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2. Outer dynein arm docking complex subunit 2 polymorphism rs7893462 modulates hepatocellular carcinoma susceptibility and can serve as an overall survival biomarker for hepatitis B virus-related hepatocellular carcinoma after hepatectomy: a cohort study with a long-term follow-up

Author

Zeng, Zhiming, Liao, Xiwen, Huang, Ketuan, Han, Chuangye, Qin, Wei, Su, Hao, Ye, Xinping, Yang, Chengkun, Zhou, Xin, Wei, Yongguang, Mo, Shutian, Liu, Junqi, Lan, Chenlu, Huang, Xinlei, Huang, Zaida, Peng, Kai, Gao, Qiang, Peng, Tao, and Zhu, Guangzhi

Published
2023
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6. Acyl-CoA Binding Domain Containing 4 Polymorphism rs4986172 and Expression Can Serve as Overall Survival Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma Patients After Hepatectomy

Author

Huang,Huasheng, Liao,Xiwen, Zhu,Guangzhi, Han,Chuangye, Wang,Xiang-Kun, Yang,Chengkun, Zhou,Xin, Liang,Tianyi, Huang,Ketuan, Peng,Tao, Huang,Huasheng, Liao,Xiwen, Zhu,Guangzhi, Han,Chuangye, Wang,Xiang-Kun, Yang,Chengkun, Zhou,Xin, Liang,Tianyi, Huang,Ketuan, and Peng,Tao

Abstract

Huasheng Huang,* Xiwen Liao,* Guangzhi Zhu, Chuangye Han, Xiangkun Wang, Chengkun Yang, Xin Zhou, Tianyi Liang, Ketuan Huang, Tao Peng Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tao Peng; Xiwen Liao, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Shuang Yong Road 6, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China, Tel +86-771-5356528, Fax +86-771-5350031, Email pengtaogmu@163.com; LXWen1991@hotmail.comBackground: The aim of our study was to evaluate the potential of expression and single nucleotide polymorphism of Acyl-CoA binding domain containing 4 (ACBD4) gene as prognosis biomarkers in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after hepatectomy.Methods: HBV-related HCC patients from the First Affiliated Hospital of Guangxi Medical University and GSE14520 were included in the current study, as well as The Cancer Genome Atlas (TCGA) HCC verification cohort. Prognostic analysis and multiple functional enrichment analysis methods were used to evaluate the prognostic value and potential biological functions of the ACBD4 gene in HBV-related HCC.Results: We found that ACBD4 gene is highly expressed in normal liver tissues and markedly down-regulated in HBV-related HCC tissues. ACBD4 gene was significantly related to overall survival (OS) of HCC in TCGA and GSE14520 cohorts, and patients with low ACBD4 expression were markedly related to poor OS. Rs4986172 was observed as an OS biomarker after hepatectomy in the Guangxi HBV-related HCC cohort. The OS of rs4986172 GG genotype was worse than that of HCC patients with A allele (AA and AG genotypes). Multifunctional enrichment analysis suggested that ACBD4 gene is closely related to the meta

Published
2022

7. Acyl-CoA Binding Domain Containing 4 Polymorphism rs4986172 and Expression Can Serve as Overall Survival Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma Patients After Hepatectomy

Author

Huang, Huasheng, primary, Liao, Xiwen, additional, Zhu, Guangzhi, additional, Han, Chuangye, additional, Wang, Xiang-Kun, additional, Yang, Chengkun, additional, Zhou, Xin, additional, Liang, Tianyi, additional, Huang, Ketuan, additional, and Peng, Tao, additional

Published
2022
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8. Laparoscopic versus open hepatectomy for hepatocellular carcinoma with cirrhosis: a single-center propensity score matching analysis

Author

He, Yongfei, primary, Fang, Dalang, additional, Liang, Tianyi, additional, Mo, Shutian, additional, Meng, Yuhua, additional, Chen, Zijun, additional, Zhao, Shuqi, additional, Liao, Yuan, additional, Huang, Ketuan, additional, Nong, Shunqiang, additional, Zhou, Weijie, additional, Han, Chuangye, additional, and Peng, Tao, additional

Published
2021
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9. Intraoperative Indocyanine Green Retention Test of Left Hemiliver in Decision-Making for Patients With Hepatocellular Carcinoma Undergoing Right Hepatectomy

