Search

Your search keyword '"Huang, Qingyuan"' showing total 320 results
Start Over Author "Huang, Qingyuan"
320 results on '"Huang, Qingyuan"'

2. Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages

Author

Zhao, Yue, Gao, Jian, Wang, Jun, Fan, Fanfan, Cheng, Chao, Qian, Danwen, Guo, Ran, Zhang, Yang, Ye, Ting, Augustine, Marcellus, Lin, Yicong, Shang, Jun, Li, Hang, Pan, Yunjian, Huang, Qingyuan, Chen, Haiqing, Han, Han, Gao, Zhendong, Wang, Qiming, Zhang, Shiyue, Zhang, Mou, Fu, Fangqiu, Yan, Yueren, Fernandez Patel, Shanila, Vendramin, Roberto, Yuan, Hui, Zhang, Yawei, Xiang, Jiaqing, Hu, Hong, Sun, Yihua, Li, Yuan, Litchfield, Kevin, Cao, Zhiwei, and Chen, Haiquan

Published
2024
Full Text
View/download PDF

5. Selective Mediastinal Lymph Node Dissection Strategy for Clinical T1N0 Invasive Lung Cancer: A Prospective, Multicenter, Clinical Trial

Author

Zhang, Yang, Deng, Chaoqiang, Zheng, Qiang, Qian, Bin, Ma, Junjie, Zhang, Chunyang, Jin, Yan, Shen, Xuxia, Zang, Yibing, Guo, Yufeng, Fu, Fangqiu, Li, Hang, Zheng, Shanbo, Wu, Haoxuan, Huang, Qingyuan, Wang, Shengping, Liu, Quan, Ye, Ting, Sun, Yihua, Zhang, Yawei, Xiang, Jiaqing, Hu, Hong, Li, Yuan, and Chen, Haiquan

Published
2023
Full Text
View/download PDF

9. Nosema bombycis: A remarkable unicellular parasite infecting insects.

Author

Huang, Qingyuan, Hu, Wanying, Meng, Xianzhi, Chen, Jie, and Pan, Guoqing

Subjects
*WHOLE genome sequencing, *MOLECULAR evolution, *MICROSPORIDIA, *MICROSPORIDIOSIS, *SILKWORMS
Abstract

Microsporidia are opportunistic fungal‐like pathogens that cause microsporidiosis, which results in significant economic losses and threatens public health. Infection of domesticated silkworms by the microsporidium Nosema bombycis causes pébrine disease, for which this species of microsporidia has received much attention. Research has been conducted extensively on this microsporidium over the past few decades to better understand its infection, transmission, host–parasite interaction, and detection. Several tools exist to study this species including the complete genome sequence of N. bombycis. In addition to the understanding of N. bombycis being important for the silkworm industry, this species has become a model organism for studying microsporidia. Research on biology of N. bombycis will contribute to the development of knowledge regarding microsporidia and potential antimicrosporidia drugs. Furthermore, this will provide insight into the molecular evolution and functioning of other fungal pathogens. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

14. Prevalence and characterisation of class 1 and 2 integrons in multi-drug resistant Staphylococcus aureus isolates from pig farms in Chongqing, China

Author

Ye Chao, Hou Fengqing, Xu Dongyi, Huang Qingyuan, Chen Xia, Zeng Zheng, Peng Yuanyi, and Fang Rendong

Subjects
pig, staphylococcus aureus, antibiotic resistance, integrons, resistance gene cassettes, Veterinary medicine, SF600-1100
Abstract

Integrons are mobile DNA elements that allow for acquisition and dissemination of antibiotic-resistance genes among pig farm-derived bacteria. Limited information is available on integrons of Staphylococcus aureus from pig farms. The aim of this study was to characterise and investigate the prevalence of class 1 and 2 integrons in multi-drug resistant (MDR) S. aureus isolates from pig farms.

