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6. Lack of adipocyte FAM20C improves whole body glucose homeostasis.

Author

Deng, Liping, Huang, Yanshan, Zhao, Feifei, Chen, Puxin, and Huang, Xiaohong

Subjects
*FATTY liver, *KNOCKOUT mice, *INSULIN sensitivity, *ADIPOSE tissues, *TISSUE expansion
Abstract

FAM20C, a member of the family with sequence similarity 20, is involved in many physiological functions. Obesity, characterized by excessive accumulation of adipose tissue, has attracted more and more attention as a worldwide health problem. Here we generated adipocyte‐specific FAM20C knockout mice to investigate the role of FAM20C in adipose tissue expansion and obesity. Our results demonstrate that knockout mice are protected against high fat diet‐induced obesity, adiposity, and fatty liver disease. Additionally, knockout mice exhibited improved metabolic phenotypes, including enhanced glucose tolerance and insulin sensitivity compared with control mice. Furthermore, we observed reduced inflammatory infiltration and collagen deposition in the adipose tissues of knockout mice. Taken together, our results indicate that targeting FAM20C in adipocytes may be a promising strategy for the treatment of obesity and associated metabolic disorders. [ABSTRACT FROM AUTHOR]

Published
2024
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7. DR10627, a Novel Dual Glucagon‑like Peptide‑1 and Gastric Inhibitory Polypeptide Receptor Agonist for the Treatment of Obesity and Type 2 Diabetes Mellitus

Author

Shao,Yujian, Chen,Yonglu, Zhu,Mingyue, Liu,Yuanyuan, Fang,Chen, Wang,Minjun, Sun,Peng, Fu,Weiling, Huang,Jing, Sheng,Shimei, Huang,Yanshan, Shao,Yujian, Chen,Yonglu, Zhu,Mingyue, Liu,Yuanyuan, Fang,Chen, Wang,Minjun, Sun,Peng, Fu,Weiling, Huang,Jing, Sheng,Shimei, and Huang,Yanshan

Abstract

Yujian Shao,1,2 Yonglu Chen,2 Mingyue Zhu,3 Yuanyuan Liu,2 Chen Fang,3 Minjun Wang,2 Peng Sun,3 Weiling Fu,2 Jing Huang,3 Shimei Sheng,2 Yanshan Huang2 1Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Innovative Drug Discovery and Development, Zhejiang Doer Biologics Co., Ltd, Hangzhou, Zhejiang, People’s Republic of China; 3First Research Institute, Zhejiang Heze Pharmaceutical Technology Co., Ltd, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Yanshan Huang, Department of Innovative Drug Discovery and Development, Zhejiang Doer Biologics Co., Ltd, Hangzhou, Zhejiang, People’s Republic of China, Email yanshanhuang@doerbio.comIntroduction: Diabetes and obesity are momentous risk factors threatening people’s lives and health. Currently available incretin analogue glucagon-like peptide 1 (GLP-1) possesses huge hypoglycemic effect with the unsatisfactory effect of weight loss. Co-agonists targeting GLP-1R plus glucagon receptor (GCGR) or gastric inhibitory polypeptide receptor (GIPR) show synergistic benefits in glycaemic control and weight loss. Here, we describe a novel dual GIP and GLP-1 receptor agonist, DR10627, and performed a preclinical assessment of it.Methods: The agonistic ability of DR10627 was indirectly assessed by inducing cAMP accumulation in Chinese hamster ovary (CHO) cells transfected with GLP-1R or GIPR in vitro. The plasma pharmacokinetics of DR10627 were analysed in cynomolgus monkeys. The OGTTs were performed in Sprague‑Dawley (SD) rats. The glucose lowering effects were evaluated by repeated administration of DR10627 in diabetic (db/db) mice for 4 weeks. The effects of anti-obesity and improving metabolism of DR10627 were evaluated by repeated administration of DR10627 in diet-induced obesity (DIO) mice for 57 days.Results: DR10627 had the capacity to activate both GLP-1R and GIPR in vitro. The terminal half-life of DR10627 was found to be appr