Author

Yu, Tingdong, primary, Ye, Xinping, additional, Wen, Zhang, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Han, Chuangye, additional, Huang, Ketuan, additional, Qin, Wei, additional, Liao, Xiwen, additional, Yang, Chengkun, additional, Liu, Zhen, additional, Wang, Xiangkun, additional, Xu, Banghao, additional, Su, Ming, additional, Lv, Zili, additional, Lau, Wan Yee, additional, and Peng, Tao, additional

Published
2021
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10. UXT antisense RNA 1 sever as a novel prognostic long non-coding RNA in early stage pancreatic ductal adenocarcinoma patients after receiving pancreaticoduodenectomy

Author

Liao, Xiwen, primary, Huang, Rui, additional, Wang, Xiangkun, additional, Huang, Ketuan, additional, Yang, Chengkun, additional, Zhou, Xin, additional, Han, Chuangye, additional, Su, Hao, additional, Ye, Xinping, additional, Liu, Kang, additional, Zhu, Guangzhi, additional, and Peng, Tao, additional

Published
2021
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11. Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms

Author

Zhou, Xin, primary, Liao, Xiwen, additional, Wang, Xiangkun, additional, Huang, Ketuan, additional, Yang, Chengkun, additional, Yu, Tingdong, additional, Han, Chuangye, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Han, Quanfa, additional, Chen, Zijun, additional, Huang, Jianlv, additional, Gong, Yizhen, additional, Ruan, Guotian, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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12. Integrated analysis of competing endogenous RNA network revealing potential prognostic biomarkers of hepatocellular carcinoma

Author

Liao, Xiwen, Wang, Xiangkun, Huang, Ketuan, Han, Chuangye, Deng, Jianlong, Yu, Tingdong, Yang, Chengkun, Huang, Rui, Liu, Xiaoguang, Yu, Long, Zhu, Guangzhi, Su, Hao, Qin, Wei, Zeng, Xianmin, Han, Bowen, Han, Quanfa, Liu, Zhengqian, Zhou, Xin, Gong, Yizhen, Liu, Zhengtao, Huang, Jianly, Winkler, Cheryl A., O'Brien, Stephen J., Ye, Xinping, Peng, Tao, Liao, Xiwen, Wang, Xiangkun, Huang, Ketuan, Han, Chuangye, Deng, Jianlong, Yu, Tingdong, Yang, Chengkun, Huang, Rui, Liu, Xiaoguang, Yu, Long, Zhu, Guangzhi, Su, Hao, Qin, Wei, Zeng, Xianmin, Han, Bowen, Han, Quanfa, Liu, Zhengqian, Zhou, Xin, Gong, Yizhen, Liu, Zhengtao, Huang, Jianly, Winkler, Cheryl A., O'Brien, Stephen J., Ye, Xinping, and Peng, Tao

Abstract

Objective: The goal of our study is to identify a competing endogenous RNA (ceRNA) network using dysregulated RNAs between HCC tumors and the adjacent normal liver tissues from The Cancer Genome Atlas (TCGA) datasets, and to investigate underlying prognostic indicators in hepatocellular carcinoma (HCC) patients. Methods: All of the RNA- and miRNA-sequencing datasets of HCC were obtained from TCGA, and dysregulated RNAs between HCC tumors and the adjacent normal liver tissues were investigated by DESeq and edgeR algorithm. Survival analysis was used to confirm underlying prognostic indicators. Results: In the present study, we constructed a ceRNA network based on 16 differentially expressed genes (DEGs), 7 differentially expressed microRNAs and 34 differentially expressed long non-coding RNAs (DELs). Among these dysregulated RNAs, three DELs (AP002478.1, HTR2A-AS1, and ERVMER61-1) and six DEGs (enhancer of zeste homolog 2 [EZH2], kinesin family member 23 [KIF23], chromobox 2 [CBX2], centrosomal protein 55 [CEP55], cell division cycle 25A [CDC25A], and claspin [CLSPN]) were used for construct a prognostic signature for HCC overall survival (OS), and performed well in HCC OS (adjusted P<0.0001, adjusted hazard ratio = 2.761, 95% confidence interval = 1.838-4.147). Comprehensive survival analysis demonstrated that this prognostic signature may be act as an independent prognostic indicator of HCC OS. Functional assessment of these dysregulated DEGs in the ceRNA network and gene set enrichment of this prognostic signature suggest that both were enriched in the biological processes and pathways of the cell cycle, cell division and cell proliferation. Conclusions: Our current study constructed a ceRNA network for HCC, and developed a prognostic signature that may act as an independent indicator for HCC OS., QC 20190624