Published
2020
Full Text
View/download PDF

16. Value of adjuvant chemotherapy for patients with pT2N0M0 non‐small cell lung cancer receiving radical resection.

Author

Chen, Shiqi, Yang, Siqian, Zhao, Yue, Zhang, Yang, Huang, Qingyuan, Wu, Haoxuan, Hu, Hong, Sun, Yihua, Zhang, Yawei, Xiang, Jiaqing, Ye, Ting, and Chen, Haiquan

Subjects
LUNG cancer, ADJUVANT chemotherapy, ADENOCARCINOMA, MULTIPLE regression analysis, MULTIVARIATE analysis, TREATMENT effectiveness, CANCER patients, TUMOR classification, SURVIVAL analysis (Biometry), DESCRIPTIVE statistics, RESEARCH funding, PROPORTIONAL hazards models, OVERALL survival
Abstract

Background: Associations between adjuvant chemotherapy (ACT) and the improvement in survival for patients with pT2N0M0 non‐small cell lung cancer (NSCLC) who received R0 resection remain controversial. This study aimed to evaluate the value of ACT for patients with pT2N0M0 NSCLCs, and to identify the subgroups who could benefit from ACT. Methods: Multivariable Cox proportional hazards regression models were used to estimate independent prognostic factors. High‐risk factor (HRF) included visceral pleural invasion (VPI), lymphovascular invasion (LVI) and poor differentiation/undifferentiated tumors. Results: Of the 899 patients, 277 (30.8%) patients received ACT. More younger patients (p < 0.001) and male patients (p = 0.007) received ACT. With the increase of pathological tumor size (p < 0.001) and the number of HRFs (p < 0.001), there was a significant rise in the proportion of patients receiving ACT. For all patients, ACT could not improve recurrence‐free survival (RFS) (p = 0.672) and overall survival (OS) (p = 0.306). For patients with pathological stage IIA or radiological pure‐solid tumors, ACT could significantly improve the OS (p = 0.011 and p = 0.037, respectively), and multivariate analysis revealed that ACT was an independent prognostic factor for patients with pathological stage IIA (p = 0.005). ACT could improve the OS significantly in patients with pathological stage IB pure‐solid lung adenocarcinoma (LUAD) (p = 0.043). Conclusion: ACT was valuable for patients with pathological stage IIA (pT2bN0M0) and patients with radiological pure‐solid LUAD of pathological stage IB. A combination of radiological features and pathological subtypes could be helpful when selecting patients with pT2N0M0 NSCLCs for ACT. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

17. Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages

Author

Chen, Haiquan, primary, Zhao, Yue, additional, Gao, Jian, additional, Wang, Jun, additional, Fan, Fanfan, additional, Cheng, Chao, additional, Qian, Danwen, additional, Guo, Ran, additional, Zhang, Yang, additional, Ye, Ting, additional, Augustine, Marcellus, additional, Li, Hang, additional, Pan, Yunjian, additional, Huang, Qingyuan, additional, Chen, Haiqing, additional, Han, Han, additional, Gao, Zhendong, additional, Fu, Fangqiu, additional, Yan, Yueren, additional, Patel, Shanila, additional, Vendramin, Roberto, additional, Yuan, Hui, additional, Zhang, Yawei, additional, Xiang, Jiaqing, additional, Hu, Hong, additional, Sun, Yihua, additional, Li, Yuan, additional, Litchfield, Kevin, additional, and Cao, Zhiwei, additional

Published
2023
Full Text
View/download PDF

21. Figure S2 from In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma

Author

Li, Fei, primary, Huang, Qingyuan, primary, Luster, Troy A., primary, Hu, Hai, primary, Zhang, Hua, primary, Ng, Wai-Lung, primary, Khodadadi-Jamayran, Alireza, primary, Wang, Wei, primary, Chen, Ting, primary, Deng, Jiehui, primary, Ranieri, Michela, primary, Fang, Zhaoyuan, primary, Pyon, Val, primary, Dowling, Catríona M., primary, Bagdatlioglu, Ece, primary, Almonte, Christina, primary, Labbe, Kristen, primary, Silver, Heather, primary, Rabin, Alexandra R., primary, Jani, Kandarp, primary, Tsirigos, Aristotelis, primary, Papagiannakopoulos, Thales, primary, Hammerman, Peter S., primary, Velcheti, Vamsidhar, primary, Freeman, Gordon J., primary, Qi, Jun, primary, Miller, George, primary, and Wong, Kwok-Kin, primary