Published
2024

8. P‐83: The Development of Mask‐Reduction Technology in LTPS LCD.

Author

Lan, Xuexin, Liu, Bingping, Lin, Chunrong, Zheng, Lihua, Huang, Yanshan, Chen, Shaoyun, and Yang, Xianyan

Subjects
MANUFACTURING processes, PRICES
Abstract

In order to gain a price advantage in the competition with AMOLED and a‐Si LCD, the manufacturing process of LTPS LCD is simplified. Several mask‐reduction technologies such as SALDD, LSM lessness, and PLN lessness are developed, and LTPS LCD with 9‐mask, 8‐mask, and 7‐mask technologies has been mass produced. [ABSTRACT FROM AUTHOR]

Published
2024
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9. The optimal time and clinical implications of measurable residual disease detection in mantle cell lymphoma

Author

Yi, Shuhua, primary, Yan, Yuting, additional, Huang, Yanshan, additional, Yu, Ying, additional, li, yuxi, additional, Lv, Rui, additional, Wang, Tingyu, additional, Xiong, Wenjie, additional, Wang, Yi, additional, Wang, Qi, additional, Liu, Wei, additional, An, Gang, additional, Sui, Weiwei, additional, Xu, Yan, additional, Huang, Wenyang, additional, Zou, Dehui, additional, and Qiu, Lugui, additional

Published
2023
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10. DR10627, a Novel Dual Glucagon‑like Peptide‑1 and Gastric Inhibitory Polypeptide Receptor Agonist for the Treatment of Obesity and Type 2 Diabetes Mellitus.

Author

Shao, Yujian, Chen, Yonglu, Zhu, Mingyue, Liu, Yuanyuan, Fang, Chen, Wang, Minjun, Sun, Peng, Fu, Weiling, Huang, Jing, Sheng, Shimei, and Huang, Yanshan

Subjects
GASTRIC inhibitory polypeptide, TYPE 2 diabetes, WEIGHT loss, GLUCAGON-like peptide 1, GLUCAGON receptors, INSULIN
Abstract

Introduction: Diabetes and obesity are momentous risk factors threatening people's lives and health. Currently available incretin analogue glucagon-like peptide 1 (GLP-1) possesses huge hypoglycemic effect with the unsatisfactory effect of weight loss. Co-agonists targeting GLP-1R plus glucagon receptor (GCGR) or gastric inhibitory polypeptide receptor (GIPR) show synergistic benefits in glycaemic control and weight loss. Here, we describe a novel dual GIP and GLP-1 receptor agonist, DR10627, and performed a preclinical assessment of it. Methods: The agonistic ability of DR10627 was indirectly assessed by inducing cAMP accumulation in Chinese hamster ovary (CHO) cells transfected with GLP-1R or GIPR in vitro. The plasma pharmacokinetics of DR10627 were analysed in cynomolgus monkeys. The OGTTs were performed in Sprague‑Dawley (SD) rats. The glucose lowering effects were evaluated by repeated administration of DR10627 in diabetic (db/db) mice for 4 weeks. The effects of anti-obesity and improving metabolism of DR10627 were evaluated by repeated administration of DR10627 in diet-induced obesity (DIO) mice for 57 days. Results: DR10627 had the capacity to activate both GLP-1R and GIPR in vitro. The terminal half-life of DR10627 was found to be approximately 4.19– 5.8 h in cynomolgus monkeys. DR10627 had a great improvement in oral glucose tolerance in SD rats. Moreover, DR10627 had a potent glucose-lowering effect in db/db mice, and the hypoglycemic effect of 18 nmol/kg DR10627 was better than that of 50 nmol/kg liraglutide. In addition, 10 and 30 nmol/kg DR10627 possessed the ability of potentiating the weight-loss, lipid-lowing efficacy and improving metabolism to a greater extent than 80 nmol/kg liraglutide. Conclusion: Preclinical assessment demonstrated that administration of DR10627 resulted in glucose lowering in SD rats and db/db mice, and substantial body weight reduction and metabolism improvement in DIO mice. DR10627 is a promising agent deserving further investigation for the treatment of type 2 diabetes and obesity. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Oligosecretory Waldenström macroglobulinemia exhibits excellent treatment response and outcomes

