cases in the control group. The incidence rates (per 100,000 person-months) of urticaria were 37.2 and 32.5 in the study and control groups, respectively. The relative risk is 1.1 (95% CI = 1.0-1.3) indicating no significant correlation between MP and urticaria. The multivariate analysis revealed that the risk of urticaria with MP infection (aHR = 1.1, P = 0.1058) had no statistically significance difference compared to the control group. However, the risk of urticaria in MP-infected patients aged between 20 and 59 years old was found to have increased (aHR = 1.6, 95% CI = 1.1-2.2) prior to a diagnosis.
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- 2019
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7. Risk of primary Sjogren's Syndrome following human papillomavirus infections: a nationwide population-based cohort study.
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Huang-Hsi Chen, Sheng-Kai Ma, Kevin, Chen Dong, Wen-Jung Chang, Kuan-Rong Gao, Wuu-Tsun Perng, Jing-Yang Huang, and Cheng-Chung Wei, James
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SJOGREN'S syndrome ,HUMAN papillomavirus ,VIRUS diseases ,PAPILLOMAVIRUS diseases ,INFECTION - Abstract
Introduction: Viral infection is an exogeneous factor for primary Sjogren's syndrome (pSS). This study investigated the association between human papillomavirus (HPV) infections and pSS through a nationwide population based cohort study. Methods: Patients with HPV infections between January, 1999 and December, 2013 were included. The incidence of new-onset pSS in patients with HPV infections and non-HPV controls were derived. The multiple Cox regression model derived the risk of pSS in patients with HPV infections. Subgroup analysis and sensitivity analysis were performed to validate the association. Results: During a follow-up period of 12 years, the adjusted hazard ratio (aHR) of pSS in patients with HPV infections was significantly higher than that in non-HPV controls (aHR=1.64, 95% CI=1.47-1.83, P<0.001). The risk of pSS increased with age and the risk increased by 2.64-fold (95% CI= 2.37-2.93) for those older than 45 years. The significant association between HPV infections and the risk of pSS persisted in the sensitivity analysis restricted in HPV infections that lasted over 12 months (aHR=1.63, 95%CI=1.45-1.83, P<0.0001). Subgroup analyses revealed that both male (aHR=1.83, 95%CI=1.47-2.28, P<0.0001) and female (aHR=1.58, 95%CI=1.40-1.79, P<0.0001) patients with HPV infections and HPVinfected patients aged between 16 and 45 years (aHR=1.60, 95%CI=1.34-1.91, P<0.0001) and over 45 years (aHR=1.67, 95%CI=1.46-1.91, P<0.0001) were associated with a significantly greater risk of pSS. Conclusion: Patients with HPV infections presented with a significantly higher risk of pSS, regardless of age and sex. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Effect of early eradication therapy on systemic lupus erythematosus risk in patients with Helicobacter pylori infection: a nationwide population-based cohort study
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Huang-Hsi Chen, Meng-Che Wu, James Cheng-Chung Wei, and Jing-Yang Huang
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030203 arthritis & rheumatology ,medicine.medical_specialty ,Helicobacter pylori infection ,biology ,business.industry ,macromolecular substances ,Population based ,Helicobacter pylori ,biology.organism_classification ,03 medical and health sciences ,Population based cohort ,0302 clinical medicine ,Rheumatology ,Internal medicine ,medicine ,030211 gastroenterology & hepatology ,In patient ,business ,Cohort study - Abstract
Background This study aimed to investigate whether early eradication therapy influences systemic lupus erythematosus (SLE) risk in patients with Helicobacter pylori (HP) infection. Methods We identified 41,653 patients with HP infection in Taiwan from 2000 to 2013. The patient population was divided into early (within three months) and late (after three months) eradication cohorts. age, sex, co-morbidities and medical visits were matched at a 1:1 ratio. Multiple Cox regression, sensitivity analysis and stratified analysis were used to estimate SLE adjusted hazard ratios (aHR). Results The relative risk of SLE was 0.75 (95% confidence interval 0.43–1.31) in the early eradication cohort. After multivariate adjustment, the SLE risk was non-significantly lower in the early eradication cohort than in the late eradication cohort (aHR = 0.74, 95% CI 0.42–1.29). Stratified analysis revealed that early eradication could significantly reduce SLE risk during the three-year follow-up period (aHR = 0.16, 95% CI 0.05–0.53, p for interaction = 0.0013). Compared to eradication within three months of diagnosis, eradication within 3–36 months and >36 months corresponded with SLE aHRs of 4.78 (95% CI 1.19–19.20) and 7.66 (95% CI 2.17–27.05), respectively, when the follow-up period was less than three years. Conclusion Early HP eradication could significantly reduce SLE risk, especially in the first three-year follow-up.