Published
2023
Full Text
View/download PDF

22. Data from In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma

Author

Li, Fei, primary, Huang, Qingyuan, primary, Luster, Troy A., primary, Hu, Hai, primary, Zhang, Hua, primary, Ng, Wai-Lung, primary, Khodadadi-Jamayran, Alireza, primary, Wang, Wei, primary, Chen, Ting, primary, Deng, Jiehui, primary, Ranieri, Michela, primary, Fang, Zhaoyuan, primary, Pyon, Val, primary, Dowling, Catríona M., primary, Bagdatlioglu, Ece, primary, Almonte, Christina, primary, Labbe, Kristen, primary, Silver, Heather, primary, Rabin, Alexandra R., primary, Jani, Kandarp, primary, Tsirigos, Aristotelis, primary, Papagiannakopoulos, Thales, primary, Hammerman, Peter S., primary, Velcheti, Vamsidhar, primary, Freeman, Gordon J., primary, Qi, Jun, primary, Miller, George, primary, and Wong, Kwok-Kin, primary

Published
2023
Full Text
View/download PDF

23. Table S1 from In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma

Author

Li, Fei, primary, Huang, Qingyuan, primary, Luster, Troy A., primary, Hu, Hai, primary, Zhang, Hua, primary, Ng, Wai-Lung, primary, Khodadadi-Jamayran, Alireza, primary, Wang, Wei, primary, Chen, Ting, primary, Deng, Jiehui, primary, Ranieri, Michela, primary, Fang, Zhaoyuan, primary, Pyon, Val, primary, Dowling, Catríona M., primary, Bagdatlioglu, Ece, primary, Almonte, Christina, primary, Labbe, Kristen, primary, Silver, Heather, primary, Rabin, Alexandra R., primary, Jani, Kandarp, primary, Tsirigos, Aristotelis, primary, Papagiannakopoulos, Thales, primary, Hammerman, Peter S., primary, Velcheti, Vamsidhar, primary, Freeman, Gordon J., primary, Qi, Jun, primary, Miller, George, primary, and Wong, Kwok-Kin, primary

Published
2023
Full Text
View/download PDF

24. Characterization of Heat-labile Uracil-DNA Glycosylase from Oncorhynchus mykiss and its Application for Carry-over Contamination Control in RT-qPCR

Author

Huang, Qingyuan, Zhang, Yaqi, Hu, Wenhao, Chen, Keqi, Zhang, Jian, Luo, Zhidan, and Lu, Chen

Abstract

Background: Heat-labile uracil-DNA glycosylase (HL-UDG) is commonly employed to eliminate carry-over contamination in DNA amplifications. However, the prevailing HL-UDG is markedly inactivated at 50°C, rendering it unsuitable for specific one-step RT-qPCR protocols utilizing reverse transcriptase at an optimal temperature of 42°C.Objective: This study aimed to explore novel HL-UDG with lower inactivation temperature and for recombinant expression.Methods: The gene encoding an HL-UDG was cloned from the cold-water fish rainbow trout (Oncorhynchus mykiss) and expressed in Escherichia coli with high yield. The thermostability of this enzyme and other enzymatic characteristics were thoroughly examined. The novel HL-UDG was then applied for controlling carry-over contamination in one-step RT-qPCR.Results: This recombinantly expressed truncated HL-UDG of rainbow trout (OmUDG) exhibited high amino acids similarity (84.1% identity) to recombinant Atlantic cod UDG (rcUDG) and was easily denatured at 40°C. The optimal pH of OmUDG was 8.0, and the optimal concentrations of both Na+ and K+were 10 mM. Since its inactivation temperature was lower than that of rcUDG, the OmUDG could be used to eliminate carry-over contamination in one-step RT-qPCR with moderate reverse transcription temperature.Conclusion: We successfully identified and recombinantly expressed a novel HL-UDG with an inactivation temperature of 40°C. It is suitable for eliminating carry-over contamination in one-step RT-qPCR.