Published
2019
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13. Genetic variants and Expression of Cytochrome p450 Oxidoreductase Predict Postoperative Survival in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma

Author

Huang, Ketuan, Liao, Xiwen, Han, Chuangye, Wang, Xiangkun, Yu, Tingdong, Yang, Chengkun, Liu, Xiaoguang, Yu, Long, Chen, Zhiwei, Qin, Wei, Zhu, Guangzhi, Su, Hao, Liu, Zhengqian, Zeng, Xianmin, Zhou, Xin, Lu, Sicong, Huang, Jianlv, Liang, Yu, Liu, Zhengtao, Deng, Jianlong, Ye, Xinping, Peng, Tao, Huang, Ketuan, Liao, Xiwen, Han, Chuangye, Wang, Xiangkun, Yu, Tingdong, Yang, Chengkun, Liu, Xiaoguang, Yu, Long, Chen, Zhiwei, Qin, Wei, Zhu, Guangzhi, Su, Hao, Liu, Zhengqian, Zeng, Xianmin, Zhou, Xin, Lu, Sicong, Huang, Jianlv, Liang, Yu, Liu, Zhengtao, Deng, Jianlong, Ye, Xinping, and Peng, Tao

Abstract

Our current study investigates the prognostic values of genetic variants and mRNA expression of cytochrome p450 oxidoreductase (POR) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). A total of 19 candidate single nucleotide polymorphisms (SNPs) located in the exons of POR were genotyped using Sanger sequencing from 476 HBV-related HCC patients who underwent hepatectomy between 2003 and 2013. The mRNA expression of POR in 212 patients with HBV-related HCC was obtained from GSE14520 dataset. Survival analysis was performed to investigate the association of POR variants and mRNA expression with overall survival (OS) and recurrence-free survival (RFS). Nomograms were used to predict the prognosis of HBV-related HCC patients. Gene set enrichment analysis (GSEA) was used to investigate the mechanism of POR in HBV-related HCC prognosis. The polymorphism POR-rs1057868 was significantly associated with HBV-related HCC OS (CT/TT vs. CC, hazard ratio [HR] = 0.69, 95% confidence interval [CI] = [0.54, 0.88], P = 0.003), but not significantly associated with RFS (CT/TT vs. CC, P = 0.378). POR mRNA expression was also significantly associated with HBV-related HCC OS (high vs. low, HR = 0.61, 95% CI = [0.38, 0.97], P= 0.036), but not significantly associated with the RFS (high vs. low, P = 0.201). Two nomograms were developed to predict the HBV-related HCC OS. Furthermore, GSEA suggests that multiple gene sets were significantly enriched in liver cancer survival and recurrence, as well as POR-related target therapy in the liver. In conclusion, our study suggests that POR-rs1057868 and mRNA expression may serve as a potential postoperative prognosis biomarker in HBV-related HCC., QC 20190325

Published
2019
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14. Comprehensive investigation of key biomarkers and pathways in hepatitis B virus-related hepatocellular carcinoma

Author

Liao, Xiwen, Yu, Tingdong, Yang, Chengkun, Huang, Ketuan, Wang, Xiangkun, Han, Chuangye, Huang, Rui, Liu, Xiaoguang, Yu, Long, Zhu, Guangzhi, Su, Hao, Qin, Wei, Deng, Jianlong, Zeng, Xianmin, Han, Bowen, Han, Quanfa, Liu, Zhengqian, Zhou, Xin, Liu, Junqi, Gong, Yizhen, Liu, Zhengtao, Huang, Jianlv, Lu, Lei, Ye, Xinping, Peng, Tao, Liao, Xiwen, Yu, Tingdong, Yang, Chengkun, Huang, Ketuan, Wang, Xiangkun, Han, Chuangye, Huang, Rui, Liu, Xiaoguang, Yu, Long, Zhu, Guangzhi, Su, Hao, Qin, Wei, Deng, Jianlong, Zeng, Xianmin, Han, Bowen, Han, Quanfa, Liu, Zhengqian, Zhou, Xin, Liu, Junqi, Gong, Yizhen, Liu, Zhengtao, Huang, Jianlv, Lu, Lei, Ye, Xinping, and Peng, Tao

