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Your search keyword '"Huang, Zi-Liang"' showing total 11 results
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11 results on '"Huang, Zi-Liang"'

4. SARS-CoV-2 causes a significant stress response mediated by small RNAs in the blood of COVID-19 patients

Author

Liu, Xi, Wen, Yan-Zi, Huang, Zi-Liang, Shen, Xia, Wang, Jun-Hao, Luo, Yi-Hai, Chen, Wen-Xin, Lun, Zhao-Rong, Li, Hui-Bin, Qu, Liang-Hu, Shan, Hong, and Zheng, Ling-Ling

Subjects
stress, microRNAs (miRNAs), small RNAs, Drug Discovery, Molecular Medicine, coronavirus disease 2019 (COVID-19), Original Article, Therapeutics. Pharmacology, RM1-950, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), tRNA-derived small RNAs (tsRNAs)
Abstract

SARS-CoV-2 has had a serious impact on the world. In this study, small RNAs from the blood of COVID-19 patients with moderate or severe symptoms were extracted for high-throughput sequencing and analysis. Interestingly, the levels of a special group of tRNA-derived small RNAs (tsRNAs) were found to be dramatically upregulated after SARS-CoV-2 infection, particularly in COVID-19 patients with severe symptoms. In particular, the 3'CCA tsRNAs from Gly-tRNA were highly consistent with the inflammation indicator C-reactive protein (CRP). In addition, we found that the majority of significantly changed microRNAs (miRNAs) were associated with endoplasmic reticulum (ER)/unfolded protein response (UPR) sensors, which may lead to the induction of proinflammatory cytokine and immune responses. This study found that SARS-CoV-2 infection caused significant changes in the levels of stress-associated small RNAs in patient blood and their potential functions. Our research revealed that the cells of COVID-19 patients undergo tremendous stress and respond, which can be reflected or regulated by sncRNAs, thus providing potential thought for therapeutic intervention in COVID-19 by modulating small RNA levels or activities., Graphical Abstract, Analysis of small RNA sequencing data revealed that tsRNA and microRNA levels in the blood of COVID-19 patients have undergone drastic changes, and these changes are related to stress responses. It implies that small RNA has the potential to be a drug or therapeutic target for COVID-19.

Published
2021

7. ColorCells: a database of expression, classification and functions of lncRNAs in single cells.

Author

Zheng, Ling-Ling, Xiong, Jing-Hua, Zheng, Wu-Jian, Wang, Jun-Hao, Huang, Zi-Liang, Chen, Zhi-Rong, Sun, Xin-Yao, Zheng, Yi-Min, Zhou, Ke-Ren, Li, Bin, Liu, Shun, Qu, Liang-Hu, and Yang, Jian-Hua

Subjects
LINCRNA, CLASSIFICATION
Abstract

Although long noncoding RNAs (lncRNAs) have significant tissue specificity, their expression and variability in single cells remain unclear. Here, we developed ColorCells (http://rna.sysu.edu.cn/colorcells/), a resource for comparative analysis of lncRNAs expression, classification and functions in single-cell RNA-Seq data. ColorCells was applied to 167 913 publicly available scRNA-Seq datasets from six species, and identified a batch of cell-specific lncRNAs. These lncRNAs show surprising levels of expression variability between different cell clusters, and has the comparable cell classification ability as known marker genes. Cell-specific lncRNAs have been identified and further validated by in vitro experiments. We found that lncRNAs are typically co-expressed with the mRNAs in the same cell cluster, which can be used to uncover lncRNAs' functions. Our study emphasizes the need to uncover lncRNAs in all cell types and shows the power of lncRNAs as novel marker genes at single cell resolution. [ABSTRACT FROM AUTHOR]

Published
2021
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