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Advanced glycation end products (AGEs) in food products may bring health risks. Meat is a rich source of AGEs due to high protein and fat content, and thermal processing and storage further accelerate the formation of AGEs in meat. However, there is no comprehensive review of the formation of AGEs in meat during processing and storage. This paper summarized the types, structures and the formation of AGEs in meat during processing and storage. Meanwhile, the pathologic effects of AGEs and the inhibition of AGEs generation were also highlighted. Finally, the remaining limitations and future research directions about AGEs were discussed. The review of AGEs has important implications for food and human health. Although great progress has been made both in medicine and food science about AGEs, more valuable references and suggestions for AGEs to people should be provided in the future. [ABSTRACT FROM AUTHOR]

The aim of this work was to investigate the effect and correlation of boiled, deep-fried and roast thermal processing on Nε -carboxymethyllysine and Nε-carboxyethyllysine formation in prepared chicken breast. The three heat processing results indicated that oxidation was one main reason to affect advanced glycation end products (AGEs) formation. For boiled and deep-fried, protein and lipid oxidation could promote the AGEs (P < 0.05), while protein oxidation may inhibit AGEs formation by roast processing (P < 0.05). Furthermore, Maillard reaction showed an important effect on L*, a* and b* values, and the content of AGEs could be easily determined by the changes of meat color. As conclusion, Maillard reaction and oxidation were two key factors to influence the AGEs formation in prepared chicken breast by thermal processing. [ABSTRACT FROM AUTHOR]

The objective of this work was to investigate the effects of pan frying on the formation of two typical advanced glycation end products (AGEs) named N ϵ -carboxymethyllysine (CML) and N ϵ -carboxyethyllysine (CEL) in prepared chicken breast. The marinated chicken breast was pan fried for 1 to 6 min, and then protein, fat, moisture, carbonyl, sulfhydryl, thiobarbituric acid reactive substances, chroma (a*, b*, L*), absorbance at 294 and 420 nm, and AGE (CEL) levels were measured once a minute. Pearson's correlation was determined and indicated that moisture was significantly negatively correlated with Maillard reaction and AGEs ( P < 0.05), fat and protein contents were significantly positively correlated with AGEs ( P < 0.05), and a* values were positively correlated with Maillard reaction and CEL ( P < 0.05). Protein and lipid oxidation played an important role on the correlation of AGEs. In conclusion, Maillard reaction and oxidation reaction are two important factors affecting AGE formation.

Objective: To evaluate the clinical efficacy on the treatment of the low-middle frequency sudden hearing loss with postaurical injection of methylprednisolone., Method: The 80 cases of the low-middle frequency sudden hearing loss were randomly divided into postaurical injection and oral hormone groups. The postaurical injection group (42 cases) received the postaurical injection of methylprednisolone, 40 mg/2 d, combined with the treatment of Ginkgo dipyidamolum and Alprostadil for 14 d; The oral hormone group (38 cases) received the oral prednisone, 1 mg/kg/d, administrated once on the morning for 3 d, if effective, prolonging for another 2 d, as mentioned above for Ginkgo dipyidamolum and Alprostadil., Result: The total effective rate was 88.10% in postaurical injection group and 86. 4o%in oral hormone group. There was no significant difference between the twbogroups( P> 0. 5)., Conclusion: Postaurical injection of methylprednisolone for the low-middle frequency sudden hearing loss is effective, safe and simple, which may be an alternative for systemic administration of gulcocorticoid.

Objective: To analyze the oncological outcomes, functional outcomes in patients undergoing supracricoid partial laryngectomy (SCPL). Provide clinical experience for application of SCPL., Method: A retrospective analysis of the 115 cases with laryngeal carcinoma accepted SCPL in our department from Jan 1996 to Dec 2004. Use the Kaplan-Meier method to analyze the patients'survival rate. Evaluate the value of reserve larynx function., Result: The 5-years survival rates and the decannulation rate was 80.8%, 99.1% respectively; and the average decannulation time was 22.25 days. The mean time of removal of gastric tube was 9.57 days. The function of CHEP was superior to CHP. The vocal function of 115 cases were all achieved in general communication., Conclusion: SCPL get better oncological and functional outcomes and allows the preservation of the basic function of the larynx. It's a safe, effective technique and deserved to generalization.

Objective: To evaluate the treatment of advanced tonsillar carcinoma by radiotherapy plus salvage surgery (R+S) or surgery coupling with postoperative radiotherapy (S+R)., Method: Clinical data of 48 patients with advanced tonsillar carcinoma who were treated in The 2nd Affiliated Hospital of Sun Yat-sen University from June 1996 to June 2004 was retrospectively analyzed. The patients were divided into R+S group (group A, 21 cases) and S+R group (group B, 27 cases). Treatment outcomes were compared between these two groups. The QOL (quality of life) scale of Washington University (UW-QOL) was used to investigate the patient's quality of life., Result: The 5-year survival rates were 42.9% in group A and 45.8% in group B, there was no significant statistical difference between the two groups (P < 0.05). Both the two treatment modalities could reduce the QOL in some degree. The average QOL score of 46 patients was 661.00 +/- 98.52 , group A was 696.09 + 90.70, while group B was 631.52 +/- 96.74, there was a significant statistical difference between the two groups (P < 0.05)., Conclusion: The two treatment modalities reached similar survivals. However, compared with the S+R, some patients who accepted treatment of R+S could avoid composite resection, reduce functional lesion and improve the QOL.