Abstract

Objective: Our study is aim to explore potential key biomarkers and pathways in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) using genome-wide expression profile dataset and methods. Methods: Dataset from the GSE14520 is used as the training cohort and The Cancer Genome Atlas dataset as the validation cohort. Differentially expressed genes (DEGs) screening were performed by the limma package. Gene set enrichment analysis (GSEA), weighted gene co-expression network analysis (WGCNA), gene ontology, the Kyoto Encyclopedia of Genes and Genomes, and risk score model were used for pathway and genes identification. Results: GSEA revealed that several pathways and biological processes are associated with hepatocarcinogenesis, such as the cell cycle, DNA repair, and p53 pathway. A total of 160 DEGs were identified. The enriched functions and pathways of the DEGs included toxic substance decomposition and metabolism processes, and the P450 and p53 pathways. Eleven of the DEGs were identified as hub DEGs in the WGCNA. In survival analysis of hub DEGs, high expression of PRC1 and TOP2A were significantly associated with poor clinical outcome of HBV-related HCC, and shown a good performance in HBV-related HCC diagnosis. The prognostic signature consisting of PRC1 and TOP2A also doing well in the prediction of HBV-related HCC prognosis. The diagnostic and prognostic values of PRC1 and TOP2A was confirmed in TCGA HCC patients. Conclusions: Key biomarkers and pathways identified in the present study may enhance the comprehend of the molecular mechanisms underlying hepatocarcinogenesis. Additionally, mRNA expression of PRC1 and TOP2A may serve as potential diagnostic and prognostic biomarkers for HBV-related HCC., QC 20191107

Published
2019
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15. Prognostic value of Kinesin‐4 family genes mRNA expression in early‐stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy

Author

Han, Quanfa, primary, Han, Chuangye, additional, Liao, Xiwen, additional, Huang, Ketuan, additional, Wang, Xiangkun, additional, Yu, Tingdong, additional, Yang, Chengkun, additional, Li, Guanghui, additional, Han, Bowen, additional, Zhu, Guangzhi, additional, Liu, Zhengqian, additional, Zhou, Xin, additional, Liu, Junqi, additional, Su, Hao, additional, Shang, Liming, additional, Peng, Tao, additional, and Ye, Xinping, additional

Published
2019
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16. Clinical significance and prospective molecular mechanism of C‑C motif chemokine receptors in patients with early‑stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy

Author

Zhou, Xin, primary, Liao, Xiwen, additional, Wang, Xiangkun, additional, Huang, Ketuan, additional, Yang, Chengkun, additional, Yu, Tingdong, additional, Liu, Junqi, additional, Han, Chuangye, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Qin, Wei, additional, Han, Quanfa, additional, Liu, Zhengqian, additional, Huang, Jianlv, additional, Gong, Yizhen, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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17. Diagnostic and prognostic value of WNT family gene expression in hepatitis B virus‑related hepatocellular carcinoma

Author

Han, Quanfa, primary, Wang, Xiangkun, additional, Liao, Xiwen, additional, Han, Chuangye, additional, Yu, Tingdong, additional, Yang, Chengkun, additional, Li, Guanghui, additional, Han, Bowen, additional, Huang, Ketuan, additional, Zhu, Guangzhi, additional, Liu, Zhengqian, additional, Zhou, Xin, additional, Su, Hao, additional, Shang, Liming, additional, Gong, Yizhen, additional, Song, Xiaowei, additional, Peng, Tao, additional, and Ye, Xinping, additional

Published
2019
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18. Genome-Wide Profiling Reveals the Landscape of Prognostic Alternative Splicing Signatures in Pancreatic Ductal Adenocarcinoma

Author

Yang, Chengkun, primary, Wu, Qiongyuan, additional, Huang, Ketuan, additional, Wang, Xiangkun, additional, Yu, Tingdong, additional, Liao, Xiwen, additional, Huang, Jianlu, additional, Zhu, Guangzhi, additional, Gong, Yizhen, additional, Han, Chuangye, additional, Su, Hao, additional, Qin, Wei, additional, and Peng, Tao, additional

Published
2019
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19. Investigation of the clinical significance and prospective molecular mechanisms of cystatin genes in patients with hepatitis B virus‑related hepatocellular carcinoma

Author

Zhou, Xin, primary, Wang, Xiangkun, additional, Huang, Ketuan, additional, Liao, Xiwen, additional, Yang, Chengkun, additional, Yu, Tingdong, additional, Liu, Junqi, additional, Han, Chuangye, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Qin, Wei, additional, Han, Quanfa, additional, Liu, Zhengqian, additional, Huang, Jianlv, additional, Gong, Yizhen, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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21. Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy

Author

Wang, Xiangkun, primary, Liao, Xiwen, additional, Yang, Chengkun, additional, Huang, Ketuan, additional, Yu, Tingdong, additional, Yu, Long, additional, Han, Chuangye, additional, Zhu, Guangzhi, additional, Zeng, Xianmin, additional, Liu, Zhengqian, additional, Zhou, Xin, additional, Qin, Wei, additional, Su, Hao, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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22. Genetic variants and Expression of Cytochrome p450 Oxidoreductase Predict Postoperative Survival in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma

Author

Huang, Ketuan, primary, Liao, Xiwen, additional, Han, Chuangye, additional, Wang, Xiangkun, additional, Yu, Tingdong, additional, Yang, Chengkun, additional, Liu, Xiaoguang, additional, Yu, Long, additional, Chen, Zhiwei, additional, Qin, Wei, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Liu, Zhengqian, additional, Zeng, Xianmin, additional, Zhou, Xin, additional, Lu, Sicong, additional, Huang, Jianlv, additional, Liang, Yu, additional, Liu, Zhengtao, additional, Deng, Jianlong, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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23. Clustered microRNAs hsa-miR-221-3p/hsa-miR-222-3p and their targeted genes might be prognostic predictors for hepatocellular carcinoma

Author

Wang, Xiangkun, primary, Liao, Xiwen, additional, Huang, Ketuan, additional, Zeng, Xianmin, additional, Liu, Zhengqian, additional, Zhou, Xin, additional, Yu, Tingdong, additional, Yang, Chengkun, additional, Yu, Long, additional, Wang, Qiaoqi, additional, Han, Chuangye, additional, Zhu, Guangzhi, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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24. Integrated analysis of competing endogenous RNA network revealing potential prognostic biomarkers of hepatocellular carcinoma

Author

Liao, Xiwen, primary, Wang, Xiangkun, additional, Huang, Ketuan, additional, Han, Chuangye, additional, Deng, Jianlong, additional, Yu, Tingdong, additional, Yang, Chengkun, additional, Huang, Rui, additional, Liu, Xiaoguang, additional, Yu, Long, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Qin, Wei, additional, Zeng, Xianmin, additional, Han, Bowen, additional, Han, Quanfa, additional, Liu, Zhengqian, additional, Zhou, Xin, additional, Gong, Yizhen, additional, Liu, Zhengtao, additional, Huang, Jianlv, additional, Winkler, Cheryl A, additional, O'Brien, Stephen J., additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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25. Comprehensive investigation of key biomarkers and pathways in hepatitis B virus-related hepatocellular carcinoma

Author

Liao, Xiwen, primary, Yu, Tingdong, additional, Yang, Chengkun, additional, Huang, Ketuan, additional, Wang, Xiangkun, additional, Han, Chuangye, additional, Huang, Rui, additional, Liu, Xiaoguang, additional, Yu, Long, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Qin, Wei, additional, Deng, Jianlong, additional, Zeng, Xianmin, additional, Han, Bowen, additional, Han, Quanfa, additional, Liu, Zhengqian, additional, Zhou, Xin, additional, Liu, Junqi, additional, Gong, Yizhen, additional, Liu, Zhengtao, additional, Huang, Jianlv, additional, Lu, Lei, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2019
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26. Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome–Wide Association Study

Author

Yang, Chengkun, primary, Han, Chuangye, additional, Wang, Xiangkun, additional, Liao, Xiwen, additional, Liu, Xiaoguang, additional, Qin, Wei, additional, Yu, Long, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Lu, Sicong, additional, Chen, Zhiwei, additional, Yu, Tingdong, additional, Liu, Zhen, additional, Huang, Ketuan, additional, Liu, Zhengtao, additional, Liang, Yu, additional, Huang, Jianlu, additional, and Peng, Tao, additional

Published
2018
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27. Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms.

