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696 results on '"Huang, Congxin"'

4. Variation and disparity in awareness of atrial fibrillation in China: A national cross-sectional study

Author

Shi, Shaobo, Zhao, Qingyan, Wu, Gang, Yan, Hong, Yu, Bin, Zheng, Qiangsun, Li, Yigang, Zheng, Liangrong, Yuan, Yiqiang, Zhong, Jingquan, Xu, Jian, Wu, Yanqing, Xu, Jing, Chen, Lin, Li, Shufeng, Jiang, Jian, Wang, Jingfeng, Fan, Jie, Chen, Minglong, Tang, Baopeng, Li, Wei, Wu, Qiang, Shi, Bei, Zhou, Shenghua, Zhao, Xingsheng, Yin, Yuehui, Zhang, Zheng, Zhong, Guoqiang, Han, Xuebin, Liu, Fan, Wu, Ming, Gao, Lianjun, Yang, Bo, Tang, Yanhong, Huang, He, and Huang, Congxin

Published
2024
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12. Prevalence and risk of atrial fibrillation in China: A national cross-sectional epidemiological study

Author

Shi, Shaobo, Tang, Yanhong, Zhao, Qingyan, Yan, Hong, Yu, Bin, Zheng, Qiangsun, Li, Yigang, Zheng, Liangrong, Yuan, Yiqiang, Zhong, Jingquan, Xu, Jian, Wu, Yanqing, Xu, Jing, Chen, Lin, Li, Shufeng, Jiang, Jian, Wang, Jingfeng, Fan, Jie, Chen, Minglong, Tang, Baopeng, Li, Wei, Wu, Qiang, Shi, Bei, Zhou, Shenghua, Zhao, Xingsheng, Yin, Yuehui, Zhang, Zheng, Zhong, Guoqiang, Han, Xuebin, Liu, Fan, Wu, Ming, Gao, Lianjun, Yang, Bo, Huang, He, and Huang, Congxin

Published
2022
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26. List of Contributors

Author

Belkowska-Woloczko, Dorota, primary, Berglund, Larry G., additional, Cao, Guangyu, additional, Coxon, Chris, additional, Curd, Eric F., additional, Goodfellow, Howard D., additional, Hagström, Kim, additional, Huang, Congxin, additional, Hyttinen, Marko, additional, Jussila, Kirsi, additional, Justo-Alonso, Maria, additional, Juvonen, Risto, additional, Kalliokoski, Pentti, additional, Kaufman, Jonathan W., additional, Kosonen, Risto, additional, Landström, Ulf, additional, Li, Angui, additional, Li, Xianting, additional, Liu, Peng, additional, Ma, Jishuai, additional, Mathisen, Hans Martin, additional, Mundt, Elisabeth, additional, Pasanen, Pertti, additional, Piirilä, Päivi, additional, Posokhin, Vladimir, additional, Railio, Jorma, additional, Ratcliff, Mike, additional, Rissanen, Sirkka, additional, Rysä, Jaana, additional, Saarinen, Pekka, additional, Savolainen, Kai M., additional, Shao, Xiaoliang, additional, Shilkrot, Eugene, additional, Skistad, Håkon, additional, Strongin, Andrey, additional, Viluksela, Matti, additional, Wenaas, Terje Arne, additional, White, Paul, additional, Yang, Yang, additional, Zhang, Tengfei, additional, Zhao, Fuyun, additional, Zhivov, Alexander, additional, and Zhou, Bin, additional

Published
2020
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29. Research and Application of Evaporative Cooling Ventilation and Salty Moisture Corrosion Prevention Technology for Steam Turbine House

