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11. Haplotype-resolved Chromosomal-Level Genome Assembly Reveals Regulatory Variations in Mulberry Fruit Anthocyanin Content

Author

Xia, Zhongqiang, primary, Fan, Wei, additional, Liu, Duanyang, additional, Chen, Yuane, additional, Lv, Jing, additional, Xu, Mengxia, additional, Zhang, Meirong, additional, Ren, Zuzhao, additional, Chen, Xuefei, additional, Wang, Xiujuan, additional, Li, Liang, additional, Zhu, Panpan, additional, Liu, Changying, additional, Song, Zhiguang, additional, Huang, Chuanshu, additional, Wang, Xiling, additional, Wang, Shuchang, additional, and Zhao, Aichun, additional

Published
2024
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13. p27 specifically decreases in squamous carcinoma, and mediates NNK‐induced transformation of human bronchial epithelial cells.

Author

Peng, Minggang, Meng, Hao, Wang, Jingjing, Guo, Mengxin, Li, Tengda, Qian, Xiaohui, Chen, Ruifan, Jin, Honglei, and Huang, Chuanshu

Subjects
GENE expression, CELL transformation, SMOKING, CIGARETTE smoke, UBIQUITIN ligases
Abstract

Lung cancer remains the leading cause of cancer‐related deaths, with cigarette smoking being the most critical factor, linked to nearly 90% of lung cancer cases. NNK, a highly carcinogenic nitrosamine found in tobacco, is implicated in the lung cancer‐causing effects of cigarette smoke. Although NNK is known to mutate or activate certain oncogenes, its potential interaction with p27 in modulating these carcinogenic effects is currently unexplored. Recent studies have identified specific downregulation of p27 in human squamous cell carcinoma, in contrast to adenocarcinoma. Additionally, exposure to NNK significantly suppresses p27 expression in human bronchial epithelial cells. Subsequent studies indicates that the downregulation of p27 is pivotal in NNK‐induced cell transformation. Mechanistic investigations have shown that reduced p27 expression leads to increased level of ITCH, which facilitates the degradation of Jun B protein. This degradation in turn, augments miR‐494 expression and its direct regulation of JAK1 mRNA stability and protein expression, ultimately activating STAT3 and driving cell transformation. In summary, our findings reveal that: (1) the downregulation of p27 increases Jun B expression by upregulating Jun B E3 ligase ITCH, which then boosts miR‐494 transcription; (2) Elevated miR‐494 directly binds to 3′‐UTR of JAK1 mRNA, enhancing its stability and protein expression; and (3) The JAK1/STAT3 pathway is a downstream effector of p27, mediating the oncogenic effect of NNK in lung cancer. These findings provide significant insight into understanding the participation of mechanisms underlying p27 inhibition of NNK induced lung squamous cell carcinogenic effect. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Transcriptomics and metabolomics profiling coumestrol and psoralen synthesis pathways and potential regulators in Inonotus hispidus L-1.

Author

LIU Yan, HUANG Chuanshu, YANG Biwen, XIANG Shuxiang, TANG Lu, HUANG Yue, WU Jun, SONG Zhiguang, and XING Kangkang

Subjects
TRANSCRIPTOMES, METABOLOMICS, PSORALENS
Abstract

Copyright of Mycosystema is the property of Mycosystema Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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30. Supplemental Figure 1 from Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis

Author

Jiang, Guosong, primary, Wu, Amy D., primary, Huang, Chao, primary, Gu, Jiayan, primary, Zhang, Liping, primary, Huang, Haishan, primary, Liao, Xin, primary, Li, Jingxia, primary, Zhang, Dongyun, primary, Zeng, Xingruo, primary, Jin, Honglei, primary, Huang, Haojie, primary, and Huang, Chuanshu, primary

Published
2023
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31. Supplemental Figure 2 from Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis

Author

Jiang, Guosong, primary, Wu, Amy D., primary, Huang, Chao, primary, Gu, Jiayan, primary, Zhang, Liping, primary, Huang, Haishan, primary, Liao, Xin, primary, Li, Jingxia, primary, Zhang, Dongyun, primary, Zeng, Xingruo, primary, Jin, Honglei, primary, Huang, Haojie, primary, and Huang, Chuanshu, primary

Published
2023
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32. Data from Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis

Author

Jiang, Guosong, primary, Wu, Amy D., primary, Huang, Chao, primary, Gu, Jiayan, primary, Zhang, Liping, primary, Huang, Haishan, primary, Liao, Xin, primary, Li, Jingxia, primary, Zhang, Dongyun, primary, Zeng, Xingruo, primary, Jin, Honglei, primary, Huang, Haojie, primary, and Huang, Chuanshu, primary

Published
2023
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33. Supplemental Figure 3 from Isorhapontigenin (ISO) Inhibits Invasive Bladder Cancer Formation In Vivo and Human Bladder Cancer Invasion In Vitro by Targeting STAT1/FOXO1 Axis

Author

Jiang, Guosong, primary, Wu, Amy D., primary, Huang, Chao, primary, Gu, Jiayan, primary, Zhang, Liping, primary, Huang, Haishan, primary, Liao, Xin, primary, Li, Jingxia, primary, Zhang, Dongyun, primary, Zeng, Xingruo, primary, Jin, Honglei, primary, Huang, Haojie, primary, and Huang, Chuanshu, primary