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- 2020
9. Methotrexate at middle and high accumulative doses might be associated with lower risk of new-onset cancers in patients with rheumatoid arthritis: a nationwide population-based cohort study
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Huang-Hsi Chen, Yao-Min Hung, Wuu-Tsun Perng, Jeng-Yuan Chiou, James Cheng-Chung Wei, Renin Chang, Chia-Hung Kao, and Cheng-Li Lin
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rheumatoid arthritis ,medicine.medical_specialty ,Diseases of the musculoskeletal system ,Lower risk ,methotrexate ,New onset ,03 medical and health sciences ,Population based cohort ,0302 clinical medicine ,Rheumatology ,Internal medicine ,cohort study ,medicine ,cancer ,Orthopedics and Sports Medicine ,In patient ,030212 general & internal medicine ,Original Research ,030203 arthritis & rheumatology ,business.industry ,Cancer ,medicine.disease ,RC925-935 ,Rheumatoid arthritis ,Methotrexate ,business ,medicine.drug ,Cohort study - Abstract
Background: We investigated whether taking methotrexate (MTX) is associated with a lower risk of new-onset cancers in patients with rheumatoid arthritis (RA). Methods: We conducted a 12-year retrospective cohort study from a population-based National Health Insurance Research Database in Taiwan. A total of 21,699 patients with newly diagnosed RA were enrolled during 2000–2009. The overall cancer rate was compared between 10,352 new users of MTX and 11,347 non-users. We used the WHO Defined Daily Dose (DDD) as a tool to assess drug exposure. Cox proportional hazard regression models were used to estimate the hazard ratio (HR) of disease after controlling for demographics and other comorbidities. Results: After adjusting for age, sex, cancer-related comorbidities, and RA-combined medication, the HR of cancer risk was 0.87 (95% CI = 0.74–1.02) for the MTX user group compared with the MTX non-user group. The cumulative incidence of cancer in the MTX non-user group was significantly higher than that of the MTX user group (log-rank test p Conclusion: MTX at middle and high accumulative doses might be associated with lower risk of new-onset cancers in patients with RA.
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- 2020
10. Relationship between Helicobacter pylori infection and psoriasis: a nationwide population-based longitudinal cohort study
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Jing-Yang Huang, Kevin Sheng-Kai Ma, Huang-Hsi Chen, Meng-Che Wu, and James Cheng-Chung Wei
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Adult ,Male ,medicine.medical_specialty ,Population ,Taiwan ,Observational Study ,Risk Assessment ,Helicobacter Infections ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Psoriasis ,Internal medicine ,medicine ,cohort study ,Humans ,030212 general & internal medicine ,Longitudinal Studies ,education ,Aged ,education.field_of_study ,Helicobacter pylori ,Proportional hazards model ,business.industry ,Hazard ratio ,General Medicine ,psoriasis ,Middle Aged ,medicine.disease ,Confidence interval ,population-based ,030220 oncology & carcinogenesis ,Relative risk ,Female ,Risk assessment ,business ,Cohort study ,Research Article - Abstract
Background: In the current literature, studies assessing the role of Helicobacter pylori (HP) infection in psoriasis have reported conflicting data. Therefore, we investigated the association between HP infection and psoriasis using a nationwide population-based longitudinal cohort study. Methods: We identified 41,539 patients with HP infection and 83,078 matched controls between 2000 and 2013 from the Longitudinal Health Insurance Research Database of the National Health Insurance Research Database in Taiwan. Propensity score analysis was used to match age, sex, comorbidities, and medical visits at a ratio of 1:2. Multiple Cox regression analysis was used to estimate the adjusted hazard ratio of psoriasis. Furthermore, sensitivity tests and a stratified analysis were conducted. Results: The incidence rates of psoriasis did not differ significantly between the HP and control cohorts (4.58 vs 4.20 per 100,000 person-months, crude relative risk: 1.092, 95% confidence interval: 0.917–1.302). After multivariate adjustment, no significant difference in psoriasis risk was observed in patients with HP infection (adjusted hazard ratio: 1.081, 95% confidence interval: 0.907–1.288). Risk of psoriasis was significantly higher in men and the elderly, and in those with diabetes, hyperlipidemia, chronic obstructive pulmonary disease, or tuberculosis. Stratified analysis also confirmed that HP infection was not correlated with an increased risk of psoriasis based on follow-up duration, sex, and age. Conclusion: This retrospective population-based longitudinal cohort study, conducted in Taiwan, found no association between HP infection and risk of psoriasis. Further research may be warranted.