Author

Huang Congxin and Wang Zhiyang

Subjects
Environmental sciences, GE1-350
Abstract

This paper focus on Pakistan Hub coal-fired 2×660MW power project which located in the coast areas with high temperature and high salty moisture. The category of corrosivity of atmosphere in Pakistan Hub is C5. The high salty moisture will increase the corrosion of indoor equipment and structures in turbine house, which threaten the safe and stable operation of power plant. Direct evaporative cooling (DEC) technology is used to cool the centralized supply air for the turbine building. To prevent the salty moisture air being supplied into turbine building causes corrosion for indoor equipment and structures, the desalting moisture filter has been developed and combined with the evaporating cooling unit, which realized the large-scale engineering application. The efficiency of desalting moisture filter reaches more than 93% tested in Tongji University and VTT in Finland, under the condition of the design outdoor temperature of 38.9 °C in Karachi, the supply air temperature is 24.4 °C, which ensures the operating environments of working area and meeting the occupational hygiene requirements and anti-salt spray corrosion requirements.

Published
2022
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30. Cadherin‐5 facilitated the differentiation of human induced pluripotent stem cells into sinoatrial node‐like pacemaker cells by regulating β‐catenin.

Author

Zhang, Wei, Wang, Fengyuan, Yin, Lin, Tang, Yanhong, Wang, Xi, and Huang, Congxin

Subjects
INDUCED pluripotent stem cells, PACEMAKER cells, CATENINS, CADHERINS, HEART cells, VASCULAR endothelial cells, TISSUE adhesions
Abstract

Our study was conducted to investigate whether cadherin‐5 (CDH5), a vascular endothelial cell adhesion glycoprotein, could facilitate the differentiation of human induced pluripotent stem cells (hiPSCs) into sinoatrial node‐like pacemaker cells (SANLPCs), following previous findings of silk‐fibroin hydrogel‐induced direct conversion of quiescent cardiomyocytes into pacemaker cells in rats through the activation of CDH5. In this study, the differentiating hiPSCs were treated with CDH5 (40 ng/mL) between Day 5 and 7 during cardiomyocytes differentiation. The findings in the present study demonstrated that CDH5 stimulated the expression of pacemaker‐specific markers while suppressing markers associated with working cardiomyocytes, resulting in an increased proportion of SANLPCs among hiPSCs‐derived cardiomyocytes (hiPSC‐CMs) population. Moreover, CDH5 induced typical electrophysiological characteristics resembling cardiac pacemaker cells in hiPSC‐CMs. Further mechanistic investigations revealed that the enriched differentiation of hiPSCs into SANLPCs induced by CDH5 was partially reversed by iCRT14, an inhibitor of β‐catenin. Therefore, based on the aforementioned findings, it could be inferred that the regulation of β‐catenin by CDH5 played a crucial role in promoting the enriched differentiation of hiPSCs into SANLPCs, which presents a novel avenue for the construction of biological pacemakers in forthcoming research. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Atrial Fibrillation Better Care Pathway Adherent Care Improves Outcomes in Chinese Patients With Atrial Fibrillation

Author

Guo, Yutao, primary, Imberti, Jacopo F., additional, Kotalczyk, Agnieszka, additional, Wang, Yutang, additional, Lip, Gregory Y.H., additional, Lip, Gregory YH., additional, Li, Xiaoying, additional, Ma, Changsheng, additional, Zhang, Shu, additional, Huang, Congxin, additional, Yang, Jiefu, additional, and Liu, Meilin, additional

Published
2022
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47. Blocking Intermediate-Conductance Calcium-Activated Potassium Channels in the Macrophages Around Ganglionated Plexi Suppresses Atrial Fibrillation Vulnerability in Canines With Rapid Atrial Pacing

Author

Ma, Yazhe, Fu, Yuntao, Wang, Youcheng, Yang, Mei, Yao, Yajun, He, Shanqing, Liu, Dishiwen, Cao, Zhen, Wang, Xi, Tang, Yanhong, Zhao, Qingyan, and Huang, Congxin

