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Your search keyword '"Huang, Cuiqing"' showing total 21 results
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21 results on '"Huang, Cuiqing"'

6. Structure of Venezuelan equine encephalitis virus with its receptor LDLRAD3

Author

Ma, Bingting, Huang, Cuiqing, Ma, Jun, Xiang, Ye, and Zhang, Xinzheng

Subjects
Physiological aspects, Development and progression, Causes of, Health aspects, Equine encephalomyelitis -- Causes of -- Development and progression, RNA viruses -- Physiological aspects, Membrane proteins -- Physiological aspects -- Health aspects
Abstract

Author(s): Bingting Ma [sup.1] , Cuiqing Huang [sup.2] [sup.3] , Jun Ma [sup.2] , Ye Xiang [sup.1] , Xinzheng Zhang [sup.2] [sup.3] Author Affiliations: (1) Beijing Advanced Innovation Center for [...], Venezuelan equine encephalitis virus (VEEV) is an enveloped RNA virus that causes encephalitis and potentially mortality in infected humans and equines.sup.1. At present, no vaccines or drugs are available that prevent or cure diseases caused by VEEV. Low-density lipoprotein receptor class A domain-containing 3 (LDLRAD3) was recently identified as a receptor for the entry of VEEV into host cells.sup.2. Here we present the cryo-electron microscopy structure of the LDLRAD3 extracellular domain 1 (LDLRAD3-D1) in complex with VEEV virus-like particles at a resolution of 3.0 Å. LDLRAD3-D1 has a cork-like structure and is inserted into clefts formed between adjacent VEEV E2-E1 heterodimers in the viral-surface trimer spikes through hydrophobic and polar contacts. Mutagenesis studies of LDLRAD3-D1 identified residues that are involved in the key interactions with VEEV. Of note, some of the LDLRAD3-D1 mutants showed a significantly increased binding affinity for VEEV, suggesting that LDLRAD3-D1 may serve as a potential scaffold for the development of inhibitors of VEEV entry. Our structures provide insights into alphavirus assembly and the binding of receptors to alphaviruses, which may guide the development of therapeutic countermeasures against alphaviruses. The cryo-electron microscopy structure of domain 1 of the LDLRAD3 receptor in complex with virus-like particles of Venezuelan equine encephalitis virus (VEEV) provides insights into the assembly and entry of VEEV and other alphaviruses.

Published
2021
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10. A multifunctional nanotheranostic agent potentiates erlotinib to EGFR wild-type non-small cell lung cancer

Author

Wang, Duo, Zhou, Jun, Fang, Weimin, Huang, Cuiqing, Chen, Zerong, Fan, Meng, Zhang, Ming-Rong, Xiao, Zeyu, Kuan, Hu, and Luo, Liangping

Subjects
neoplasms, respiratory tract diseases
Abstract

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), such as Erlotinib, have demonstrated remarkable efficacy in the treatment of non-small cell lung cancer (NSCLC) patients with mutated EGFR. However, the efficacy of EGFR-TKIs in wild-type (wt) EGFR tumours has been shown to be marginal. Methods that can sensitize Erlotinib to EGFR wild-type NSCLC remain rare. Herein, we developed a multifunctional superparamagnetic nanotheranostic agent as a novel strategy to potentiate Erlotinib to EGFR-wt NSCLCs. Our results demonstrate that the nanoparticles can co-escort Erlotinib and a vascular epithermal growth factor (VEGF) inhibitor, Bevacizumab (Bev), to EGFR-wt tumours. The nanotheranostic agent exhibits remarkable effects as an inhibitor of EGFR-wt tumour growth. Moreover, Bev normalizes the tumour embedded vessels, further promoting the therapeutic efficacy of Erlotinib. In addition, the tumour engagement of the nanoparticles and the vascular normalization could be tracked by magnetic resonance imaging (MRI). Collectively, our study, for the first time, demonstrated that elaborated nanoparticles could be employed as a robust tool to potentiate Erlotinib to EGFR-wt NSCLC, paving the way for imaging-guided nanotheranostics for refractory NSCLCs expressing EGFR wild-type genes.

Published
2021

20. Precise delivery of a multifunctional nanosystem for MRI-guided cancer therapy and monitoring of tumor response by functional diffusion-weighted MRI

Author

Xiao, Zeyu, primary, Chan, Leung, additional, Zhang, Dong, additional, Huang, Cuiqing, additional, Mei, Chaoming, additional, Gao, Peng, additional, Huang, Yanyu, additional, Liang, Jianye, additional, He, Lizhen, additional, Shi, Changzheng, additional, Chen, Tianfeng, additional, and Luo, Liangping, additional

Published
2019
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