Published
2024
Full Text
View/download PDF

27. Table S1 from Epigenetic CRISPR Screens Identify Npm1 as a Therapeutic Vulnerability in Non–Small Cell Lung Cancer

Author

Li, Fei, primary, Ng, Wai-Lung, primary, Luster, Troy A., primary, Hu, Hai, primary, Sviderskiy, Vladislav O., primary, Dowling, Catríona M., primary, Hollinshead, Kate E.R., primary, Zouitine, Paula, primary, Zhang, Hua, primary, Huang, Qingyuan, primary, Ranieri, Michela, primary, Wang, Wei, primary, Fang, Zhaoyuan, primary, Chen, Ting, primary, Deng, Jiehui, primary, Zhao, Kai, primary, So, Hon-Cheong, primary, Khodadadi-Jamayran, Alireza, primary, Xu, Mousheng, primary, Karatza, Angeliki, primary, Pyon, Val, primary, Li, Shuai, primary, Pan, Yuanwang, primary, Labbe, Kristen, primary, Almonte, Christina, primary, Poirier, John T., primary, Miller, George, primary, Possemato, Richard, primary, Qi, Jun, primary, and Wong, Kwok-Kin, primary

Published
2023
Full Text
View/download PDF

28. Data from Epigenetic CRISPR Screens Identify Npm1 as a Therapeutic Vulnerability in Non–Small Cell Lung Cancer

Author

Li, Fei, primary, Ng, Wai-Lung, primary, Luster, Troy A., primary, Hu, Hai, primary, Sviderskiy, Vladislav O., primary, Dowling, Catríona M., primary, Hollinshead, Kate E.R., primary, Zouitine, Paula, primary, Zhang, Hua, primary, Huang, Qingyuan, primary, Ranieri, Michela, primary, Wang, Wei, primary, Fang, Zhaoyuan, primary, Chen, Ting, primary, Deng, Jiehui, primary, Zhao, Kai, primary, So, Hon-Cheong, primary, Khodadadi-Jamayran, Alireza, primary, Xu, Mousheng, primary, Karatza, Angeliki, primary, Pyon, Val, primary, Li, Shuai, primary, Pan, Yuanwang, primary, Labbe, Kristen, primary, Almonte, Christina, primary, Poirier, John T., primary, Miller, George, primary, Possemato, Richard, primary, Qi, Jun, primary, and Wong, Kwok-Kin, primary

Published
2023
Full Text
View/download PDF

29. Supplementary Data from Epigenetic CRISPR Screens Identify Npm1 as a Therapeutic Vulnerability in Non–Small Cell Lung Cancer

Author

Li, Fei, primary, Ng, Wai-Lung, primary, Luster, Troy A., primary, Hu, Hai, primary, Sviderskiy, Vladislav O., primary, Dowling, Catríona M., primary, Hollinshead, Kate E.R., primary, Zouitine, Paula, primary, Zhang, Hua, primary, Huang, Qingyuan, primary, Ranieri, Michela, primary, Wang, Wei, primary, Fang, Zhaoyuan, primary, Chen, Ting, primary, Deng, Jiehui, primary, Zhao, Kai, primary, So, Hon-Cheong, primary, Khodadadi-Jamayran, Alireza, primary, Xu, Mousheng, primary, Karatza, Angeliki, primary, Pyon, Val, primary, Li, Shuai, primary, Pan, Yuanwang, primary, Labbe, Kristen, primary, Almonte, Christina, primary, Poirier, John T., primary, Miller, George, primary, Possemato, Richard, primary, Qi, Jun, primary, and Wong, Kwok-Kin, primary

Published
2023
Full Text
View/download PDF

34. Prevalence and genotyping distribution of Enterocytozoon bieneusi in diarrheic pigs in Chongqing and Sichuan provinces, China

Author

Ghebremichael, Samson Teweldeberhan, primary, Meng, Xianzhi, additional, Wei, Junhong, additional, Yang, Yujiao, additional, Huang, Qingyuan, additional, Luo, Lie, additional, Xiang, Heng, additional, Chen, Jie, additional, Abo-Kadoum, M. A., additional, Li, Tian, additional, Liu, Xiao, additional, Bao, Jialing, additional, Zhou, Zeyang, additional, and Pan, Guoqing, additional