Subjects
Physiology, Physiology (medical)
Abstract

Previous studies have indicated that ganglionated plexi (GP) function influences atrial fibrillation (AF) vulnerability, and intermediate-conductance calcium-activated potassium channels (SK4) have a close relationship with cardiomyocyte automaticity and the induction of AF. However, the effects of the SK4 inhibitor on GP function and AF vulnerability are unknown. Eighteen beagles were randomly divided into a control group (n = 6), rapid atrial pacing (RAP) group (n = 6), and triarylmethane-34 (TRAM-34, an SK4 inhibitor) group (n = 6). TRAM-34 (0.3 ml, 15 mmol/L) and saline were locally injected into GPs in the TRAM-34 group dogs and dogs from the other groups, respectively. After that, dogs in the RAP and TRAM-34 groups were subjected to RAP, and the neural activity of anterior right GP (ARGP) and atrial electrophysiology were measured. The levels of inflammatory cytokines and function of macrophages in the ARGP were measured in the three groups. At 10 min after TRAM-34 injection, ARGP activity and atrial electrophysiology did not significantly change. The atrial pacing shortened effective refractory period (ERP) values at all sites and increased the AF vulnerability and ARGP neural activity, while TRAM-34 reversed these changes. The levels of CD68 + cells, induced nitric oxide synthase (iNOS), interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in the ARGP tissues were higher in the RAP group and TRAM-34 group than they were in the control group. Furthermore, the levels of the CD68 + cells, iNOS, and inflammatory cytokines in the ARGP tissues were higher in the pacing group than those in the TRAM-34 group. Based on these results, administration of TRAM-34 into the atrial GP can suppress GP activity and AF vulnerability during atrial pacing. The effects of TRAM-34 might be related to macrophage polarization and the inflammatory response of GP.

Published
2022

49. Inhibition of intermittent calcium‐activated potassium channel (SK4) attenuates Ang II‐induced hypertrophy of human‐induced stem cell‐derived cardiomyocytes via targeting Ras–Raf–MEK1/2–ERK1/2 and CN–NFAT signaling pathways

Author

Zhao, Hongyi, Wang, Xi, Tang, Yanhong, Zhao, Qingyan, and Huang, Congxin

Subjects
CALCIUM-dependent potassium channels, POTASSIUM channels, ATRIAL natriuretic peptides, CARDIAC hypertrophy, BRAIN natriuretic factor, CELLULAR signal transduction, WESTERN immunoblotting
Abstract

Cardiac hypertrophy caused by angiotensin II (Ang II) is essential for the pathological process of heart failure. The intermediate calcium‐activated potassium channel (SK4) has been shown to be involved in the process of the inflammatory response, cell proliferation, and apoptosis. However, the role of SK4 in cardiac hypertrophy has not been elucidated. Cardiac hypertrophy in human‐induced pluripotent stem cells‐derived cardiomyocytes (HiPSC‐CMs) was induced by Ang II. Cells were transfected with SK4 adenovirus or treated with SK4 inhibitor (TRAM‐34). TUNEL staining was used to assess the levels of apoptosis. Real‐time polymerase chain reaction and Western blot analysis were used to measure messenger RNA (mRNA) and protein levels, respectively. The present results showed that SK4 expression was upregulated in HiPSC‐CMs stimulated by Ang II. The downregulation of SK4 by a specific inhibitor TRAM‐34 markedly ameliorated cardiac hypertrophy (reflected by the mRNA levels of atrial natriuretic peptide, brain natriuretic peptide, and β‐myosin heavy chain) and apoptosis (reflected by the level of Caspase 3, Bax, and Bcl‐2) induced by Ang II treatment. The action of SK4 in cardiac hypertrophy was mediated by Ras–Raf–mitogen‐activated protein kinases 1/2 (MEK1/2)–extracellular‐regulated protein kinases 1/2 (ERK1/2) and calcineurin (CN)–nuclear factors of activated T cells (NFAT) activation. Our studies demonstrated that inhibition of SK4 significantly alleviated cardiac hypertrophy induced by Ang II in hiPSC‐CMs by targeting Ras–Raf–MEK1/2–ERK1/2 signaling and CN–NFAT signaling pathway. Our studies suggest that SK4 may serve as a potential therapeutic target that could delay hypertrophy. [ABSTRACT FROM AUTHOR]

Published
2023
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