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By adopting sodium silicate as a major material, SiO2 nanoparticles (size in 8–15 nm waterdispersiod was prepared by ion exchanging. The effects of sodium silicate concentration, surfacemodifying time, temperature and technological conditions on their diameter, size distribution and dispersion stability were also studied. The result show that, the hydrophilic lipophlic and hydrophiliclipophilic SiO2 nanoparticles waterdispersoid can be prepared through different kinds of surfacemodifiers and the optimum reaction conditions have been determined as follows: sodium silicate solution concentration: 8 w%; silicone dosage: 3% of the total mass of nano SiO2 waterdispersoid; adding way and time of surfacemodifier: continual dropping for 2h; surfacemodifying temperature: 60–70°C. [ABSTRACT FROM AUTHOR]

Aim: To explore the relationship between ocular and systemic conditions and the impact of ocular complications on the quality of life (QOL) in patients after allogeneic hematopoietic stem cell transplantation (ALLO-HSCT)., Methods: Forty-four patients with severe hematopoietic disease were enrolled after ALLO-HSCT at our center from July 2018 to October 2020. They completed two questionnaires: the Ocular Surface Disease Index (OSDI) and the quality-of-life scale for Chinese patients with visual impairment (SQOL-DV1). Ocular conditions and systemic conditions were also assessed., Results: Eye damage was correlated with total bilirubin ( P =0.005), and gamma-glutamyl transferase (GGT) ( P =0.021). There was no significant correlation between the overall QOL score and OSDI ( P =0.8226) or SQOL-DV1 ( P =0.9526) scores. The OSDI and the overall QOL score were not correlated with ocular conditions, including best-corrected visual acuity (BCVA), intraocular pressure, Schirmer tear test II, sodium fluorescein staining, tear film breakup time, and tear meniscus height. SQOL-DV1 was correlated with BCVA ( P =0.0007), sodium fluorescein staining ( P =0.007), and tear film breakup time ( P =0.0146)., Conclusion: In some patients, early ocular symptoms are not evident after ALLO-HSCT, while ocular surface complications can be observed after a comprehensive ophthalmological examination. Especially for those with elevated total bilirubin or GGT, regular ophthalmic follow-up visits are essential to diagnose and treat ocular graft versus host disease (oGVHD), especially for patients with elevated total bilirubin or GGT., (International Journal of Ophthalmology Press.)

To observe the expression of cyclin D1, hTERT, and telomerase activity in MNC, HL-60, HL-60A and to explore their effects on leukemogenesis and drug-resistance, normal human peripheral blood mononuclear cells, HL-60 cells sensitive to adriamycin and HL-60A cells resistant to adriamycin were investigated. The cell cycle was analyzed by flow cytometry, and the apoptosis was analyzed by Annexin V-FITC(+) PI staining. Expressions of cyclin D1 and hTERT were determined by real-time PCR and Western blot. Telomerase activity was detected by TRAP-ELISA. The results indicated that the percentage of MNC, HL-60 and HL-60A in S phase was (10.21 + 2.11)%, (44.93 + 3.00)%, and (51.38 + 1.10)% respectively; the percentage of apoptosis cells was (16.14 + 2.13)%, (7.53 + 0.92)%, (4.15 + 0.96)% respectively; the expression of mRNA and protein for cyclin D1 and hTERT increased; the telomerase activities of HL-60 and HL-60A were higher (p = 0.000), whereas the difference between HL-60 and HL-60A was no statistically significant (p = 0.232); positive correlation between cyclin D1, hTERT and telomerase activity had been found (p < 0.01). It is concluded that the cells of S phase increased while the apoptotic cells decreased in HL-60 and HL-60A, especially in HL-60A, which may be due to the up-regulation of cyclin D1, hTERT and telomerase activity.