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- 2020
11. Effect of early eradication therapy on systemic lupus erythematosus risk in patients with
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Meng-Che, Wu, Jing-Yang, Huang, Huang-Hsi, Chen, and James Cheng-Chung, Wei
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Adult ,Male ,Taiwan ,Comorbidity ,Middle Aged ,Risk Assessment ,Helicobacter Infections ,Time-to-Treatment ,Cohort Studies ,Treatment Outcome ,Risk Factors ,Humans ,Lupus Erythematosus, Systemic ,Female ,Aged ,Proportional Hazards Models - Abstract
This study aimed to investigate whether early eradication therapy influences systemic lupus erythematosus (SLE) risk in patients withWe identified 41,653 patients with HP infection in Taiwan from 2000 to 2013. The patient population was divided into early (within three months) and late (after three months) eradication cohorts. age, sex, co-morbidities and medical visits were matched at a 1:1 ratio. Multiple Cox regression, sensitivity analysis and stratified analysis were used to estimate SLE adjusted hazard ratios (aHR).The relative risk of SLE was 0.75 (95% confidence interval 0.43-1.31) in the early eradication cohort. After multivariate adjustment, the SLE risk was non-significantly lower in the early eradication cohort than in the late eradication cohort (aHR = 0.74, 95% CI 0.42-1.29). Stratified analysis revealed that early eradication could significantly reduce SLE risk during the three-year follow-up period (aHR = 0.16, 95% CI 0.05-0.53,Early HP eradication could significantly reduce SLE risk, especially in the first three-year follow-up.
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- 2020
12. sj-pdf-3-tab-10.1177_1759720X20981221 – Supplemental material for Methotrexate at middle and high accumulative doses might be associated with lower risk of new-onset cancers in patients with rheumatoid arthritis: a nationwide population-based cohort study
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Wuu-Tsun Perng, Hung, Yao-Min, Renin Chang, Lin, Cheng-Li, Jeng-Yuan Chiou, Huang-Hsi Chen, Chia-Hung Kao, and Wei, James Cheng-Chung
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FOS: Clinical medicine ,110604 Sports Medicine ,FOS: Health sciences ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,110314 Orthopaedics - Abstract
Supplemental material, sj-pdf-3-tab-10.1177_1759720X20981221 for Methotrexate at middle and high accumulative doses might be associated with lower risk of new-onset cancers in patients with rheumatoid arthritis: a nationwide population-based cohort study by Wuu-Tsun Perng, Yao-Min Hung, Renin Chang, Cheng-Li Lin, Jeng-Yuan Chiou, Huang-Hsi Chen, Chia-Hung Kao and James Cheng-Chung Wei in Therapeutic Advances in Musculoskeletal Disease
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- 2020
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13. sj-pdf-1-tab-10.1177_1759720X20981221 – Supplemental material for Methotrexate at middle and high accumulative doses might be associated with lower risk of new-onset cancers in patients with rheumatoid arthritis: a nationwide population-based cohort study
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Wuu-Tsun Perng, Hung, Yao-Min, Renin Chang, Lin, Cheng-Li, Jeng-Yuan Chiou, Huang-Hsi Chen, Chia-Hung Kao, and Wei, James Cheng-Chung
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FOS: Clinical medicine ,110604 Sports Medicine ,FOS: Health sciences ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,110314 Orthopaedics - Abstract
Supplemental material, sj-pdf-1-tab-10.1177_1759720X20981221 for Methotrexate at middle and high accumulative doses might be associated with lower risk of new-onset cancers in patients with rheumatoid arthritis: a nationwide population-based cohort study by Wuu-Tsun Perng, Yao-Min Hung, Renin Chang, Cheng-Li Lin, Jeng-Yuan Chiou, Huang-Hsi Chen, Chia-Hung Kao and James Cheng-Chung Wei in Therapeutic Advances in Musculoskeletal Disease
