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Your search keyword '"Huang, Xuedan"' showing total 26 results
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26 results on '"Huang, Xuedan"'

4. Anti-obesity effect of blumea balsamifera extract in 3T3-L1 preadipocytes and adipocytes

Author

Kubota, Hiroaki, Kojima-Yuasa, Akiko, Morii, Risako, Huang, Xuedan, Norikura, Toshio, Rho, Sook-Nyung, and Matsui-Yuasa, Isao

Subjects
Obesity -- Prevention, Materia medica, Vegetable -- Usage, Materia medica, Vegetable -- Health aspects, Plant extracts -- Usage, Plant extracts -- Health aspects, Fat cells -- Research, Fat cells -- Control, Fat cells -- Physiological aspects, Medicinal plants -- Usage, Medicinal plants -- Health aspects, Health
Published
2009

5. Effect of zizyphus jujuba extract on the inhibition of adipogenesis in 3T3-L1 preadipocytes

Author

Kubota, Hiroaki, Morii, Risako, Kojima-Yuasa, Akiko, Huang, Xuedan, Yano, Yosihisa, and Matsui-Yuasa, Isao

Subjects
Materia medica, Vegetable -- Usage, Materia medica, Vegetable -- Health aspects, Plant extracts -- Usage, Plant extracts -- Health aspects, Obesity -- Care and treatment, Medicine, Chinese -- Usage, Medicine, Chinese -- Health aspects, Gene expression -- Research, Gene expression -- Physiological aspects, Health
Published
2009

6. Combination of zizyphus jujuba and green tea extracts exerts excellent cytotoxic activity in HepG2 cells via reducing the expression of APRIL

Author

Huang, Xuedan, Kojima-Yuasa, Akiko, Xu, Shenghui, Kennedy, David Opare, Hasuma, Tadayoshi, and Matsui-Yuasa, Isao

Subjects
Materia medica, Vegetable -- Usage, Materia medica, Vegetable -- Health aspects, Plant extracts -- Usage, Plant extracts -- Health aspects, Green tea -- Usage, Green tea -- Health aspects, Hepatoma -- Care and treatment, Gene expression -- Control, Health
Published
2009

8. Anticancer activities and mechanisms of blumea balsamifera extract in hepatocellular carcinoma cells

Author

Norikura, Toshio, Kojima-Yuasa, Akiko, Shimizu, Miki, Huang, Xuedan, Xu, Shenghui, Kametani, Saeda, Rho, Sook-Nyung, Kennedy, David Opare, and Matsui-Yuasa, Isao

Subjects
Medicinal plants -- Usage, Medicinal plants -- Health aspects, Hepatoma -- Care and treatment, Materia medica, Vegetable -- Usage, Materia medica, Vegetable -- Health aspects, Plant extracts -- Usage, Plant extracts -- Health aspects, Health
Published
2008

12. The Adverse Effects of Ephedra Herb and the Safety of Ephedrine Alkaloids-free Ephedra Herb Extract (EFE)

Author

Odaguchi, Hiroshi, primary, Hyuga, Sumiko, additional, Sekine, Mariko, additional, Nakamori, Shunsuke, additional, Takemoto, Hiroaki, additional, Huang, Xuedan, additional, Oshima, Naohiro, additional, Shimada, Norimoto, additional, Yang, Jinwei, additional, Amakura, Yoshiaki, additional, Hyuga, Masashi, additional, Uchiyama, Nahoko, additional, Kobayashi, Yoshinori, additional, Hakamatsuka, Takashi, additional, Goda, Yukihiro, additional, and Hanawa, Toshihiko, additional

Published
2019
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15. Anti-steatosis compounds from leaves of <italic>Mallotus furetianus</italic>.

Author

Huang, Xuedan, Xu, Mingzhu, Shirahata, Tatsuya, Li, Wei, Koike, Kazuo, Kojima-Yuasa, Akiko, Yuasa, Isao, and Kobayashi, Yoshinori

Abstract

There is no drug administration-approved therapy for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). In this study, eight compounds, gallic acid (1), methyl gallate (2), corilagin (3), 3,4,8,9,10-pentahydroxydibenzo[b,d]pyran-6-one (4), repandinin B (5), (Z)-3-hexenyl-β-D-glucopyranoside (6), (+)-lyoniresinol-3α-O-α-L-rhamnopyranoside (7) and mallophenol A (8) were isolated from the active fractions of Mallotus furetianus. Three compounds, (6, 7 and 8) revealed potent anti-steatosis activity in the oleic acid (OA)-induced steatosis cell model, with the minimum effective concentration of 0.05 (6), 0.0005 (7) and 0.0005 (8) μg/mL, which were much lower than the control compound, fibrate (72.4 μg/mL). [ABSTRACT FROM AUTHOR]

