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18. Cognitive Factors in Predicting Continued Use of Information Systems with Technology Adoption Models

Author

Huang, Chi-Cheng

Abstract

Introduction: The ultimate viability of an information system is dependent on individuals' continued use of the information system. In this study, we use the technology acceptance model and the theory of interpersonal behaviour to predict continued use of information systems. Method: We established a Web questionnaire on the mySurvey Website and recruited participants via social networks. Data were collected from a sample of 1,154 Webmail users in Taiwan. Analysis: Our models are analysed using the partial least squares structural equation modelling method. Results: The results of this study indicate that (1) the theory of interpersonal behaviour has better ability to predict continued use than the technology acceptance model; (2) the technology acceptance model has a better ability to predict intention to continue use than the theory of interpersonal behaviour; (3) the combination between the technology acceptance model and the theory of interpersonal behaviour is properly able to explain continued use of information systems; and (4) multiple group analysis indicates that two relations in the combined model differ significantly between light experience users and heavy experience users. Conclusions: The technology acceptance model and the theory of interpersonal behaviour should not be viewed as alternative but as supplementary models. Moreover, the integration of such two models can properly predict continued use of information systems.

Published
2017

31. Listening to Your Own Willingness to Continue Using Contact Tracing Apps: The Roles of Personal Norms.

Author

Huang, Chi-Cheng, Guo, Bo-Xu, Chen, Jian-Ting, and Wu, Zhi-Hual

Subjects
*CONTACT tracing, *INFORMATION technology, *STRUCTURAL equation modeling, *SOCIAL norms, *MOBILE apps
Abstract

AbstractCOVID-19 became a global epidemic after its breakout in December 2019. With the help of information technology, many countries developed contact tracing systems to reduce the spread of the epidemic. Although the WHO declared in May 2023 that COVID-19 is no longer a global public health emergency, the virus is still constantly changing and endangering individuals worldwide. In Taiwan, Social Distancing APP is a voluntary contact tracing app that has been downloaded and utilized approximately 9.5 million times. However, adoption remains low. To prevent the spread of the epidemic and encourage more people to use it, understanding the factors influencing continuance intentions to use social distancing apps is an important topic. The research model is composed of two parts: the modified expectation confirmation model (ECM) and personal norms. Our research model was assessed using data from a sample of 501 users of social distancing apps and was analyzed using the partial least squares structural equation model (PLS-SEM). The results of this study suggest that (1) personal norms are the most important factor influencing continuance intention, followed by satisfaction, perceived usefulness, and descriptive norms; (2) personal norms fully mediate the relationship between injunctive norms and continuance intention; (3) personal norms partially mediate the relationship between descriptive norms and continuance intention; (4) personal norms negatively moderate the relationship between satisfaction and continuance intention; and (5) personal norms positively moderate the relationship between disappointment and continuance intention. This study also discusses the implications of a modified ECM and personal norms for continuance intention to use contact tracing apps. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Genomic Alterations of Tumors in HER2-Low Breast Cancers

Author

Tsai, Yi-Fang, primary, Huang, Chi-Cheng, additional, Hsu, Chih-Yi, additional, Feng, Chin-Jung, additional, Lin, Yen-Shu, additional, Chao, Ta-Chung, additional, Lai, Jiun-I, additional, Lien, Pei-Ju, additional, Liu, Chun-Yu, additional, Chiu, Jen-Hwey, additional, and Tseng, Ling-Ming, additional

Published
2024
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36. Prevalent landscape of tumor genomic alterations of luminal B1 breast cancers using a comprehensive genomic profiling assay in Taiwan

Author

Chen, Bo-Fang, primary, Tsai, Yi-Fang, additional, Lien, Pei-Ju, additional, Lin, Yen-Shu, additional, Feng, Chin-Jung, additional, Chen, Yen-Jen, additional, Cheng, Han-Fang, additional, Liu, Chun-Yu, additional, Chao, Ta-Chung, additional, Lai, Jiun-I., additional, Tseng, Ling-Ming, additional, and Huang, Chi-Cheng, additional

Published
2023
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44. Clinical and Genotypic Insights Into Higher Prevalence of Palbociclib Associated Neutropenia in Asian Patients.

Author

Lai, Jiun-I, Kuo, Ting-Hao, Huang, Kuan-Jung, Chai, Laura Min Xuan, Lee, Mei-Hsuan, Liu, Chun-Yu, Tsai, Yi-Fang, Huang, Chi-Cheng, Tseng, Ling-Ming, Hsu, Cheng-Chih, and Chao, Ta-Chung

Subjects
PERITONEAL dialysis, PROTEIN-tyrosine kinase inhibitors, BREAST tumors, DRUG administration, SEVERITY of illness index, RETROSPECTIVE studies, TREATMENT effectiveness, DESCRIPTIVE statistics, GAS chromatography, MASS spectrometry, PHARMACOKINETICS, PROGRESSION-free survival, GENOTYPES, NEUTROPENIA, CYCLIN-dependent kinases, GENOMES, CHEMICAL inhibitors
Abstract

Background CDK4/6 inhibitors (CDK4/6i) have shown great efficacy in prolonging progression-free survival and is the current standard of care for hormone positive (HR(+)) metastatic breast cancer (mBC). Despite well tolerability and ease of use, the most common side effect of CDK4/6i is myelosuppression, with neutropenia the most prevalent adverse effect. Studies show that the prevalence and severity of neutropenia are more marked in Asian patients, although details remain obscure. Methods In this study, we retrospectively analyzed 105 Taiwanese patients who received palbociclib for HR(+) HER2(−) mBC at the Taipei Veterans General Hospital. To investigate a possible genetic association for high prevalence of neutropenia, we queried the Taiwan Biobank with publicly available germline databases (ALFA, gnomAD, ExAC, 1000 Genomes project, HapMap), for the allele frequencies of 4 neutropenia-related SNPs (ABCB1_rs1045642, ABCB1_rs1128503, ERCC1_rs3212986, ERCC1_rs11615) and compared between different ethnicities. In addition, one of the patients was a long-term patient with peritoneal dialysis. We quantified the levels of palbociclib in her serum and peritoneal fluid by liquid chromatography-mass spectrometry (LC-MS). Results Interestingly, in our cohort, early neutropenia nadir (occurred within 56 days of start) was associated with worse treatment outcome, while occurrence of grade 3/4 neutropenia was associated with better outcome. We observed an extremely high incidence of neutropenia (96.2% any grade, 70.4% grade 3/4). In the analyzed germline databases, we discovered a higher SNP frequency of the T allele in ABCB1_rs1128503, a lower frequency of T allele in ABCB1_rs1045642, and a higher SNP frequency of G allele in ERCC1_rs11615. We observed that palbociclib levels in peritoneal dialysate ranged from around 20-50 ppb, and serum levels reached 100-110 ppb during drug administration and decreased to <10 ppb during discontinuation. Conclusion Our retrospective analysis of real world palbociclib use reveals an association with grade 3/4 neutropenia with better outcome and early neutropenia nadir with worse outcome. Our findings of Asian specific SNPs support a predisposition toward profound and prevalent neutropenia in Asian patients under CDK4/6i. We also report the first pharmacokinetics analysis on a patient with peritoneal dialysis receiving CDK4/6i. In summary, our study provides novel clinical and genotypic insights into CDK4/6i associated neutropenia. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Optimizing Aesthetic-Based Photo Retargeting

Author

Liu, Damon Shing-Min, Huang, Chi-Cheng, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Chen, Yaxi, editor, Christie, Marc, editor, and Tan, Wenrong, editor

Published
2017
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