Author

Xiong, Wenjie, primary, Yu, Ying, additional, Sun, Chunyan, additional, Du, Juan, additional, Cai, Zhen, additional, Wang, Zanzan, additional, Cao, Xinxin, additional, Yan, Yuting, additional, Chen, Jiawen, additional, Huang, Yanshan, additional, Jiang, Zhongxing, additional, Wang, Huihan, additional, Niu, Ting, additional, Yang, Guangzhong, additional, Xue, Hua, additional, Li, Bingzong, additional, Huang, Honghui, additional, Li, Zhenling, additional, Liu, Qinhua, additional, Li, Fei, additional, Bai, Ou, additional, Mao, Min, additional, Fu, Rong, additional, Wang, Ling, additional, Li, Chunrui, additional, Chu, Xiaoxia, additional, Liu, Lihong, additional, Dong, Yujun, additional, Wang, Luqun, additional, Luo, Jun, additional, Wei, Yongqiang, additional, Cui, Rui, additional, Qiu, Lugui, additional, Li, Jian, additional, and Yi, Shuhua, additional

Published
2023
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13. Real-world treatment patterns, discontinuation and clinical outcomes in patients with B-cell lymphoproliferative diseases treated with BTK inhibitors in China

Author

Yan, Yuting, primary, Lv, Rui, additional, Wang, Tingyu, additional, Yu, Ying, additional, Huang, Yanshan, additional, Xiong, Wenjie, additional, Li, Yuxi, additional, Sui, Weiwei, additional, Wang, Qi, additional, Huang, Wenyang, additional, An, Gang, additional, Zou, Dehui, additional, Wang, Jianxiang, additional, Qiu, Lugui, additional, and Yi, Shuhua, additional

Published
2023
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16. Minimal residual disease status improved the response evaluation in patients with Waldenström’s macroglobulinemia

Author

Xiong, Wenjie, primary, Wang, Zanzan, additional, Wang, Tingyu, additional, Yu, Ying, additional, Huang, Yanshan, additional, Sun, Hao, additional, Chen, Jiawen, additional, Lyu, Rui, additional, Wang, Huijun, additional, Yan, Yuting, additional, Wang, Qi, additional, Liu, Wei, additional, An, Gang, additional, Sui, Weiwei, additional, Huang, Wenyang, additional, Zou, Dehui, additional, Xiao, Zhijian, additional, Wang, Jianxiang, additional, Ouyang, Guifang, additional, Qiu, Lugui, additional, and Yi, Shuhua, additional

Published
2023
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20. the novel Technology Development of 7Mask for LTPS-LCD

Author

Yan, Dandan, primary, Lan, Xuexin, additional, Liu, Bingping, additional, Huang, Yanshan, additional, Wu, Xiaoxiao, additional, Wei, Xiangkang, additional, Nie, Honghong, additional, Yang, Keshi, additional, Deng, Chao, additional, Chen, Guozhao, additional, and Yang, Xianyan, additional

Published
2022
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22. Oligosecretory Waldenström Macroglobulinemia Patients Exhibit Excellent Treatment Response and Outcomes

Author

Yu, Ying, primary, Xiong, Wenjie, additional, Wang, Zanzan, additional, Yan, Yuting, additional, Chen, Jiawen, additional, Huang, Yanshan, additional, Cao, Xinxin, additional, Jiang, Zhongxing, additional, Wang, Huihan, additional, Cai, Zhen, additional, Du, Juan, additional, Sun, Chunyan, additional, Niu, Ting, additional, Yang, Guangzhong, additional, Xue, Hua, additional, Li, Bingzong, additional, Huang, Honghui, additional, Li, Zhenling, additional, Liu, Qinhua, additional, Li, Fei, additional, Bai, Ou, additional, Mao, Min, additional, Fu, Rong, additional, Wang, Ling, additional, Li, Chunrui, additional, Chu, Xiaoxia, additional, Liu, Lihong, additional, Dong, Yujun, additional, Wang, Luqun, additional, Luo, Jun, additional, Wei, Yongqiang, additional, Qiu, Lugui, additional, Li, Jian, additional, and Yi, ShuHua, additional