Published
2018
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24. Mechanism of Growth Inhibitory Effect of Blumea balsamiferaExtract in Hepatocellular Carcinoma

Author

NORIKURA, Toshio, KOJIMA-YUASA, Akiko, SHIMIZU, Miki, HUANG, Xuedan, XU, Shenghui, KAMETANI, Saeda, RHO, Sook-Nyung, KENNEDY, David Opare, and MATSUI-YUASA, Isao

Abstract

Blumea balsamiferais known to improve physiological disorders such as rheumatism and hypertension, but its anticancer activity has not been well elucidated. In this study, we found that Blumea balsamiferaMeOH extract (BME) induced growth-inhibitory activity in rat and human hepatocellular carcinoma cells without cytotoxicity in rat hepatocytes which were used as a normal cell model. BME induced cell cycle arrest at the G1 phase viadecreases in the expression of cyclin-E and phosphorylation of retinoblastoma protein. Furthermore, BME reduced the level of a proliferation-inducing ligand, that stimulates tumor cell growth. These findings suggest that BME has possible therapeutic potential in hepatoma cancer patients and that depletion of cellular APRIL is an important mechanism in the growth-inhibitory effect of BME.

Published
2008
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25. Anti-steatosis compounds from leaves of Mallotus furetianus.

Author

Huang X, Xu M, Shirahata T, Li W, Koike K, Kojima-Yuasa A, Yuasa I, and Kobayashi Y

Subjects
Gallic Acid analogs & derivatives, Gallic Acid isolation & purification, Gallic Acid pharmacology, Glucosides isolation & purification, Glucosides pharmacology, Hep G2 Cells, Humans, Hydrolyzable Tannins isolation & purification, Hydrolyzable Tannins pharmacology, Non-alcoholic Fatty Liver Disease chemically induced, Oleic Acid toxicity, Mallotus Plant chemistry, Non-alcoholic Fatty Liver Disease drug therapy, Plant Leaves chemistry
Abstract

There is no drug administration-approved therapy for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). In this study, eight compounds, gallic acid (1), methyl gallate (2), corilagin (3), 3,4,8,9,10-pentahydroxydibenzo[b,d]pyran-6-one (4), repandinin B (5), (Z)-3-hexenyl-β-D-glucopyranoside (6), (+)-lyoniresinol-3α-O-α-L-rhamnopyranoside (7) and mallophenol A (8) were isolated from the active fractions of Mallotus furetianus. Three compounds, (6, 7 and 8) revealed potent anti-steatosis activity in the oleic acid (OA)-induced steatosis cell model, with the minimum effective concentration of 0.05 (6), 0.0005 (7) and 0.0005 (8) μg/mL, which were much lower than the control compound, fibrate (72.4 μg/mL).

Published
2018
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26. Mechanism of growth inhibitory effect of Blumea balsamifera extract in hepatocellular carcinoma.

Author

Norikura T, Kojima-Yuasa A, Shimizu M, Huang X, Xu S, Kametani S, Rho SN, Kennedy DO, and Matsui-Yuasa I

Subjects
Animals, Carcinoma, Hepatocellular drug therapy, Carcinoma, Hepatocellular genetics, Cell Cycle drug effects, Cell Line, Tumor, Cell Proliferation drug effects, Cell Survival drug effects, Cyclin E metabolism, Ethanol chemistry, Gene Expression Regulation, Neoplastic drug effects, Growth Inhibitors therapeutic use, Humans, Methanol chemistry, Nucleic Acid Synthesis Inhibitors pharmacology, Nucleic Acid Synthesis Inhibitors therapeutic use, Phosphorylation drug effects, Plant Extracts therapeutic use, Protein Processing, Post-Translational drug effects, Rats, Retinoblastoma metabolism, Tumor Necrosis Factor Ligand Superfamily Member 13 metabolism, Asteraceae chemistry, Carcinoma, Hepatocellular pathology, Growth Inhibitors pharmacology, Plant Extracts pharmacology
Abstract

Blumea balsamifera is known to improve physiological disorders such as rheumatism and hypertension, but its anticancer activity has not been well elucidated. In this study, we found that Blumea balsamifera MeOH extract (BME) induced growth-inhibitory activity in rat and human hepatocellular carcinoma cells without cytotoxicity in rat hepatocytes which were used as a normal cell model. BME induced cell cycle arrest at the G1 phase via decreases in the expression of cyclin-E and phosphorylation of retinoblastoma protein. Furthermore, BME reduced the level of a proliferation-inducing ligand, that stimulates tumor cell growth. These findings suggest that BME has possible therapeutic potential in hepatoma cancer patients and that depletion of cellular APRIL is an important mechanism in the growth-inhibitory effect of BME.

Published
2008
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