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1. Tenecteplase and alteplase in acute ischaemic stroke thrombolysis : clinical and imaging study

Author: Huang, Xuya
Subjects: 616.8, RC Internal medicine
Abstract: Introduction: Intravenous thrombolysis in acute ischaemic stroke with alteplase improves clinical outcomes, but it has limited efficacy and is associated with increased risk of intracranial haemorrhage. An improved tissue plasminogen activator, tenecteplase, was evidenced to be at least equally effective with lower risk of haemorrhage in acute myocardial infarction thrombolysis. To date, two completed phase II randomised controlled studies comparing tenecteplase and alteplase in acute ischaemic strokes showed variable results. Methods: A literature review of thrombolytic agents used in myocardial infarction and acute ischaemic stroke was performed, followed by a retrospective investigation of the bolus-to- infusion delay of alteplase administration. The main focus of this thesis is the report of our single centre phase II randomised controlled trial that compared tenecteplase (0.25mg/kg, maximum 25mg) and alteplase (0.9mg/kg, maximum 90mg, 10% as the initial bolus, following by one hour infusion with the rest of the dose) in acute ischaemic stroke thrombolysis using advanced imaging as biomarkers. Imaging comprised baseline computed tomography (CT), CT perfusion (CTP) and CT angiography (CTA), and CT+CTA at 24-48 hours. The primary end-point was penumbral salvage (CTP-defined penumbra volume minus follow-up CT infarct volume). A sub-study of coagulation and fibrinolysis analysis of the two agents was performed by comparing a group of coagulation variables measured pre-treatment, 3-12 hours, and 24±3 hours post thrombolysis. An individual patient data (IPD) meta-analysis was carried out using all three completed tenecteplase/alteplase comparison studies in stroke thrombolysis. We compared clinical outcomes including modified Rankin scale at 3 months, early neurological improvement at 24 hours, intracerebral haemorrhage rate and mortality at 3 months between all three tenecteplase doses (0.1mg/kg, 0.25 mg/kg, and 0.4mg/kg) examined and standard alteplase. Imaging outcomes including penumbra salvage, recanalisation rates were also compared using the data from the two studies that had advance imaging carried out. Results: Delay between the initial bolus and the subsequent infusion in administration of alteplase is common. This may reduce the likelihood of achieving a good functional outcome. Among the 104 patients recruited in ATTEST trial, 71 contributed to the imaging primary outcome. No significant differences were observed for penumbral salvage [68 (SD 28) % tenecteplase vs 68 (SD 23) % alteplase], mean difference 1% (95% confidence interval -10%, 12%, p=0·81) or for any secondary end-point. The SICH incidence (1/52, 2% vs 2/51, 4%, by SITS-MOST definition, p=0·55; by ECASS-2 definition, 3/52, 6% tenecteplase vs 4/51, 8% alteplase, p=0.59) did not differed significantly. There was a trend towards lower ICH risk in the tenecteplase group (8/52 tenecteplase, 15% vs 14/51 alteplase, 29%, p=0·091). Compared to baseline, alteplase caused significant hypofibrinogenaemia (p=0.002), prolonged Prothrombin Time (PT) (p=0.011), hypoplasminogenaemia (p=0.001) and lower Factor V (p=0.002) at 3-12 hours after administration with persistent hypofibrinogenaemia at 24h (p=0.011), while only minor hypoplasminogenaemia (P=0.029) was seen in the tenecteplase group. Tenecteplase consumed less plasminogen (p < 0.001) and fibrinogen (p=0.002) compared with alteplase. In a pooled analysis, tenecteplase 0.25mg/kg had the greatest odds to achieve early neurological improvement (OR [95%CI] 3.3 [1.5, 7.2], p=0.093), excellent functional outcome (mRS 0-1) at three months (OR [95%CI] 1.9 [0.8, 4.4], p= 0.28), with reduced odds of ICH (OR [95%CI] 0.6 [0.2, 1.8], P=0.43) compared with alteplase. Only 19 patients were treated with tenecteplase 0.4mg/kg, which showed increased odds of SICH compared with alteplase (OR [95% CI] 6.2 [0.7, 56.3]). In the two studies where advanced imaging was performed, the imaging outcomes did not differ in the IPD analysis. Conclusion: Tenecteplase 0.25 mg/kg has the potential to be a better alternative to alteplase. It can be given as a single bolus, does not cause disruption to systemic coagulation, and is possibly safer and more effective in clot lysis. Further phase III study to compare tenecteplase and alteplase in acute ischaemic stroke is warranted.
Published: 2016

2. High on-clopidogrel platelet reactivity in ischaemic stroke or transient ischaemic attack: Systematic review and meta-analysis

Author: Alakbarzade, Vafa, Huang, Xuya, Ster, Irina Chis, McEntagart, Meriel, and Pereira, Anthony C.
Published: 2020
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3. Winning hearts and minds: ECG reporting in the first seizure clinic

Author: Huang, Xuya, Malek, N., Simpson, J., Kalladka, D., Dunn, F. G., and Leach, J. P.
Published: 2021
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4. Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Author: Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, Malcolm, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, Mitra, Dipayan, Bhatnagar, Priya, du Plessis, Johannes, Joshi, Yogish, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, 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Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Sprigg, Nikola, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayanan, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, 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Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, 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Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, OConnell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, Thomas, Kelly, Minks, David P, Rodrigues, Mark A, du Plessis, Johann C, Dennis, Martin S, Murray, Gordon D, Newby, David E, Sandercock, Peter A G, Stephen, Jacqueline, Sudlow, Cathie L M, Werring, David J, Whiteley, William N, Wardlaw, Joanna M, and White, Philip M
Published: 2019
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5. Observer Agreement on Computed Tomography Perfusion Imaging in Acute Ischemic Stroke

Author: El-Tawil, Salwa, Mair, Grant, Huang, Xuya, Sakka, Eleni, Palmer, Jeb, Ford, Ian, Kalra, Lalit, Wardlaw, Joanna, Muir, Keith W., Adami, Alessandro, Cerase, Alfonso, Garcia, Ana, von Heijne, Anders, Peeters, Andre, von Heijne, Anders, Zini, Andrea, Carneiro, Angelo, Patterson, Chris, Roffe, Christine, Freedman, Daniel, Scoffings, Daniel, Krieger, Derk W, Mitra, Dipayan, Berge, Eivind, Cora, Elena Adela, O’Brien, Eoin, Bertholds, Eric, Murat, Ethem, Moreton, Fiona, Tan, Garryck, Potter, Gillian, Rinaldi, Giuseppe, Madigan, Jeremy, Leyon, Joe, Du Plessis, Johann, Hewitt, Jonathan, Alves, José Eduardo, Egido, Jose, Sztriha, Laszlo, Esbjoernsson, Magnus, Correia, Manuel, Griebe, Martin, Dharmasiri, Michelle, Kirmi, Olga, Geraghty, Olivia, García-Bermejo, Pablo, Sutton, Patrick, Bhogal, Pervinder, White, Philip, Ferdinand, Phillip, Anjum, Qazi, Sellar, Robin, von Kummer, Rüdiger, Andole, Sreeman, Vundavalli, Sriram, Webb, Thomas, Das, Tilak, Matys, Tomasz, Goddard, Tony, Gontu, Vamsi, Sawlani, Vijay, Puetz, Volker, and Whiteley, Will
Published: 2019
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6. Incidental Findings On Magnetic Resonance Imaging Of The Internal Auditory Meatus For Vestibular Schwannoma; A Systematic Review

Author: Sooby, Paul, primary, Huang, Xuya, additional, and Kontorinis, Georgios, additional
Published: 2022
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7. The Impact of CT Perfusion Threshold on Predicted Viable and Nonviable Tissue Volumes in Acute Ischemic Stroke

Author: Huang, Xuya, Kalladka, Dheeraj, Cheripelli, Bharath Kumar, Moreton, Fiona Catherine, and Muir, Keith W.
Published: 2017
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8. Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke: Analysis of 2 Randomized Controlled Trials

Author: Bivard, Andrew, Huang, Xuya, McElduff, Patrick, Levi, Christopher R., Campbell, Bruce C.V., Cheripelli, Bharath Kumar, Kalladka, Dheeraj, Moreton, Fiona Catherine, Ford, Ian, Bladin, Christopher F., Davis, Stephen M., Donnan, Geoffrey A., Muir, Keith W., and Parsons, Mark W.
Published: 2017
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9. Intravenous Thrombolysis for Acute Stroke: Current Standards and Future Directions

Author: Ramani, Lucille, Huang, Xuya, Cheripelli, Bharathkumar, and Muir, Keith W.
Published: 2015
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10. Interaction of Recanalization, Intracerebral Hemorrhage, and Cerebral Edema After Intravenous Thrombolysis

Author: Cheripelli, Bharath Kumar, Huang, Xuya, MacIsaac, Rachael, and Muir, Keith W.
Published: 2016
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11. Coagulation and Fibrinolytic Activity of Tenecteplase and Alteplase in Acute Ischemic Stroke

Author: Huang, Xuya, Moreton, Fiona Catherine, Kalladka, Dheeraj, Cheripelli, Bharath Kumar, MacIsaac, Rachael, Tait, R. Campbell, and Muir, Keith W.
Published: 2015
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12. Clinical Outcomes after Intravenous Alteplase in Elderly Patients with Acute Ischaemic Stroke: A Retrospective Analysis of Patients Treated at a Tertiary Neurology Centre in England from 2013 to 2018

Author: Huang, Xuya, primary, Nash, Phillip, additional, Alakbarzade, Vafa, additional, Clarke, Brian, additional, and Pereira, Anthony C., additional
Published: 2021
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13. Mapping of planation surfaces in the southwest region of Hubei Province, China—Using the DEM-derived painted relief model

Author: Li, Hui / 李辉, Huang, Xuya / 黄徐娅, Deng, Qinglu / 邓清禄, Kusky, Timothy M., and Cai, Xiaobin / 蔡晓斌
Published: 2012
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14. Application of the modern ophiolite concept with special reference to Precambrian ophiolites

Author: Kusky, Timothy M., Wang, Lu, Dilek, Yildirim, Robinson, Paul, Peng, SongBai, and Huang, XuYa
Published: 2011
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15. LARGE CT PERFUSION–DEFINED MISMATCH PREDICTS EARLY IMPROVEMENT AFTER IV THROMBOLYSIS IN ACUTE ISCHAEMIC STROKE

Author: Collins, Patrick D, Dani, Krishna A, Moreton, Fiona, Huang, Xuya, MacDougall, Niall JJ, McVerry, Ferghal, Macleod, Mary Joan, Wardlaw, Joanna M, and Muir, Keith W
Published: 2013
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16. Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Author: Thomalla, Götz, primary, Boutitie, Florent, additional, Ma, Henry, additional, Koga, Masatoshi, additional, Ringleb, Peter, additional, Schwamm, Lee H, additional, Wu, Ona, additional, Bendszus, Martin, additional, Bladin, Christopher F, additional, Campbell, Bruce C V, additional, Cheng, Bastian, additional, Churilov, Leonid, additional, Ebinger, Martin, additional, Endres, Matthias, additional, Fiebach, Jochen B, additional, Fukuda-Doi, Mayumi, additional, Inoue, Manabu, additional, Kleinig, Timothy J, additional, Latour, Lawrence L, additional, Lemmens, Robin, additional, Levi, Christopher R, additional, Leys, Didier, additional, Miwa, Kaori, additional, Molina, Carlos A, additional, Muir, Keith W, additional, Nighoghossian, Norbert, additional, Parsons, Mark W, additional, Pedraza, Salvador, additional, Schellinger, Peter D, additional, Schwab, Stefan, additional, Simonsen, Claus Z, additional, Song, Shlee S, additional, Thijs, Vincent, additional, Toni, Danilo, additional, Hsu, Chung Y, additional, Wahlgren, Nils, additional, Yamamoto, Haruko, additional, Yassi, Nawaf, additional, Yoshimura, Sohei, additional, Warach, Steven, additional, Hacke, Werner, additional, Toyoda, Kazunori, additional, Donnan, Geoffrey A, additional, Davis, Stephen M, additional, Gerloff, Christian, additional, Acosta, Boris Raul, additional, Aegidius, Karen, additional, Albiker, Christian, additional, Alegiani, Anna, additional, Almendrote, Miriam, additional, Alonso, Angelika, additional, Althaus, Katharina, additional, Amarenco, Pierre, additional, Amiri, Hemasse, additional, Anders, Bettina, additional, Aniculaesei, Adriana, additional, Appleton, Jason, additional, Arenillas, Juan, additional, Back, Christina, additional, Bähr, Christian, additional, Bardutzky, Jürgen, additional, Baronnet-Chauvet, Flore, additional, Bathe-Peters, Rouven, additional, Bayer-Karpinska, Anna, additional, Becerra, Juan L., additional, Beck, Christoph, additional, Belchí Guillamon, Olga, additional, Benoit, Amandine, additional, Berhoune, Nadia, additional, Bindila, Daniela, additional, Birchenall, Julia, additional, Blanc-Lasserre, Karine, additional, Blanco Gonzales, Miguel, additional, Bobinger, Tobias, additional, Bodechtel, Ulf, additional, Bodiguel, Eric, additional, Bojaryn, Urszula, additional, Bonnet, Louise, additional, Bouamra, Benjamin, additional, Bourgeois, Paul, additional, Breuer, Lorenz, additional, Breynaert, Ludovic, additional, Broughton, David, additional, Brouns, Raf, additional, Brugirard, Sébastian, additional, Bruneel, Bart, additional, Buggle, Florian, additional, Cakmak, Serkan, additional, Calleja, Ana, additional, Calvet, David, additional, Carrera, David, additional, Chen, Hsin-Chieh, additional, Cheripelli, Bharath, additional, Cho, Tae-Hee, additional, Choe, Chi-un, additional, Choy, Lillian, additional, Christensen, Hanne, additional, Ciatipis, Mareva, additional, Cloud, Geoffrey, additional, Cogez, Julien, additional, Cortijo, Elisa, additional, Crozier, Sophie, additional, Damgaard, Dorte, additional, Dani, Krishna, additional, De Coene, Beatrijs, additional, De Hollander, Isabel, additional, De Keyser, Jacques, additional, De Klippel, Nina, additional, De Maeseneire, Charlotte, additional, De Smedt, Ann, additional, del Mar Castellanos Rodrigo, Maria, additional, Deltour, Sandrine, additional, Demeestere, Jelle, additional, Derex, Laurent, additional, Desfontaines, Philippe, additional, Dittrich, Ralf, additional, Dixit, Anand, additional, Dobbels, Laurens, additional, Domigo, Valérie, additional, Dorado, Laura, additional, Druart, Charlotte, additional, Dupont, Kristina Hougaard, additional, Dusart, Anne, additional, Dziewas, Rainer, additional, Ebner, Matthias, additional, Edjali-Goujon, Myriam, additional, Eisele, Philipp, additional, El Tawil, Salwa, additional, Elhfnawy, Ahmed, additional, Etexberria, Ana, additional, Evans, Nicholas, additional, Fandler, Simon, additional, Fazekas, Franz, additional, Felix, Sandra, additional, Fiebach, Jochen B., additional, Fiehler, Jens, additional, Filipov, Alexandra, additional, Filipski, Katharina, additional, Fleischmann, Robert, additional, Foerch, Christian, additional, Ford, Ian, additional, Gaenslen, Alexandra, additional, Galinovic, Ivana, additional, Gancedo, Elena Meseguer, additional, Ganeshan, Ramanan, additional, García Esperón, Carlos, additional, Garrido, Alicia, additional, Gattringer, Thomas, additional, Geraghty, Olivia, additional, Geran, Rohat, additional, Gerner, Stefan, additional, Godon-Hardy, Sylvie, additional, Göhler, Jos, additional, Golsari, Amir, additional, Gomis, Meritxell, additional, Gorriz, David, additional, Gramse, Verena, additional, Grau, Laia, additional, Griebe, Martin, additional, Guerrero, Cristina, additional, Guerzoglu, Damla, additional, Guettier, Sophie, additional, Guiraud, Vincent, additional, Gumbinger, Christoph, additional, Gunreben, Ignaz, additional, Haertig, Florian, additional, Hametner, Christian, additional, Hanseeuw, Bernard, additional, Hansen, Andreas, additional, Hansen, Jakob, additional, Harbo, Thomas, additional, Harloff, Andreas, additional, Harmel, Peter, additional, Häusler, Karl Georg, additional, Heinen, Florian, additional, Held, Valentin, additional, Hellwig, Simon, additional, Hemelsoet, Dimitri, additional, Hennerici, Michael, additional, Herm, Juliane, additional, Hermans, Sylvia, additional, Hernández, María, additional, Hervas Vicente, Jose, additional, Hjort, Niels, additional, Hobeanu, Cristina, additional, Hobohm, Carsten, additional, Höfner, Elmar, additional, Hohenbichler, Katharina, additional, Hommel, Marc, additional, Hoppe, Julia, additional, Hornberger, Eva, additional, Hoyer, Carolin, additional, Huang, Xuya, additional, Ipsen, Nils, additional, Isern, Irina, additional, Ispierto, Lourdes, additional, Iversen, Helle, additional, Jeppesen, Lise, additional, Jimenez, Marta, additional, Jungehülsing, Jan, additional, Jüttler, Eric, additional, Kalladka, Dheeraj, additional, Kallmünzer, Bernd, additional, Kar, Arindam, additional, Kellert, Lars, additional, Kemmling, André, additional, Kessler, Tobias, additional, Khan, Usman, additional, Klein, Matthias, additional, Kleinschnitz, Christoph, additional, Klockziem, Matti, additional, Knops, Michael, additional, Koehler, Luzie, additional, Koehrmann, Martin, additional, Kohlfürst, Heinz, additional, Kollmar, Rainer, additional, Kraft, Peter, additional, Krause, Thomas, additional, Kristensen, Bo, additional, Kröber, Jan M., additional, Kurka, Natalia, additional, Ladoux, Alexandre, additional, Laloux, Patrice, additional, Lamy, Catherine, additional, Landrault, Emmanuelle, additional, Lauer, Arne, additional, Lebely, Claire, additional, Leempoel, Jonathan, additional, Lees, Kennedy, additional, Leger, Anne, additional, Legrand, Laurence, additional, Li, Lin, additional, Löbbe, Anna-Mareike, additional, London, Frederic, additional, Lopez-cancio, Elena, additional, Lorenz, Matthias, additional, Louw, Stephen, additional, Lovelock, Caroline, additional, Lozano Sánchez, Manuel, additional, Lucente, Giuseppe, additional, Lückl, Janos, additional, Luna, Alain, additional, Macha, Kosmas, additional, Machet, Alexandre, additional, Mackenrodt, Daniel, additional, Madzar, Dominik, additional, Majoie, Charles, additional, Männer, Anika, additional, Maqueda, Vicky, additional, Marstrand, Jacob, additional, Martinez, Alicia, additional, Marzina, Annika, additional, Mechthouff, Laura, additional, Meden, Per, additional, Meersman, Guy, additional, Meier, Julia, additional, Mellerio, Charles, additional, Menn, Oliver, additional, Meyer, Nadja, additional, Michalski, Dominik, additional, Michels, Peter, additional, Michelsen, Lene, additional, Millán Torne, Monica, additional, Minnerup, Jens, additional, Modrau, Boris, additional, Moeller, Sebastian, additional, Møller, Anette, additional, Morel, Nathalie, additional, Moreton, Fiona, additional, Morin, Ludovic, additional, Moulin, Thierry, additional, Moynihan, Barry, additional, Mueller, Anne K., additional, Muir, Keith W., additional, Mulero, Patricia, additional, Mundiyanapurath, Sibu, additional, Mutzenbach, Johannes, additional, Nagel, Simon, additional, Naggara, Oliver, additional, Nallasivan, Arumugam, additional, Navalpotro, Irene, additional, Nave, Alexander H., additional, Nederkoorn, Paul, additional, Neeb, Lars, additional, Neugebauer, Hermann, additional, Neumann-Haefelin, Tobias, additional, Oberndorfer, Stefan, additional, Opherk, Christian, additional, Oppel, Lorenz, additional, Oppenheim, Catherine, additional, Orthgieß, Johannes, additional, Ostergaard, Leif, additional, Paindeville, Perrine, additional, Palomeras, Ernest, additional, Panitz, Verena, additional, Patel, Bhavni, additional, Peeters, Andre, additional, Peeters, Dirk, additional, Pellisé, Anna, additional, Pelz, Johann, additional, Pereira, Anthony, additional, Pérez de la Ossa, Natalia, additional, Perry, Richard, additional, Petraza, Salvador, additional, Peysson, Stéphane, additional, Pfeilschifter, Waltraud, additional, Pichler, Alexander, additional, Pierskalla, Alexandra, additional, Pledl, Hans-Werner, additional, Poli, Sven, additional, Pomrehn, Katrin, additional, Poulsen, Marika, additional, Prats, Luis, additional, Presas, Silvia, additional, Prohaska, Elisabeth, additional, Puetz, Volker, additional, Puig, Josep, additional, Puig Alcántara, Josep, additional, Purrucker, Jan, additional, Quenardelle, Veronique, additional, Ramachandran, Sankaranarayanan, additional, Raphaelle, Soulliard, additional, Raposo, Nicolas, additional, Reiff, Tilman, additional, Remmers, Michel, additional, Renou, Pauline, additional, Ribitsch, Martin, additional, Richter, Hardy, additional, Ritter, Martin, additional, Ritzenthaler, Thomas, additional, Rodier, Gilles, additional, Rodriguez-Regent, Christine, additional, Rodríguez-Yáñez, Manuel, additional, Roennefarth, Maria, additional, Roffe, Christine, additional, Rosenbaum, Sverre, additional, Rosso, Charlotte, additional, Röther, Joachim, additional, Rozanski, Michal, additional, Ruiz de Morales, Noelia, additional, Russo, Francesca, additional, Rutgers, Matthieu, additional, Sagnier, Sharmilla, additional, Samson, Yves, additional, Sánchez, Josep, additional, Sauer, Tamara, additional, Schäfer, Jan H., additional, Schieber, Simon, additional, Schill, Josef, additional, Schlak, Dennis, additional, Schlemm, Ludwig, additional, Schmidt, Sein, additional, Schonewille, Wouter, additional, Schröder, Julian, additional, Schulz, Andreas, additional, Schurig, Johannes, additional, Schwarting, Sönke, additional, Schwarz, Alexander, additional, Schwarzbach, Christopher, additional, Seidel, Matthias, additional, Seiler, Alexander, additional, Sembill, Jochen, additional, Serena Leal, Joaquin, additional, Shetty, Ashit, additional, Sibon, Igor, additional, Simonsen, Claus Z., additional, Singer, Oliver, additional, Sivagnanaratham, Aravinth, additional, Smets, Ide, additional, Smith, Craig, additional, Soors, Peter, additional, Sprigg, Nikola, additional, Spruegel, Maximilian, additional, Stark, David, additional, Steinert, Susanne, additional, Stösser, Sebastian, additional, Stuermlinger, Markus, additional, Swinnen, Bart, additional, Tamazyan, Ruben, additional, Tembl, Jose, additional, Terceno Izaga, Mikel, additional, Thomalla, Götz, additional, Touze, Emmanuel, additional, Truelsen, Thomas, additional, Turc, Guillaume, additional, Turine, Gaetane, additional, Tütüncü, Serdar, additional, Tyrell, Pippa, additional, Ustrell, Xavier, additional, Vadot, Wilfried, additional, Vallet, Anne-Evelyne, additional, Vallet, Pauline, additional, van den Berg, Lucie, additional, van den Berg, Sophie, additional, van Eendenburg, Cecile, additional, Van Hooff, Robbert-Jan, additional, van Sloten, Isabelle, additional, Vanacker, Peter, additional, Vancaester, Evelien, additional, Vanderdonckt, Patrick, additional, Vandermeeren, Yves, additional, Vanhee, Frederik, additional, Veltkamp, Roland, additional, Vestergaard, Karsten, additional, Viguier, Alain, additional, Vilas, Dolores, additional, Villringer, Kersten, additional, Voget, Dieke, additional, von Schrader, Jörg, additional, von Weitzel, Paul, additional, Warburton, Elisabeth, additional, Weber, Claudia, additional, Weber, Jörg, additional, Wegscheider, Karl, additional, Wegscheider, Mirko, additional, Weimar, Christian, additional, Weinstich, Karin, additional, Weise, Christopher, additional, Weise, Gesa, additional, Willems, Chris, additional, Winder, Klemens, additional, Wittayer, Matthias, additional, Wolf, Marc, additional, Wolf, Martin, additional, Wolff, Valerie, additional, Wollboldt, Christian, additional, Wollenweber, Frank, additional, Wouters, Anke, additional, Yalo, Bertrand, additional, Yger, Marion, additional, Younan, Nadia, additional, Yperzeele, Laetita, additional, Zegarac, Vesna, additional, Zeiner, Pia, additional, Ziemann, Ulf, additional, Zonneveld, Thomas, additional, Zuber, Mathieu, additional, Akutsu, Tsugio, additional, Aoki, Junya, additional, Arakawa, Shuji, additional, Doijiri, Ryosuke, additional, Egashira, Yusuke, additional, Enomoto, Yukiko, additional, Furui, Eisuke, additional, Furuta, Konosuke, additional, Gotoh, Seiji, additional, Hamasaki, Toshimitsu, additional, Hasegawa, Yasuhiro, additional, Hirano, Teryuki, additional, Homma, Kazunari, additional, Ichijyo, Masahiko, additional, Ide, Toshihiro, additional, Igarashi, Shuichi, additional, Iguchi, Yasuyuki, additional, Ihara, Masafumi, additional, Ikenouchi, Hajime, additional, Inoue, Tsuyoshi, additional, Itabashi, Ryo, additional, Ito, Yasuhiro, additional, Iwama, Toru, additional, Kamiyama, Kenji, additional, Kamiyoshi, Shoko, additional, Kanai, Haruka, additional, Kanematsu, Yasuhisa, additional, Kanzawa, Takao, additional, Kimura, Kazumi, additional, Kitayama, Jiro, additional, Kitazono, Takanari, additional, Kondo, Rei, additional, Kudo, Kohsuke, additional, Kusumi, Masayoshi, additional, Kuwahara, Ken, additional, Matsumoto, Shoji, additional, Matsuoka, Hideki, additional, Mihara, Ban, additional, Minematsu, Kazuo, additional, Miura, Ken, additional, Morita, Naomi, additional, Mouri, Wataru, additional, Murata, Kayo, additional, Nagakane, Yoshinari, additional, Nakase, Taizen, additional, Ohara, Hiromi, additional, Ohara, Nobuyuki, additional, Ohnishi, Hideyuki, additional, Ohta, Hajime, additional, Ohtaki, Masafumi, additional, Ohtani, Ryo, additional, Ohtsuki, Toshiho, additional, Ohyama, Hideo, additional, Okada, Takashi, additional, Okada, Yasushi, additional, Osaki, Masato, additional, Sakai, Nobuyuki, additional, Sanbongi, Yoshiki, additional, Sasaki, Naoshi, additional, Sasaki, Makoto, additional, Sato, Shoichiro, additional, Seki, Kenta, additional, Shimizu, Wataru, additional, Shiokawa, Yoshiaki, additional, Sozu, Takashi, additional, Suzuki, Junichiro, additional, Suzuki, Rieko, additional, Takagi, Yasushi, additional, Takizawa, Shunya, additional, Tanahashi, Norio, additional, Tanaka, Eijiro, additional, Tanaka, Ryota, additional, Tateishi, Yohei, additional, Terada, Tomoaki, additional, Terasaki, Tadashi, additional, Todo, Kenichi, additional, Tokunaga, Azusa, additional, Tsujino, Akira, additional, Ueda, Toshihiro, additional, Uesaka, Yoshikazu, additional, Uotani, Mihoko, additional, Urabe, Takao, additional, Watanabe, Masao, additional, Yagita, Yoshiki, additional, Yakushiji, Yusuke, additional, Yasui, Keizo, additional, Yonehara, Toshiro, additional, Yoshimura, Shinichi, additional, Aarnio, K., additional, Alemseged, F., additional, Anderson, C., additional, Ang, T., additional, Archer, M.L., additional, Attia, J., additional, Bailey, P., additional, Balabanski, A., additional, Barber, A., additional, Barber, P.A., additional, Bernhardt, J., additional, Bivard, A., additional, Blacker, D., additional, Bladin, C.F., additional, Brodtmann, A., additional, Cadilhac, D., additional, Campbell, B.C.V., additional, Carey, L., additional, Celestino, S., additional, Chan, L., additional, Chang, W.H., additional, ChangI, A., additional, Chen, C.H., additional, Chen, C.-I., additional, Chen, H.F., additional, Chen, T.C., additional, Chen, W.H., additional, Chen, Y.Y., additional, Cheng, C.A., additional, Cheong, E., additional, Chiou, Y.W., additional, Choi, P.M., additional, Chu, H.J., additional, Chuang, C.S., additional, Chung, T.C., additional, Churilov, L., additional, Clissold, B., additional, Connelly, A., additional, Coote, S., additional, Coulton, B., additional, Cowley, E., additional, Cranefield, J., additional, Curtze, S., additional, D'Este, C., additional, Davis, S.M., additional, Day, S., additional, Desmond, P.M., additional, Dewey, H.M., additional, Ding, C., additional, Donnan, G.A., additional, Drew, R., additional, Eirola, S., additional, Field, D., additional, Frost, T., additional, Garcia-Esperon, C., additional, George, K., additional, Gerraty, R., additional, Grimley, R., additional, Guo, Y.C., additional, Hankey, G., additional, Harvey, J., additional, Ho, S.C., additional, Hogan, K., additional, Howells, D., additional, Hsiao, P.M., additional, Hsu, C.H., additional, Hsu, C.T., additional, Hsu, C.-S., additional, Hsu, J.P., additional, Hsu, Y.D., additional, Hsu, Y.T., additional, Hu, C.J., additional, Huang, C.C., additional, Huang, H.Y., additional, Huang, M.Y., additional, Huang, S.C., additional, Huang, W.S., additional, Jackson, D., additional, Jeng, J.S., additional, Jiang, S.K., additional, Kaauwai, L., additional, Kasari, O., additional, King, J., additional, Kleinig, T.J., additional, Koivu, M., additional, Kolbe, J., additional, Krause, M., additional, Kuan, C.W., additional, Kung, W.L., additional, Kyndt, C., additional, Lau, C.L., additional, Lee, A., additional, Lee, C.Y., additional, Lee, J.T., additional, Lee, Y., additional, Lee, Y.C., additional, Levi, C., additional, Levi, C.R., additional, Lien, L.M., additional, Lim, J.C., additional, Lin, C.C., additional, Lin, C.H., additional, Lin, C.M., additional, Lin, D., additional, Liu, C.H., additional, Liu, J., additional, Lo, Y.C., additional, Loh, P.S., additional, Low, E., additional, Lu, C.H., additional, Lu, C.J., additional, Lu, M.K., additional, Ly, J., additional, Ma, H., additional, Macaulay, L., additional, Macdonnell, R., additional, Mackey, E., additional, Macleod, M., additional, Mahadevan, J., additional, Maxwell, V., additional, McCoy, R., additional, McDonald, A., additional, McModie, S., additional, Meretoja, A., additional, Mishra, S., additional, Mitchell, P.J., additional, Miteff, F., additional, Moore, A., additional, Muller, C., additional, Ng, F., additional, Ng, F.C., additional, Ng, J-L., additional, O'Brian, W., additional, O'Collins, V., additional, Oxley, T.J., additional, Parsons, M.W., additional, Patel, S., additional, Peng, G.S., additional, Pesavento, L., additional, Phan, T., additional, Rodrigues, E., additional, Ross, Z., additional, Sabet, A., additional, Sallaberger, M., additional, Salvaris, P., additional, Shah, D., additional, Sharma, G., additional, Sibolt, G., additional, Simpson, M., additional, Singhal, S., additional, Snow, B., additional, Spratt, N., additional, Stark, R., additional, Sturm, J., additional, Sun, M.C., additional, Sun, Y., additional, Sung, P.S., additional, Sung, Y.F., additional, Suzuki, M., additional, Tan, M., additional, Tang, S.C., additional, Tatlisumak, T., additional, Thijs, V., additional, Tiainen, M., additional, Tsai, C.H., additional, Tsai, C.K., additional, Tsai, C.L., additional, Tsai, H.T., additional, Tsai, L.K., additional, Tseng, C.H., additional, Tseng, L.T., additional, Tsoleridis, J., additional, Tu, H., additional, Tu, H.T-H., additional, Vallat, W., additional, Virta, J., additional, Wang, W.C., additional, Wang, Y.T., additional, Waters, M., additional, Weir, L., additional, Wijeratne, T., additional, Williams, C., additional, Wilson, W., additional, Wong, A.A., additional, Wong, K., additional, Wu, T.Y., additional, Wu, Y.H., additional, Yan, B., additional, Yang, F.C., additional, Yang, Y.W., additional, Yassi, N., additional, Yeh, H.L., additional, Yeh, J.H., additional, Yeh, S.J., additional, Yen, C.H., additional, Young, D., additional, Ysai, C.L., additional, Zhang, W.W., additional, Zhao, H., additional, Zhao, L., additional, Althaus-Knaurer, Katharina, additional, Berrouschot, Jörg, additional, Bluhmki, Erich, additional, Bovi, Paolo, additional, Chatellier, Gilles, additional, Cove, Lynda, additional, Davis, Stephen, additional, Dixit, A., additional, Donnan, Geoffrey, additional, Ehrenkrona, Christina, additional, Eschenfelder, Christoph, additional, Fatar, Marc, additional, Francisco Arenillas, Juan, additional, Gruber, Franz, additional, Kala, Lalit, additional, Kapeller, Peter, additional, Kaste, Markku, additional, Kessler, Christof, additional, Köhrmann, Martin, additional, Laage, Rico, additional, Lees, Kennedy R., additional, Luna Rodriguez, Alain, additional, Mas, Jean-Louis, additional, Mikulik, Robert, additional, Molina, Carlos, additional, Muddegowda, Girish, additional, Muir, Keith, additional, Niederkorn, Kurt, additional, Nuñez, Xavier, additional, Schellinger, Peter, additional, Serena, Joaquin, additional, Sobesky, Jan, additional, Steiner, Thorsten, additional, Svenson, Ann-Sofie, additional, von Kummer, Rüdiger, additional, Wardlaw, Joanna, additional, Betensky, Rebecca A., additional, Boulouis, Gregoire, additional, Carandang, Raphael A., additional, Copen, William A., additional, Cougo, Pedro, additional, Cutting, Shawna, additional, Drake, Kendra, additional, Ford, Andria L., additional, Hallenbeck, John, additional, Harris, Gordon J., additional, Hoesch, Robert, additional, Hsia, Amie, additional, Kase, Carlos, additional, Latour, Lawrence, additional, Lev, Michael H., additional, Muzikansky, Alona, additional, Nagaraja, Nandakumar, additional, Schwamm, Lee H., additional, Searls, Eric, additional, Song, Shlee S., additional, Starkman, Sidney, additional, Yoo, Albert J., additional, and Zand, Ramin, additional
Published: 2020
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17. Observer agreement on CT Perfusion imaging in acute ischemic stroke