Published
2022
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26. Flexible Polyimide Nanorod/Graphene Framework as an Organic Cathode for Rechargeable Sodium-Ion Batteries

Author

Ma Jian, Sheng Han, Huang Yanshan, Yu Luo, and Kong Yue

Subjects
Materials science, Graphene, Sodium, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Cathode, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, law.invention, General Energy, chemistry, Chemical engineering, law, Electrode, Nanorod, Thermal stability, Physical and Theoretical Chemistry, 0210 nano-technology, Polyimide
Abstract

Organic carbonyl compounds are the promising electrodes for sodium-ion batteries (SIBs), given their sustainable promising and remarkable thermal stability. In this paper, a three-dimensional (3D) ...

Published
2021
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28. Abstract 2857: DR30303, a SMART-VHHBody powered anti-CLDN18.2 VHH-Fc with enhanced ADCC activity for the treatment of gastric and pancreatic cancers

Author

Fang, Yongliang, primary, Yao, Gaofeng, additional, Zhong, Weixiang, additional, Duan, Wenwen, additional, Zhou, Zhenxing, additional, Wen, Xiaofang, additional, Chen, Yonglu, additional, Fang, Jingjin, additional, Wang, Yongwei, additional, Jiang, Weiqin, additional, Xu, Junfang, additional, and Huang, Yanshan, additional

Published
2022
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29. Flexible Phosphorus-Doped Graphene/Metal–Organic Framework-Derived Porous Fe2O3 Anode for Lithium-Ion Battery

Author

Jibo Jiang, Sheng Han, Huang Yanshan, Kong Yue, Liu Shunchang, Yuanting Li, Ma Jian, and Qiongyu Zhou

Subjects
Materials science, Graphene, Doping, Energy Engineering and Power Technology, chemistry.chemical_element, Lithium-ion battery, Anode, law.invention, Phosphorus doped, Chemical engineering, chemistry, law, Materials Chemistry, Electrochemistry, Chemical Engineering (miscellaneous), Metal-organic framework, Electrical and Electronic Engineering, Porosity, Carbon
Abstract

Porous metal oxides and heteroatomic doping of carbon materials were extensively studied in lithium-ion batteries (LIBs). We designed an assembly of porous Fe2O3 nanoframework into three-dimensiona...

Published
2020
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31. SnO2 Quantum Dots@Graphene Framework as a High-Performance Flexible Anode Electrode for Lithium-Ion Batteries

Author

Huang Yanshan, Gao Li, Ma Jian, Guisheng Wu, Chang Bin, Sheng Han, and Tiancai Jiang

Subjects
Materials science, Graphene, business.industry, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Tin oxide, 01 natural sciences, 0104 chemical sciences, Anode, law.invention, chemistry, law, Quantum dot, Electrode, Optoelectronics, General Materials Science, Lithium, 0210 nano-technology, business, Capacity loss, Current density
Abstract

Three-dimensional (3D) layered tin oxide quantum dots/graphene framework (SnO2 QDs@GF) were designed through anchoring SnO2 QD on the graphene surface under the hydrothermal reaction. SnO2 QDs@GF have a 3D skeleton with a large number of mesopores and ultrasmall SnO2 QDs with a large surface area. The unique design of this structure improves the specific area and promotes ion transport. The mechanically strong SnO2 QDs@GF can directly be used as the anode of lithium-ion batteries (LIBs); it displays a high reversible capacity (1300 mA h g-1 at 100 mA g-1), excellent rate performance (642 mA h g-1 at 2000 mA g-1), and superior cyclic stability (when the current density is 10 A g-1, the capacity loss is less than 2% after 5000 cycles). This novel synthetic method can further be expanded for the production of other quantum dots/graphene composites with a 3D structure as high-performance electrodes for LIBs.

