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A string of recent social events and crises has proved that the network is free in the real sense only if this kind of freedom is under supervision. Network supervision by the Chinese government has undergone an evolutionary process and at present it is faced with some realistic predicaments and challenges such as the composition of supervisory subjects, the scope of supervisory content, the selection of supervisory modes and the creation of a positive public opinion on network supervision. The new path design of network supervision in China should follow a systematic philosophical reflection. Most importantly, supervisory behaviors should conform to the well-accepted values of supervision, follow the rules of net operation, make good use of dialectics and integrate netizens' creativity with their self-discipline. In addition, the Chinese government should learn to utilize philosophical methods to formulate practicable measures of network supervision, handle the main conflicts in network supervision, pay close attention to net incidents, and strengthen the regulation and legislation of network supervision. [ABSTRACT FROM AUTHOR]

To compare the intestinal absorption and metabolism of icariin in different osteoporosis rat models. Ovariectomy and intragastric administration of cyclophosphamide were used to establish two kinds of rat osteoporosis models. Then the rat intestinal perfusion was conducted, and HPLC was used to measure and calculate the permeability coefficients of icariin in different intestines and production amount of metabolites. Western blot was used to detect LPH enzyme expression in two models. Experimental results showed that both ovariectomy and intragastric administration of cyclophosphamide 4.5 mg•kg⁻¹ could reduce rat bone density and successfully construct the rat osteoporosis models. The apparent permeability coefficient Papp of 20 μmol icariin in duodenum, jejunum, ileum, colon was 5.695, 5.224, 1.492, 0.520 respectively in sham operation group; 3.876, 3.608, 0.863, and 0.291 in ovariectomized group; 4.945, 3.601, 1.990, 1.042 in normal saline group; 3.301, 2.108, 1.209, 1.233 in cyclophosphamide-induced osteoporosis model group. In addition, the protein expression levels of LPH enzyme in two model groups were lower than those in normal group. The absorption and metabolism of icariin in two kinds of osteoporosis models was lower than that in sham operation group and normal saline group; the reduction of expression level of LPH enzymes in rat intestine of different osteoporosis models was one of the reasons for leading to the reduced intestinal absorption and metabolism of icariin., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Chinese Pharmaceutical Association.)

A polyoxovanadium borate (H2 dap)6H[V12B16O54(OH)4] · 12H2O (dap=1,2-diaminopropane) with novel structure was hydrothermally synthesized and characterized by the single crystal X-ray diffraction. It crystallizes in triclinic system with space group Piand unit cell parameters a=19.027(4), b=16.142(3) Å, c=26.679(5) Å, α=90°, β=101.06(3)°, γ=90°, V=8042(3) Å3, Z=4, Dc=1.962 g · cm(-3), μ=1.456 mm(-1), F(000)=4776, the final R1=0.0626, wR2=0.1927, S=1.003,for 7635 observed reflections with I>2σ(I). It is showed that the compound 1 is composed of V12B16 clusters unit and dap which is as a counter ion, and a two-dimensional layered structure is obtained by the effect of hydrogen bonding between the cluster units and dap, and between the layers via strong hydrogen bonds to form a three-dimensional supramolecular structure. The compound 1 were also characterized by IR, two-dimensional infrared (2D IR) correlation spectroscopy with magnetic and thermal perturbation, UV/Vis DRS spectra. The relationship between the structure and spectroscopy properties was discussed. The IR spectrum showed that the antisymmetric stretching vibration absorption peak νas (V-Oμ) and symmetric stretching vibration absorption peaks νs (V-Oμ) appeared at 775 and 683 cm(-1) respectively, whereas the vibration absorption peak in ν(B-O) of BO3 and the vibration absorption peak in ν(B-O) of BO4 appeared at 1350 and 1050 cm(-1) respectively. The response of the stretching vibrations of B-O and V-O was detected in the 2D IR correlation spectra with magentic perturbation. In addition, the response of the stretching vibrations of B-OH, B-O and V-O-V was detected in the 2D IR correlation spectra with thermal perturbation.