Author

Zhou, Xin, Liao, Xiwen, Wang, Xiangkun, Huang, Ketuan, Yang, Chengkun, Yu, Tingdong, Han, Chuangye, Zhu, Guangzhi, Su, Hao, Han, Quanfa, Chen, Zijun, Huang, Jianlv, Gong, Yizhen, Ruan, Guotian, Ye, Xinping, and Peng, Tao

Subjects
PHOSPHOLIPASE C, PANCREATIC enzymes, PROPORTIONAL hazards models
Abstract

The purpose of this investigation was to explore the prognostic value of phospholipase C delta (PLCD) genes in early stage pancreatic ductal adenocarcinoma (PDAC) and its potential molecular mechanisms. The prognostic value of PLCD genes in early stage PDAC was assessed using the Kaplan‐Meier method and multivariate Cox proportional hazards regression model. Genome‐wide correlation analysis was performed on PLCD3 to identify the highly correlated genes in the transcriptome. Then, PLCD3 and these correlated genes together underwent a bioinformatics analysis to elucidate the potential molecular biological functions of PLCD3 in PDAC. PLCD1 and PLCD3 are significantly overexpressed in PDAC. In PDAC patients, PLCD3 is overexpressed in certain groups of people with a history of alcoholism (P =.032). High expression of PLCD3 was found to be associated with lower overall survival (OS) of patients with early stage PDAC (P =.020; adjusted P =.016). A combination of PLCD3 and clinical variables was able to better predict the outcome of patients with early stage PDAC. These clinical variables are histological grade (P =.001; adjusted P =.001), targeted molecular therapy (P <.001; adjusted P <.001), radiation therapy (P =.002; adjusted P =.039), and residual resection (P =.001; adjusted P =.002). The bioinformatics analysis revealed that PLCD3 is associated with angiogenesis, intracellular signal transduction, and regulation of cell proliferation. In conclusion, PLCD3 may be a potential prognostic biomarker for early stage PDAC. [ABSTRACT FROM AUTHOR]

Published
2020
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33. Identification of Potential Prognostic Long Non-Coding RNA Biomarkers for Predicting Survival in Patients with Hepatocellular Carcinoma

Author

Liao, Xiwen, primary, Yang, Chengkun, additional, Huang, Rui, additional, Han, Chuangye, additional, Yu, Tingdong, additional, Huang, Ketuan, additional, Liu, Xiaoguang, additional, Yu, Long, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Wang, Xiangkun, additional, Qin, Wei, additional, Deng, Jianlong, additional, Zeng, Xianmin, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2018
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34. Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma

Author

Liao, Xiwen, primary, Liu, Xiaoguang, additional, Yang, Chengkun, additional, Wang, Xiangkun, additional, Yu, Tingdong, additional, Han, Chuangye, additional, Huang, Ketuan, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Qin, Wei, additional, Huang, Rui, additional, Yu, Long, additional, Deng, Jianlong, additional, Zeng, Xianmin, additional, Ye, Xinping, additional, and Peng, Tao, additional

Published
2018
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35. Genome-scale analysis to identify prognostic markers in patients with early-stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy

Author

Liao,Xiwen, Huang,Ketuan, Huang,Rui, Liu,Xiaoguang, Han,Chuangye, Yu,Long, Yu,Tingdong, Yang,Chengkun, Wang,Xiangkun, Peng,Tao, Liao,Xiwen, Huang,Ketuan, Huang,Rui, Liu,Xiaoguang, Han,Chuangye, Yu,Long, Yu,Tingdong, Yang,Chengkun, Wang,Xiangkun, and Peng,Tao

Abstract

Xiwen Liao,1,* Ketuan Huang,1,* Rui Huang,2 Xiaoguang Liu,1,3 Chuangye Han,1 Long Yu,1,4 Tingdong Yu,1 Chengkun Yang,1 Xiangkun Wang,1 Tao Peng1 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, 2Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 3Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 4Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China *These authors contributed equally to this work Background: Molecular analysis is a promising source of clinically useful prognostic biomarkers. The aim of this investigation was to identify prognostic biomarkers for patients with early-stage pancreatic ductal adenocarcinoma (PDAC) after pancreaticoduodenectomy.Methods: An RNA sequencing dataset of PDAC was obtained from The Cancer Genome Atlas. Survival analysis and weighted gene co-expression network analysis were used to investigate the prognostic markers of early-stage PDAC after pancreaticoduodenectomy.Results: Using whole genome expression level screening, we identified 1,238 markers that were related to the prognosis of PDAC after pancreaticoduodenectomy, and identified 9 hub genes (ARHGAP30, HCLS1, CD96, FAM78A, ARHGAP15, SLA2, CD247, GVINP1, and IL16) using the weighted gene co-expression network analysis approach. We also constructed a signature comprising the 9 hub genes and weighted by the regression coefficient derived from a multivariate Cox proportional hazards regression model to divide patients into a high-risk group, with increased risk of death, and a low-risk group, with significantly improved overall survival (adjusted P=0.026, adjusted HR =0.513, 95% CI =0.285–0.924). The prognostic signature of the 9 genes demonstrated good performance for predicting 1-year overall survival (area under the respective receiver operating charact