Published
2020
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32. Reduced graphene oxide promoted assembly of graphene@polyimide film as a flexible cathode for high-performance lithium-ion battery

Author

Ma Jian, Chang Bin, Huang Yanshan, Yuanting Li, Mingan Zhou, Sheng Han, Gao Li, and Tiancai Jiang

Subjects
Materials science, Graphene, General Chemical Engineering, Oxide, General Chemistry, Electrochemistry, Cathode, Lithium-ion battery, law.invention, chemistry.chemical_compound, Chemical engineering, chemistry, law, Electrode, Layer (electronics), Polyimide
Abstract

Organic carbonyl polymers have been gradually used as the cathode in lithium-ion batteries (LIB). However, there are some limits in most organic polymers, such as low reversible capacity, poor rate performance, cycle instability, etc., due to low electrochemical conductivity. To mitigate the limits, we propose a strategy based on polyimide (PI)/graphene electroactive materials coated with reduced graphene oxide to prepare a flexible film (G@PI/RGO) by solvothermal and vacuum filtration processes. As a flexible cathode for LIB, it provides a reversible capacity of 198 mA h g−1 at 30 mA g−1 and excellent rate performance of 100 mA h g−1 at high current densities of 6000 mA g−1, and even a super long cycle performance (2500 cycles, 70% capacity retention). The excellent performance results in a special layer structure in which the electroactive PI was anchored and coated by the graphene. The present synthetic method can be further applied to construct other high-performance organic electrodes in energy storage.

Published
2020
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36. Aggregation Kinetics of TiO2Nanoparticles in Human and Artificial Sweat Solutions: Effects of Particle Properties and Sweat Constituents

Author

Li, Jing, Dong, Jiawei, Huang, Yanshan, Su, Jiana, Xie, Yu, Wu, Yundang, Tang, Wei, Li, Yongtao, Huang, Weilin, and Chen, Chengyu

Abstract

Dermal penetration potentials of titanium dioxide nanoparticles (TiO2NPs) may be affected by aggregation upon contact with sweat. This study investigated the aggregation kinetics of three TiO2NPs in thirty human sweat samples and four artificial sweat standards. Effects of particle concentration, sweat type, and inorganic (sodium chloride, disodium hydrogen phosphate, and sodium dihydrogen phosphate) and organic (l-histidine, lactic acid, and urea) constituents were examined. Three TiO2NPs remained colloidally stable in >20/30 human sweat samples and showed significant negative correlations (P< 0.01) between aggregation rates and |zeta potentials|. They aggregated rapidly over 20 min to >750 nm in three artificial sweat standards, while remained more stable in the International-Standard-Organization-pH-5.5 standard. Aggregation behaviors of three TiO2NPs mostly followed the Derjaguin–Landau–Verwey–Overbeek (DLVO) theory, allowing for determining their critical coagulation concentrations in inorganic constituents (15–491 mM) and Hamaker constants (3.3–7.9 × 10–21J). Higher concentrations of particles, inorganic constituents, and l-histidine destabilized three TiO2NPs, whereas urea inhibited aggregation. Three TiO2NPs adsorbed organic sweat constituents via complexation with amino or carboxyl groups, with isotherms following the Langmuir model. Correlation analyses further suggested that the adsorbed organic constituents may stabilize three TiO2NPs against aggregation in sweat by steric hindrance.

Published
2022
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37. Electrochemical fabrication of reduced MoS2-based portable molecular imprinting nanoprobe for selective SERS determination of theophylline

Author

Sun Yingxin, Yue Cao, Yuanting Li, Huang Yanshan, Sheng Han, and Yang Yuanyuan

Subjects
chemistry.chemical_classification, Materials science, 010401 analytical chemistry, Nanochemistry, Nanoprobe, Nanoparticle, 02 engineering and technology, Polymer, Surface-enhanced Raman spectroscopy, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Analytical Chemistry, chemistry, Colloidal gold, Electrode, 0210 nano-technology, Molecular imprinting, Nuclear chemistry
Abstract