Author: El-Tawil, Salwa, Mair, Grant, Huang, Xuya, Sakka, Eleni, Palmer, Jeb, Ford, Ian, Kalra, Lalit, Wardlaw, Joanna, and Muir, Keith W.
Abstract: No abstract available.
Published: 2019

18. Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial

Author: Al-Shahi Salman, Rustam, Dennis, MS, Sandercock, PAG, Sudlow, CLM, Wardlaw, JM, Whiteley, WN, Murray, GD, Stephen, J, Newby, DE, Sprigg, N, Werring, DJ, White, PM, Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, MR, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, Mitra, Dipayan, Bhatnagar, Priya, du Plessis, Johannes, Joshi, Yogish, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, Joanne, Bhakri, Harbens, Guyler, Paul, Sinha, Devesh, Loganathan, Thayalini, Siddiqui, Amber, Siddiqui, Anwer, Coward, Lucy, Kunhunny, Swapna, Tysoe, Sharon, Orath Prabakaran, Rajalakshmi, Kelavkar, Shyam, Rashmi, Sindhu, Ngo, David, Ng, Kheng Xiong, Menon, Nisha, Shah, Sweni, Barber, Mark, Esson, Derek, Brodie, Fiona, Anjum, Talat, Wani, Mushtaq, Krishnan, Manju, Quinn, Leanne, Spencer, Jayne, Jones, Terry, Thompson-Jones, Helen, Dacey, Lynne, Chenna, Srikanth, Storton, Sharon, Thomas, Sarah, Beaty, Teresa, Treadwell, Shelley, Davies, Caroline, Tucker, Susan, Connor, Lynda, Slade, Peter, Gainard, Glyn, Muddegowda, Girish, Sanyal, Ranjan, Remegoso, Alda, Abano, Nenette, Causley, Chelsea, Carpio, Racquel, Stevens, Stephanie, Butler, Adrian, Varquez, Resti, Denic, Hayley, Alipio, Francis, Moores, Andrew, Barry, Adrian, Maguire, Holly, Grocott, Jeanette, Finney, Kay, Lyjko, Sue, Roffe, Christine, Hiden, Joanne, Ferdinand, Phillip, Cvoro, Vera, Ullah, Khalil, Chapman, Nicola, Couser, Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayana, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, Buckle, Steve, Wallace, Rebecca, Mardania, Rina, Gray, Jane, Triscott, Claire, Nair, Anand, Greig, Jill, Rana, Pratap, Robinson, Matthew, Alam, Mohammad Irfan, Wilson, Duncan, Watchurst, Caroline, Brezitski, Maria, Crook, Luci, Jones, Ifan, Banaras, Azra, Patel, Krishna, Erande, Renuka, Hogan, Caroline, Hostettler, Isabel, Ashton, Amy, Feerick, Shez, Francia, Nina, Oji, Nnebuife, Elliott, Emma, Al-Mayhani, Talal, Dutta, Dipankar, Brown, Pauline, Ward, Deborah, Davis, Fiona, Turfrey, Jennifer, Hughes, Chloe, Collins, Kayleigh, Bakawala, Rehana, O'Connell, Susan, Glass, Jon, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Chapman, Kath, Young, Andrew, Bergin, Adrian, Sigsworth, Andrew, Manoj, Aravind, Fletcher, Glyn, Lopez, Paula, Cox, Penelope, Wilkinson, Mark, Fitzsimmons, Paul, Sharma, Nikhil, Choulerton, James, Button, Denise, Dow, Lindsey, Gbadamoshi, Lukuman, Avis, Joanne, Madigan, Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, Amy, Guthrie, Lucy Belle, Clarke, Samantha, Hassan, Ahamad, Waugh, Dean, Veraque, Emelda, Makawa, Linetty, Kambafwile, Mary, Randall, Marc, Papavasileiou, Vasileios, Cullen, Claire, Peters, Jenny, Thant, Hlaing, Ingram, Tanya, Zoe, Mellor, Durairaj, Ramesh, Harrison, Melanie, Stevenson, Sarah, Shackcloth, Daniela, Ewing, Jordan, Sutton, Victoria, McCarron, Mark, McKee, Jacqueline, Doherty, Mandy, McVerry, Ferghal, Blair, Caroline, MacLeod, Mary, Irvine, Janice, Gow, Heather, Furnace, Jacqueline, Joyson, Anu, Jagpal, Baljit, Ross, Sarah, Klaasen, Katrina, Nelson, Sandra, Clarke, Rebecca, Crouch, Nichola, MacLennan, Beverly, Taylor, Vicky, Epstein, Daniel, Shukla, Avani, Krishnamurthy, Vinodh, Nicholas, Paul, Qureshi, Sammie, Webber, Adam, Penge, Justin, Ramadan, Hawraman, Maguire, Stuart, Patterson, Chris, Bellfield, Ruth, Hairsine, Brigid, Stewart, Kelvin, Hooley, Michaela, Quinn, Outi, Richard, Bella, Moseley, Sally, Edwards, Mandy, Lawson, Heidi, Tayler, Michelle, Pai, Yogish, Dhakal, Mahesh, Esisi, Bernard, Dima, Sofia, Smith, Gemma Marie, Garside, Mark, Naeem, Muhammad, Baliga, Vidya, Rogers, Gill, Brown, Ellen, Bruce, David, Hayman, Rachel, Clayton, Susan, Gamble, Ed, Grue, Rebecca, Charles, Bethan, Hague, Adam, Blane, Sujata, Lambert, Caroline, Chaudhry, Afnan, Harrison, Thomas, Saastamoinen, Kari, Hove, Dionne, Howaniec, Laura, Grimwood, Gemma, Redjep, Ozlem, Humphries, Fiona, Argandona, Lucia, Cuenoud, Larissa, Erumere, Esther, Amlani, Sageet, Auld, Grace, Salek-Haddadi, Afraim, Schulz, Ursula, Kennedy, James, Ford, Gary, Mathieson, Philip, Reckless, Ian, Teal, Rachel, Lenti, Giulia, Harston, George, O'Brien, Eoin, Mcgee, Joanne, Mitchell, Jennifer, Amis, Elaine, Handley, Dominic, Kelly, Siobhan, Zachariah, George, Francis, Jobbin, Crisp, Sarah, Sesay, Juliana, Finlay, Sarah, Hayhoe, Helen, Hannon, Niamh, Hughes, Tom, Morse, Bethan, De Berker, Henry, Tallantyre, Emma, Osman, Ahmed, White, Susan, Schwarz, Stefan, Jelley, Benjamin, Yadava, Rajendra, Azhar, Khalid, Reddan, Julie, Sangombe, Mirriam, Stafford, Samantha, Fotherby, Ken, Morgan, Debbie, Baig, Farrukh, Jennings-Preece, Karla, Butler, Donna, Ahmad, Nasar, Willberry, Angela, Stevens, Angela, Rai, Baljinder, Siddegowda, Prasad, Howard, Peter, Hyatt, Lisa, Dobson, Tracey, Jarrett, David, Ponnambath, Suheil, Tandy, Jane, Harrington-Davies, Yasmin, Butler, Rebecca, James, Claire, Valentine, Stacey, Suttling, Anne, Langhorne, Peter, Kerr, Gillian, Wright, Fiona, Graham, Ruth, McAlpine, Christine, Iqbal, Mohammad Shahzad, Humphreys, Louise, Pasco, Kath, Balazikova, Olga, Nasim, Ashraf, Peixoto, Cassilda, Gallagher, Louise, Shahmehri, Shahrzad, Ghosh, Sandip, Barrie, Elizabeth, Gilmour, Danielle, Henry, Margo, Webb, Tom, Cowie, Linda, Rudenko, Hannah, McDonald, Shanni, Schumacher, Natasha, Walker, Susannah, Cosier, Tracey, Verrion, Anna, Beranova, Eva, Thomson, Audrey, Venter, Marius, Kar, Arindam, Mashate, Sheila, Harvey, Kirsten, Gardener, Léjeune, Nguyen, Vinh, Halse, Omid, Geraghty, Olivia, Hazel, Beth, Wilding, Peter, Tilley, Victoria, Cassidy, Tim, McClelland, Beverley, Bokhari, Maria, England, Timothy, Maddula, Mohana, Donnelly, Richard, Findlay, Paul, Macaden, Ashish, Shread, Ian, Barr, Charlotte, Mohd Nor, Azlisham, Brown, Claire, Persad, Nicola, Eglinton, Charlotte, Weinling, Marie, Hyams, Benjamin, Shah, Alex, Baker, John, Byrne, Anthony, McGhee, Caroline, Smart, Amanda, Copeland, Claire, Carpenter, Michael, Walker, Marion, Davey, Richard, Needle, Ann, Fathima, Razik, Bateman, Gavin, Datta, Prabal, Stanners, Andrew, Jackson, Linda, Ball, Julie, Davis, Michelle, Atkinson, Natalie, Fawcett, Michelle, Thompson, Teresa, Guy, Helen, Hogg, Valerie, Hays, Carole, Woodward, Stephen, Haque, Mohammad, Hakim, Eluzai, Symonds, Stuart, Maanoosi, Mehran, Herman, Jane, Black, Toby, Miriam, Skelton, Clarke, Caroline, Anthony, Alpha, Tribbeck, Michele, Cronin, Julie, Mead, Denise, Fennelly, Ruth, McIlmoyle, James, Dickinson, Christina, Jeffs, Carol, Anwar, Sajjad, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, O'Connell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, Kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, and Thomas, Kelly
Abstract: Background:\ud Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used safely is unclear. We aimed to estimate the relative and absolute effects of antiplatelet therapy on recurrent intracerebral haemorrhage and whether this risk might exceed any reduction of occlusive vascular events.\ud \ud Methods:\ud The REstart or STop Antithrombotics Randomised Trial (RESTART) was a prospective, randomised, open-label, blinded endpoint, parallel-group trial at 122 hospitals in the UK. We recruited adults (≥18 years) who were taking antithrombotic (antiplatelet or anticoagulant) therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage, discontinued antithrombotic therapy, and survived for 24 h. Computerised randomisation incorporating minimisation allocated participants (1:1) to start or avoid antiplatelet therapy. We followed participants for the primary outcome (recurrent symptomatic intracerebral haemorrhage) for up to 5 years. We analysed data from all randomised participants using Cox proportional hazards regression, adjusted for minimisation covariates. This trial is registered with ISRCTN (number ISRCTN71907627).\ud \ud Findings:\ud Between May 22, 2013, and May 31, 2018, 537 participants were recruited a median of 76 days (IQR 29–146) after intracerebral haemorrhage onset: 268 were assigned to start and 269 (one withdrew) to avoid antiplatelet therapy. Participants were followed for a median of 2·0 years (IQR [1·0– 3·0]; completeness 99·3%). 12 (4%) of 268 participants allocated to antiplatelet therapy had recurrence of intracerebral haemorrhage compared with 23 (9%) of 268 participants allocated to avoid antiplatelet therapy (adjusted hazard ratio 0·51 [95% CI 0·25–1·03]; p=0·060). 18 (7%) participants allocated to antiplatelet therapy experienced major haemorrhagic events compared with 25 (9%) participants allocated to avoid antiplatelet therapy (0·71 [0·39–1·30]; p=0·27), and 39 [15%] participants allocated to antiplatelet therapy had major occlusive vascular events compared with 38 [14%] allocated to avoid antiplatelet therapy (1·02 [0·65–1·60]; p=0·92).\ud \ud Interpretation:\ud These results exclude all but a very modest increase in the risk of recurrent intracerebral haemorrhage with antiplatelet therapy for patients on antithrombotic therapy for the prevention of occlusive vascular disease when they developed intracerebral haemorrhage. The risk of recurrent intracerebral haemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention.
Published: 2019

19. Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases : subgroup analyses of the RESTART randomised, open-label trial