Published
2017

36. NLRCandNLRXgene family mRNA expression and prognostic value in hepatocellular carcinoma

Author

Wang, Xiangkun, primary, Yang, Chengkun, additional, Liao, Xiwen, additional, Han, Chuangye, additional, Yu, Tingdong, additional, Huang, Ketuan, additional, Yu, Long, additional, Qin, Wei, additional, Zhu, Guangzhi, additional, Su, Hao, additional, Liu, Xiaoguang, additional, Ye, Xinping, additional, Chen, Bin, additional, Peng, Minhao, additional, and Peng, Tao, additional

Published
2017
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38. PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy

Author

Liao, Xiwen, primary, Han, Chuangye, additional, Qin, Wei, additional, Liu, Xiaoguang, additional, Yu, Long, additional, Zhu, Guangzhi, additional, Yu, Tingdong, additional, Lu, Sicong, additional, Su, Hao, additional, Liu, Zhen, additional, Chen, Zhiwei, additional, Yang, Chengkun, additional, Huang, Ketuan, additional, Liu, Zhengtao, additional, Liang, Yu, additional, Huang, Jianlu, additional, Dong, Jiahong, additional, Li, Lequn, additional, Qin, Xue, additional, Ye, Xinping, additional, Xiao, Kaiyin, additional, Peng, Minhao, additional, and Peng, Tao, additional

Published
2017
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39. ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma

Author

Zhu, Guangzhi, primary, Liao, Xiwen, additional, Han, Chuangye, additional, Liu, Xiaoguang, additional, Yu, Long, additional, Qin, Wei, additional, Lu, Sicong, additional, Su, Hao, additional, Chen, Zhiwei, additional, Liu, Zhengtao, additional, Liang, Yu, additional, Huang, Jianlu, additional, Yu, Tingdong, additional, Yang, Chengkun, additional, Huang, Ketuan, additional, Shang, Liming, additional, Ye, Xinping, additional, Li, Lequn, additional, Qin, Xue, additional, Xiao, Kaiyin, additional, Peng, Minhao, additional, and Peng, Tao, additional

Published
2017
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41. NLRC and NLRX gene family mRNA expression and prognostic value in hepatocellular carcinoma.

Author

Wang, Xiangkun, Yang, Chengkun, Liao, Xiwen, Han, Chuangye, Yu, Tingdong, Huang, Ketuan, Yu, Long, Qin, Wei, Zhu, Guangzhi, Su, Hao, Liu, Xiaoguang, Ye, Xinping, Chen, Bin, Peng, Minhao, and Peng, Tao

Subjects
LIVER cancer, HEPATECTOMY, IMMUNE response, GENE expression, CANCER relapse
Abstract

Nucleotide-binding oligomerization domain ( NOD)-like receptor ( NLR)C and NLRX family proteins play a key role in the innate immune response. The relationship between these proteins and hepatocellular carcinoma ( HCC) remains unclear. This study investigated the prognostic significance of NLRC and NLRX family protein levels in HCC patients. Data from 360 HCC patients in The Cancer Genome Atlas database and 231 patients in the Gene Expression Omnibus database were analyzed. Kaplan-Meier analysis and a Cox regression model were used to determine median survival time ( MST) and overall and recurrence-free survival by calculating the hazard ratio ( HR) and 95% confidence interval ( CI). High NOD2 and low NLRX1 expression in tumor tissue was associated with short MST (P = 0.012 and 0.014, respectively). A joint-effects analysis of NOD2 and NLRX1 combined revealed that groups III and IV had reduced risk of death from HCC as compared to group I (adjusted P = 0.001, adjusted HR = 0.31, 95% CI = 0.16-0.61 and adjusted P = 0.043, adjusted HR = 0.63, 95%CI = 0.41-0.99, respectively). NOD2 and NLRX1 expression levels are potential prognostic markers in HCC following hepatectomy. [ABSTRACT FROM AUTHOR]

Published
2017
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