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Your search keyword '"Huang, Qingtian"' showing total 16 results
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16 results on '"Huang, Qingtian"'

7. Bilirubin inhibits lung carcinogenesis by up-regulating cystatin A expression in tumor-infiltrating macrophages

Author

Huang, Qingtian, primary, Zhang, Na, additional, Wang, Jiangtuan, additional, Xu, Hua, additional, Yao, Leyi, additional, Yang, Qianqian, additional, Yan, Ding, additional, Chen, Xi, additional, Xue, Qian, additional, Xiao, Min, additional, Wu, Jiawen, additional, Wu, Xueheng, additional, Liu, Qin, additional, Tang, Daolin, additional, Chen, Xin, additional, Li, Xiaofen, additional, and Liu, Jinbao, additional

Published
2023
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10. Short Term Exposure to Bilirubin Induces Encephalopathy Similar to Alzheimer’s Disease in Late Life

Author

Chen, Haoyu, primary, Liang, Lu, additional, Xu, Hua, additional, Xu, Jia, additional, Yao, Leyi, additional, Li, Yanling, additional, Tan, Yufan, additional, Li, Xiaofen, additional, Huang, Qingtian, additional, Yang, Zhenjun, additional, Wu, Jiawen, additional, Chen, Jinghong, additional, Huang, Hongbiao, additional, Wang, Xuejun, additional, Zhang, Chang-E., additional, and Liu, Jinbao, additional

Published
2020
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11. Short Term Exposure to Bilirubin Induces Encephalopathy Similar to Alzheimer's Disease in Late Life

Author

Chen, Haoyu, primary, Liang, Lu, additional, Xu, Hua, additional, Xu, Jia, additional, Yao, Leyi, additional, Li, Yanling, additional, Tan, Yufan, additional, Li, Xiaofen, additional, Huang, Qingtian, additional, Yang, Zhenjun, additional, Wu, Jiawen, additional, Chen, Jinghong, additional, Huang, Hongbiao, additional, Wang, Xuejun, additional, Zhang, Chang-E, additional, and Liu, Jinbao, additional

Published
2019
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16. A new gold(I) complex-Au(PPh 3 )PT is a deubiquitinase inhibitor and inhibits tumor growth.

Author

Li X, Huang Q, Long H, Zhang P, Su H, and Liu J

Subjects
A549 Cells, Animals, Cell Line, Tumor, Cell Proliferation drug effects, Cell Survival drug effects, Enzyme Inhibitors pharmacology, Gene Expression Regulation, Neoplastic, Gold, Humans, Leukemia, Myeloid, Acute enzymology, Lung Neoplasms enzymology, Mice, Mice, Nude, Organogold Compounds chemistry, Organogold Compounds pharmacology, Xenograft Model Antitumor Assays, Deubiquitinating Enzymes antagonists & inhibitors, Enzyme Inhibitors administration & dosage, Leukemia, Myeloid, Acute drug therapy, Lung Neoplasms drug therapy, Organogold Compounds administration & dosage, Organophosphorus Compounds chemistry, Organoplatinum Compounds chemistry
Abstract

Background: Ubiquitin-proteasome system (UPS) is integral to cell survival by maintaining protein homeostasis, and its dysfunction has been linked to cancer and several other human diseases. Through counteracting ubiquitination, deubiquitinases (DUBs) can either positively or negatively regulate UPS function, thereby representing attractive targets of cancer therapies. Previous studies have shown that metal complexes can inhibit tumor growth through targeting the UPS; however, novel metal complexes with higher specificity for cancer therapy are still lacking., Methods: We synthesized a new gold(I) complex, Au(PPh 3 )PT. The inhibitory activity of Au(PPh 3 )PT on the UPS and the growth of multiple cancer cell types were tested in vitro, ex vivo, and in vivo. Furthermore, we compared the efficacy of Au(PPh 3 )PT with other metal compounds in inhibition of UPS function and tumor growth., Findings: Here we report that (i) a new gold(I) complex-pyrithione, i.e., Au(PPh 3 )PT, induced apoptosis in two lung cancer cell lines A549 and NCI-H1299; (ii) Au(PPh 3 )PT severely impaired UPS proteolytic function; (iii) Au(PPh 3 )PT selectively inhibited 19S proteasome-associated DUBs (UCHL5 and USP14) and other non-proteasomal DUBs with minimal effects on the function of 20S proteasome; (iv) Au(PPh 3 )PT induced apoptosis in cancer cells from acute myeloid leukemia patients; (v) Au(PPh 3 )PT effectively suppressed the growth of lung adenocarcinoma xenografts in nude mice; and (vi) Au (PPh 3 )PT elicited less cytotoxicity in normal cells than several other metal compounds., Interpretation: Together, this study discovers a new gold(I) complex to be an effective inhibitor of the DUBs and a potential anti-cancer drug. FUND: The National High Technology Research and Development Program of China, the project of Guangdong Province Natural Science Foundation, the projects from Foundation for Higher Education of Guangdong, the project from Guangzhou Medical University for Doctor Scientists, the Medical Scientific Research Foundation of Guangdong Province, and the Guangzhou Key Medical Discipline Construction Project Fund., (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2019
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