Author: Al-Shahi Salman, Rustam, Minks, David P., Mitra, Dipayan, Rodrigues, Mark A., Bhatnagar, Priya, du Plessis, Johann C., Joshi, Yogish, Dennis, Martin, Murray, Gordon D., Newby, David E., Sandercock, Peter A.G., Sprigg, Nikola, Stephen, Jacqueline, Sudlow, Cathie, Werring, David J., Whiteley, William, Wardlaw, Joanna M., White, Philip M., Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, Malcolm, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, du Plessis, Johannes, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, Joanne, Bhakri, Harbens, Guyler, Paul, Sinha, Devesh, Loganathan, Thayalini, Siddiqui, Amber, Siddiqui, Anwer, Coward, Lucy, Kunhunny, Swapna, Tysoe, Sharon, Orath Prabakaran, Rajalakshmi, Kelavkar, Shyam, Rashmi, Sindhu, Ngo, David, Ng, Kheng Xiong, Menon, Nisha, Shah, Sweni, Barber, Mark, Esson, Derek, Brodie, Fiona, Anjum, Talat, Wani, Mushtaq, Krishnan, Manju, Quinn, Leanne, Spencer, Jayne, Jones, Terry, Thompson-Jones, Helen, Dacey, Lynne, Chenna, Srikanth, Storton, Sharon, Thomas, Sarah, Beaty, Teresa, Treadwell, Shelley, Davies, Caroline, Tucker, Susan, Connor, Lynda, Slade, Peter, Gainard, Glyn, Muddegowda, Girish, Sanyal, Ranjan, Remegoso, Alda, Abano, Nenette, Causley, Chelsea, Carpio, Racquel, Stevens, Stephanie, Butler, Adrian, Varquez, Resti, Denic, Hayley, Alipio, Francis, Moores, Andrew, Barry, Adrian, Maguire, Holly, Grocott, Jeanette, Finney, Kay, Lyjko, Sue, Roffe, Christine, Hiden, Joanne, Ferdinand, Phillip, Cvoro, Vera, Ullah, Khalil, Chapman, Nicola, Couser, Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayanan, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, Buckle, Steve, Wallace, Rebecca, Mardania, Rina, Gray, Jane, Triscott, Claire, Nair, Anand, Greig, Jill, Rana, Pratap, Robinson, Matthew, Alam, Mohammad Irfan, Werring, David, Wilson, Duncan, Watchurst, Caroline, Brezitski, Maria, Crook, Luci, Jones, Ifan, Banaras, Azra, Patel, Krishna, Erande, Renuka, Hogan, Caroline, Hostettler, Isabel, Ashton, Amy, Feerick, Shez, Francia, Nina, Oji, Nnebuife, Elliott, Emma, Al-Mayhani, Talal, Dutta, Dipankar, Brown, Pauline, Ward, Deborah, Davis, Fiona, Turfrey, Jennifer, Hughes, Chloe, Collins, Kayleigh, Bakawala, Rehana, O'Connell, Susan, Glass, Jon, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Chapman, Kath, Young, Andrew, Bergin, Adrian, Sigsworth, Andrew, Manoj, Aravind, Fletcher, Glyn, Lopez, Paula, Cox, Penelope, Wilkinson, Mark, Fitzsimmons, Paul, Sharma, Nikhil, Choulerton, James, Button, Denise, Dow, Lindsey, Gbadamoshi, Lukuman, Avis, Joanne, Madigan, Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, Amy, Guthrie, Lucy Belle, Clarke, Samantha, Hassan, Ahamad, Waugh, Dean, Veraque, Emelda, Makawa, Linetty, Kambafwile, Mary, Randall, Marc, Papavasileiou, Vasileios, Cullen, Claire, Peters, Jenny, Thant, Hlaing, Ingram, Tanya, Zoe, Mellor, Durairaj, Ramesh, Harrison, Melanie, Stevenson, Sarah, Shackcloth, Daniela, Ewing, Jordan, Sutton, Victoria, McCarron, Mark, McKee, Jacqueline, Doherty, Mandy, McVerry, Ferghal, Blair, Caroline, MacLeod, Mary, Irvine, Janice, Gow, Heather, Furnace, Jacqueline, Joyson, Anu, Jagpal, Baljit, Ross, Sarah, Klaasen, Katrina, Nelson, Sandra, Clarke, Rebecca, Crouch, Nichola, MacLennan, Beverly, Taylor, Vicky, Epstein, Daniel, Shukla, Avani, Krishnamurthy, Vinodh, Nicholas, Paul, Qureshi, Sammie, Webber, Adam, Penge, Justin, Ramadan, Hawraman, Maguire, Stuart, Patterson, Chris, Bellfield, Ruth, Hairsine, Brigid, Stewart, Kelvin, Hooley, Michaela, Quinn, Outi, Richard, Bella, Moseley, Sally, Edwards, Mandy, Lawson, Heidi, Tayler, Michelle, Pai, Yogish, Dhakal, Mahesh, Esisi, Bernard, Dima, Sofia, Smith, Gemma Marie, Garside, Mark, Naeem, Muhammad, Baliga, Vidya, Rogers, Gill, Brown, Ellen, Bruce, David, Hayman, Rachel, Clayton, Susan, Gamble, Ed, Grue, Rebecca, Charles, Bethan, Hague, Adam, Blane, Sujata, Lambert, Caroline, Chaudhry, Afnan, Harrison, Thomas, Saastamoinen, Kari, Hove, Dionne, Howaniec, Laura, Grimwood, Gemma, Redjep, Ozlem, Humphries, Fiona, Argandona, Lucia, Cuenoud, Larissa, Erumere, Esther, Amlani, Sageet, Auld, Grace, Salek-Haddadi, Afraim, Schulz, Ursula, Kennedy, James, Ford, Gary, Mathieson, Philip, Reckless, Ian, Teal, Rachel, Lenti, Giulia, Harston, George, O'Brien, Eoin, Mcgee, Joanne, Mitchell, Jennifer, Amis, Elaine, Handley, Dominic, Kelly, Siobhan, Zachariah, George, Francis, Jobbin, Crisp, Sarah, Sesay, Juliana, Finlay, Sarah, Hayhoe, Helen, Hannon, Niamh, Hughes, Tom, Morse, Bethan, De Berker, Henry, Tallantyre, Emma, Osman, Ahmed, White, Susan, Schwarz, Stefan, Jelley, Benjamin, Yadava, Rajendra, Azhar, Khalid, Reddan, Julie, Sangombe, Mirriam, Stafford, Samantha, Fotherby, Ken, Morgan, Debbie, Baig, Farrukh, Jennings-Preece, Karla, Butler, Donna, Ahmad, Nasar, Willberry, Angela, Stevens, Angela, Rai, Baljinder, Siddegowda, Prasad, Howard, Peter, Hyatt, Lisa, Dobson, Tracey, Jarrett, David, Ponnambath, Suheil, Tandy, Jane, Harrington-Davies, Yasmin, Butler, Rebecca, James, Claire, Valentine, Stacey, Suttling, Anne, Langhorne, Peter, Kerr, Gillian, Wright, Fiona, Graham, Ruth, McAlpine, Christine, Iqbal, Mohammad Shahzad, Humphreys, Louise, Pasco, Kath, Balazikova, Olga, Nasim, Ashraf, Peixoto, Cassilda, Gallagher, Louise, Shahmehri, Shahrzad, Ghosh, Sandip, Barrie, Elizabeth, Gilmour, Danielle, Henry, Margo, Webb, Tom, Cowie, Linda, Rudenko, Hannah, McDonald, Shanni, Schumacher, Natasha, Walker, Susannah, Cosier, Tracey, Verrion, Anna, Beranova, Eva, Thomson, Audrey, Venter, Marius, Kar, Arindam, Mashate, Sheila, Harvey, Kirsten, Gardener, Léjeune, Nguyen, Vinh, Halse, Omid, Geraghty, Olivia, Hazel, Beth, Wilding, Peter, Tilley, Victoria, Cassidy, Tim, McClelland, Beverley, Bokhari, Maria, England, Timothy, Maddula, Mohana, Donnelly, Richard, Findlay, Paul, Macaden, Ashish, Shread, Ian, Barr, Charlotte, Mohd Nor, Azlisham, Brown, Claire, Persad, Nicola, Eglinton, Charlotte, Weinling, Marie, Hyams, Benjamin, Shah, Alex, Baker, John, Byrne, Anthony, McGhee, Caroline, Smart, Amanda, Copeland, Claire, Carpenter, Michael, Walker, Marion, Davey, Richard, Needle, Ann, Fathima, Razik, Bateman, Gavin, Datta, Prabal, Stanners, Andrew, Jackson, Linda, Ball, Julie, Davis, Michelle, Atkinson, Natalie, Fawcett, Michelle, Thompson, Teresa, Guy, Helen, Hogg, Valerie, Hays, Carole, Woodward, Stephen, Haque, Mohammad, Hakim, Eluzai, Symonds, Stuart, Maanoosi, Mehran, Herman, Jane, Black, Toby, Miriam, Skelton, Clarke, Caroline, Anthony, Alpha, Tribbeck, Michele, Cronin, Julie, Mead, Denise, Fennelly, Ruth, McIlmoyle, James, Dickinson, Christina, Jeffs, Carol, Anwar, Sajjad, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, OConnell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, Thomas, Kelly, Al-Shahi Salman, Rustam, Minks, David P., Mitra, Dipayan, Rodrigues, Mark A., Bhatnagar, Priya, du Plessis, Johann C., Joshi, Yogish, Dennis, Martin, Murray, Gordon D., Newby, David E., Sandercock, Peter A.G., Sprigg, Nikola, Stephen, Jacqueline, Sudlow, Cathie, Werring, David J., Whiteley, William, Wardlaw, Joanna M., White, Philip M., Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, Malcolm, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, du Plessis, Johannes, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, Joanne, Bhakri, Harbens, Guyler, Paul, Sinha, Devesh, Loganathan, Thayalini, Siddiqui, Amber, Siddiqui, Anwer, Coward, Lucy, Kunhunny, Swapna, Tysoe, Sharon, Orath Prabakaran, Rajalakshmi, Kelavkar, Shyam, Rashmi, Sindhu, Ngo, David, Ng, Kheng Xiong, Menon, Nisha, Shah, Sweni, Barber, Mark, Esson, Derek, Brodie, Fiona, Anjum, Talat, Wani, Mushtaq, Krishnan, Manju, Quinn, Leanne, Spencer, Jayne, Jones, Terry, Thompson-Jones, Helen, Dacey, Lynne, Chenna, Srikanth, Storton, Sharon, Thomas, Sarah, Beaty, Teresa, Treadwell, Shelley, Davies, Caroline, Tucker, Susan, Connor, Lynda, Slade, Peter, Gainard, Glyn, Muddegowda, Girish, Sanyal, Ranjan, Remegoso, Alda, Abano, Nenette, Causley, Chelsea, Carpio, Racquel, Stevens, Stephanie, Butler, Adrian, Varquez, Resti, Denic, Hayley, Alipio, Francis, Moores, Andrew, Barry, Adrian, Maguire, Holly, Grocott, Jeanette, Finney, Kay, Lyjko, Sue, Roffe, Christine, Hiden, Joanne, Ferdinand, Phillip, Cvoro, Vera, Ullah, Khalil, Chapman, Nicola, Couser, Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayanan, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, Buckle, Steve, Wallace, Rebecca, Mardania, Rina, Gray, Jane, Triscott, Claire, Nair, Anand, Greig, Jill, Rana, Pratap, Robinson, Matthew, Alam, Mohammad Irfan, Werring, David, Wilson, Duncan, Watchurst, Caroline, Brezitski, Maria, Crook, Luci, Jones, Ifan, Banaras, Azra, Patel, Krishna, Erande, Renuka, Hogan, Caroline, Hostettler, Isabel, Ashton, Amy, Feerick, Shez, Francia, Nina, Oji, Nnebuife, Elliott, Emma, Al-Mayhani, Talal, Dutta, Dipankar, Brown, Pauline, Ward, Deborah, Davis, Fiona, Turfrey, Jennifer, Hughes, Chloe, Collins, Kayleigh, Bakawala, Rehana, O'Connell, Susan, Glass, Jon, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Chapman, Kath, Young, Andrew, Bergin, Adrian, Sigsworth, Andrew, Manoj, Aravind, Fletcher, Glyn, Lopez, Paula, Cox, Penelope, Wilkinson, Mark, Fitzsimmons, Paul, Sharma, Nikhil, Choulerton, James, Button, Denise, Dow, Lindsey, Gbadamoshi, Lukuman, Avis, Joanne, Madigan, Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, Amy, Guthrie, Lucy Belle, Clarke, Samantha, Hassan, Ahamad, Waugh, Dean, Veraque, Emelda, Makawa, Linetty, Kambafwile, Mary, Randall, Marc, Papavasileiou, Vasileios, Cullen, Claire, Peters, Jenny, Thant, Hlaing, Ingram, Tanya, Zoe, Mellor, Durairaj, Ramesh, Harrison, Melanie, Stevenson, Sarah, Shackcloth, Daniela, Ewing, Jordan, Sutton, Victoria, McCarron, Mark, McKee, Jacqueline, Doherty, Mandy, McVerry, Ferghal, Blair, Caroline, MacLeod, Mary, Irvine, Janice, Gow, Heather, Furnace, Jacqueline, Joyson, Anu, Jagpal, Baljit, Ross, Sarah, Klaasen, Katrina, Nelson, Sandra, Clarke, Rebecca, Crouch, Nichola, MacLennan, Beverly, Taylor, Vicky, Epstein, Daniel, Shukla, Avani, Krishnamurthy, Vinodh, Nicholas, Paul, Qureshi, Sammie, Webber, Adam, Penge, Justin, Ramadan, Hawraman, Maguire, Stuart, Patterson, Chris, Bellfield, Ruth, Hairsine, Brigid, Stewart, Kelvin, Hooley, Michaela, Quinn, Outi, Richard, Bella, Moseley, Sally, Edwards, Mandy, Lawson, Heidi, Tayler, Michelle, Pai, Yogish, Dhakal, Mahesh, Esisi, Bernard, Dima, Sofia, Smith, Gemma Marie, Garside, Mark, Naeem, Muhammad, Baliga, Vidya, Rogers, Gill, Brown, Ellen, Bruce, David, Hayman, Rachel, Clayton, Susan, Gamble, Ed, Grue, Rebecca, Charles, Bethan, Hague, Adam, Blane, Sujata, Lambert, Caroline, Chaudhry, Afnan, Harrison, Thomas, Saastamoinen, Kari, Hove, Dionne, Howaniec, Laura, Grimwood, Gemma, Redjep, Ozlem, Humphries, Fiona, Argandona, Lucia, Cuenoud, Larissa, Erumere, Esther, Amlani, Sageet, Auld, Grace, Salek-Haddadi, Afraim, Schulz, Ursula, Kennedy, James, Ford, Gary, Mathieson, Philip, Reckless, Ian, Teal, Rachel, Lenti, Giulia, Harston, George, O'Brien, Eoin, Mcgee, Joanne, Mitchell, Jennifer, Amis, Elaine, Handley, Dominic, Kelly, Siobhan, Zachariah, George, Francis, Jobbin, Crisp, Sarah, Sesay, Juliana, Finlay, Sarah, Hayhoe, Helen, Hannon, Niamh, Hughes, Tom, Morse, Bethan, De Berker, Henry, Tallantyre, Emma, Osman, Ahmed, White, Susan, Schwarz, Stefan, Jelley, Benjamin, Yadava, Rajendra, Azhar, Khalid, Reddan, Julie, Sangombe, Mirriam, Stafford, Samantha, Fotherby, Ken, Morgan, Debbie, Baig, Farrukh, Jennings-Preece, Karla, Butler, Donna, Ahmad, Nasar, Willberry, Angela, Stevens, Angela, Rai, Baljinder, Siddegowda, Prasad, Howard, Peter, Hyatt, Lisa, Dobson, Tracey, Jarrett, David, Ponnambath, Suheil, Tandy, Jane, Harrington-Davies, Yasmin, Butler, Rebecca, James, Claire, Valentine, Stacey, Suttling, Anne, Langhorne, Peter, Kerr, Gillian, Wright, Fiona, Graham, Ruth, McAlpine, Christine, Iqbal, Mohammad Shahzad, Humphreys, Louise, Pasco, Kath, Balazikova, Olga, Nasim, Ashraf, Peixoto, Cassilda, Gallagher, Louise, Shahmehri, Shahrzad, Ghosh, Sandip, Barrie, Elizabeth, Gilmour, Danielle, Henry, Margo, Webb, Tom, Cowie, Linda, Rudenko, Hannah, McDonald, Shanni, Schumacher, Natasha, Walker, Susannah, Cosier, Tracey, Verrion, Anna, Beranova, Eva, Thomson, Audrey, Venter, Marius, Kar, Arindam, Mashate, Sheila, Harvey, Kirsten, Gardener, Léjeune, Nguyen, Vinh, Halse, Omid, Geraghty, Olivia, Hazel, Beth, Wilding, Peter, Tilley, Victoria, Cassidy, Tim, McClelland, Beverley, Bokhari, Maria, England, Timothy, Maddula, Mohana, Donnelly, Richard, Findlay, Paul, Macaden, Ashish, Shread, Ian, Barr, Charlotte, Mohd Nor, Azlisham, Brown, Claire, Persad, Nicola, Eglinton, Charlotte, Weinling, Marie, Hyams, Benjamin, Shah, Alex, Baker, John, Byrne, Anthony, McGhee, Caroline, Smart, Amanda, Copeland, Claire, Carpenter, Michael, Walker, Marion, Davey, Richard, Needle, Ann, Fathima, Razik, Bateman, Gavin, Datta, Prabal, Stanners, Andrew, Jackson, Linda, Ball, Julie, Davis, Michelle, Atkinson, Natalie, Fawcett, Michelle, Thompson, Teresa, Guy, Helen, Hogg, Valerie, Hays, Carole, Woodward, Stephen, Haque, Mohammad, Hakim, Eluzai, Symonds, Stuart, Maanoosi, Mehran, Herman, Jane, Black, Toby, Miriam, Skelton, Clarke, Caroline, Anthony, Alpha, Tribbeck, Michele, Cronin, Julie, Mead, Denise, Fennelly, Ruth, McIlmoyle, James, Dickinson, Christina, Jeffs, Carol, Anwar, Sajjad, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, OConnell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, and Thomas, Kelly
Published: 2019

20. Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Author: Neurologie, Brain, Circulatory Health, Al-Shahi Salman, Rustam, Minks, David P., Mitra, Dipayan, Rodrigues, Mark A., Bhatnagar, Priya, du Plessis, Johann C., Joshi, Yogish, Dennis, Martin, Murray, Gordon D., Newby, David E., Sandercock, Peter A.G., Sprigg, Nikola, Stephen, Jacqueline, Sudlow, Cathie, Werring, David J., Whiteley, William, Wardlaw, Joanna M., White, Philip M., Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, Malcolm, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, du Plessis, Johannes, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, Joanne, Bhakri, Harbens, Guyler, Paul, Sinha, Devesh, Loganathan, Thayalini, Siddiqui, Amber, Siddiqui, Anwer, Coward, Lucy, Kunhunny, Swapna, Tysoe, Sharon, Orath Prabakaran, Rajalakshmi, Kelavkar, Shyam, Rashmi, Sindhu, Ngo, David, Ng, Kheng Xiong, Menon, Nisha, Shah, Sweni, Barber, Mark, Esson, Derek, Brodie, Fiona, Anjum, Talat, Wani, Mushtaq, Krishnan, Manju, Quinn, Leanne, Spencer, Jayne, Jones, Terry, Thompson-Jones, Helen, Dacey, Lynne, Chenna, Srikanth, Storton, Sharon, Thomas, Sarah, Beaty, Teresa, Treadwell, Shelley, Davies, Caroline, Tucker, Susan, Connor, Lynda, Slade, Peter, Gainard, Glyn, Muddegowda, Girish, Sanyal, Ranjan, Remegoso, Alda, Abano, Nenette, Causley, Chelsea, Carpio, Racquel, Stevens, Stephanie, Butler, Adrian, Varquez, Resti, Denic, Hayley, Alipio, Francis, Moores, Andrew, Barry, Adrian, Maguire, Holly, Grocott, Jeanette, Finney, Kay, Lyjko, Sue, Roffe, Christine, Hiden, Joanne, Ferdinand, Phillip, Cvoro, Vera, Ullah, Khalil, Chapman, Nicola, Couser, Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayanan, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, Buckle, Steve, Wallace, Rebecca, Mardania, Rina, Gray, Jane, Triscott, Claire, Nair, Anand, Greig, Jill, Rana, Pratap, Robinson, Matthew, Alam, Mohammad Irfan, Werring, David, Wilson, Duncan, Watchurst, Caroline, Brezitski, Maria, Crook, Luci, Jones, Ifan, Banaras, Azra, Patel, Krishna, Erande, Renuka, Hogan, Caroline, Hostettler, Isabel, Ashton, Amy, Feerick, Shez, Francia, Nina, Oji, Nnebuife, Elliott, Emma, Al-Mayhani, Talal, Dutta, Dipankar, Brown, Pauline, Ward, Deborah, Davis, Fiona, Turfrey, Jennifer, Hughes, Chloe, Collins, Kayleigh, Bakawala, Rehana, O'Connell, Susan, Glass, Jon, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Chapman, Kath, Young, Andrew, Bergin, Adrian, Sigsworth, Andrew, Manoj, Aravind, Fletcher, Glyn, Lopez, Paula, Cox, Penelope, Wilkinson, Mark, Fitzsimmons, Paul, Sharma, Nikhil, Choulerton, James, Button, Denise, Dow, Lindsey, Gbadamoshi, Lukuman, Avis, Joanne, Madigan, Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, Amy, Guthrie, Lucy Belle, Clarke, Samantha, Hassan, Ahamad, Waugh, Dean, Veraque, Emelda, Makawa, Linetty, Kambafwile, Mary, Randall, Marc, Papavasileiou, Vasileios, Cullen, Claire, Peters, Jenny, Thant, Hlaing, Ingram, Tanya, Zoe, Mellor, Durairaj, Ramesh, Harrison, Melanie, Stevenson, Sarah, Shackcloth, Daniela, Ewing, Jordan, Sutton, Victoria, McCarron, Mark, McKee, Jacqueline, Doherty, Mandy, McVerry, Ferghal, Blair, Caroline, MacLeod, Mary, Irvine, Janice, Gow, Heather, Furnace, Jacqueline, Joyson, Anu, Jagpal, Baljit, Ross, Sarah, Klaasen, Katrina, Nelson, Sandra, Clarke, Rebecca, Crouch, Nichola, MacLennan, Beverly, Taylor, Vicky, Epstein, Daniel, Shukla, Avani, Krishnamurthy, Vinodh, Nicholas, Paul, Qureshi, Sammie, Webber, Adam, Penge, Justin, Ramadan, Hawraman, Maguire, Stuart, Patterson, Chris, Bellfield, Ruth, Hairsine, Brigid, Stewart, Kelvin, Hooley, Michaela, Quinn, Outi, Richard, Bella, Moseley, Sally, Edwards, Mandy, Lawson, Heidi, Tayler, Michelle, Pai, Yogish, Dhakal, Mahesh, Esisi, Bernard, Dima, Sofia, Smith, Gemma Marie, Garside, Mark, Naeem, Muhammad, Baliga, Vidya, Rogers, Gill, Brown, Ellen, Bruce, David, Hayman, Rachel, Clayton, Susan, Gamble, Ed, Grue, Rebecca, Charles, Bethan, Hague, Adam, Blane, Sujata, Lambert, Caroline, Chaudhry, Afnan, Harrison, Thomas, Saastamoinen, Kari, Hove, Dionne, Howaniec, Laura, Grimwood, Gemma, Redjep, Ozlem, Humphries, Fiona, Argandona, Lucia, Cuenoud, Larissa, Erumere, Esther, Amlani, Sageet, Auld, Grace, Salek-Haddadi, Afraim, Schulz, Ursula, Kennedy, James, Ford, Gary, Mathieson, Philip, Reckless, Ian, Teal, Rachel, Lenti, Giulia, Harston, George, O'Brien, Eoin, Mcgee, Joanne, Mitchell, Jennifer, Amis, Elaine, Handley, Dominic, Kelly, Siobhan, Zachariah, George, Francis, Jobbin, Crisp, Sarah, Sesay, Juliana, Finlay, Sarah, Hayhoe, Helen, Hannon, Niamh, Hughes, Tom, Morse, Bethan, De Berker, Henry, Tallantyre, Emma, Osman, Ahmed, White, Susan, Schwarz, Stefan, Jelley, Benjamin, Yadava, Rajendra, Azhar, Khalid, Reddan, Julie, Sangombe, Mirriam, Stafford, Samantha, Fotherby, Ken, Morgan, Debbie, Baig, Farrukh, Jennings-Preece, Karla, Butler, Donna, Ahmad, Nasar, Willberry, Angela, Stevens, Angela, Rai, Baljinder, Siddegowda, Prasad, Howard, Peter, Hyatt, Lisa, Dobson, Tracey, Jarrett, David, Ponnambath, Suheil, Tandy, Jane, Harrington-Davies, Yasmin, Butler, Rebecca, James, Claire, Valentine, Stacey, Suttling, Anne, Langhorne, Peter, Kerr, Gillian, Wright, Fiona, Graham, Ruth, McAlpine, Christine, Iqbal, Mohammad Shahzad, Humphreys, Louise, Pasco, Kath, Balazikova, Olga, Nasim, Ashraf, Peixoto, Cassilda, Gallagher, Louise, Shahmehri, Shahrzad, Ghosh, Sandip, Barrie, Elizabeth, Gilmour, Danielle, Henry, Margo, Webb, Tom, Cowie, Linda, Rudenko, Hannah, McDonald, Shanni, Schumacher, Natasha, Walker, Susannah, Cosier, Tracey, Verrion, Anna, Beranova, Eva, Thomson, Audrey, Venter, Marius, Kar, Arindam, Mashate, Sheila, Harvey, Kirsten, Gardener, Léjeune, Nguyen, Vinh, Halse, Omid, Geraghty, Olivia, Hazel, Beth, Wilding, Peter, Tilley, Victoria, Cassidy, Tim, McClelland, Beverley, Bokhari, Maria, England, Timothy, Maddula, Mohana, Donnelly, Richard, Findlay, Paul, Macaden, Ashish, Shread, Ian, Barr, Charlotte, Mohd Nor, Azlisham, Brown, Claire, Persad, Nicola, Eglinton, Charlotte, Weinling, Marie, Hyams, Benjamin, Shah, Alex, Baker, John, Byrne, Anthony, McGhee, Caroline, Smart, Amanda, Copeland, Claire, Carpenter, Michael, Walker, Marion, Davey, Richard, Needle, Ann, Fathima, Razik, Bateman, Gavin, Datta, Prabal, Stanners, Andrew, Jackson, Linda, Ball, Julie, Davis, Michelle, Atkinson, Natalie, Fawcett, Michelle, Thompson, Teresa, Guy, Helen, Hogg, Valerie, Hays, Carole, Woodward, Stephen, Haque, Mohammad, Hakim, Eluzai, Symonds, Stuart, Maanoosi, Mehran, Herman, Jane, Black, Toby, Miriam, Skelton, Clarke, Caroline, Anthony, Alpha, Tribbeck, Michele, Cronin, Julie, Mead, Denise, Fennelly, Ruth, McIlmoyle, James, Dickinson, Christina, Jeffs, Carol, Anwar, Sajjad, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, OConnell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, Thomas, Kelly, Neurologie, Brain, Circulatory Health, Al-Shahi Salman, Rustam, Minks, David P., Mitra, Dipayan, Rodrigues, Mark A., Bhatnagar, Priya, du Plessis, Johann C., Joshi, Yogish, Dennis, Martin, Murray, Gordon D., Newby, David E., Sandercock, Peter A.G., Sprigg, Nikola, Stephen, Jacqueline, Sudlow, Cathie, Werring, David J., Whiteley, William, Wardlaw, Joanna M., White, Philip M., Baigent, Colin, Lasserson, Daniel, Sullivan, Frank, Carrie, Johanna, Rojas, Javier, Amoils, Shannon, Bamford, John, Armitage, Jane, Rinkel, Gabriel, Lowe, Gordon, Emberson, Jonathan, Innes, Karen, Dinsmore, Lynn, Drever, Jonathan, Williams, Carol, Perry, David, McGill, Connor, Buchanan, David, Walker, Allan, Hutchison, Aidan, Matthews, Christopher, Fraser, Ruth, McGrath, Aileen, Deary, Ann, Anderson, Rosemary, Walker, Pauli, Hansen, Christian, Parker, Richard, Rodriguez, Aryelly, Macleod, Malcolm, Gattringer, Thomas, Palmer, Jeb, Sakka, Eleni, Adil-Smith, Jennifer, Minks, David, du Plessis, Johannes, Lerpiniere, Christine, O'Brien, Richard, Burgess, Seona, Mead, Gillian, Paulton, Ruth, Doubal, Fergus, McCormick, Katrina, Hunter, Neil, Taylor, Pat, Parakramawansha, Ruwan, Perry, Jack, Blair, Gordon, MacRaild, Allan, Parry-Jones, Adrian, Johnes, Mary, Lee, Stephanie, Shaw, Kelly Marie, Burger, Ilse, Punter, Martin, Ingham, Andrea, Perez, Jane, Naing, Zin, Morell, Jordi, Marsden, Tracy, Hall, Andrea, Marshall, Sally, Harrison, Louise, Jarapa, Rowilson, Wood, Edith, O'Loughlin, Victoria, Cohen, David, Davies, Silvie, Njoku, Kelechi, Mpelembue, Mushiya, Burgess, Laura, Licenik, Radim, Ngwako, Mmua, Nisar, Nabeela, Niranchanan, Rangah, Roganova, Tatjana, Bathula, Rajaram, Devine, Joseph, David, Anette, Oshodi, Anne, Guo, Fenglin, Owoyele, Emmanuelle, Sukdeo, Varthi, Ballantine, Robert, Abbdul-saheb, Mudhar, Chamberlain, Angela, Chandrakumar, Aberami, Poku, Philip, Harkness, Kirsty, Blank, Catrin, Richards, Emma, Ali, Ali, Kibutu, Faith, Balitska, Olesia, Birchall, Kathryn, Bayliss, Pauline, Doyle, Clare, Stocks, Kathy, Majis, Arshad, Howe, Jo, Kamara, Christine, Barron, Luke, Maatouk, Ahmad, Lindert, Ralf, Dakin, Katy, Redgrave, Jessica, Bhaskaran, Biju, Salih, Isam, Kelly, Debs, Szabo, Susan, Tomlin, Dawn, Bearne, Helen, Buxton, Jean, Fitzell, Pauline, Ayres, Georgina, Saulat, Afaq, Horan, Kathleen, Garfield-Smith, Joanne, Bhakri, Harbens, Guyler, Paul, Sinha, Devesh, Loganathan, Thayalini, Siddiqui, Amber, Siddiqui, Anwer, Coward, Lucy, Kunhunny, Swapna, Tysoe, Sharon, Orath Prabakaran, Rajalakshmi, Kelavkar, Shyam, Rashmi, Sindhu, Ngo, David, Ng, Kheng Xiong, Menon, Nisha, Shah, Sweni, Barber, Mark, Esson, Derek, Brodie, Fiona, Anjum, Talat, Wani, Mushtaq, Krishnan, Manju, Quinn, Leanne, Spencer, Jayne, Jones, Terry, Thompson-Jones, Helen, Dacey, Lynne, Chenna, Srikanth, Storton, Sharon, Thomas, Sarah, Beaty, Teresa, Treadwell, Shelley, Davies, Caroline, Tucker, Susan, Connor, Lynda, Slade, Peter, Gainard, Glyn, Muddegowda, Girish, Sanyal, Ranjan, Remegoso, Alda, Abano, Nenette, Causley, Chelsea, Carpio, Racquel, Stevens, Stephanie, Butler, Adrian, Varquez, Resti, Denic, Hayley, Alipio, Francis, Moores, Andrew, Barry, Adrian, Maguire, Holly, Grocott, Jeanette, Finney, Kay, Lyjko, Sue, Roffe, Christine, Hiden, Joanne, Ferdinand, Phillip, Cvoro, Vera, Ullah, Khalil, Chapman, Nicola, Couser, Mandy, Pound, Susan, Mcauley, Sean, Raghunathan, Senthil, Shelton, Faye, Hedstrom, Amanda, Godfrey, Margi, Havard, Diane, Buck, Amanda, Krishnan, Kailash, Gilzeane, Nicola, Roffe, Jack, Clarke, Judith, Whittamore, Katherine, Sheikh, Saima, Keshvara, Rekha, Jordan, Carla, Jackson, Benjamin, Wilkes, Gwendoline, Appleton, Jason, Law, Zhe, Matias, Oliver, Vasileiadis, Evangelos, Mason, Cathy, Parry, Anthea, Landers, Geraldine, Holden, Melinda, Aweid, Basaam, Rashed, Khalid, Balian, Linda, Vickers, Carinna, Keeling, Elizabeth, Board, Sarah, Allison, Joanna, Buckley, Clare, Williams-Yesson, Barbara, Board, Joanne, Pitt-Kerby, Tressy, Tanate, Alfonso, Wood, Diane, Kini, Manohar, Chadha, Dinesh, Walstow, Deborah, Fong, Rosanna, Luder, Robert, Adesina, Tolu, Gallagher, Jill, Bridger, Hayley, Murali, Elodie, Bhargava, Maneesh, van Someren, Chloe, Harrington, Frances, Mate, Abhijit, James, Ali, Courtauld, Gillian, Schofield, Christine, Adie, Katja, Lucas, Linda, Bond, Kirsty, Maund, Bev, Ellis, Sam, Mudd, Paul, James, Martin, Keenan, Samantha, Bowring, Angela, Cageao, Julie, Kingwell, Hayley, Roughan, Caroline, Hemsley, Anthony, Sword, Jane, Strain, David, Miller, Keniesha, Goff, Anita, Gupwell, Karin, Thorpe, Kevin, Emsley, Hedley, Punekar, Shuja, McLoughlin, Alison, Sultan, Sulaiman, Gregory, Bindu, Raj, Sonia, Doyle, Donna, Muir, Keith, Smith, Wilma, Welch, Angela, Moreton, Fiona, Cheripelli, Bharath Kumar, El Tawil, Salwa, Kalladka, Dheeraj, Huang, Xuya, Day, Nicola, Ramachandran, Sankaranarayanan, Crosbie, Caroline, Elliot, Jennifer, Rudd, Tony, Marks, Katherine, Bhalla, Ajay, Birns, Jonathan, Kullane, Sagal, Weir, Nic, Allen, Christopher, Pressly, Vanessa, Crawford, Pam, Battersby-Wood, Emma, Blades, Alex, Egerton, Shuna, Walters, Ashleigh, Evans, Sue, Marigold, James Richard, Smith, Fiona, Howard, Gabriella, Gartrell, Imogen, Smith, Simon, Creeden, Robyn, Cox, Chloe, Boxall, Cherish, Hewitt, Jonathan, Nott, Claire, Sarah, Procter, Whiteman, Jessica, Buckle, Steve, Wallace, Rebecca, Mardania, Rina, Gray, Jane, Triscott, Claire, Nair, Anand, Greig, Jill, Rana, Pratap, Robinson, Matthew, Alam, Mohammad Irfan, Werring, David, Wilson, Duncan, Watchurst, Caroline, Brezitski, Maria, Crook, Luci, Jones, Ifan, Banaras, Azra, Patel, Krishna, Erande, Renuka, Hogan, Caroline, Hostettler, Isabel, Ashton, Amy, Feerick, Shez, Francia, Nina, Oji, Nnebuife, Elliott, Emma, Al-Mayhani, Talal, Dutta, Dipankar, Brown, Pauline, Ward, Deborah, Davis, Fiona, Turfrey, Jennifer, Hughes, Chloe, Collins, Kayleigh, Bakawala, Rehana, O'Connell, Susan, Glass, Jon, Broughton, David, Tryambake, Dinesh, Dixon, Lynn, Chapman, Kath, Young, Andrew, Bergin, Adrian, Sigsworth, Andrew, Manoj, Aravind, Fletcher, Glyn, Lopez, Paula, Cox, Penelope, Wilkinson, Mark, Fitzsimmons, Paul, Sharma, Nikhil, Choulerton, James, Button, Denise, Dow, Lindsey, Gbadamoshi, Lukuman, Avis, Joanne, Madigan, Barbara, McCann, Stephanie, Shaw, Louise, Howcroft, Deborah, Lucas, Suzanne, Stone, Andrew, Cluckie, Gillian, Lovelock, Caroline, Clarke, Brian, Chopra, Neha, Clarke, Natasha, Patel, Bhavini, Kennedy, Kate, Williams, Rebecca, Blight, Adrian, O'Reilly, Joanna, Orefo, Chukwuka, Dayal, Nilofer, Ghatala, Rita, Adedoyin, Temi, Watson, Fran, Trippier, Sarah, Choy, Lillian, Moynihan, Barry, Khan, Usman, Jones, Val, Jeyaraj, Naomi, Kerin, Lourda, Thavanesan, Kamy, Tiwari, Divya, Cox, Chantel, Ljubez, Anja, Tucker, Laura, Iqbal, Arshi, Bagnall, Caroline, Keltos, Marketa, Roberts, Josh, Jupp, Becky, Ovington, Catherine, Rogers, Emily, David, Owen, Bell, Jo, Longland, Barbara, Hann, Gail, Cooper, Martin, Nasar, Mohammad, Rajapakse, Anoja, Wynter, Inez, Anwar, Ijaz, Skinner, Helen, Nozedar, Tarn, McArdle, Damian, Kumar, Balakrishna, Crawford, Susan, Annamalai, Arunkumar, Ramshaw, Alex, Holmes, Clare, Caine, Sarah, Osborn, Mairead, Dodd, Emily, Murphy, Peter, Devitt, Nicola, Baker, Pauline, Steele, Amy, Guthrie, Lucy Belle, Clarke, Samantha, Hassan, Ahamad, Waugh, Dean, Veraque, Emelda, Makawa, Linetty, Kambafwile, Mary, Randall, Marc, Papavasileiou, Vasileios, Cullen, Claire, Peters, Jenny, Thant, Hlaing, Ingram, Tanya, Zoe, Mellor, Durairaj, Ramesh, Harrison, Melanie, Stevenson, Sarah, Shackcloth, Daniela, Ewing, Jordan, Sutton, Victoria, McCarron, Mark, McKee, Jacqueline, Doherty, Mandy, McVerry, Ferghal, Blair, Caroline, MacLeod, Mary, Irvine, Janice, Gow, Heather, Furnace, Jacqueline, Joyson, Anu, Jagpal, Baljit, Ross, Sarah, Klaasen, Katrina, Nelson, Sandra, Clarke, Rebecca, Crouch, Nichola, MacLennan, Beverly, Taylor, Vicky, Epstein, Daniel, Shukla, Avani, Krishnamurthy, Vinodh, Nicholas, Paul, Qureshi, Sammie, Webber, Adam, Penge, Justin, Ramadan, Hawraman, Maguire, Stuart, Patterson, Chris, Bellfield, Ruth, Hairsine, Brigid, Stewart, Kelvin, Hooley, Michaela, Quinn, Outi, Richard, Bella, Moseley, Sally, Edwards, Mandy, Lawson, Heidi, Tayler, Michelle, Pai, Yogish, Dhakal, Mahesh, Esisi, Bernard, Dima, Sofia, Smith, Gemma Marie, Garside, Mark, Naeem, Muhammad, Baliga, Vidya, Rogers, Gill, Brown, Ellen, Bruce, David, Hayman, Rachel, Clayton, Susan, Gamble, Ed, Grue, Rebecca, Charles, Bethan, Hague, Adam, Blane, Sujata, Lambert, Caroline, Chaudhry, Afnan, Harrison, Thomas, Saastamoinen, Kari, Hove, Dionne, Howaniec, Laura, Grimwood, Gemma, Redjep, Ozlem, Humphries, Fiona, Argandona, Lucia, Cuenoud, Larissa, Erumere, Esther, Amlani, Sageet, Auld, Grace, Salek-Haddadi, Afraim, Schulz, Ursula, Kennedy, James, Ford, Gary, Mathieson, Philip, Reckless, Ian, Teal, Rachel, Lenti, Giulia, Harston, George, O'Brien, Eoin, Mcgee, Joanne, Mitchell, Jennifer, Amis, Elaine, Handley, Dominic, Kelly, Siobhan, Zachariah, George, Francis, Jobbin, Crisp, Sarah, Sesay, Juliana, Finlay, Sarah, Hayhoe, Helen, Hannon, Niamh, Hughes, Tom, Morse, Bethan, De Berker, Henry, Tallantyre, Emma, Osman, Ahmed, White, Susan, Schwarz, Stefan, Jelley, Benjamin, Yadava, Rajendra, Azhar, Khalid, Reddan, Julie, Sangombe, Mirriam, Stafford, Samantha, Fotherby, Ken, Morgan, Debbie, Baig, Farrukh, Jennings-Preece, Karla, Butler, Donna, Ahmad, Nasar, Willberry, Angela, Stevens, Angela, Rai, Baljinder, Siddegowda, Prasad, Howard, Peter, Hyatt, Lisa, Dobson, Tracey, Jarrett, David, Ponnambath, Suheil, Tandy, Jane, Harrington-Davies, Yasmin, Butler, Rebecca, James, Claire, Valentine, Stacey, Suttling, Anne, Langhorne, Peter, Kerr, Gillian, Wright, Fiona, Graham, Ruth, McAlpine, Christine, Iqbal, Mohammad Shahzad, Humphreys, Louise, Pasco, Kath, Balazikova, Olga, Nasim, Ashraf, Peixoto, Cassilda, Gallagher, Louise, Shahmehri, Shahrzad, Ghosh, Sandip, Barrie, Elizabeth, Gilmour, Danielle, Henry, Margo, Webb, Tom, Cowie, Linda, Rudenko, Hannah, McDonald, Shanni, Schumacher, Natasha, Walker, Susannah, Cosier, Tracey, Verrion, Anna, Beranova, Eva, Thomson, Audrey, Venter, Marius, Kar, Arindam, Mashate, Sheila, Harvey, Kirsten, Gardener, Léjeune, Nguyen, Vinh, Halse, Omid, Geraghty, Olivia, Hazel, Beth, Wilding, Peter, Tilley, Victoria, Cassidy, Tim, McClelland, Beverley, Bokhari, Maria, England, Timothy, Maddula, Mohana, Donnelly, Richard, Findlay, Paul, Macaden, Ashish, Shread, Ian, Barr, Charlotte, Mohd Nor, Azlisham, Brown, Claire, Persad, Nicola, Eglinton, Charlotte, Weinling, Marie, Hyams, Benjamin, Shah, Alex, Baker, John, Byrne, Anthony, McGhee, Caroline, Smart, Amanda, Copeland, Claire, Carpenter, Michael, Walker, Marion, Davey, Richard, Needle, Ann, Fathima, Razik, Bateman, Gavin, Datta, Prabal, Stanners, Andrew, Jackson, Linda, Ball, Julie, Davis, Michelle, Atkinson, Natalie, Fawcett, Michelle, Thompson, Teresa, Guy, Helen, Hogg, Valerie, Hays, Carole, Woodward, Stephen, Haque, Mohammad, Hakim, Eluzai, Symonds, Stuart, Maanoosi, Mehran, Herman, Jane, Black, Toby, Miriam, Skelton, Clarke, Caroline, Anthony, Alpha, Tribbeck, Michele, Cronin, Julie, Mead, Denise, Fennelly, Ruth, McIlmoyle, James, Dickinson, Christina, Jeffs, Carol, Anwar, Sajjad, Howard, Joanne, Jones, Kirsty, Dhar, Saikat, Clay, Caroline, Siddiq, Muhammad, Ivatts, Simone, Baird, Yolanda, Sally, Moore, Amey, Isobel, Newton, Sophie, Clayton-Evans, Lisa, Chadbourn, Indra, Rayessa, Rayessa, Naylor, Charde, Rodgers, Alicia, Wilson, Lisa, Wilson, Sarah, Clarkson, Emma, Davies, Ruth, Owings, Paula, Sangster, Graeme, Gott, Valerie, Little, Victoria, Weir, Pauline, Cherian, Suja, Jose, Deepa, Moroney, Helen, Downham, Susan, Dodd, Angela, Vettimootal Johnson, Venetia, Codd, Laura, Robinson, Naomi, Ahmed, Ashraf, Albazzaz, Mo, Johnson, Sharon, Denniss, Carol, Cunningham, Mishell, Zahoor, Tajammal, Webster, Timothy, Leason, Sandra, Haider, Syed, Chatterjee, Kausic, Nallasivan, Arumugam, Perkins, Charlotte, Seagrave, Samantha, Jenkins, Colin, Price, Fiona, Hughes, Claire, Mercer, Lily, Hussain, Malik, Brown, Sarah, Harvey, Miriam, Homan, Jane, Khan, Mohammad, Whiting, Robert, Foote, Leanne, Hunt, Nicholas, Durman, Helen, Brotherton, Lucy, Foot, Jayne, Pawley, Corinne, Foster, Eliza, Whitcher, Alison, Metcalf, Kneale, Jagger, Jenny, McDonald, Susan, Waterfield, Kelly, Sutton, Patrick, Shinh, Naval, Anversha, Ajmal, Ravenhill, Garth, Greenwood, Richard, Saada, Janak, Wiltshire, Alison, Perfitt, Rebekah, Andole, Sreeman, Gadapa, Naveen, Dunne, Karen, Krommyda, Magdalini, Burssens, Evelyne, King, Sam, Plewa, Catherine, Smyth, Nigel, Wilson, Jenny, Giallombardo, Elio, Sykes, Lucy, Kumar, Pradeep, Barker, James, Huggett, Isabel, Dunn, Linda, Culmsee, Charlotte, Thomas, Philip, Myint, Min, Brew, Helen, Majmudar, Nikhil, OConnell, Janice, Bunea, George, Fox, Charlotte, Gulliver, Diane, Smith, Andrew, Mokoena, Betty, Sattar, Naweed, Krishnamurthy, Ramesh, Osborne, Emily, Wilson, David, Wroath, Belinda, Dynan, Kevin, Power, Michael, Thompson, Susan, Adell, Victoria, Orugun, Enoch, Poultney, Una, Glover, Rachel, Crowther, Hannah, Thornthwaite, Sarah, Wiggam, Ivan, Wallace, Aine, Kerr, Enda, Fulton, Ailsa, Hunter, Annemarie, Tauro, Suzanne, Cuddy, Sarah, Mangion, David, Hardwick, Anne, Markova, Skarlet, Lawrence, Tara, Constantin, Carmen, Fletcher, Jo, Thomas, Isobel, Pettitt, Kerry, Sekaran, Lakshmanan, Tate, Margaret, Bharaj, Kiranjit, Simon, Rohan, Justin, Frances, Sethuraman, Sakthivel, Phiri, Duke, Mohammed, Niaz, Chauhan, Meena, Elfandi, Khaled, Khan, Uzma, Eveson, David, Mistri, Amit, Manning, Lisa, Khan, Shagufta, Patel, Champa, Moqsith, Mohammed, Sattar, Saira, Lam, Man Yee, Musarrat, Kashif, Stephens, Claire, Kalathil, Latheef, Miller, Richard, Salehin, Maqsud, Gautam, Nikki, Bailey, Duncan, Amor, Kelly, Meir, Julie, Nicolson, Anne, Imam, Javed, Wood, Lisa, White, Julie, Sajid, Mahmud, Ghaly, George, Ball, Margaret, Gascoyne, Rachel, Proeschel, Harald, Sharpe, Simon, Horton, Sarah, Beaves, Emily, Jones, Stephanie, Yip, Brigitte, Bell, Murdina, MacLiver, Linda, MacInnes, Brian, Sims, Don, Hurley, Jennifer, Willmot, Mark, Sutton, Claire, Littleton, Edward, Maiden, Susan, Jones, Rachael, Cunningham, James, Green, Carole, Bates, Michelle, Shekhar, Raj, Gilham, Ellie, Ahmed, Iman, Crown, Rachel, Fuller, Tracy, Goorah, Neetish, Bell, Angela, Kelly, Christine, Singh, Arun, Walford, Jamie, Tomlinson, Benjamin, Patel, Farzana, Duberley, Stephen, Kane, Ingrid, Rajkumar, Chakravarthi, Gaylard, Jane, Breeds, Joanna, Gainsborough, Nicola, Pitt-Ford, Alexandra, Barbon, Emma, Latter, Laura, Thompson, Philip, Hervey, Simon, Krishnamoorthy, Shrivakumar, Vassallo, Joseph, Walter, Deborah, Cochrane, Helen, Srinivasan, Meena, Campbell, Robert, Donaldson, Denise, Motherwell, Nichola, Hurford, Frances, Mukherjee, Indranil, Kenton, Antony, Nyabadza, Sheila, Martin, Irene, Hunt, Benjamin, Hassan, Hardi, O'Toole, Sarah, Dallol, Bander, Putterill, Janet, Jha, Ratneshwari, Gallifent, Rachel, Kakar, Puneet, Pusalkar, Aparna, Chan, kelly, Dangri, Puneet, Beadle, Hannah, Cook, Angela, Crabtree, Karen, Subramonian, Santhosh, Owusu-Agyei, Peter, Temple, Natalie, Butterworth-Cowin, Nicola, Ragab, Suzanne, Knops, Kerstin, Jinks, Emma, Dickson, Christine, Gleave, Laura, Dube, Judith, Leggett, Jacqui, Garcia, Tatiana, Ispoglou, Sissy, Evans, Rachel, Ankolekar, Sandeep, Hayes, Anne, Ni, Hlaing, Rahman, Bithi, Milligan, Josette, Graham, Carol, Jose, Josin, Keegan, Breffni, Kelly, Jim, Dewar, Richard, White, James, and Thomas, Kelly
Published: 2019