Published
2023
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38. Induction of p27 contributes to inhibitory effect of isorhapontigenin (ISO) on malignant transformation of human urothelial cells

Author

Huang, Maowen, Hua, Xiaohui, Xu, Jiheng, Tian, Zhongxian, Wang, Jiajing, Chen, Hengchao, Wang, Xuyao, Shu, Peng, Ye, Hongyan, Shu, Jianfeng, and Huang, Chuanshu

Subjects
Cell Biology, Molecular Biology, Developmental Biology
Abstract

Bladder cancer (BC) is the most expensive cancer to manage on a per-patient basis, costing about $4 billion in total healthcare expenditure per annum in America alone. Therefore, identifying a natural compound for prevention of BC is of tremendous importance for managing this disease. Previous studies have identified isorhapontigenin (ISO) as having an 85% preventive effect against invasive BC formation induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN). The results showed here that ISO treatment inhibited EGF-induced cell transformation of human urothelial cells through induction of tumor suppressor p27 transcription secondary to activation of an E2F1-dependentpathway.ISOtreatmentrenderedcellsresistanttoEGF-induced anchorage-independent growth concurrent with p27 protein induction in both UROtsa and SV-HUC-1 cells. ISO inhibition of EGF-induced cell transformation could be completely reversed by knockdown of p27, indicating that this protein was essential for the noted ISO inhibitory action. Mechanistic studies revealed that ISO treatment resulted in increased expression of E2F1, which in turn bound to its binding site in p27 promoter and initiated p27 transcription. The E2F1 induction was due to the elevation of its translation caused by ISO-induced miR-205 downregulation. Consistently, miR-205 was found to be overexpressed in human BCs, and ectopic expression of miR-205 mitigated ISO inhibitory effects against EGF-induced outcomes. Collectively, the results here demonstrate that ISO exhibits its preventive effect on EGF-induced human urothelial cell transformation by induction of p27 through a miR-205/E2F1 axis. This is distinct from what has been described for the therapeutic effects of ISO on human BC cells.

Published
2022

39. Supplementary Figure 1-6, Supplementary Tables 1-3 from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure

Author

Huang, Haishan, primary, Pan, Xiaofu, primary, Jin, Honglei, primary, Li, Yang, primary, Zhang, Lin, primary, Yang, Caili, primary, Liu, Pei, primary, Liu, Ya, primary, Chen, Lili, primary, Li, Jingxia, primary, Zhu, Junlan, primary, Zeng, Xingruo, primary, Fu, Kai, primary, Chen, Guorong, primary, Gao, Jimin, primary, and Huang, Chuanshu, primary

Published
2023
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40. Data from Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization

Author

So, Jae Young, primary, Skrypek, Nicolas, primary, Yang, Howard H., primary, Merchant, Anand S., primary, Nelson, George W., primary, Chen, Wei-Dong, primary, Ishii, Hiroki, primary, Chen, Jennifer M., primary, Hu, Gangqing, primary, Achyut, Bhagelu R., primary, Yoon, Esther C., primary, Han, Liying, primary, Huang, Chuanshu, primary, Cam, Margaret C., primary, Zhao, Keji, primary, Lee, Maxwell P., primary, and Yang, Li, primary

Published
2023
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41. Table S1 from Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization

Author

So, Jae Young, primary, Skrypek, Nicolas, primary, Yang, Howard H., primary, Merchant, Anand S., primary, Nelson, George W., primary, Chen, Wei-Dong, primary, Ishii, Hiroki, primary, Chen, Jennifer M., primary, Hu, Gangqing, primary, Achyut, Bhagelu R., primary, Yoon, Esther C., primary, Han, Liying, primary, Huang, Chuanshu, primary, Cam, Margaret C., primary, Zhao, Keji, primary, Lee, Maxwell P., primary, and Yang, Li, primary

Published
2023
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42. supplementary methods and figure legends from PHLPP2 Downregulation Contributes to Lung Carcinogenesis Following B[a]P/B[a]PDE Exposure

Author

Huang, Haishan, primary, Pan, Xiaofu, primary, Jin, Honglei, primary, Li, Yang, primary, Zhang, Lin, primary, Yang, Caili, primary, Liu, Pei, primary, Liu, Ya, primary, Chen, Lili, primary, Li, Jingxia, primary, Zhu, Junlan, primary, Zeng, Xingruo, primary, Fu, Kai, primary, Chen, Guorong, primary, Gao, Jimin, primary, and Huang, Chuanshu, primary

Published
2023
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43. Figure S3 from Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization

Author

So, Jae Young, primary, Skrypek, Nicolas, primary, Yang, Howard H., primary, Merchant, Anand S., primary, Nelson, George W., primary, Chen, Wei-Dong, primary, Ishii, Hiroki, primary, Chen, Jennifer M., primary, Hu, Gangqing, primary, Achyut, Bhagelu R., primary, Yoon, Esther C., primary, Han, Liying, primary, Huang, Chuanshu, primary, Cam, Margaret C., primary, Zhao, Keji, primary, Lee, Maxwell P., primary, and Yang, Li, primary

Published
2023
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