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- 2020
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14. sj-pdf-2-tab-10.1177_1759720X20981221 – Supplemental material for Methotrexate at middle and high accumulative doses might be associated with lower risk of new-onset cancers in patients with rheumatoid arthritis: a nationwide population-based cohort study
- Author
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Wuu-Tsun Perng, Hung, Yao-Min, Renin Chang, Lin, Cheng-Li, Jeng-Yuan Chiou, Huang-Hsi Chen, Chia-Hung Kao, and Wei, James Cheng-Chung
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FOS: Clinical medicine ,110604 Sports Medicine ,FOS: Health sciences ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,110314 Orthopaedics - Abstract
Supplemental material, sj-pdf-2-tab-10.1177_1759720X20981221 for Methotrexate at middle and high accumulative doses might be associated with lower risk of new-onset cancers in patients with rheumatoid arthritis: a nationwide population-based cohort study by Wuu-Tsun Perng, Yao-Min Hung, Renin Chang, Cheng-Li Lin, Jeng-Yuan Chiou, Huang-Hsi Chen, Chia-Hung Kao and James Cheng-Chung Wei in Therapeutic Advances in Musculoskeletal Disease
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- 2020
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15. Impact of chronic urticaria on systemic lupus erythematosus: A nationwide population-based study in Taiwan
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James Cheng-Chung Wei, Su-Boon Yong, Jing-Yang Huang, Kuan-Wen Su, Hsing-Ju Wu, and Huang-Hsi Chen
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Adult ,Male ,medicine.medical_specialty ,Urticaria ,Population ,Taiwan ,Comorbidity ,Dermatology ,Disease ,medicine.disease_cause ,Risk Assessment ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Risk Factors ,immune system diseases ,Internal medicine ,Humans ,Lupus Erythematosus, Systemic ,Medicine ,skin and connective tissue diseases ,education ,Chronic urticaria ,Retrospective Studies ,education.field_of_study ,business.industry ,Incidence ,Incidence (epidemiology) ,Hazard ratio ,General Medicine ,Length of Stay ,Middle Aged ,Immune dysregulation ,medicine.disease ,030220 oncology & carcinogenesis ,Chronic Disease ,Female ,business ,Cohort study - Abstract
Chronic urticaria (CU) may be closely pathogenically related to systemic lupus erythematosus (SLE). This study aims to investigate the association between CU and SLE patients in Taiwan. A nationwide population-based cohort study from 1997 to 2013 was conducted. Investigated subjects were selected from the Taiwan National Health Insurance Research Database using the International Classification of Disease, Ninth Revision code. Participants consisted of 13 845 subjects newly diagnosed with CU from 2003 to 2013. We estimated the incidence risk of SLE among patients with CU by time-to-event analysis. Patients with CU were more likely to be female, and had a significant difference in urbanization and length of hospital stays (P < 0.0001). The incidence rates of SLE for the CU and control groups were 3.55 and 1.68, respectively. The crude hazard ratio of SLE among subjects with CU was 2.113 compared with the non-urticarial control group. After adjusting the demographic, length of hospital stay and comorbidity, the adjusted hazard ratio (aHR) of SLE was still significantly higher in the CU group (aHR = 2.113) compared with the control group. The use of non-steroidal anti-inflammatory drugs or corticosteroids may decrease the risk of SLE in patients with CU (P = 0.0216 and 0.0120, respectively). In conclusion, CU is associated with a higher risk of incidental SLE in this population-based, nationwide, cohort study. Inflammation and immune dysregulation are considered two potential mechanisms. Clinically, patients with urticaria should be carefully evaluated for risk of future SLE.
