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Your search keyword '"Huang, Chiung-Yao"' showing total 268 results
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268 results on '"Huang, Chiung-Yao"'

1. Constructing a System for Effective Implementation of Strategic Corporate Social Responsibility

Author

Huang, Chiung-Yao, Fu, Chung-Jen, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Barolli, Leonard, editor, Xhafa, Fatos, editor, Javaid, Nadeem, editor, and Enokido, Tomoya, editor

Published
2019
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25. Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin

Author

Wei Wen-Chi, Lin Sheng-Yen, Chen Yi-Jyun, Wen Chih-Chun, Huang Chiung-Yao, Palanisamy Arulselvan, Yang Ning-Sun, and Sheu Jyh-Horng

Subjects
Briarane-type diterpene, TPA-induced mouse dermatitis, Dendritic cells, Vascular permeability, Edema, Medicine
Abstract

Abstract Background Skin is the largest organ in the body, and is directly exposed to extrinsic assaults. As such, the skin plays a central role in host defense and the cutaneous immune system is able to elicit specific local inflammatory and systemic immune responses against harmful stimuli. 12-O-tetradecanoylphorbol-13-acetate (TPA) can stimulate acute and chronic inflammation and tumor promotion in skin. TPA-induced dermatitis is thus a useful in vivo pharmacological platform for drug discovery. In this study, the inhibitory effect of briarane-type diterpenes (BrDs) from marine coral Briareum excavatum on TPA-induced dermatitis and dendritic cell (DC) function was explored. Methods Evans blue dye exudation was used to determine vascular permeability. H&E-stained skin section was used to determine the formation of edema in mouse abdominal skin. We also used immunohistochemistry staining and western blot assays to evaluate the activation of specific inflammation makers and key mediators of signaling pathway in the mouse skin. Furthermore, mouse bone marrow DCs were used to determine the relationship between the chemical structure of BrDs and their regulation of DC function. Results BrD1 remarkably suppressed TPA-induced vascular permeability and edema in skin. At the biochemical level, BrD1 inhibited TPA-induced expression of cyclooxygenase-2, inducible nitric oxide synthase and matrix metalloproteinase-9, the key indicators of cutaneous inflammation. This inhibition was apparently mediated by interference with the Akt/NF-κB-mediated signaling network. BrD1 also inhibited TNF-α and IL-6 expression in LPS-stimulated BMDCs. The 8, 17-epoxide of BrDs played a crucial role in the inhibition of IL-6 expression, and replacement of the C-12 hydroxyl group with longer esters in BrDs gradually decreased this inhibitory activity. Conclusions Our results suggest that BrDs warrant further investigation as natural immunomodulatory agents for control of inflammatory skin diseases.

Published
2011
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32. Correction: Huang, H.W.; et al. Sinularin Selectively Kills Breast Cancer Cells Showing G2/M Arrest, Apoptosis, and Oxidative DNA Damage. Molecules 2018, 23, 849

Author

Huang, Hurng-Wern, primary, Tang, Jen-Yang, additional, Ou-Yang, Fu, additional, Wang, Hui-Ru, additional, Guan, Pei-Ying, additional, Huang, Chiung-Yao, additional, Chen, Chung-Yi, additional, Hou, Ming-Feng, additional, Sheu, Jyh-Horng, additional, and Chang, Hsueh-Wei, additional

Published
2018
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40. Reactive oxygen species mediate soft corals-derived sinuleptolide-induced antiproliferation and DNA damage in oral cancer cells

Author

Chang,Yung-Ting, Huang,Chiung-Yao, Tang,Jen-Yang, Liaw,Chih-Chuang, Li,Ruei-Nian, Liu,Jing-Ru, Sheu,Jyh-Horng, Chang,Hsueh-Wei, Chang,Yung-Ting, Huang,Chiung-Yao, Tang,Jen-Yang, Liaw,Chih-Chuang, Li,Ruei-Nian, Liu,Jing-Ru, Sheu,Jyh-Horng, and Chang,Hsueh-Wei

Abstract

Yung-Ting Chang,1,2,* Chiung-Yao Huang,3,* Jen-Yang Tang,4,5 Chih-Chuang Liaw,1,3 Ruei-Nian Li,6 Jing-Ru Liu,6 Jyh-Horng Sheu,1,3,7,8 Hsueh-Wei Chang6,9–12 1Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung, Taiwan; 2Doctoral Degree Program in Marine Biotechnology, Academia Sinica, Taipei, Taiwan; 3Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan; 4Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 5Department of Radiation Oncology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan; 6Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan; 7Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan; 8Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan; 9Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, Taiwan; 10Cancer Center, Kaohsiung Medical University Hospital; Kaohsiung Medical University, Kaohsiung, Taiwan; 11Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 12Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohsiung, Taiwan *These authors contributed equally to this work Abstract: We previously reported that the soft coral-derived bioactive substance, sinuleptolide, can inhibit the proliferation of oral cancer cells in association with oxidative stress. The functional role of oxidative stress in the cell-killing effect of sinuleptolide on oral cancer cells was not investigated as yet. To address this question, we introduced the reactive oxygen species (ROS) scavenger (N-acetylcysteine [NAC]) in a pretreatment to evaluate the sinuleptolide-induced changes to cell viability, morphology, intracellular ROS, mitochon

Published
2017

41. Applying activity-based costing information to improve managerial decisions in relation to market orientation

Author

Chen, Yu-Cheng, Huang, Chiung-Yao, Lin, Anchor Y., and Huang, Stephanie Wei-Ling

Subjects
Activity-based costing -- Usage, Customer relationship management -- Analysis, Customer relationship management -- Methods, Customer relationship management, Business, international
Abstract

Byline: Yu-Cheng Chen, Chiung-Yao Huang, Anchor Y. Lin, Stephanie Wei-Ling Huang Based on the approach of information process, this study aims to contribute to the activity-based costing (ABC) literature by linking the relationship between ABC information and the managerial decisions of market orientation. This study also contributes to the practical operation of a firm by applying the philosophy of market orientation to the implementation of an ABC system. In summary, this study focuses on how ABC information could be used in response to special orders, reduce inter-departmental conflicts and to manage customer relationships.

Published
2010

46. Isoprenoids from the Soft Coral Sarcophyton glaucum

Author

Chao, Chih-Hua, primary, Li, Wen-Liang, additional, Huang, Chiung-Yao, additional, Ahmed, Atallah F., additional, Dai, Chang-Feng, additional, Wu, Yang-Chang, additional, Lu, Mei-Chin, additional, Liaw, Chih-Chuang, additional, and Sheu, Jyh-Horng, additional

Published
2017
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