21. Winning hearts and minds: ECG reporting in the first seizure clinic.

Author: Xuya Huang, Malek, N., Simpson, J., Kalladka, D., Dunn, F. G., Leach, J. P., and Huang, Xuya
Abstract: Background and Aims: An electrocardiogram (ECG) is a mandatory test for anyone presenting with loss of consciousness. Many referrals to the first seizure clinic (FSC) are caused by syncope. We assessed the sensitivity of neurologists' ECG reporting in detecting rhythm abnormalities including some potentially life-threatening cardiac conditions.Methods: We audited patients referred to a FSC in Glasgow over 4 years. All ECGs were interpreted by the attending neurologist as standard practice. Subsequently, two cardiologists reviewed the ECGs independently.Results: Of 160 consecutive patients, 92 patients (58%) were diagnosed as having seizures, 43 (27%) as syncope, and 25 (16%) were unclassified. Twenty eight ECGs thought to be normal by the neurologist were considered abnormal by the cardiologist, including three with long corrected QT interval. The proportion of abnormal ECGs and disparity in reporting between neurologists and cardiologists persisted independent of the underlying diagnosis.Conclusion: Reporting of ECGs by non-cardiologists may not be adequately sensitive in picking up potentially life threatening cardiac conditions. Cardiologist input into FSCs is recommended to enhance the diagnostic yield. [ABSTRACT FROM AUTHOR]
Published: 2021
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22. The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial

Author: Al-Shahi Salman, Rustam, Dennis, Martin S., Murray, Gordon D., Innes, Karen, Drever, Jonathan, Dinsmore, Lynn, Williams, Carol, White, Philip M., Whiteley, William N., Sandercock, Peter A. G., Sudlow, Cathie L. M., Newby, David E., Sprigg, Nikola, Werring, David J., Langhorne, Peter, McAlpine, Christine, Kerr, Gillian, Muir, Keith, Kalladka, Dheeraj, Smith, Wilma, Moreton, Fiona, Cheripelli, Bharath Kumar, Huang, Xuya, El Tawil, Salwa, Ramachandran, Sankaranarayana, and Elliot, Jennifer
Subjects: cardiovascular diseases
Abstract: Background: \ud For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is unclear whether starting antiplatelet drugs results in an increase in the risk of recurrent ICH or a beneficial net reduction of all serious vascular events compared to avoiding antiplatelet drugs.\ud \ud Methods/design: \ud The REstart or STop Antithrombotics Randomised Trial (RESTART) is an investigator-led, randomised, open, assessor-blind, parallel-group, randomised trial comparing starting versus avoiding antiplatelet drugs for adults surviving antithrombotic-associated ICH at 122 hospital sites in the United Kingdom. RESTART uses a central, web-based randomisation system using a minimisation algorithm, with 1:1 treatment allocation to which central research staff are masked. Central follow-up includes annual postal or telephone questionnaires to participants and their general (family) practitioners, with local provision of information about adverse events and outcome events. The primary outcome is recurrent symptomatic ICH. The secondary outcomes are: symptomatic haemorrhagic events; symptomatic vaso-occlusive events; symptomatic stroke of uncertain type; other fatal events; modified Rankin Scale score; adherence to antiplatelet drug(s). The magnetic resonance imaging (MRI) sub-study involves the conduct of brain MRI according to a standardised imaging protocol before randomisation to investigate heterogeneity of treatment effect according to the presence of brain microbleeds. Recruitment began on 22 May 2013. The target sample size is at least 720 participants in the main trial (at least 550 in the MRI sub-study).\ud \ud Discussion: \ud Final results of RESTART will be analysed and disseminated in 2019.\ud \ud Trial registration: \ud ISRCTN71907627 (www.isrctn.com/ISRCTN71907627). Prospectively registered on 25 April 2013.
Published: 2018

23. Comparing mismatch strategies for patients being considered for ischemic stroke tenecteplase trials

Author: Bivard, Andrew, primary, Huang, Xuya, additional, Levi, Christopher R, additional, Campbell, Bruce CV, additional, Cheripelli, Bharath K, additional, Chen, Chushuang, additional, Kalladka, Dheeraj, additional, Moreton, Fiona C, additional, Ford, Ian, additional, Davis, Stephen M, additional, Donnan, Geoffrey A, additional, Muir, Keith W, additional, and Parsons, Mark W, additional
Published: 2019
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24. Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Author: Al-Shahi Salman, Rustam, primary, Minks, David P, additional, Mitra, Dipayan, additional, Rodrigues, Mark A, additional, Bhatnagar, Priya, additional, du Plessis, Johann C, additional, Joshi, Yogish, additional, Dennis, Martin S, additional, Murray, Gordon D, additional, Newby, David E, additional, Sandercock, Peter A G, additional, Sprigg, Nikola, additional, Stephen, Jacqueline, additional, Sudlow, Cathie L M, additional, Werring, David J, additional, Whiteley, William N, additional, Wardlaw, Joanna M, additional, White, Philip M, additional, Baigent, Colin, additional, Lasserson, Daniel, additional, Sullivan, Frank, additional, Carrie, Johanna, additional, Rojas, Javier, additional, Amoils, Shannon, additional, Bamford, John, additional, Armitage, Jane, additional, Rinkel, Gabriel, additional, Lowe, Gordon, additional, Emberson, Jonathan, additional, Innes, Karen, additional, Dinsmore, Lynn, additional, Drever, Jonathan, additional, Williams, Carol, additional, Perry, David, additional, McGill, Connor, additional, Buchanan, David, additional, Walker, Allan, additional, Hutchison, Aidan, additional, Matthews, Christopher, additional, Fraser, Ruth, additional, McGrath, Aileen, additional, Deary, Ann, additional, Anderson, Rosemary, additional, Walker, Pauli, additional, Hansen, Christian, additional, Parker, Richard, additional, Rodriguez, Aryelly, additional, Macleod, Malcolm, additional, Gattringer, Thomas, additional, Palmer, Jeb, additional, Sakka, Eleni, additional, Adil-Smith, Jennifer, additional, Minks, David, additional, du Plessis, Johannes, additional, Lerpiniere, Christine, additional, O'Brien, Richard, additional, Burgess, Seona, additional, Mead, Gillian, additional, Paulton, Ruth, additional, Doubal, Fergus, additional, McCormick, Katrina, additional, Hunter, Neil, additional, Taylor, Pat, additional, Parakramawansha, Ruwan, additional, Perry, Jack, additional, Blair, Gordon, additional, MacRaild, Allan, additional, Parry-Jones, Adrian, additional, Johnes, Mary, additional, Lee, Stephanie, additional, Shaw, Kelly Marie, additional, Burger, Ilse, additional, Punter, Martin, additional, Ingham, Andrea, additional, Perez, Jane, additional, Naing, Zin, additional, Morell, Jordi, additional, Marsden, Tracy, additional, Hall, Andrea, additional, Marshall, Sally, additional, Harrison, Louise, additional, Jarapa, Rowilson, additional, Wood, Edith, additional, O'Loughlin, Victoria, additional, Cohen, David, additional, Davies, Silvie, additional, Njoku, Kelechi, additional, Mpelembue, Mushiya, additional, Burgess, Laura, additional, Licenik, Radim, additional, Ngwako, Mmua, additional, Nisar, Nabeela, additional, Niranchanan, Rangah, additional, Roganova, Tatjana, additional, Bathula, Rajaram, additional, Devine, Joseph, additional, David, Anette, additional, Oshodi, Anne, additional, Guo, Fenglin, additional, Owoyele, Emmanuelle, additional, Sukdeo, Varthi, additional, Ballantine, Robert, additional, Abbdul-saheb, Mudhar, additional, Chamberlain, Angela, additional, Chandrakumar, Aberami, additional, Poku, Philip, additional, Harkness, Kirsty, additional, Blank, Catrin, additional, Richards, Emma, additional, Ali, Ali, additional, Kibutu, Faith, additional, Balitska, Olesia, additional, Birchall, Kathryn, additional, Bayliss, Pauline, additional, Doyle, Clare, additional, Stocks, Kathy, additional, Majis, Arshad, additional, Howe, Jo, additional, Kamara, Christine, additional, Barron, Luke, additional, Maatouk, Ahmad, additional, Lindert, Ralf, additional, Dakin, Katy, additional, Redgrave, Jessica, additional, Bhaskaran, Biju, additional, Salih, Isam, additional, Kelly, Debs, additional, Szabo, Susan, additional, Tomlin, Dawn, additional, Bearne, Helen, additional, Buxton, Jean, additional, Fitzell, Pauline, additional, Ayres, Georgina, additional, Saulat, Afaq, additional, Horan, Kathleen, additional, Garfield-Smith, Joanne, additional, Bhakri, Harbens, additional, Guyler, Paul, additional, Sinha, Devesh, additional, Loganathan, Thayalini, additional, Siddiqui, Amber, additional, Siddiqui, Anwer, additional, Coward, Lucy, additional, Kunhunny, Swapna, additional, Tysoe, Sharon, additional, Orath Prabakaran, Rajalakshmi, additional, Kelavkar, Shyam, additional, Rashmi, Sindhu, additional, Ngo, David, additional, Ng, Kheng Xiong, additional, Menon, Nisha, additional, Shah, Sweni, additional, Barber, Mark, additional, Esson, Derek, additional, Brodie, Fiona, additional, Anjum, Talat, additional, Wani, Mushtaq, additional, Krishnan, Manju, additional, Quinn, Leanne, additional, Spencer, Jayne, additional, Jones, Terry, additional, Thompson-Jones, Helen, additional, Dacey, Lynne, additional, Chenna, Srikanth, additional, Storton, Sharon, additional, Thomas, Sarah, additional, Beaty, Teresa, additional, Treadwell, Shelley, additional, Davies, Caroline, additional, Tucker, Susan, additional, Connor, Lynda, additional, Slade, Peter, additional, Gainard, Glyn, additional, Muddegowda, Girish, additional, Sanyal, Ranjan, additional, Remegoso, Alda, additional, Abano, Nenette, additional, Causley, Chelsea, additional, Carpio, Racquel, additional, Stevens, Stephanie, additional, Butler, Adrian, additional, Varquez, Resti, additional, Denic, Hayley, additional, Alipio, Francis, additional, Moores, Andrew, additional, Barry, Adrian, additional, Maguire, Holly, additional, Grocott, Jeanette, additional, Finney, Kay, additional, Lyjko, Sue, additional, Roffe, Christine, additional, Hiden, Joanne, additional, Ferdinand, Phillip, additional, Cvoro, Vera, additional, Ullah, Khalil, additional, Chapman, Nicola, additional, Couser, Mandy, additional, Pound, Susan, additional, Mcauley, Sean, additional, Raghunathan, Senthil, additional, Shelton, Faye, additional, Hedstrom, Amanda, additional, Godfrey, Margi, additional, Havard, Diane, additional, Buck, Amanda, additional, Krishnan, Kailash, additional, Gilzeane, Nicola, additional, Roffe, Jack, additional, Clarke, Judith, additional, Whittamore, Katherine, additional, Sheikh, Saima, additional, Keshvara, Rekha, additional, Jordan, Carla, additional, Jackson, Benjamin, additional, Wilkes, Gwendoline, additional, Appleton, Jason, additional, Law, Zhe, additional, Matias, Oliver, additional, Vasileiadis, Evangelos, additional, Mason, Cathy, additional, Parry, Anthea, additional, Landers, Geraldine, additional, Holden, Melinda, additional, Aweid, Basaam, additional, Rashed, Khalid, additional, Balian, Linda, additional, Vickers, Carinna, additional, Keeling, Elizabeth, additional, Board, Sarah, additional, Allison, Joanna, additional, Buckley, Clare, additional, Williams-Yesson, Barbara, additional, Board, Joanne, additional, Pitt-Kerby, Tressy, additional, Tanate, Alfonso, additional, Wood, Diane, additional, Kini, Manohar, additional, Chadha, Dinesh, additional, Walstow, Deborah, additional, Fong, Rosanna, additional, Luder, Robert, additional, Adesina, Tolu, additional, Gallagher, Jill, additional, Bridger, Hayley, additional, Murali, Elodie, additional, Bhargava, Maneesh, additional, van Someren, Chloe, additional, Harrington, Frances, additional, Mate, Abhijit, additional, James, Ali, additional, Courtauld, Gillian, additional, Schofield, Christine, additional, Adie, Katja, additional, Lucas, Linda, additional, Bond, Kirsty, additional, Maund, Bev, additional, Ellis, Sam, additional, Mudd, Paul, additional, James, Martin, additional, Keenan, Samantha, additional, Bowring, Angela, additional, Cageao, Julie, additional, Kingwell, Hayley, additional, Roughan, Caroline, additional, Hemsley, Anthony, additional, Sword, Jane, additional, Strain, David, additional, Miller, Keniesha, additional, Goff, Anita, additional, Gupwell, Karin, additional, Thorpe, Kevin, additional, Emsley, Hedley, additional, Punekar, Shuja, additional, McLoughlin, Alison, additional, Sultan, Sulaiman, additional, Gregory, Bindu, additional, Raj, Sonia, additional, Doyle, Donna, additional, Muir, Keith, additional, Smith, Wilma, additional, Welch, Angela, additional, Moreton, Fiona, additional, Cheripelli, Bharath Kumar, additional, El Tawil, Salwa, additional, Kalladka, Dheeraj, additional, Huang, Xuya, additional, Day, Nicola, additional, Ramachandran, Sankaranarayanan, additional, Crosbie, Caroline, additional, Elliot, Jennifer, additional, Rudd, Tony, additional, Marks, Katherine, additional, Bhalla, Ajay, additional, Birns, Jonathan, additional, Kullane, Sagal, additional, Weir, Nic, additional, Allen, Christopher, additional, Pressly, Vanessa, additional, Crawford, Pam, additional, Battersby-Wood, Emma, additional, Blades, Alex, additional, Egerton, Shuna, additional, Walters, Ashleigh, additional, Evans, Sue, additional, Marigold, James Richard, additional, Smith, Fiona, additional, Howard, Gabriella, additional, Gartrell, Imogen, additional, Smith, Simon, additional, Creeden, Robyn, additional, Cox, Chloe, additional, Boxall, Cherish, additional, Hewitt, Jonathan, additional, Nott, Claire, additional, Sarah, Procter, additional, Whiteman, Jessica, additional, Buckle, Steve, additional, Wallace, Rebecca, additional, Mardania, Rina, additional, Gray, Jane, additional, Triscott, Claire, additional, Nair, Anand, additional, Greig, Jill, additional, Rana, Pratap, additional, Robinson, Matthew, additional, Alam, Mohammad Irfan, additional, Werring, David, additional, Wilson, Duncan, additional, Watchurst, Caroline, additional, Brezitski, Maria, additional, Crook, Luci, additional, Jones, Ifan, additional, Banaras, Azra, additional, Patel, Krishna, additional, Erande, Renuka, additional, Hogan, Caroline, additional, Hostettler, Isabel, additional, Ashton, Amy, additional, Feerick, Shez, additional, Francia, Nina, additional, Oji, Nnebuife, additional, Elliott, Emma, additional, Al-Mayhani, Talal, additional, Dennis, Martin, additional, Sudlow, Cathie, additional, Whiteley, William, additional, Al-Shahi Salman, Rustam, additional, Dutta, Dipankar, additional, Brown, Pauline, additional, Ward, Deborah, additional, Davis, Fiona, additional, Turfrey, Jennifer, additional, Hughes, Chloe, additional, Collins, Kayleigh, additional, Bakawala, Rehana, additional, O'Connell, Susan, additional, Glass, Jon, additional, Broughton, David, additional, Tryambake, Dinesh, additional, Dixon, Lynn, additional, Chapman, Kath, additional, Young, Andrew, additional, Bergin, Adrian, additional, Sigsworth, Andrew, additional, Manoj, Aravind, additional, Fletcher, Glyn, additional, Lopez, Paula, additional, Cox, Penelope, additional, Wilkinson, Mark, additional, Fitzsimmons, Paul, additional, Sharma, Nikhil, additional, Choulerton, James, additional, Button, Denise, additional, Dow, Lindsey, additional, Gbadamoshi, Lukuman, additional, Avis, Joanne, additional, Madigan, Barbara, additional, McCann, Stephanie, additional, Shaw, Louise, additional, Howcroft, Deborah, additional, Lucas, Suzanne, additional, Stone, Andrew, additional, Cluckie, Gillian, additional, Lovelock, Caroline, additional, Clarke, Brian, additional, Chopra, Neha, additional, Clarke, Natasha, additional, Patel, Bhavini, additional, Kennedy, Kate, additional, Williams, Rebecca, additional, Blight, Adrian, additional, O'Reilly, Joanna, additional, Orefo, Chukwuka, additional, Dayal, Nilofer, additional, Ghatala, Rita, additional, Adedoyin, Temi, additional, Watson, Fran, additional, Trippier, Sarah, additional, Choy, Lillian, additional, Moynihan, Barry, additional, Khan, Usman, additional, Jones, Val, additional, Jeyaraj, Naomi, additional, Kerin, Lourda, additional, Thavanesan, Kamy, additional, Tiwari, Divya, additional, Cox, Chantel, additional, Ljubez, Anja, additional, Tucker, Laura, additional, Iqbal, Arshi, additional, Bagnall, Caroline, additional, Keltos, Marketa, additional, Roberts, Josh, additional, Jupp, Becky, additional, Ovington, Catherine, additional, Rogers, Emily, additional, David, Owen, additional, Bell, Jo, additional, Longland, Barbara, additional, Hann, Gail, additional, Cooper, Martin, additional, Nasar, Mohammad, additional, Rajapakse, Anoja, additional, Wynter, Inez, additional, Anwar, Ijaz, additional, Skinner, Helen, additional, Nozedar, Tarn, additional, McArdle, Damian, additional, Kumar, Balakrishna, additional, Crawford, Susan, additional, Annamalai, Arunkumar, additional, Ramshaw, Alex, additional, Holmes, Clare, additional, Caine, Sarah, additional, Osborn, Mairead, additional, Dodd, Emily, additional, Murphy, Peter, additional, Devitt, Nicola, additional, Baker, Pauline, additional, Steele, Amy, additional, Guthrie, Lucy Belle, additional, Clarke, Samantha, additional, Hassan, Ahamad, additional, Waugh, Dean, additional, Veraque, Emelda, additional, Makawa, Linetty, additional, Kambafwile, Mary, additional, Randall, Marc, additional, Papavasileiou, Vasileios, additional, Cullen, Claire, additional, Peters, Jenny, additional, Thant, Hlaing, additional, Ingram, Tanya, additional, Zoe, Mellor, additional, Durairaj, Ramesh, additional, Harrison, Melanie, additional, Stevenson, Sarah, additional, Shackcloth, Daniela, additional, Ewing, Jordan, additional, Sutton, Victoria, additional, McCarron, Mark, additional, McKee, Jacqueline, additional, Doherty, Mandy, additional, McVerry, Ferghal, additional, Blair, Caroline, additional, MacLeod, Mary, additional, Irvine, Janice, additional, Gow, Heather, additional, Furnace, Jacqueline, additional, Joyson, Anu, additional, Jagpal, Baljit, additional, Ross, Sarah, additional, Klaasen, Katrina, additional, Nelson, Sandra, additional, Clarke, Rebecca, additional, Crouch, Nichola, additional, MacLennan, Beverly, additional, Taylor, Vicky, additional, Epstein, Daniel, additional, Shukla, Avani, additional, Krishnamurthy, Vinodh, additional, Nicholas, Paul, additional, Qureshi, Sammie, additional, Webber, Adam, additional, Penge, Justin, additional, Ramadan, Hawraman, additional, Maguire, Stuart, additional, Patterson, Chris, additional, Bellfield, Ruth, additional, Hairsine, Brigid, additional, Stewart, Kelvin, additional, Hooley, Michaela, additional, Quinn, Outi, additional, Richard, Bella, additional, Moseley, Sally, additional, Edwards, Mandy, additional, Lawson, Heidi, additional, Tayler, Michelle, additional, Pai, Yogish, additional, Dhakal, Mahesh, additional, Esisi, Bernard, additional, Dima, Sofia, additional, Smith, Gemma Marie, additional, Garside, Mark, additional, Naeem, Muhammad, additional, Baliga, Vidya, additional, Rogers, Gill, additional, Brown, Ellen, additional, Bruce, David, additional, Hayman, Rachel, additional, Clayton, Susan, additional, Gamble, Ed, additional, Grue, Rebecca, additional, Charles, Bethan, additional, Hague, Adam, additional, Blane, Sujata, additional, Lambert, Caroline, additional, Chaudhry, Afnan, additional, Harrison, Thomas, additional, Saastamoinen, Kari, additional, Hove, Dionne, additional, Howaniec, Laura, additional, Grimwood, Gemma, additional, Redjep, Ozlem, additional, Humphries, Fiona, additional, Argandona, Lucia, additional, Cuenoud, Larissa, additional, Erumere, Esther, additional, Amlani, Sageet, additional, Auld, Grace, additional, Salek-Haddadi, Afraim, additional, Schulz, Ursula, additional, Kennedy, James, additional, Ford, Gary, additional, Mathieson, Philip, additional, Reckless, Ian, additional, Teal, Rachel, additional, Lenti, Giulia, additional, Harston, George, additional, O'Brien, Eoin, additional, Mcgee, Joanne, additional, Mitchell, Jennifer, additional, Amis, Elaine, additional, Handley, Dominic, additional, Kelly, Siobhan, additional, Zachariah, George, additional, Francis, Jobbin, additional, Crisp, Sarah, additional, Sesay, Juliana, additional, Finlay, Sarah, additional, Hayhoe, Helen, additional, Hannon, Niamh, additional, Hughes, Tom, additional, Morse, Bethan, additional, De Berker, Henry, additional, Tallantyre, Emma, additional, Osman, Ahmed, additional, White, Susan, additional, Schwarz, Stefan, additional, Jelley, Benjamin, additional, Yadava, Rajendra, additional, Azhar, Khalid, additional, Reddan, Julie, additional, Sangombe, Mirriam, additional, Stafford, Samantha, additional, Fotherby, Ken, additional, Morgan, Debbie, additional, Baig, Farrukh, additional, Jennings-Preece, Karla, additional, Butler, Donna, additional, Ahmad, Nasar, additional, Willberry, Angela, additional, Stevens, Angela, additional, Rai, Baljinder, additional, Siddegowda, Prasad, additional, Howard, Peter, additional, Hyatt, Lisa, additional, Dobson, Tracey, additional, Jarrett, David, additional, Ponnambath, Suheil, additional, Tandy, Jane, additional, Harrington-Davies, Yasmin, additional, Butler, Rebecca, additional, James, Claire, additional, Valentine, Stacey, additional, Suttling, Anne, additional, Langhorne, Peter, additional, Kerr, Gillian, additional, Wright, Fiona, additional, Graham, Ruth, additional, McAlpine, Christine, additional, Iqbal, Mohammad Shahzad, additional, Humphreys, Louise, additional, Pasco, Kath, additional, Balazikova, Olga, additional, Nasim, Ashraf, additional, Peixoto, Cassilda, additional, Gallagher, Louise, additional, Shahmehri, Shahrzad, additional, Ghosh, Sandip, additional, Barrie, Elizabeth, additional, Gilmour, Danielle, additional, Henry, Margo, additional, Webb, Tom, additional, Cowie, Linda, additional, Rudenko, Hannah, additional, McDonald, Shanni, additional, Schumacher, Natasha, additional, Walker, Susannah, additional, Cosier, Tracey, additional, Verrion, Anna, additional, Beranova, Eva, additional, Thomson, Audrey, additional, Venter, Marius, additional, Kar, Arindam, additional, Mashate, Sheila, additional, Harvey, Kirsten, additional, Gardener, Léjeune, additional, Nguyen, Vinh, additional, Halse, Omid, additional, Geraghty, Olivia, additional, Hazel, Beth, additional, Wilding, Peter, additional, Tilley, Victoria, additional, Cassidy, Tim, additional, McClelland, Beverley, additional, Bokhari, Maria, additional, England, Timothy, additional, Maddula, Mohana, additional, Donnelly, Richard, additional, Findlay, Paul, additional, Macaden, Ashish, additional, Shread, Ian, additional, Barr, Charlotte, additional, Mohd Nor, Azlisham, additional, Brown, Claire, additional, Persad, Nicola, additional, Eglinton, Charlotte, additional, Weinling, Marie, additional, Hyams, Benjamin, additional, Shah, Alex, additional, Baker, John, additional, Byrne, Anthony, additional, McGhee, Caroline, additional, Smart, Amanda, additional, Copeland, Claire, additional, Carpenter, Michael, additional, Walker, Marion, additional, Davey, Richard, additional, Needle, Ann, additional, Fathima, Razik, additional, Bateman, Gavin, additional, Datta, Prabal, additional, Stanners, Andrew, additional, Jackson, Linda, additional, Ball, Julie, additional, Davis, Michelle, additional, Atkinson, Natalie, additional, Fawcett, Michelle, additional, Thompson, Teresa, additional, Guy, Helen, additional, Hogg, Valerie, additional, Hays, Carole, additional, Woodward, Stephen, additional, Haque, Mohammad, additional, Hakim, Eluzai, additional, Symonds, Stuart, additional, Maanoosi, Mehran, additional, Herman, Jane, additional, Black, Toby, additional, Miriam, Skelton, additional, Clarke, Caroline, additional, Anthony, Alpha, additional, Tribbeck, Michele, additional, Cronin, Julie, additional, Mead, Denise, additional, Fennelly, Ruth, additional, McIlmoyle, James, additional, Dickinson, Christina, additional, Jeffs, Carol, additional, Anwar, Sajjad, additional, Howard, Joanne, additional, Jones, Kirsty, additional, Dhar, Saikat, additional, Clay, Caroline, additional, Siddiq, Muhammad, additional, Ivatts, Simone, additional, Baird, Yolanda, additional, Sally, Moore, additional, Amey, Isobel, additional, Newton, Sophie, additional, Clayton-Evans, Lisa, additional, Chadbourn, Indra, additional, Rayessa, Rayessa, additional, Naylor, Charde, additional, Rodgers, Alicia, additional, Wilson, Lisa, additional, Wilson, Sarah, additional, Clarkson, Emma, additional, Davies, Ruth, additional, Owings, Paula, additional, Sangster, Graeme, additional, Gott, Valerie, additional, Little, Victoria, additional, Weir, Pauline, additional, Cherian, Suja, additional, Jose, Deepa, additional, Moroney, Helen, additional, Downham, Susan, additional, Dodd, Angela, additional, Vettimootal Johnson, Venetia, additional, Codd, Laura, additional, Robinson, Naomi, additional, Ahmed, Ashraf, additional, Albazzaz, Mo, additional, Johnson, Sharon, additional, Denniss, Carol, additional, Cunningham, Mishell, additional, Zahoor, Tajammal, additional, Webster, Timothy, additional, Leason, Sandra, additional, Haider, Syed, additional, Chatterjee, Kausic, additional, Nallasivan, Arumugam, additional, Perkins, Charlotte, additional, Seagrave, Samantha, additional, Jenkins, Colin, additional, Price, Fiona, additional, Hughes, Claire, additional, Mercer, Lily, additional, Hussain, Malik, additional, Brown, Sarah, additional, Harvey, Miriam, additional, Homan, Jane, additional, Khan, Mohammad, additional, Whiting, Robert, additional, Foote, Leanne, additional, Hunt, Nicholas, additional, Durman, Helen, additional, Brotherton, Lucy, additional, Foot, Jayne, additional, Pawley, Corinne, additional, Foster, Eliza, additional, Whitcher, Alison, additional, Metcalf, Kneale, additional, Jagger, Jenny, additional, McDonald, Susan, additional, Waterfield, Kelly, additional, Sutton, Patrick, additional, Shinh, Naval, additional, Anversha, Ajmal, additional, Ravenhill, Garth, additional, Greenwood, Richard, additional, Saada, Janak, additional, Wiltshire, Alison, additional, Perfitt, Rebekah, additional, Andole, Sreeman, additional, Gadapa, Naveen, additional, Dunne, Karen, additional, Krommyda, Magdalini, additional, Burssens, Evelyne, additional, King, Sam, additional, Plewa, Catherine, additional, Smyth, Nigel, additional, Wilson, Jenny, additional, Giallombardo, Elio, additional, Sykes, Lucy, additional, Kumar, Pradeep, additional, Barker, James, additional, Huggett, Isabel, additional, Dunn, Linda, additional, Culmsee, Charlotte, additional, Thomas, Philip, additional, Myint, Min, additional, Brew, Helen, additional, Majmudar, Nikhil, additional, OConnell, Janice, additional, Bunea, George, additional, Fox, Charlotte, additional, Gulliver, Diane, additional, Smith, Andrew, additional, Mokoena, Betty, additional, Sattar, Naweed, additional, Krishnamurthy, Ramesh, additional, Osborne, Emily, additional, Wilson, David, additional, Wroath, Belinda, additional, Dynan, Kevin, additional, Power, Michael, additional, Thompson, Susan, additional, Adell, Victoria, additional, Orugun, Enoch, additional, Poultney, Una, additional, Glover, Rachel, additional, Crowther, Hannah, additional, Thornthwaite, Sarah, additional, Wiggam, Ivan, additional, Wallace, Aine, additional, Kerr, Enda, additional, Fulton, Ailsa, additional, Hunter, Annemarie, additional, Tauro, Suzanne, additional, Cuddy, Sarah, additional, Mangion, David, additional, Hardwick, Anne, additional, Markova, Skarlet, additional, Lawrence, Tara, additional, Constantin, Carmen, additional, Fletcher, Jo, additional, Thomas, Isobel, additional, Pettitt, Kerry, additional, Sekaran, Lakshmanan, additional, Tate, Margaret, additional, Bharaj, Kiranjit, additional, Simon, Rohan, additional, Justin, Frances, additional, Sethuraman, Sakthivel, additional, Phiri, Duke, additional, Mohammed, Niaz, additional, Chauhan, Meena, additional, Elfandi, Khaled, additional, Khan, Uzma, additional, Eveson, David, additional, Mistri, Amit, additional, Manning, Lisa, additional, Khan, Shagufta, additional, Patel, Champa, additional, Moqsith, Mohammed, additional, Sattar, Saira, additional, Lam, Man Yee, additional, Musarrat, Kashif, additional, Stephens, Claire, additional, Kalathil, Latheef, additional, Miller, Richard, additional, Salehin, Maqsud, additional, Gautam, Nikki, additional, Bailey, Duncan, additional, Amor, Kelly, additional, Meir, Julie, additional, Nicolson, Anne, additional, Imam, Javed, additional, Wood, Lisa, additional, White, Julie, additional, Sajid, Mahmud, additional, Ghaly, George, additional, Ball, Margaret, additional, Gascoyne, Rachel, additional, Proeschel, Harald, additional, Sharpe, Simon, additional, Horton, Sarah, additional, Beaves, Emily, additional, Jones, Stephanie, additional, Yip, Brigitte, additional, Bell, Murdina, additional, MacLiver, Linda, additional, MacInnes, Brian, additional, Sims, Don, additional, Hurley, Jennifer, additional, Willmot, Mark, additional, Sutton, Claire, additional, Littleton, Edward, additional, Maiden, Susan, additional, Jones, Rachael, additional, Cunningham, James, additional, Green, Carole, additional, Bates, Michelle, additional, Shekhar, Raj, additional, Gilham, Ellie, additional, Ahmed, Iman, additional, Crown, Rachel, additional, Fuller, Tracy, additional, Goorah, Neetish, additional, Bell, Angela, additional, Kelly, Christine, additional, Singh, Arun, additional, Walford, Jamie, additional, Tomlinson, Benjamin, additional, Patel, Farzana, additional, Duberley, Stephen, additional, Kane, Ingrid, additional, Rajkumar, Chakravarthi, additional, Gaylard, Jane, additional, Breeds, Joanna, additional, Gainsborough, Nicola, additional, Pitt-Ford, Alexandra, additional, Barbon, Emma, additional, Latter, Laura, additional, Thompson, Philip, additional, Hervey, Simon, additional, Krishnamoorthy, Shrivakumar, additional, Vassallo, Joseph, additional, Walter, Deborah, additional, Cochrane, Helen, additional, Srinivasan, Meena, additional, Campbell, Robert, additional, Donaldson, Denise, additional, Motherwell, Nichola, additional, Hurford, Frances, additional, Mukherjee, Indranil, additional, Kenton, Antony, additional, Nyabadza, Sheila, additional, Martin, Irene, additional, Hunt, Benjamin, additional, Hassan, Hardi, additional, O'Toole, Sarah, additional, Dallol, Bander, additional, Putterill, Janet, additional, Jha, Ratneshwari, additional, Gallifent, Rachel, additional, Kakar, Puneet, additional, Pusalkar, Aparna, additional, Chan, kelly, additional, Dangri, Puneet, additional, Beadle, Hannah, additional, Cook, Angela, additional, Crabtree, Karen, additional, Subramonian, Santhosh, additional, Owusu-Agyei, Peter, additional, Temple, Natalie, additional, Butterworth-Cowin, Nicola, additional, Ragab, Suzanne, additional, Knops, Kerstin, additional, Jinks, Emma, additional, Dickson, Christine, additional, Gleave, Laura, additional, Dube, Judith, additional, Leggett, Jacqui, additional, Garcia, Tatiana, additional, Ispoglou, Sissy, additional, Evans, Rachel, additional, Ankolekar, Sandeep, additional, Hayes, Anne, additional, Ni, Hlaing, additional, Rahman, Bithi, additional, Milligan, Josette, additional, Graham, Carol, additional, Jose, Josin, additional, Keegan, Breffni, additional, Kelly, Jim, additional, Dewar, Richard, additional, White, James, additional, and Thomas, Kelly, additional
Published: 2019
Full Text: View/download PDF