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- 2018
16. Patients with urticaria are at a higher risk of anaphylaxis: A nationwide population-based retrospective cohort study in Taiwan
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Jing-Yang Huang, James Cheng-Chung Wei, Su-Boon Yong, and Huang-Hsi Chen
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Adult ,Male ,Allergy ,medicine.medical_specialty ,Urticaria ,Population ,Taiwan ,Comorbidity ,Dermatology ,Young Adult ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Patient Education as Topic ,Risk Factors ,immune system diseases ,Internal medicine ,medicine ,Humans ,skin and connective tissue diseases ,education ,Anaphylaxis ,Retrospective Studies ,Asthma ,030201 allergy ,education.field_of_study ,business.industry ,Confounding ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Confidence interval ,Rheumatoid arthritis ,Female ,business - Abstract
The clinical features of urticaria and anaphylaxis are similar, and they share common causal immune-mediated pathways. We aimed to investigate the risk of anaphylaxis among patients with urticaria. A 12-year population-based retrospective cohort study was conducted. Investigated subjects were identified from the Taiwan National Health Insurance Research Database by the International Classification of Disease, Ninth Revision, Clinical Modification. We included 126 031 subjects with newly diagnosed urticaria and 252 062 matched controls between 2000 and 2013. Risk of anaphylaxis among patients with urticaria was calculated by calculating adjusted hazards ratios (HR) after matching for confounding comorbidities. Urticaria was more common in women than it was in men (58% vs 42%), with a peak onset age of 20-40 years. The number of comorbidities including asthma, allergic rhinitis, herpes zoster, hepatitis B and C, rheumatoid arthritis and gout were higher in patients with urticaria than that in age- and sex-matched controls. The crude HR for anaphylaxis among urticaria subjects was 2.883 (95% confidence interval [CI], 2.787-2.982; P < 0.001). After adjustment for potential confounders which have been proposed to increase the risk of anaphylaxis, patients with urticaria were found to be at a significantly high risk of anaphylaxis with an adjusted HR of 2.529 (95% CI, 2.442-2.619; P < 0.001). We conclude that the incidence rate of anaphylaxis is significantly high in patients with urticaria in Taiwan.
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- 2018
17. Impact of mycoplasma pneumonia infection on urticaria: A nationwide, population-based retrospective cohort study in Taiwan
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Wei-Chu Yeh, Jing-Yang Huang, Hsing-Ju Wu, James Cheng-Chung Wei, Tung-Ming Chang, Huang-Hsi Chen, and Su-Boon Yong
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Male ,Bacterial Diseases ,Mycoplasma Pneumonia ,Urticaria ,Pulmonology ,Pathology and Laboratory Medicine ,Pediatrics ,030207 dermatology & venereal diseases ,Mycoplasma ,0302 clinical medicine ,Risk Factors ,immune system diseases ,Medicine and Health Sciences ,Mycoplasma Pneumoniae ,Longitudinal Studies ,Child ,skin and connective tissue diseases ,education.field_of_study ,Multidisciplinary ,Incidence ,Incidence (epidemiology) ,Hazard ratio ,Middle Aged ,Bacterial Pathogens ,Infectious Diseases ,Medical Microbiology ,Child, Preschool ,Medicine ,Female ,Pathogens ,Pediatric Infections ,Research Article ,Cohort study ,Adult ,medicine.medical_specialty ,Adolescent ,Science ,Population ,Taiwan ,Mollicutes ,Dermatology ,Microbiology ,Young Adult ,03 medical and health sciences ,Diagnostic Medicine ,Streptococcal Infections ,Internal medicine ,Pneumonia, Mycoplasma ,parasitic diseases ,Upper Respiratory Tract Infections ,medicine ,Humans ,Propensity Score ,education ,Microbial Pathogens ,Proportional Hazards Models ,Retrospective Studies ,030203 arthritis & rheumatology ,Bacteria ,Proportional hazards model ,business.industry ,Organisms ,Biology and Life Sciences ,Retrospective cohort study ,Pneumonia ,medicine.disease ,Relative risk ,Multivariate Analysis ,Respiratory Infections ,Mycoplasma pneumonia ,business - Abstract