A new portable molecular imprinting polymer (MIP)-SERS nanoprobe is fabricated by a convenient electrochemical method. Single-layered MoS2 is electrochemically reduced on a screen-printed electrode as the scaffold. Functional monomers o-phenylenediamine (oPD), template theophylline (THP), and SERS-active Au nanoparticles (AuNPs) are then one-step electropolymerized on the scaffold. The morphology of the nanoprobe is found to be a three-dimensional and porous structure. The abundant AuNPs with the size of 45~50 nm are trapped within the growing MIP instead of being confined to the surface. The thickness of MIP film is calculated to 25.1 nm. The nanoprobe displays a strong SERS effect for THP using 532 nm as excitation wavelength with a detection limit (LOD) of 0.01 nM. The SERS peak intensity at 1487 cm−1 increases linearly with the concentration of THP in the range 0.1 nM to 0.1 mM. After the template is removed, the imprint-removed nanoprobe is generated for selective binding of THP. The re-binding kinetics study implies the portable MIP-SERS nanoprobe can reach the adsorption equilibrium within 8 min. This nanoprobe exhibits low SERS interference for structural analogues theobromine (THB) and caffeine (CAF). The nanoprobe was employed to THP determination in tea drink samples, with recoveries ranging from 99.0 to 102.0% and relative standard deviations of

Published
2020
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38. Research on Intelligent Power Automation Technology Based on Edge Computing of Power Internet of Things

Author

Lai Weiping, Su Zhiyong, Huang Yanshan, and Zhang Yanghua

Subjects
Power management, radio frequency identification, lcsh:GE1-350, 0209 industrial biotechnology, business.industry, Computer science, 02 engineering and technology, Application layer, Automation, power equipment, Smart power, 020303 mechanical engineering & transports, 020901 industrial engineering & automation, 0203 mechanical engineering, Production manager, Management system, Radio-frequency identification, power internet of things edge computing, business, Telecommunications, Edge computing, lcsh:Environmental sciences, intelligent power automation
Abstract

With the rapid development of modern economy and the rapid promotion of science and technology, electricity is the realistic need for further transformation of various industries in contemporary society. Because the traditional power management mode is relatively backward and the automation level of different industries is uneven, these will limit the development of intelligent power automation. Therefore, based on the edge computing of power Internet of Things, this paper studies intelligent power automation technology, which is of great value for realizing power automation and improving the management level of power equipment. In this paper, aiming at the research of intelligent power automation technology, based on the edge computing of power Internet of Things, the Internet of Things system based on RFID technology is studied. This system constructs the basic architecture of Internet of Things for smart power applications. The architecture is composed of sensing layer, network layer and application layer, which is used to realize information collection, identification and transmission, and its application in the production management of power Internet of Things. This paper analyzes the functional requirements, factors to be considered, main features and main functions of power equipment management system, gives the design ideas of power equipment management system, and designs an intelligent power equipment system based on edge computing of power Internet of Things. The research results show that RFID technology based on edge computing of power Internet of Things is feasible to realize intelligent power automation, can solve some problems in current power technology, and is of great significance to realize intelligent power automation.

Published
2020

39. Three-Dimensional Graphene-based N-doped Carbon Composites as High-Performance Anode Materials for Sodium-ion Batteries

Author

Sheng Han, Chang Bin, Jing Chen, Huang Yanshan, Wei Wei, Zhang Xiaojie, Zhou Ming'an, and Bin Dai

Subjects
Battery (electricity), Chemistry, Graphene, Carbonization, Organic Chemistry, chemistry.chemical_element, Sodium-ion battery, 02 engineering and technology, General Chemistry, engineering.material, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Biochemistry, 0104 chemical sciences, law.invention, Anode, Coating, law, engineering, Composite material, 0210 nano-technology, Layer (electronics), Carbon
Abstract

A nitrogen-doped carbon layer coating on a 3D graphene framework (NCL@GF) was produced by the in-situ polymerization of a uniform polyimide layer on the graphene framework surface and a carbonization process. The NCL@GF exhibited a 3D macroporous structure with uniform N-doped porous carbon layers and a high 5.4 at. % nitrogen content, which not only effectively enhanced the active sites but also facilitated fast ion and electron transport in the 3D pathways. Consequently, the NCL@GF as the anode of a sodium-ion battery (SIB) exhibited a discharge capacity of 357 mAh g-1 at 0.1 A g-1 after 200 cycles, a remarkable rate capability with a capacity of 122 mAh g-1 at 8 A g-1 , and a super long cycle life with a capacity retention of 70 % capacity after 2500 cycles at 0.5 A g-1 . Such performance is superior to that of previously reported carbon or graphene-based composites.

Published
2018
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