25. Management of a wake-up stroke

Author: Huang, Xuya, primary, Alakbarzade, Vafa, additional, Khandanpour, Nader, additional, and Pereira, Anthony C, additional
Published: 2019
Full Text: View/download PDF

26. Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

Author: Dennis, Martin, primary, Mead, Gillian, additional, Forbes, John, additional, Graham, Catriona, additional, Hackett, Maree, additional, Hankey, Graeme J, additional, House, Allan, additional, Lewis, Stephanie, additional, Lundström, Erik, additional, Sandercock, Peter, additional, Innes, Karen, additional, Williams, Carol, additional, Drever, Jonathan, additional, Mcgrath, Aileen, additional, Deary, Ann, additional, Fraser, Ruth, additional, Anderson, Rosemary, additional, Walker, Pauli, additional, Perry, David, additional, Mcgill, Connor, additional, Buchanan, David, additional, Chun, Yvonne, additional, Dinsmore, Lynn, additional, Maschauer, Emma, additional, Barugh, Amanda, additional, Mikhail, Shadia, additional, Blair, Gordon, additional, Hoeritzauer, Ingrid, additional, Scott, Maggie, additional, Fraser, Greig, additional, Lawrence, Katherine, additional, Shaw, Alison, additional, Williamson, Judith, additional, Burgess, David, additional, Macleod, Malcolm, additional, Morales, Dan, additional, Sullivan, Frank, additional, Brady, Marian, additional, French, Ray, additional, Van Wijck, Frederike, additional, Watkins, Caroline, additional, Proudfoot, Fiona, additional, Skwarski, Joanna, additional, Mcgowan, Diane, additional, Murphy, Rachael, additional, Burgess, Seona, additional, Rutherford, William, additional, Mccormick, Katrina, additional, Buchan, Ruaridh, additional, Macraild, Allan, additional, Paulton, Ruth, additional, Fazal, Adnan, additional, Taylor, Pat, additional, Parakramawansha, Ruwan, additional, Hunter, Neil, additional, Perry, Jack, additional, Bamford, John, additional, Waugh, Dean, additional, Veraque, Emelda, additional, Bedford, Caroline, additional, Kambafwile, Mary, additional, Idrovo, Luis, additional, Makawa, Linetty, additional, Smalley, Paula, additional, Randall, Marc, additional, Thirugnana-Chandran, Tharani, additional, Hassan, Ahamad, additional, Vowden, Richard, additional, Jackson, Joanne, additional, Bhalla, Ajay, additional, Rudd, Anthony, additional, Tam, Chi Kai, additional, Birns, Jonathan, additional, Gibbs, Charlotte, additional, Lee Carbon, Leonie, additional, Cattermole, Elizabeth, additional, Marks, Katherine, additional, Cape, Angela, additional, Hurley, Lisa, additional, Kullane, Sagal, additional, Smyth, Nigel, additional, Eglinton, Charlotte, additional, Wilson, Jennifer, additional, Giallombardo, Elio, additional, Frith, Angela, additional, Reidy, Paul, additional, Pitt, Matthew, additional, Sykes, Lucy, additional, Dellafera, Deborah, additional, Croome, Victoria, additional, Kerwood, Lauriane, additional, Hancevic, Mirea, additional, Narh, Christina, additional, Merritt, Carley, additional, Duffy, John, additional, Cooke, Duncan, additional, Willson, Juliet, additional, Ali, Ali, additional, Naqvi, Aaizza, additional, Kamara, Christine, additional, Bowler, Helen, additional, Bell, Simon, additional, Jackson, Tracy, additional, Harkness, Kirsty, additional, Stocks, Kathy, additional, Duty, Suzanna, additional, Doyle, Clare, additional, Dunn, Geoffrey, additional, Endean, Keith, additional, Claydon, Fiona, additional, Richards, Emma, additional, Howe, Jo, additional, Lindert, Ralf, additional, Majid, Arshad, additional, Dakin, Katy, additional, Maatouk, Ahmad, additional, Barron, Luke, additional, Meegada, Madana, additional, Rana, Pratap, additional, Nair, Anand, additional, Brighouse-Johnson, Christine, additional, Greig, Jill, additional, Kyu, Myint, additional, Prasad, Sanjeev, additional, Robinson, Matthew, additional, Alam, Irfan, additional, Mclean, Belinda, additional, Greenhalgh, Lindsay, additional, Ahmed, Zenab, additional, Roffe, Christine, additional, Brammer, Susan, additional, Beardmore, Carole, additional, Finney, Kay, additional, Barry, Adrian, additional, Hollinshead, Paul, additional, Grocott, Jeanette, additional, Maguire, Holly, additional, Natarajan, Indira, additional, Chembala, Jayan, additional, Sanyal, Ranjan, additional, Lijko, Sue, additional, Abano, Nenette, additional, Remegoso, Alda, additional, Ferdinand, Phillip, additional, Stevens, Stephanie, additional, Varquez, Resti, additional, Causley, Chelsea, additional, Butler, Adrian, additional, Whitmore, Philip, additional, Stephen, Caroline, additional, Carpio, Racquel, additional, Hiden, Joanne, additional, Muddegowda, Girish, additional, Denic, Hayley, additional, Sword, Jane, additional, Curwen, Ross, additional, James, Martin, additional, Mudd, Paul, additional, Hall, Fiona, additional, Cageao, Julie, additional, Keenan, Samantha, additional, Roughan, Caroline, additional, Kingwell, Hayley, additional, Hemsley, Anthony, additional, Lohan, Christoph, additional, Davenport, Sue, additional, Bowring, Angela, additional, Chapter, Tamika, additional, Hough, Max, additional, Strain, David, additional, Gupwell, Karin, additional, Miller, Keniesha, additional, Goff, Anita, additional, Cusack, Ellie, additional, Todd, Shirley, additional, Partridge, Rebecca, additional, Jennings, Georgiana, additional, Thorpe, Kevin, additional, Stephenson, Jacquelyn, additional, Littlewood, Kelly, additional, Barber, Mark, additional, Brodie, Fiona, additional, Marshall, Steven, additional, Esson, Derek, additional, Coburn, Irene, additional, Mcinnes, Caroline, additional, Ross, Fiona, additional, Bowie, Emma, additional, Barcroft, Heather, additional, Withers, Victoria, additional, Miller, Laura, additional, Willcoxson, Paul, additional, Donninson, Michelle, additional, Evans, Richard, additional, Daniel, Di, additional, Coyle, John, additional, Keeling, Michael, additional, Wanklyn, Peter, additional, Elliott, Mark, additional, Wightman, John, additional, Iveson, Elizabeth, additional, Dyer, Natasha, additional, Porteous, Anne-Marie, additional, Haritakis, Monica, additional, Ward, Mandy, additional, Doughty, Lucy, additional, Carr, Lisa, additional, O Neill, Mark, additional, Anazodo, Cosmas, additional, Wood, Paul, additional, Cottrell, Poppy, additional, Donne, Cheryl, additional, Rodriguez, Romina, additional, Mir, Ruhail, additional, Westmoreland, Jax, additional, Bell, Judith, additional, Emms, Christopher, additional, Wright, Lorraine, additional, Clark Brown, Pearl, additional, Bamford, Elizabeth, additional, Stanners, Andrew, additional, Carpenter, Mike, additional, Datta, Prabal, additional, Davey, Richard, additional, Needle, Ann, additional, Eastwood, Marjorie Jane, additional, Razik, Fathima Zeena, additional, Ghouri, Imran, additional, Bateman, Gavin, additional, Archer, Judy, additional, Balasubramanian, Venkatesh, additional, Bowers, Richard, additional, Ball, Julie, additional, Benton, Louise, additional, Jackson, Linda, additional, Ellam, Julie, additional, Norton, Kate, additional, Guyler, Paul, additional, Dowling, Terry, additional, Tysoe, Sharon, additional, Harman, Paula, additional, Kundu, Ashish, additional, Omodunbi, Ololade, additional, Loganathan, Thayalini, additional, Chandler, Stuart, additional, Noor, Shanas, additional, Siddiqui, Anwer, additional, Siddiqui, Amber, additional, Kunhunny, Swapna, additional, Sinha, Devesh, additional, Sheppard, Martin, additional, Rashmi, Sindhu, additional, France, Elena, additional, Orath Prabakaran, Rajalakshmi, additional, Wilson, Laura, additional, Ropun, Amiirah, additional, Kelavkar, Shyam, additional, Ng, Kheng Xiong, additional, Kamuriwo, Lucy, additional, Shah, Sweni, additional, Mangion, David, additional, Constantin, Camen, additional, De Michele Hock, Luigi, additional, Hardwick, Anne, additional, Borley, Jayne, additional, Markova, Skarlet, additional, Netherton, Kimberley, additional, Lawrence, Tara, additional, Fletcher, Jo, additional, Spencer, Rebecca, additional, Palmer, Helen, additional, Cullen, Claire, additional, Hamill, Dolores, additional, Durairaj, Ramesh, additional, Mellor, Zoe, additional, Fluskey, Tanya, additional, Wood, Diane, additional, Keeling, Alison, additional, Hankin, Victoria, additional, Peters, Jennifer, additional, Shackcloth, Daniela, additional, Hlaing, Thant, additional, Tangney, Rebecca, additional, Ewing, Jordan, additional, Harrison, Melanie, additional, Stevenson, Sarah, additional, Sutton, Victoria, additional, Soliman, Mohamed, additional, Hindle, Julia, additional, Watson, Elizabeth, additional, Hewitt, Claire, additional, Butler, Susie, additional, Wahishi, Ibrahim, additional, Arif, Sarwat, additional, Fields, Amy, additional, Sharma, Jagdish, additional, Brown, Rose, additional, Taylor, Caroline, additional, Bell, Sarah, additional, Leach, Simon, additional, Patterson, Chris, additional, Khan, Sophia, additional, Wilson, Helen, additional, Price, Joanne, additional, Ramadan, Hawraman, additional, Maguire, Stuart, additional, Bellfield, Ruth, additional, Hooley, Michaela, additional, Hamid, Umair, additional, Gaba, Waqar, additional, Ghulam, Robina, additional, Masters, Leslie, additional, Quinn, Outi, additional, Sekaran, Lakshmanan, additional, Tate, Margaret, additional, Mohammed, Niaz, additional, Bharaj, Kiranjit, additional, Justin, Frances, additional, Pattni, Rajan, additional, Alwis, Lanka, additional, Sethuraman, Sakthivel, additional, Robinson, Rianne, additional, Eldridge, Lianne, additional, Mintias, Susan, additional, Chauhan, Meena, additional, Tam, Chi-Kai, additional, Palmones, Jeremias, additional, Holmes, Clare, additional, Guthrie, Lucy Belle, additional, Osborn, Mairead, additional, Ball, Lindsay, additional, Caine, Sarah, additional, Steele, Amy, additional, Murphy, Peter, additional, Devitt, Nikki, additional, Leonard, Jayne, additional, Patel, Ronak, additional, Penwarden, Ian, additional, Dodd, Emily, additional, Holloway, Amy, additional, Baker, Pauline, additional, Clarke, Samantha, additional, Williams, Sandra, additional, Dow, Lindsey, additional, Wynn-Williams, Roland, additional, Kennedy, James, additional, Teal, Rachel, additional, Schulz, Ursula, additional, Ford, Gary, additional, Mathieson, Philip, additional, Reckless, Ian, additional, Deveciana, Ana, additional, Mccann, Paige, additional, Cluckie, Gillian, additional, Howell, Geoffrey, additional, Ayer, Jonathan, additional, Moynihan, Barry, additional, Ghatala, Rita, additional, Clarke, Brian, additional, Cloud, Geoffrey, additional, Patel, Bhavini, additional, Khan, Usman, additional, Al-Samarrai, Nia, additional, Trippier, Sarah, additional, Chopra, Neha, additional, Adedoyin, Temi, additional, Watson, Fran, additional, Jones, Val, additional, Zhang, Liqun, additional, Choy, Lillian, additional, Williams, Rebecca, additional, Clarke, Natasha, additional, Blight, Adrian, additional, Kennedy, Kate, additional, Dainty, Alice, additional, Selvarajah, Johann, additional, Kalladka, Dheeraj, additional, Cheripelli, Bharath, additional, Smith, Wilma, additional, Moreton, Fiona, additional, Welch, Angela, additional, Huang, Xuya, additional, Douglas, Elizabeth, additional, Lush, Audrey, additional, Day, Nicola, additional, El Tawil, Salwa, additional, Montgomery, Karen, additional, Hamilton, Helen, additional, Ritchie, Doreen, additional, Ramachandra, Sankaranarayanan, additional, Mcleish, Kirsty, additional, Thavanesan, Kamy, additional, Loganathan, Sathyabama, additional, Roberts, Josh, additional, Cox, Chantel, additional, Orr, Sarah, additional, Hogan, Alison, additional, Tiwari, Divya, additional, Hann, Gail, additional, Longland, Barbara, additional, David, Owen, additional, Bell, Jo, additional, Ovington, Catherine, additional, Rogers, Emily, additional, Bower, Rachel, additional, Keltos, Marketa, additional, Cohen, David, additional, Devine, Joseph, additional, Alwis, Lankantha, additional, Southworth, Lucy, additional, Burgess, Laura, additional, Lang, Matilda, additional, Badiani, Bhavna, additional, Guo, Fenglin, additional, Oshodi, Anne, additional, Owoyele, Emmanuelle, additional, Epie, Norah, additional, David, Anette, additional, Mpelembue, Mushiya, additional, Bathula, Rajaram, additional, Abdul-Saheb, Mudhar, additional, Chamberlain, Angela, additional, Sudkeo, Varthi, additional, Rashed, Khalid, additional, Williams-Yesson, Barbara, additional, Board, Joanne, additional, De Bruijn, Sarah, additional, Buckley, Clare, additional, Board, Sarah, additional, Allison, Joanna, additional, Keeling, Elizabeth, additional, Duckett, Tracey, additional, Donaldson, Dave, additional, Vickers, Carinna, additional, Barron, Claire, additional, Balian, Linda, additional, Wilson, Jodhi, additional, Edwards, Adam, additional, England, Timothy, additional, Hedstrom, Amanda, additional, Bedford, Elizabeth, additional, Harper, Margaret, additional, Melikyan, Elina, additional, Abbott, Wendy, additional, Subramanian, Kashmira, additional, Goldsworthy, Marie, additional, Srinivasan, Meena, additional, Yeomans, Angela, additional, Donaldson, Denise, additional, Hurford, Frances, additional, Chapman, Riquella, additional, Shahzad, Sana, additional, Motherwell, Nicki, additional, Tonks, Louise, additional, Young, Rachel, additional, Ghani, Usman, additional, Mukherjee, Indranil, additional, Dutta, Dipankar, additional, Obaid, Mudhar, additional, Brown, Pauline, additional, Davis, Fiona, additional, Ward, Deborah, additional, Turfrey, Jennifer, additional, Cartwright, Bethan, additional, Topia, Bilal, additional, Spurway, Judith, additional, Collins, Kayleigh, additional, Bakawala, Rehana, additional, Hughes, Chloe, additional, Oconnell, Susan, additional, Hill, Linda, additional, Chatterjee, Kausik, additional, Webster, Tim, additional, Haider, Syed, additional, Rushworth, Pamela, additional, Macleod, Fiona, additional, Nallasivan, Arumugam, additional, Perkins, Charlotte, additional, Burns, Edel, additional, Leason, Sandra, additional, Carter, Tom, additional, Seagrave, Samantha, additional, Sami, Eman, additional, Armstrong, Lisa, additional, Naqvi, Syed Naseem, additional, Hassan, Muhammad, additional, Parkinson, Sharron, additional, Mawer, Samantha, additional, Darnbrook, Gillian, additional, Booth, Carl, additional, Hairsine, Brigid, additional, Smith, Matthew, additional, Williamson, Sue, additional, Farquhar, Fiona, additional, Esisi, Bernard, additional, Cassidy, Tim, additional, Mankin, Gavin, additional, Mcclelland, Beverley, additional, Bokhari, Maria, additional, Sproates, David, additional, Epstein, Elliot, additional, Hurdowar, Steve, additional, Blackburn, Ruth, additional, Sukhdeep, Nazran, additional, Razak, Saika, additional, Osman, Khalid, additional, Hashmi, Amina, additional, Upton, Natasha, additional, Harrington, Frances, additional, Courtauld, Gillian, additional, Schofield, Christine, additional, Lucas, Linda, additional, Adie, Katja, additional, Bond, Kirsty, additional, Mate, Abhijit, additional, Skewes, Jo, additional, James, Ali, additional, Brodie, Carolyn, additional, Johnson, Matthew, additional, Allsop, Linda, additional, Driver, Emma, additional, Harris, Karina, additional, Drake, Mark, additional, Ellis, Sam, additional, Maund, Bev, additional, Thomas, Emma, additional, Moore, Kimberley, additional, Burn, Matthew, additional, Hamilton, Adam, additional, Mahalingam, Shageetha, additional, Misra, Amulya, additional, Reid, Farrah, additional, Benford, Adrienne, additional, Hilton, Derek, additional, Hazell, Lorraine, additional, Ofori, Keziah, additional, Thomas, Anne Louise, additional, Mathew, Moncy, additional, Dayal, Sonia, additional, Burn, Iona, additional, Fotherby, Kenneth, additional, Jennings-Preece, Karla, additional, Willberry, Angela, additional, Morgan, Debbie, additional, Butler, Donna, additional, Sahota, Gurminder, additional, Kauldhar, Kelly, additional, Ahmad, Nasar, additional, Stevens, Angela, additional, Das, Saugata, additional, Bruce, David, additional, Pai, Yogish, additional, Nyo, Khin, additional, Stephenson, Lynsey, additional, Nendick, Richard, additional, Rogers, Gill, additional, Dhakal, Mahesh, additional, Dima, Sofia, additional, Brown, Ellen, additional, Clayton, Susan, additional, Gamble, Penny, additional, Naeem, Muhammad, additional, Hayman, Rachel, additional, Burnip, Rachel, additional, Earnshaw, Philip, additional, Hargroves, David, additional, Ransom, Barbara, additional, Rudenko, Hannah, additional, Balogun, Ibrahim, additional, Griffiths, Kirsty, additional, Mears, Kim, additional, Webb, Tom, additional, Cowie, Linda, additional, Hammond, Tessa, additional, Thomson, Audrey, additional, Ceccarelli, Daniela, additional, Chattha, Navraj, additional, Beranova, Eva, additional, Verrion, Anna, additional, Gillian, Andrew, additional, Schumacher, Natasha, additional, Bahk, Anna, additional, Walker, Susannah, additional, Cvoro, Vera, additional, Chapman, Nicola, additional, Pound, Susan, additional, Cain, Rebecca, additional, Mcauley, Sean, additional, Couser, Mandy, additional, Simpson, Maria, additional, Tachtatzis, Athan, additional, Ullah, Khalil, additional, Sims, Don, additional, Jones, Rachael, additional, Smith, Jonathan, additional, Tongue, Rebecca, additional, Willmot, Mark, additional, Sutton, Claire, additional, Littleton, Edward, additional, Khaira, Jattinder, additional, Maiden, Susan, additional, Cunningham, James, additional, Green, Carole, additional, Chin, Yin-May, additional, Bates, Michelle, additional, Ahlquist, Katherine, additional, Kane, Ingrid, additional, Breeds, Joanna, additional, Sargent, Tenesa, additional, Latter, Laura, additional, Pitt