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Your search keyword '"Huang, Jianni"' showing total 24 results
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24 results on '"Huang, Jianni"'

6. Analysis of the global origin, evolution and transmission dynamics of the emerging novel variant IBDV (A2dB1b): The accumulation of critical aa‐residue mutations and commercial trade contributes to the emergence and transmission of novel variants

Author

Wang, Weiwei, primary, He, Xiumiao, additional, Zhang, Yan, additional, Qiao, Yuanzheng, additional, Shi, Jun, additional, Chen, Rui, additional, Chen, Jinnan, additional, Xiang, Yanhua, additional, Wang, Zhiyuan, additional, Chen, Guo, additional, Huang, Jianni, additional, Huang, Teng, additional, Wei, Tianchao, additional, Mo, Meilan, additional, and Wei, Ping, additional

Published
2022
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10. Pathogenicity of different H5N6 highly pathogenic avian influenza virus strains and host immune responses in chickens

Author

Chen, Zuxian, primary, Wang, Zhenyu, additional, Zhao, Xiya, additional, Guan, Yun, additional, Xue, Qian, additional, Li, Jinrong, additional, Liu, Zhiting, additional, Zhao, Bingbing, additional, He, Zhuoliang, additional, Huang, Jianni, additional, Liao, Ming, additional, Song, Yafen, additional, and Jiao, Peirong, additional

Published
2020
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14. Genetic characteristics, pathogenicity and transmission of H5N6 highly pathogenic avian influenza viruses in Southern China

Author

Qu, Nannan, primary, Zhao, Bingbing, additional, Chen, Zuxian, additional, He, Zhuoliang, additional, Li, Weiqiang, additional, Liu, Zhiting, additional, Wang, Xia, additional, Huang, Jianni, additional, Zhang, You, additional, He, Wanting, additional, Sun, Jie, additional, Qin, Zhifeng, additional, Liao, Ming, additional, and Jiao, Peirong, additional

Published
2019
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23. The complete protections induced by the oil emulsion vaccines of the novel variant infectious bursal disease viruses against the homologous challenges indicating the important roles of both VP2 and VP1 in the antigenicity and pathogenicity of the virus.

Author

Wang W, Huang Y, Zhang Y, Qiao Y, Shi J, Huang J, Huang T, Wei T, Mo M, He X, and Wei P

Abstract

Novel variant infectious bursal disease virus (nvIBDV) is an emerging genotype (A2dB1b) that can cause severe and prolonged immunosuppression in young chickens. Despite current commercial vaccines being proven to lack complete protection against nvIBDV, it remains unclear whether the oil emulsion inactivated vaccines (OEVs) of the homologous and heterologous virus or booster immunization can provide effective protection. In this study, OEVs with two types of nvIBDV isolates QZ191002 (A-nv/B-nv) and YL160304 (A-nv/B-HLJ0504-like) were prepared and evaluated the protective effects of OEVs plus the booster immunizations with different current commercial vaccines against the challenge of nvIBDVs. The results from vaccination-challenge experiments showed that nvIBDV could break through the protection provided by only one immunization dose of the commercial vaccines, with the protection rates ranging from 40% to 60%. Interestingly, even with booster immunization with different commercial vaccines, the protection rates could only be increased to 60%-80%. As expected, only the OEVs of the homologous virus could provide 100% protection against the homologous nvIBDV, which could induce high-level specific antibodies, ameliorate target organ damage, and significantly reduce the viral load of the bursal in the challenged chickens. Notably, YL160304-OEV performed better than QZ191002-OEV, providing 100% protection not only against the challenge of homologous strain but also against that of heterologous QZ191002 strain. Antibody levels of the immunized chickens gradually increased after a short decline and reached the highest level on the age of 28 days. Similarly, the percentages of lymphocytes CD4+, CD8+ T, and B in peripheral blood lymphocytes (PBLs) were significantly increased on 21 d and 28 d. Notably, despite the nvIBDV, OEVs initially induced a delayed responses in the early stages but ultimately reach higher levels of CD4+ and CD8+ T lymphocytes. The results of study suggest that even booster immunization with different commercial vaccines cannot provide complete protection against nvIBDV, while the OEVs made by the nvIBDVs can provide full protection. Moreover, YL160304-OEV exhibits a broader protective spectrum against different nvIBDV strains, making it a potential candidate for the development of new vaccine., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Wang, Huang, Zhang, Qiao, Shi, Huang, Huang, Wei, Mo, He and Wei.)

Published
2024
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24. Porcine models of acute kidney injury.

Author

Huang J, Bayliss G, and Zhuang S

Subjects
Animals, Acute Kidney Injury, Disease Models, Animal, Swine
Abstract

Pigs represent a potentially attractive model for medical research. Similar body size and physiological patterns of kidney injury that more closely mimic those described in humans make larger animals attractive for experimentation. Using larger animals, including pigs, to investigate the pathogenesis of acute kidney injury (AKI) also serves as an experimental bridge, narrowing the gap between clinical disease and preclinical discoveries. This article compares the advantages and disadvantages of large versus small AKI animal models and provides a comprehensive overview of the development and application of porcine models of AKI induced by clinically relevant insults, including ischemia-reperfusion, sepsis, and nephrotoxin exposure. The primary focus of this review is to evaluate the use of pigs for AKI studies by current investigators, including areas where more information is needed.

Published
2021
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