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We propose a human-centred model for abstraction, modelling and computing in function-driven spatial design for architecture. The primitive entities of our design conception ontology and computing framework are driven by classic notions of structure, function, and affordance in design, and are directly based on the fundamental human perceptual and analytical modalities of visual and locomotive exploration of space. With an emphasis on design semantics, our model for spatial design marks a fundamental shift from contemporary modelling and computational foundations underlying engineering-centred computer aided design systems. We demonstrate the application of our model within a system for human-centred computational design analysis and simulation. We also illustrate the manner in which our design modelling and computing framework seamlessly builds on contemporary industry data modelling standards within the architecture and construction informatics communities., Funding Agency:German Research Foundation (DFG)