Mycoplasma pneumonia (MP) infection might be pathogenically closely related to urticaria. This study is a nationwide population-based cohort study from 1997 to 2013, which investigated the association between MP infection and urticaria in Taiwan. A total of 1,175 patients were included for the study group, and 2,350 for the control group. Multivariate Cox regression analysis was performed to estimate the adjusted hazard ratio (aHR) for urticaria. Result showed that 254 patients with new-onset urticaria were involved in the study group and 465 incident cases in the control group. The incidence rates (per 100,000 person-months) of urticaria were 37.2 and 32.5 in the study and control groups, respectively. The relative risk is 1.1 (95% CI = 1.0–1.3) indicating no significant correlation between MP and urticaria. The multivariate analysis revealed that the risk of urticaria with MP infection (aHR = 1.1, P = 0.1058) had no statistically significance difference compared to the control group. However, the risk of urticaria in MP-infected patients aged between 20 and 59 years old was found to have increased (aHR = 1.6, 95% CI = 1.1–2.2) prior to a diagnosis.
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- 2019
18. Risk of dementia among patients with Sjogren's syndrome: A nationwide population-based cohort study in Taiwan
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Yu-Hsun Wang, Jing-Yang Huang, Wuu-Tsun Perng, James Cheng-Chung Wei, Huang-Hsi Chen, and Jeng-Yuan Chiou
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Male ,medicine.medical_specialty ,Databases, Factual ,Population ,Taiwan ,Comorbidity ,Rheumatology ,Risk Factors ,Internal medicine ,mental disorders ,Prevalence ,Medicine ,Dementia ,Humans ,Longitudinal Studies ,education ,Propensity Score ,Aged ,Proportional Hazards Models ,Retrospective Studies ,education.field_of_study ,business.industry ,Proportional hazards model ,Incidence (epidemiology) ,Case-control study ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Anesthesiology and Pain Medicine ,Sjogren's Syndrome ,Case-Control Studies ,Cohort ,Female ,business - Abstract
Autoimmunity may play a role in early-stage dementia. The association between Sjogren's syndrome (SS) and dementia remains unknown. This study was conducted to provide epidemiologic evidence for this relationship.This 12-year, nationwide, population-based, retrospective cohort study analyzed the risk of dementia in the SS cohort. We also investigated the incidence of dementia among patients with SS by using data from the Longitudinal Health Insurance Database 2000, maintained by the Taiwan National Health Research Institutes. To balance the prevalence of characteristics in the cohorts, we used the propensity score to match selected comorbidities in the two cohorts. We also analyzed the association between SS and dementia among patients with different potential risks by using a Cox proportional hazard model.According to the analysis of data obtained from follow-up conducted during 2000-2012, the incidence of dementia in the SS cohort was 1.21-fold that in the control cohort (95% confidence interval [CI] = 1.02-1.45, p 0.05). In the group older than 65years, the incidence of dementia was significantly high (adjusted hazard ratio [aHR] = 5.30, 95% CI = 4.26-6.60, p 0.01). After adjustment for comorbidities, including Parkinson's disease (aHR = 2.98, 95% CI = 1.80-4.94), insomnia (aHR = 1.45, 95% CI = 1.14-1.85), and hypertension (aHR = 1.43, 95% CI = 1.19-1.71), the association between SS and dementia was still significant.This 13-year, nationwide, population-based retrospective cohort study revealed patients with SS to have a higher risk of dementia.