Published
2022
Full Text
View/download PDF

37. LBKERS: A New Efficient Key Management Scheme for Wireless Sensor Networks

Author

Zeng, YingZhi, Su, JinShu, Yan, Xia, Zhao, BaoKang, Huang, QingYuan, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Zhang, Hongke, editor, Olariu, Stephan, editor, Cao, Jiannong, editor, and Johnson, David B., editor

Published
2007
Full Text
View/download PDF

38. Personalized Fair Reputation Based Resource Allocation in Grid

Author

Huang, QingYuan, Wang, YongJun, Su, JinShu, Zeng, YingZhi, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Yakhno, Tatyana, editor, and Neuhold, Erich J., editor

Published
2006
Full Text
View/download PDF

39. Spreading Activation Model for Connectivity Based Clustering

Author

Huang, QingYuan, Su, JinShu, Zeng, YingZhi, Wang, YongJun, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Yakhno, Tatyana, editor, and Neuhold, Erich J., editor

Published
2006
Full Text
View/download PDF

45. Loss of TSC1/TSC2 sensitizes immune checkpoint blockade in non–small cell lung cancer

Author

Huang, Qingyuan, primary, Li, Fei, additional, Hu, Hai, additional, Fang, Zhaoyuan, additional, Gao, Zhendong, additional, Xia, Guozhan, additional, Ng, Wai-Lung, additional, Khodadadi-Jamayran, Alireza, additional, Chen, Ting, additional, Deng, Jiehui, additional, Zhang, Hua, additional, Almonte, Christina, additional, Labbe, Kristen, additional, Han, Han, additional, Geng, Ke, additional, Tang, Sittinon, additional, Freeman, Gordon J., additional, Li, Yuan, additional, Chen, Haiquan, additional, and Wong, Kwok-Kin, additional

Published
2022
Full Text
View/download PDF

49. Spiramycin and azithromycin, safe for administration to children, exert antiviral activity against enterovirus A71 in vitro and in vivo

Author

Shinuan Zeng, Xuemin Guo, Lei Nanfeng, Meng Xiaobin, Lingbin Zeng, Huang Qingyuan, and Xinying Jiang

Subjects
0301 basic medicine, Microbiology (medical), medicine.drug_class, 030106 microbiology, Antibiotics, Azithromycin, Virus Replication, Antiviral Agents, Cell Line, Macrolide Antibiotics, Viral Proteins, 03 medical and health sciences, 0302 clinical medicine, In vivo, Chlorocebus aethiops, Drug Resistance, Viral, Spiramycin, medicine, Animals, Humans, Pharmacology (medical), 030212 general & internal medicine, Vero Cells, Antiinfective agent, business.industry, fungi, General Medicine, Virology, In vitro, Enterovirus A, Human, Cysteine Endopeptidases, HEK293 Cells, Infectious Diseases, Child, Preschool, RNA, Viral, Capsid Proteins, Viral disease, Hand, Foot and Mouth Disease, business, medicine.drug
Abstract

Hand-foot-mouth disease (HFMD) is a common viral disease in young children, mainly caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16). Specific antiviral agents are not commercially available yet. Here we report that the macrolide antibiotics spiramycin (SPM) and azithromycin (AZM) possess antiviral activities against EV-A71 and CV-A16. SPM significantly reduced EV-A71 RNA and protein levels, most likely through interfering with viral RNA replication. The SPM-resistant EV-A71 variants showed similar resistance to AZM, indicating a similar anti-EV-A71 mechanism by which these two drugs exert their functions. The mutations of these variants were reproducibly mapped to VP1 and 2A, which were confirmed to confer resistance to SPM. Animal experiments showed that AZM possesses stronger anti-infection efficacy than SPM, greatly alleviated the disease symptoms and increased the survival rate in a mouse model severely infected with EV-A71. In all, our work suggests that AZM is a potential treatment option for EV-A71-induced HFMD, whose proved safety for infants and children makes it even more promising.

Published
2019

Catalog

Books, media, physical & digital resources
See catalog results