Ford, Alexandra, additional, Gainsborough, Nicola, additional, Levett, Tom, additional, Thompson, Philip, additional, Barbon, Emma, additional, Dunne, Angela, additional, Hervey, Simon, additional, Ragab, Suzanne, additional, Sandell, Tracy, additional, Dickson, Christine, additional, Dube, Judith, additional, Power, Sharon, additional, Evans, Nick, additional, Wadams, Beverley, additional, Elitova, Savina, additional, Aubrey, Beth, additional, Garcia, Tatiana, additional, Mcilmoyle, James, additional, Jeffs, Carol, additional, Dickinson, Christina, additional, Ahmed, Anis, additional, Kumar, Sanjeev, additional, Frudd, Julie, additional, Armer, Charlotte, additional, Potter, Andrew, additional, Donaldson, Stacey, additional, Howard, Joanne, additional, Jones, Kirsty, additional, Dhar, Saikat, additional, Collas, David, additional, Sundayi, Saul, additional, Denham, Lynn, additional, Oza, Deepali, additional, Walker, Elaine, additional, Bhandari, Mohit, additional, Ispoglou, Sissy, additional, Evans, Rachel, additional, Sharobeem, Kamel, additional, Walton, Elaine, additional, Shanu, Steven, additional, Hayes, Anne, additional, Howard-Brown, Jennifer, additional, Billingham, Steven, additional, Weir, Nic, additional, Pressly, Vanessa, additional, Wood, Emma, additional, Howard, Gabriella, additional, Burton, Holly, additional, Crawford, Pam, additional, Egerton, Shuna, additional, Evans, Sue, additional, Hakkak, Jasmine, additional, Andrews, Janet, additional, Lampard, Rebecca, additional, Allen, Christopher, additional, Walters, Ashleigh, additional, Said, Rasha, additional, Marigold, James Richard, additional, Tsang, Sau-Mon, additional, Creeden, Robyn, additional, Cox, Chloe, additional, Smith, Simon, additional, Gartrell, Imogen, additional, Smith, Fiona, additional, Jenkins, Colin, additional, Pryor, Joanna, additional, Hedges, Andrew, additional, Price, Fiona, additional, Moseley, Linda, additional, Mercer, Lily, additional, Hughes, Claire, additional, Azim, Abul, additional, White, Julie, additional, Krasinska-Chavez, Milena, additional, Chaplin, Shaun, additional, Curtis, James, additional, Singh, Deepwant, additional, Imam, Javed, additional, Nicolson, Anne, additional, Alam, Sajid, additional, Whitworth, Simon, additional, Wood, Lisa, additional, Warburton, Elizabeth, additional, Kelly, Siobhan, additional, Mcgee, Joanne, additional, Markus, Hugh, additional, Chandrasena, Denish, additional, Hayden, Derek, additional, Sesay, Juliana, additional, Hayhoe, Helen, additional, Bolton, Mark, additional, Macdonald, Jane, additional, Mitchell, Jenny, additional, Farron, Charlotte, additional, Amis, Elaine, additional, Day, Diana, additional, Culbert, Ainsley, additional, Espanol, Ailene, additional, Hannon, Niamh, additional, Handley, Dominic, additional, Finlay, Sarah, additional, Crisp, Sarah, additional, Whitehead, Lynne, additional, Francis, Jobbin, additional, Oconnell, Janice, additional, Osborne, Emily, additional, Beard, Rod, additional, Krishnamurthy, Ramesh, additional, Mokoena, Langanani, additional, Sattar, Naweed, additional, Myint, Min, additional, Edwards, Michelle, additional, Smith, Andrew, additional, Corrigan, Paul, additional, Byrne, Anthony, additional, Blackburn, Joanne, additional, Mcghee, Caroline, additional, Smart, Amanda, additional, Donaldson, Fiona, additional, Copeland, Claire, additional, Wilson, Jill, additional, Scott, Rhona, additional, Fitzsimmons, Paul, additional, Lopez, Paula, additional, Wilkinson, Mark, additional, Manoj, Aravindakshan, additional, Cox, Penelope, additional, Trainor, Leona, additional, Fletcher, Glyn, additional, Denny, Lisa, additional, Kavanagh, Karen, additional, Allsop, Hannah, additional, Emsley, Hedley, additional, Sultan, Sulaiman, additional, Mcloughlin, Alison, additional, Walmsley, Benjamin, additional, Hough, Louise, additional, Ahmed, Shakeel, additional, Doyle, Donna, additional, Gregary, Bindu, additional, Raj, Sonia, additional, Nagaratnam, Kirubananthan, additional, Mannava, Neelima, additional, Haque, Nyla, additional, Shields, Norma, additional, Preston, Kate, additional, Mason, Geraldine, additional, Short, Kirsty, additional, Lumsdale, Gemma, additional, Uitenbosch, Giulia, additional, Sukys, Ugnius, additional, Valentine, Stacey, additional, Jarrett, David, additional, Dodsworth, Kerry, additional, Wands, Mary, additional, Khan, Nisa, additional, Tandy, Jane, additional, Watkinson, Catrin, additional, Golding, Wendy, additional, Butler, Rebecca, additional, Williams, Max, additional, Davies, Yasmin, additional, Yip, Keith, additional, James, Claire, additional, Suttling, Anne, additional, Maney, Aditya, additional, Gamble, Giles Edward, additional, Hague, Adam, additional, Charles, Bethan, additional, Blane, Sujata, additional, Duran, Beatriz, additional, Lambert, Caroline, additional, Stagg, Katherine, additional, Whiting, Robert, additional, Homan, Jane E, additional, Brown, Sarah, additional, Hussain, Malik, additional, Harvey, Miriam, additional, Graham, Libby, additional, Foote, Leanne, additional, Lane, Catherine, additional, Kemp, Liz (Joan), additional, Rowe, Joy, additional, Durman, Helen, additional, Foot, Jayne, additional, Brotherton, Lucy, additional, Hunt, Nicholas, additional, Pawley, Corinne, additional, Whitcher, Alison, additional, Sutton, Patrick, additional, Mcdonald, Susan, additional, Pak, Denys, additional, Wiltshire, Alison, additional, Jagger, Jennifer, additional, Metcalf, Anthony K, additional, Healey, Gail Louise, additional, Balami, Joyce, additional, Self, Clare Marie, additional, Crofts, Melissa, additional, Chakrabarti, Annie, additional, Hmu, Chit, additional, Ravenhill, Garth, additional, Grimmer, Charmaine, additional, Soe, Thandar, additional, Keshet-Price, Jocelyn, additional, Langley, Margaret, additional, Potter, Ian, additional, Tam, Pui-Lin, additional, Macleod, Mary Joan, additional, Cooper, Patricia, additional, Christie, Michael, additional, Irvine, Janice, additional, Annison, Faye, additional, Christie, David, additional, Meneses, Celia, additional, Johnson, Amber, additional, Joyson, Anu, additional, Nelson, Sandra, additional, Taylor, Vicky, additional, Reid, John, additional, Clarke, Rebecca, additional, Furnace, Jacqueline, additional, Gow, Heather, additional, Abousleiman, Youssif, additional, Beadling, Tania, additional, Collins, Sally, additional, Jones, Stuart, additional, Purcell, Jessica, additional, Bloom, Samantha, additional, Goshawk, Shelly, additional, Landicho, Marcial, additional, Sangaralingham, Sivatharshini, additional, Begum, Yasmin, additional, Mutton, Sherree, additional, Munuswamy Vaiyapuri, Elangovan, additional, Allen, Jane, additional, Lowe, Jemma, additional, Hughes, Martin, additional, Wiggam, Ivan, additional, Cuddy, Sarah, additional, Tauro, Suzanne, additional, Wells, Brian, additional, Mohd Nor, Azlisham, additional, Persad, Nicola, additional, Kalita, Maggie, additional, Weatherby, Stuart, additional, Brown, Claire, additional, Pace, Adrian, additional, Lashley, Daniel, additional, Marner, Mike, additional, Weinling, Marie, additional, Wilmshurst, Natasha, additional, Waugh, Darren, additional, Mucha, Anna, additional, Shah, Alex, additional, Baker, John, additional, Westcott, Jacqueline, additional, Cowan, Richard, additional, Vasileiadis, Evangelos, additional, Mumani, Samira, additional, Parry, Anthea, additional, Mason, Cathy, additional, Holden, Melinda, additional, Petrides, Katerina, additional, Nishiyama, Tomoko, additional, Mehta, Hina, additional, Krishnan, Manju, additional, Lynne, Dacey, additional, Thomas, Lisa, additional, Lynda, Connor, additional, Hughes, Catherine, additional, Clements, Clare, additional, Williams, Rhys, additional, Anjum, Tal, additional, Sharon, Storton, additional, Tucker, Susan, additional, Jones, Paul, additional, Colwill, Deanne, additional, Thompson Jones, Helen, additional, Chadha, Dinesh, additional, Fairweather, Mark, additional, Walstow, Deborah, additional, Fong, Rosanna, additional, Johnston, Stuart, additional, Almadenboyle, Christine, additional, Ross, Sarah, additional, Carson, Shona, additional, Nair, Priya, additional, Tenbruck, Emily, additional, Stirling, Mairi, additional, Pusalkar, Aparna, additional, Beadle, Hannah, additional, Chan, Kelly, additional, Dangri, Puneet, additional, Asokanathan, Asaipillai, additional, Rana, Anita, additional, Gohil, Sunita, additional, Massyn, Mark, additional, Aruldoss, Prabhu, additional, Cook, Angela, additional, Crabtree, Karen, additional, Dabbagh, Sura, additional, Black, Toby, additional, Clarke, Caroline, additional, Mead, Denise, additional, Fennelly, Ruth, additional, Anthony, Alpha, additional, Nardone, Linda, additional, Dimartino, Victoria, additional, Tribbeck, Michele, additional, Broughton, David, additional, Tryambake, Dinesh, additional, Dixon, Lynn, additional, Skotnicka, Agnieszka, additional, Thompson, Jane, additional, Whitehouse, Sarah, additional, Sigsworth, Andrew, additional, Wong, Jason, additional, Annamalai, Arunkumar, additional, Pagan, Julie, additional, Affley, Brendan, additional, Sunderland, Caroline, additional, Goldenberg, Lynda, additional, Khan, Atif, additional, Wilkinson, Peter, additional, Nari, Raad, additional, Abbott, Lucy, additional, Young, Emma, additional, Shakhon, Amritpal, additional, Lock, Sally, additional, Stewart, Jack, additional, Pereira, Rita, additional, Dsouza, Margaret, additional, Dunn, Sally, additional, Mckenna, Anne-Marie, additional, Cron, Nina, additional, Kidd, Michelle, additional, Hull, Grace, additional, Bunworth, Kerry, additional, Drummond, Graham, additional, Mahawish, Karim, additional, Hayes, Nicola, additional, Connell, Lynne, additional, Simpson, Jennifer, additional, Penney, Helen, additional, Punekar, Shuja, additional, Nevinson, Joanne, additional, Wareing, William, additional, Ward, Jacqueline, additional, Greenwood, Richard, additional, Austin, Duncan, additional, Banaras, Azra, additional, Hogan, Carolin, additional, Corbett, Thomas, additional, Oji, Nnebuife, additional, Elliott, Emma, additional, Brezitski, Maria, additional, Passeron, Nathalie, additional, Howaniec, Laura, additional, Watchurst, Caroline, additional, Patel, Krishna, additional, Erande, Renuka, additional, Shah, Rahi, additional, Sengupta, Nabarun, additional, Metiu, Maria, additional, Gonzalez, Celia, additional, Funnell, Sarah, additional, Margalef, Jordi, additional, Peters, Gillian, additional, Chadbourn, Indra, additional, Sivakumar, Ramachandran, additional, Saksena, Rajesh, additional, Ketley-O'donel, Jane, additional, Needle, Richard, additional, Chinery, Elaine, additional, Wright, Alison, additional, Cook, Sue, additional, Ngeh, Joseph, additional, Proeschel, Harald, additional, Cook, Paige, additional, Ashcroft, Pauline, additional, Sharpe, Simon, additional, Jones, Stephanie, additional, Jenkinson, Damian, additional, Kelly, Deborah, additional, Bray, Holly, additional, Gunathilagan, Gunaratnam, additional, Jones, Sally, additional, Tilbey, Sorrell, additional, Abubakar, Saidu, additional, Vassallo, Joseph, additional, Leonard, Dee, additional, Orrell, Lucy, additional, Hasan, Aziz, additional, Khan, Asif, additional, Qamar, Sulmaaz, additional, Graham, Susan, additional, Hewitt, Emma, additional, Awolesi, Jennifer, additional, Haque, Muhammad, additional, Kent, Alissa, additional, Bradshaw, Elizabeth, additional, Cooper, Martin, additional, Wynter, Inez, additional, Rajapakse, Anoja, additional, Janbieh, Joumana, additional, Nasar, Abu M, additional, Wade, Lynne, additional, Otter, Linda, additional, Haigh, Steve, additional, Burgoyne, Jamie-Rae, additional, Boulton, Rebecca, additional, Boulton, Andrew, additional, Rayessa, Rayessa, additional, Clarkson, Emma, additional, Rhian, Horne, additional, Fleming, Amy, additional, Mitchelson, Kim, additional, Lowthorpe, Vicki, additional, Abdul-Hamid, Ahmed, additional, Jones, Phil, additional, Duggan, Claire, additional, Hynes, Abigail, additional, Nurse, Emma, additional, Raza, Syed Abid, additional, Jones, Sarah, additional, Pallikona, Udaya, additional, Edwards, Bleddyn, additional, Morgan, Geraint, additional, Dennett, Kirsty, additional, Tench, Helen, additional, Loosley, Ronda, additional, Trugeon-Smith, Toby, additional, Jones, Rhian, additional, Williams, Richard, additional, Robson, Donna, additional, Mavinamane, Sunanda, additional, Meenakshisundaram, Sanjeevi, additional, Ranga, Lalitha, additional, Dealing, Sharon, additional, Hill, Andrew, additional, Hargreaves, Margaret, additional, Smith, Tom, additional, Bate, Julie, additional, Harrison, Linda, additional, Kirthivasan, Ramanathan, additional, Cannon, Emma, additional, Topliffe, Joanne, additional, Keskeys, Rebecca, additional, Williams, Sarah, additional, Mcneela, Fiona, additional, Cairns, Frances, additional, James, Thomas, additional, Lyle, Amanda, additional, Shah, Sheela, additional, Zachariah, George, additional, Fergey, Lauren, additional, Smolen, Susan, additional, Cooper, Lucy, additional, Bohannan, Elizabeth, additional, Omer, Siddiq, additional, Amlani, Sageet, additional, Hunter, Nadia, additional, Hawkes-Blackburn, Melissa, additional, Gulli, Giosue, additional, Peacocke, Alice, additional, Amero, Justine, additional, Burova, Maria, additional, Speirs, Ottilia, additional, Levy, Steph, additional, Francis, Lynda, additional, Holland, Susan, additional, Brotheridge, Sean, additional, Lyon, Helen, additional, Hare, Christine, additional, Jackson, Samantha, additional, Stephenson, Lorraine, additional, Al Hussayni, Samer, additional, Featherstone, James, additional, Bwalya, Agness, additional, Singh, Arun, additional, Goorah, M N, additional, Walford, Jamie, additional, Bell, Angela, additional, Kelly, Christine, additional, Rusk, Darren, additional, Sutton, Deborah, additional, Patel, Farzana, additional, Duberley, Stephen, additional, Hayes, Kathryn, additional, Hunt, Lorraine, additional, El Nour, Ahmed, additional, Honour, Sacha, additional, Box, Chloe, additional, Dyer, Simon, additional, Brown, Lynne, additional, Elliott, Kerry, additional, Temlett, Emma, additional, Paterson, John, additional, Furness, Rosie, additional, Young, Shelli, additional, Orugun, Enoch, additional, Brewer, Chris, additional, Thornthwaite, Sarah, additional, Crowther, Hannah, additional, Glover, Rachel, additional, Sein, Moe, additional, Haque, Kashif, additional, Gibson, Elspeth, additional, Wong, Sam, additional, Rotchell, Karen, additional, Burton, Karen, additional, Brookes, Lisa, additional, Bailey, Linda, additional, Lindley, Chris, additional, Murray, Abbi, additional, Waltho, Karen, additional, Holland, Maureen, additional, Kumar, Pradeep, additional, Harlekar, Purnima, additional, Booth, Laura, additional, Culmsee, Charlotte, additional, Drew, Jade, additional, Khan, Mohammad, additional, Mackenzie, Nicola, additional, Thomas, Carmel, additional, Ritchie, Jane, additional, Barker, James, additional, Haley, Michael, additional, Cotterill, Donna, additional, Lane, Lynne, additional, Little, Christine, additional, Simmons, Dawn, additional, Saunders, Glenn, additional, Dymond, Harvey, additional, Kidd, Sarah, additional, Warinton, Rachel, additional, Neves-Silva, Yara, additional, Nevajda, Branimir, additional, Villaruel, Michael, additional, Umasankar, Udayaraj, additional, Patel, Seema, additional, Man, Anna, additional, Christmas, Natasha, additional, Rangasamy, Ravi, additional, Ladner, Richard, additional, Butt, Georgina, additional, Alvares, Wilson, additional, Gadi, Narasimha, additional, Power, Michael, additional, Wroath, Belinda, additional, Dynan, Kevin, additional, Wilson, David, additional, Crothers, Sarah, additional, Leonard, Catherine, additional, Hagan, Samantha, additional, Douris, Geraldine, additional, Vahidassr, Djamil, additional, Thompson, Alastair, additional, Gallen, Brian, additional, Mckenna, Shirley, additional, Edwards, Collette, additional, Mcgoldrick, Clare, additional, Bhattad, Murdi, additional, Kawafi, Khalil, additional, Morse, Deborah, additional, Jacob, Patricia, additional, Turner, Lisa, additional, Saravanan, Narayanamoorti, additional, Johnson, Linda, additional, Humphrey, Sadie, additional, Namushi, Robert, additional, Patel, Ramesh, additional, Mclaughlin, Jemma, additional, Omahony, Paul, additional, Osikominu, Esther, additional, Orefo, Chukwuka, additional, Mcdonald, Chisha, additional, Makanju, Esther, additional, Khan, Tabindah, additional, Appiatse, Grace, additional, Stone, Helena, additional, Augustin, Martia, additional, Wardale, Alicia, additional, Salehin, Maqsud, additional, Bailey, Duncan, additional, Garcia-Alen, Luciano, additional, Kalathil, Latheef, additional, Tinsley, Sarah, additional, Jones, Taya, additional, Amor, Kelly, additional, Ritchings, Andrew, additional, Margerum, Emma, additional, Horton, Jane, additional, Miller, Richard, additional, Gautam, Nireekshana, additional, Meir, Julie, additional, Jones, Amaryl, additional, Putteril, Janet, additional, Lepore, Mirella, additional, Gallifent, Rachel, additional, Arundell, Laura-Louise, additional, Mcredmond, Catherine, additional, Goulding, Alicia, additional, Nadarajan, Vivek, additional, Laurence, Julia, additional, Fung Lo, Su, additional, Melander, Sabina, additional, Nicholas, Paul, additional, Woodford, Elizabeth, additional, Mckenzie, Gillian, additional, Le, Vietland, additional, Crause, Jacolene, additional, Luder, Robert, additional, Bhargava, Maneesh, additional, Bhome, Girish, additional, Johnson, Venetia V, additional, Chesser, Dara, additional, Bridger, Hayley, additional, Murali, Elodie, additional, Scott, Jon, additional, Morrison, Susan, additional, Burns, Amy, additional, Graham, Julie, additional, Duffy, Madeline, additional, Ali, Khalid, additional, Pitcher, Emma, additional, Gaylard, Jane, additional, Newman, Julie, additional, Punnoose, Sunil, additional, Besley, Sarah, additional, Purohit, Kirtan, additional, Rees, Amy, additional, Davy, Mark, additional, Chohan, Osman, additional, Khan, Muhammad Fozan, additional, Walker, Rachel, additional, Murray, Vicky, additional, Bent, Charlotte, additional, Oakley, Susan, additional, Peixoto, Cassilda, additional, Jones, Suzanne, additional, Livingstone, Gaybrielle, additional, Butler, Fiona, additional, Bradfield, Sally, additional, Gordon, Laura, additional, Schmit, Jenneke, additional, Wijewardane, Anika, additional, Edmunds, Tineke, additional, Wills, Rebecca, additional, Medcalf, Catherine, additional, Argandona, Lucia, additional, Cuenoud, Larissa, additional, Hassan, Hanna, additional, Erumere, Esther, additional, Ocallaghan, Aidan, additional, Gompertz, Patrick, additional, Redjep, Ozlem, additional, Auld, Grace, additional, Song, Anna, additional, Tarkas, Tillana, additional, Kabash, Hashim, additional, and Hungwe, Rumbi, additional
Published: 2019
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27. Increased deep grey matter functional connectivity of poststroke hNSC implanted ipsilesional putamen