- Published
- 2018
19. Increased risk of coronary heart disease among patients with primary Sjögren’s syndrome: a nationwide population-based cohort study
- Author
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Huang-Hsi Chen, Jing-Yang Huang, Jeng-Yuan Chiou, Lingli Dong, James Cheng-Chung Wei, and Xue-Fen Wu
- Subjects
Adult ,Male ,musculoskeletal diseases ,medicine.medical_specialty ,Adolescent ,Taiwan ,lcsh:Medicine ,Coronary Disease ,030204 cardiovascular system & hematology ,Risk Assessment ,Article ,Cohort Studies ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,Internal medicine ,Humans ,Medicine ,Cumulative incidence ,cardiovascular diseases ,Young adult ,Risk factor ,lcsh:Science ,Aged ,030203 arthritis & rheumatology ,Multidisciplinary ,business.industry ,Incidence ,Incidence (epidemiology) ,lcsh:R ,Anti-Inflammatory Agents, Non-Steroidal ,Hazard ratio ,Age Factors ,Middle Aged ,eye diseases ,stomatognathic diseases ,Sjogren's Syndrome ,Increased risk ,lcsh:Q ,Female ,Steroids ,business ,Risk assessment ,Cohort study - Abstract
To investigate the association between primary Sjögren’s syndrome (pSS) and coronary heart disease (CHD), and the influence of medications for pSS patients on risk of CHD. The authors identified 4175 patients with a new diagnosis of pSS between 2002 and 2013 from the National Health Insurance Research database. The control-to-case ratio was 4:1. The risk and cumulative incidences of CHD were calculated. The adjusted hazard ratio (HR) of CHD for pSS patients was 1.17 (1.03–1.34) after adjusting for age, sex, comorbidities, and medications. The cumulative incidence for CHD in the pSS group was significantly higher than that in the control group (log-rank p
- Published
- 2018
20. Statins can increase the risk of herpes zoster infection in Asia
- Author
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Huang-Hsi Chen, Chih-Jung Yeh, Cheng-Li Lin, Chia-Hung Kao, and Su-Yin Yeh
- Subjects
Adult ,Male ,Risk ,Microbiology (medical) ,medicine.medical_specialty ,Asia ,Statin ,Databases, Factual ,medicine.drug_class ,Comorbidity ,Herpes Zoster ,Cohort Studies ,Young Adult ,Internal medicine ,medicine ,Humans ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Proportional hazards model ,Incidence ,Incidence (epidemiology) ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Confidence interval ,Surgery ,Infectious Diseases ,Cohort ,Female ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business ,Cohort study - Abstract
This study evaluated whether statin therapy increases the risk of herpes zoster (HZ) infection in Asia. This retrospective cohort study used the Longitudinal Health Insurance Database (LHID2000). From the LHID2000, patients aged 20 years were divided into two cohorts according to their statin use and were matched at a 1:1 ratio according to propensity scores, which were calculated using a logistic regression for estimating the probability of treatment assignment. The primary outcome was HZ infection. All patients were followed from the index date until the date of HZ infection, withdrawal from the insurance system, or the end of 2011. The study included 53,069 patients receiving statin therapy as a statin cohort and 53,069 patients without statin therapy as a nonstatin cohort. The mean follow-up durations for the statin cohort and nonstatin cohort were 4.89 [standard deviation (SD) = 2.86] years and 4.75 (SD = 2.90) years, respectively. The patients in the statin cohort had a 21 % higher risk of contracting HZ infection than the patients in the nonstatin cohort [95 % confidence interval (CI) = 1.13-1.29]. The incidence of HZ infection increased with the Charlson comorbidity index (CCI) score in both cohorts. A high mean defined daily dose of the six types of statins considered in this study was associated with a significantly increased risk of HZ infection. Statin therapy can increase HZ infection in Asia. More benefit-risk evaluations for statin use are necessary in Asia.
- Published
- 2015
21. Relationship between Helicobacter pylori infection and psoriasis: a nationwide population-based longitudinal cohort study.
- Author
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Meng-Che Wu, Kevin Sheng-Kai Ma, Huang-Hsi Chen, Jing-Yang Huang, James Cheng-Chung Wei, Wu, Meng-Che, Ma, Kevin Sheng-Kai, Chen, Huang-Hsi, Huang, Jing-Yang, and Wei, James Cheng-Chung
- Published
- 2020
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