Author: Kalladka, Dheeraj, primary, Sinden, John, additional, McLean, John, additional, Moreton, Fiona Catherine, additional, Huang, Xuya, additional, and Muir, Keith W, additional
Published: 2018
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28. Impact of computed tomography perfusion imaging on the response to tenecteplase in ischemic stroke: analysis of two randomized controlled trials

Author: Bivard, Andrew, Huang, Xuya, McElduff, Patrick, Levi, Christopher R., Campbell, Bruce C.V., Cheripelli, Bharath Kumar, Kalladka, Dheeraj, Moreton, Fiona Catherine, Ford, Ian, Bladin, Christopher F., Davis, Stephen M., Donnan, Geoffrey A., Muir, Keith W., and Parsons, Mark W.
Abstract: Background: We pooled 2 clinical trials of tenecteplase compared with alteplase for the treatment of acute ischemic stroke, 1 that demonstrated superiority of tenecteplase and the other that showed no difference between the treatments in patient clinical outcomes. We tested the hypotheses that reperfusion therapy with tenecteplase would be superior to alteplase in improving functional outcomes in the group of patients with target mismatch as identified with advanced imaging.\ud Methods: We investigated whether tenecteplase-treated patients had a different 24-hour reduction in the National Institutes of Health Stroke Scale and a favorable odds ratio of a modified Rankin scale score of 0 to 1 versus 2 to 6 compared with alteplase-treated patients using linear regression to generate odds ratios. Imaging outcomes included rates of vessel recanalization and infarct growth at 24 hours and occurrence of large parenchymal hematoma. Baseline computed tomography perfusion was analyzed to assess whether patients met the target mismatch criteria (absolute mismatch volume >15 mL, mismatch ratio >1.8, baseline ischemic core
Published: 2017

29. Comparing mismatch strategies for patients being considered for ischemic stroke tenecteplase trials.

Author: Bivard, Andrew, Huang, Xuya, Levi, Christopher R, Campbell, Bruce CV, Cheripelli, Bharath K, Chen, Chushuang, Kalladka, Dheeraj, Moreton, Fiona C, Ford, Ian, Davis, Stephen M, Donnan, Geoffrey A, Muir, Keith W, and Parsons, Mark W
Subjects: *PATIENT selection, *CLINICAL trials, *TREATMENT effectiveness, *STROKE
Abstract: Background: Currently there are multiple variations of imaging-based patient selection mismatch methods in ischemic stroke. In the present study, we sought to compare the two most common mismatch methods and identify if there were different effects on the outcome of a randomized clinical trial depending on the mismatch method used. Aims: Investigate the effect of clinical and imaging-based mismatch criteria on patient outcomes of a pooled cohort from randomized trials of intravenous tenecteplase versus alteplase. Methods: Baseline clinical and imaging scores were used to categorize patients as meeting either the DAWN mismatch (baseline NIHSS ≥ 10, and age cut-offs for ischemic core volume) or DEFUSE 2 mismatch criteria (mismatch volume > 15 mL, mismatch ratio > 1.8 and ischemic core < 70 mL). We then investigated whether tenecteplase-treated patients had favorable odds of less disability (on modified Rankin scale, mRS) compared to those treated with alteplase, for clinical and imaging mismatch, respectively. Results: From 146 pooled patients, 71 received alteplase and 75 received tenecteplase. The overall pooled group did not show improved patient outcomes when treated with tenecteplase (mRS 0-1 OR 1.77, 95% CI 0.89–3.51, p = 0.102) compared with alteplase. A total of 39 (27%) patients met both clinical and imaging mismatch criteria, 25 (17%) patients met only imaging criteria, 36 (25%) met only clinical mismatch criteria and, finally, 46 (31%) did not meet either of imaging or mismatch criteria. Patients treated with tenecteplase had more favorable outcomes when they met either imaging mismatch (mRS 0–1, OR 2.33, 95% CI 1.13–5.94, p = 0.032) or clinical mismatch criteria (mRS 0–1, OR 2.15, 95% CI 1.142, 8.732, p = 0.027) but with differing proportions. Conclusion: Target mismatch selection was more inclusive and exhibited in a larger treatment effect between tenecteplase and alteplase. [ABSTRACT FROM AUTHOR]
Published: 2020
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30. ECG reporting inthe first seizure clinic: Are we missing an opportunity? (P1.280)

Author: Huang, Xuya, primary, Malek, Naveed, additional, Simpson, Joanne, additional, Kalladka, Dheeraj, additional, Dunn, Francis, additional, and Leach, John Paul, additional
Published: 2018
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31. What is the relationship among penumbra volume, collaterals, and time since onset in the first 6 h after acute ischemic stroke?

Author: Cheripelli, Bharath Kumar, Huang, Xuya, McVerry, Ferghal, and Muir, Keith
Abstract: Background: The steep, time-dependent loss of benefit from reperfusion in clinical trials is consistent with loss of penumbra over the early hours of ischemia, as observed in animal models. Human imaging studies, however, show persistent penumbra for up to 48 h. We investigated core and penumbra volumes and collateral status in relation to time after stroke onset within the first 6 h.\ud Methods: Using data from three multimodal computer tomography-based studies in acute ischemic stroke patients 15 ml, mismatch ratio > 1.8). Patients were grouped by onset to imaging time (4. 5 h, respectively, p = 0.4) nor poor collaterals (15/56 (27%), 14/47 (30%), 4/15 (27%) at 4.5 h, p = 0.9) differed significantly. Penumbra proportion was not clearly related to time to imaging (R2 = 0.003; p = 0.5) but a trend for divergent effects by collateral status was seen (slight increase in penumbra over time with good collaterals versus reduced with poor, interaction = 0.08). The proportion of patients with target mismatch did not vary by time (56%, 74%, and 67% at 4.5 h, p = 0.09).\ud Conclusions: In a cross-sectional sample imaged within 6 h, neither the proportions of penumbral tissue nor “target mismatch” varied by time from onset. A trend for reducing penumbra proportion only among those with poor collaterals may have pathophysiological and therapeutic importance.
Published: 2016

32. Arterial branching and basal ganglia lacunes: A study in pure small vessel disease

Author: Moreton, Fiona C, primary, Düring, Marco, additional, Phan, Thanh, additional, Srikanth, Velandai, additional, Beare, Richard, additional, Huang, Xuya, additional, Jouvent, Eric, additional, Chabriat, Hugues, additional, Dichgans, Martin, additional, and Muir, Keith W, additional
Published: 2017
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33. Tenecteplase in ischemic stroke offers improved recanalization

Author: Bivard, Andrew, primary, Huang, Xuya, additional, Levi, Christopher R., additional, Spratt, Neil, additional, Campbell, Bruce C.V., additional, Cheripelli, Bharath Kumar, additional, Kalladka, Dheeraj, additional, Moreton, Fiona Catherine, additional, Ford, Ian, additional, Bladin, Christopher F., additional, Davis, Stephen M., additional, Donnan, Geoffrey A., additional, Muir, Keith W., additional, and Parsons, Mark W., additional
Published: 2017
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34. Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST): phase 2 randomised clinical trial

Author: Huang, Xuya, Cheripelli, Bharath K, Lloyd, Suzanne M, Kalladka, Dheeraj, Moreton, Fiona C, Siddiqui, Aslam, Ford, Ian, and Muir, Keith W
Abstract: Background: Alteplase given within 4•5 hours of onset is the only approved medical treatment in acute ischaemic stroke. Newer thrombolytic agents may be advantageous, with higher fibrin specificity, easier administration schedules, and longer half-life. Different doses of tenectplase have been investigated previously in two small randomised trials in acute stroke in 3 or 6 hour time windows, in one study using advanced imaging-based patient selection. We evaluated the efficacy and safety of tenecteplase versus alteplase in a less selected population than previous studies, using imaging biomarkers, in order to inform the appropriate design of a definitive clinical trial.\ud Methods: In a single-centre, phase 2, prospective randomised open-label blinded end-point evaluation (PROBE) trial, adult patients with supratentorial ischaemic stroke eligible for intravenous thrombolysis within 4•5 h of onset received tenecteplase 0•25 mg/kg (maximum 25 mg) or alteplase 0•9 mg/kg (maximum 90 mg). Treatment allocation used a mixed randomisation/minimisation algorithm including age and NIHSS score, generated by an independent statistician. Imaging comprised baseline computed tomography (CT), CT perfusion (CTP) and CT angiography (CTA), and CT+CTA at 24-48 hours. The primary end-point was penumbral salvage (CTP-defined penumbra volume minus follow-up CT infarct volume.\ud Results: We recruited 104 patients (52 in each group) over 20 months. In the protocol-defined analysis of 96 confirmed stroke patients, groups were balanced for clinical characteristics. Among 71 subjects contributing to the imaging primary endpoint, no significant differences were observed for penumbral salvage [68 (SD 28) % tenecteplase vs 68 (SD 23) % alteplase], mean difference 1% (95% confidence interval -10%, 12%, p=0•81) or for any secondary end-point. Neither SICH incidence (1/52, 2% vs 2/51, 4%, by SITS-MOST definition, p=0•55; by ECASS-2 definition, 3/52, 6% tenecteplase vs 4/51, 8% alteplase, p=0.59) nor total ICH events differed significantly (8/52 tenecteplase, 15% vs 14/51 alteplase, 29%, p=0•091). The incidence of serious adverse events did not differ between groups (32 in the tenecteplase group, 3 considered probably or definitely related to drug treatment; 16 in the alteplase group, 5 considered drug-related). \ud Interpretation: Neurological and radiological outcomes did not differ between tenecteplase and alteplase. Further evaluation of tenecteplase in acute stroke is warranted.
Published: 2015

35. CT PREDICTORS OF MALIGNANT MIDDLE CEREBRAL ARTERY INFARCTION

Author: McAughtrie, Rachael, primary, Cheripelli, Bharath Kumar, additional, Moreton, Fiona Catherine, additional, Huang, Xuya, additional, Kalladka, Dheeraj, additional, MacDougall, Niall, additional, McVerry, Ferghal, additional, and Muir, Keith, additional
Published: 2016
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36. How many stroke patients might be eligible for mechanical thrombectomy?

Author: Tawil, Salwa El, primary, Cheripelli, Bharath, additional, Huang, Xuya, additional, Moreton, Fiona, additional, Kalladka, Dheeraj, additional, MacDougal, Niall JJ, additional, McVerry, Ferghal, additional, and Muir, Keith W, additional
Published: 2016
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37. Tenecteplase versus alteplase in stroke thrombolysis: An individual patient data meta-analysis of randomized controlled trials

Author: Huang, Xuya, primary, MacIsaac, Rachael, additional, Thompson, John LP, additional, Levin, Bruce, additional, Buchsbaum, Richard, additional, Haley, E Clarke, additional, Levi, Christopher, additional, Campbell, Bruce, additional, Bladin, Christopher, additional, Parsons, Mark, additional, and Muir, Keith W, additional
Published: 2016
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38. Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST): a phase 2, randomised, open-label, blinded endpoint study

Author: Huang, Xuya, primary, Cheripelli, Bharath Kumar, additional, Lloyd, Suzanne M, additional, Kalladka, Dheeraj, additional, Moreton, Fiona Catherine, additional, Siddiqui, Aslam, additional, Ford, Ian, additional, and Muir, Keith W, additional
Published: 2015
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39. Coagulation and Fibrinolytic Activity of Tenecteplase and Alteplase in Acute Ischemic Stroke.

Author: Xuya Huang, Moreton, Fiona Catherine, Kalladka, Dheeraj, Cheripelli, Bharath Kumar, MacIsaac, Rachael, Campbell Tait, R., Muir, Keith W., Huang, Xuya, and Tait, R Campbell
Published: 2015
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40. Increased deep grey matter functional connectivity of poststroke hNSC implanted ipsilesional putamen.

Author: Kalladka, Dheeraj, Sinden, John, McLean, John, Moreton, Fiona Catherine, Huang, Xuya, and Muir, Keith W.
Subjects: NEUROSCIENCES, NEURAL stem cells, HUMAN stem cells
Published: 2019
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41. Tenecteplase and alteplase in acute ischaemic stroke thrombolysis: clinical and imaging study

Author: Huang, Xuya and Huang, Xuya
Abstract: Introduction: Intravenous thrombolysis in acute ischaemic stroke with alteplase improves clinical outcomes, but it has limited efficacy and is associated with increased risk of intracranial haemorrhage. An improved tissue plasminogen activator, tenecteplase, was evidenced to be at least equally effective with lower risk of haemorrhage in acute myocardial infarction thrombolysis. To date, two completed phase II randomised controlled studies comparing tenecteplase and alteplase in acute ischaemic strokes showed variable results. Methods: A literature review of thrombolytic agents used in myocardial infarction and acute ischaemic stroke was performed, followed by a retrospective investigation of the bolus-to- infusion delay of alteplase administration. The main focus of this thesis is the report of our single centre phase II randomised controlled trial that compared tenecteplase (0.25mg/kg, maximum 25mg) and alteplase (0.9mg/kg, maximum 90mg, 10% as the initial bolus, following by one hour infusion with the rest of the dose) in acute ischaemic stroke thrombolysis using advanced imaging as biomarkers. Imaging comprised baseline computed tomography (CT), CT perfusion (CTP) and CT angiography (CTA), and CT+CTA at 24-48 hours. The primary end-point was penumbral salvage (CTP-defined penumbra volume minus follow-up CT infarct volume). A sub-study of coagulation and fibrinolysis analysis of the two agents was performed by comparing a group of coagulation variables measured pre-treatment, 3-12 hours, and 24±3 hours post thrombolysis. An individual patient data (IPD) meta-analysis was carried out using all three completed tenecteplase/alteplase comparison studies in stroke thrombolysis. We compared clinical outcomes including modified Rankin scale at 3 months, early neurological improvement at 24 hours, intracerebral haemorrhage rate and mortality at 3 months between all three tenecteplase doses (0.1mg/kg, 0.25 mg/kg, and 0.4mg/kg) examined and standard alteplase. Imaging outc

42. Tenecteplase and alteplase in acute ischaemic stroke thrombolysis: clinical and imaging study

Author: Huang, Xuya and Huang, Xuya
Abstract: Introduction: Intravenous thrombolysis in acute ischaemic stroke with alteplase improves clinical outcomes, but it has limited efficacy and is associated with increased risk of intracranial haemorrhage. An improved tissue plasminogen activator, tenecteplase, was evidenced to be at least equally effective with lower risk of haemorrhage in acute myocardial infarction thrombolysis. To date, two completed phase II randomised controlled studies comparing tenecteplase and alteplase in acute ischaemic strokes showed variable results. Methods: A literature review of thrombolytic agents used in myocardial infarction and acute ischaemic stroke was performed, followed by a retrospective investigation of the bolus-to- infusion delay of alteplase administration. The main focus of this thesis is the report of our single centre phase II randomised controlled trial that compared tenecteplase (0.25mg/kg, maximum 25mg) and alteplase (0.9mg/kg, maximum 90mg, 10% as the initial bolus, following by one hour infusion with the rest of the dose) in acute ischaemic stroke thrombolysis using advanced imaging as biomarkers. Imaging comprised baseline computed tomography (CT), CT perfusion (CTP) and CT angiography (CTA), and CT+CTA at 24-48 hours. The primary end-point was penumbral salvage (CTP-defined penumbra volume minus follow-up CT infarct volume). A sub-study of coagulation and fibrinolysis analysis of the two agents was performed by comparing a group of coagulation variables measured pre-treatment, 3-12 hours, and 24±3 hours post thrombolysis. An individual patient data (IPD) meta-analysis was carried out using all three completed tenecteplase/alteplase comparison studies in stroke thrombolysis. We compared clinical outcomes including modified Rankin scale at 3 months, early neurological improvement at 24 hours, intracerebral haemorrhage rate and mortality at 3 months between all three tenecteplase doses (0.1mg/kg, 0.25 mg/kg, and 0.4mg/kg) examined and standard alteplase. Imaging outc

43. Tenecteplase and alteplase in acute ischaemic stroke thrombolysis: clinical and imaging study

Author: Huang, Xuya and Huang, Xuya
Abstract: Introduction: Intravenous thrombolysis in acute ischaemic stroke with alteplase improves clinical outcomes, but it has limited efficacy and is associated with increased risk of intracranial haemorrhage. An improved tissue plasminogen activator, tenecteplase, was evidenced to be at least equally effective with lower risk of haemorrhage in acute myocardial infarction thrombolysis. To date, two completed phase II randomised controlled studies comparing tenecteplase and alteplase in acute ischaemic strokes showed variable results. Methods: A literature review of thrombolytic agents used in myocardial infarction and acute ischaemic stroke was performed, followed by a retrospective investigation of the bolus-to- infusion delay of alteplase administration. The main focus of this thesis is the report of our single centre phase II randomised controlled trial that compared tenecteplase (0.25mg/kg, maximum 25mg) and alteplase (0.9mg/kg, maximum 90mg, 10% as the initial bolus, following by one hour infusion with the rest of the dose) in acute ischaemic stroke thrombolysis using advanced imaging as biomarkers. Imaging comprised baseline computed tomography (CT), CT perfusion (CTP) and CT angiography (CTA), and CT+CTA at 24-48 hours. The primary end-point was penumbral salvage (CTP-defined penumbra volume minus follow-up CT infarct volume). A sub-study of coagulation and fibrinolysis analysis of the two agents was performed by comparing a group of coagulation variables measured pre-treatment, 3-12 hours, and 24±3 hours post thrombolysis. An individual patient data (IPD) meta-analysis was carried out using all three completed tenecteplase/alteplase comparison studies in stroke thrombolysis. We compared clinical outcomes including modified Rankin scale at 3 months, early neurological improvement at 24 hours, intracerebral haemorrhage rate and mortality at 3 months between all three tenecteplase doses (0.1mg/kg, 0.25 mg/kg, and 0.4mg/kg) examined and standard alteplase. Imaging outc

44. Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke: Analysis of 2 Randomized Controlled Trials.

Author: Bivard, Andrew, Huang, Xuya, McElduff, Patrick, Levi, Christopher R, Campbell, Bruce C V, Cheripelli, Bharath Kumar, Kalladka, Dheeraj, Moreton, Fiona C, Ford, Ian, Bladin, Christopher F, Davis, Stephen M, Donnan, Geoffrey A, Muir, Keith W, Parsons, Mark W, and Moreton, Fiona Catherine
Subjects: *COMPARATIVE studies, *COMPUTED tomography, *RESEARCH methodology, *MEDICAL cooperation, *PERFUSION, *RADIONUCLIDE imaging, *REPERFUSION, *RESEARCH, *STROKE, *EVALUATION research, *TISSUE plasminogen activator, *RANDOMIZED controlled trials, *TREATMENT effectiveness, *THERAPEUTICS
Abstract: Background: We pooled 2 clinical trials of tenecteplase compared with alteplase for the treatment of acute ischemic stroke, 1 that demonstrated superiority of tenecteplase and the other that showed no difference between the treatments in patient clinical outcomes. We tested the hypotheses that reperfusion therapy with tenecteplase would be superior to alteplase in improving functional outcomes in the group of patients with target mismatch as identified with advanced imaging.Methods: We investigated whether tenecteplase-treated patients had a different 24-hour reduction in the National Institutes of Health Stroke Scale and a favorable odds ratio of a modified Rankin scale score of 0 to 1 versus 2 to 6 compared with alteplase-treated patients using linear regression to generate odds ratios. Imaging outcomes included rates of vessel recanalization and infarct growth at 24 hours and occurrence of large parenchymal hematoma. Baseline computed tomography perfusion was analyzed to assess whether patients met the target mismatch criteria (absolute mismatch volume >15 mL, mismatch ratio >1.8, baseline ischemic core <70 mL, and volume of severely hypoperfused tissue <100 mL). Patients meeting target mismatch criteria were analyzed as a subgroup to identify whether they had different treatment responses from the pooled group.Results: Of 146 pooled patients, 71 received alteplase and 75 received tenecteplase. Tenecteplase-treated patients had greater early clinical improvement (median National Institutes of Health Stroke Scale score change: tenecteplase, 7; alteplase, 2; P=0.018) and less parenchymal hematoma (2 of 75 versus 10 of 71; P=0.02). The pooled group did not show improved patient outcomes when treated with tenecteplase (modified Rankin scale score 0-1: odds ratio, 1.77; 95% confidence interval, 0.89-3.51; P=0.102) compared with alteplase therapy. However, in patients with target mismatch (33 tenecteplase, 35 alteplase), treatment with tenecteplase was associated with greater early clinical improvement (median National Institutes of Health Stroke Scale score change: tenecteplase, 6; alteplase, 1; P<0.001) and better late independent recovery (modified Rankin scale score 0-1: odds ratio, 2.33; 95% confidence interval, 1.13-5.94; P=0.032) than those treated with alteplase.Conclusions: Tenecteplase may offer an improved efficacy and safety profile compared with alteplase, benefits possibly exaggerated in patients with baseline computed tomography perfusion-defined target mismatch.Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01472926. URL: https://www.anzctr.org.au. Unique identifier: ACTRN12608000466347. [ABSTRACT FROM AUTHOR]
Published: 2016
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45. What is the relationship among penumbra volume, collaterals, and time since onset in the first 6 h after acute ischemic stroke?

Author: Cheripelli BK, Huang X, McVerry F, and Muir KW
Subjects: Adult, Aged, Animals, Brain blood supply, Brain pathology, Brain Ischemia pathology, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Stroke pathology, Time Factors, Tomography, X-Ray Computed, Brain diagnostic imaging, Brain Ischemia diagnosis, Cerebrovascular Circulation, Collateral Circulation, Stroke diagnosis
Abstract: Background: The steep, time-dependent loss of benefit from reperfusion in clinical trials is consistent with loss of penumbra over the early hours of ischemia, as observed in animal models. Human imaging studies, however, show persistent penumbra for up to 48 h. We investigated core and penumbra volumes and collateral status in relation to time after stroke onset within the first 6 h., Methods: Using data from three multimodal computer tomography-based studies in acute ischemic stroke patients <6 h after onset, we measured core and penumbra volumes, collateral status, and target mismatch (defined as core volume < 50 ml, perfusion lesion volume > 15 ml, mismatch ratio > 1.8). Patients were grouped by onset to imaging time (<3, 3-4.5, 4.5-6 h). We explored correlates of penumbra proportion by multivariable linear regression., Results: Analysis included 144 subjects. Across time epochs, neither proportions of penumbra (59%, 64%, 75% at <3, 3-4.5, >4. 5 h, respectively, p = 0.4) nor poor collaterals (15/56 (27%), 14/47 (30%), 4/15 (27%) at <3, 3-4.5, >4.5 h, p = 0.9) differed significantly. Penumbra proportion was not clearly related to time to imaging (R(2) = 0.003; p = 0.5) but a trend for divergent effects by collateral status was seen (slight increase in penumbra over time with good collaterals versus reduced with poor, interaction = 0.08). The proportion of patients with target mismatch did not vary by time (56%, 74%, and 67% at <3, 3-4.5, >4.5 h, p = 0.09)., Conclusions: In a cross-sectional sample imaged within 6 h, neither the proportions of penumbral tissue nor "target mismatch" varied by time from onset. A trend for reducing penumbra proportion only among those with poor collaterals may have pathophysiological and therapeutic importance., (© 2016 World Stroke Organization.)
Published: 2016
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