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4. Cryoablation for Palliation of Painful Bone Metastases: The MOTION Multicenter Study.

Author

Jennings, Jack, Prologo, J, Garnon, Julien, Gangi, Afshin, Buy, Xavier, Palussière, Jean, Kurup, A, Callstrom, Matthew, Genshaft, Scott, Abtin, Fereidoun, Huang, Ambrose, Iannuccilli, Jason, Pilleul, Frank, Mastier, Charles, Littrup, Peter, de Baère, Thierry, and Deschamps, Frédéric

Subjects
Ablation Techniques, Metastases, Pain Management, Radiation Therapy/Oncology, Adult, Bone Neoplasms, Cryosurgery, Humans, Male, Middle Aged, Pain, Prospective Studies, Quality of Life
Abstract

PURPOSE: To assess the clinical effectiveness of cryoablation for palliation of painful bone metastases. MATERIALS AND METHODS: MOTION (Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases) (ClinicalTrials.gov NCT02511678) was a multicenter, prospective, single-arm study of adults with metastatic bone disease who were not candidates for or had not benefited from standard therapy, that took place from February 2016 to March 2018. At baseline, participants rated their pain using the Brief Pain Inventory-Short Form (reference range from 0 to 10 points); those with moderate to severe pain, who had at least one metastatic candidate tumor for ablation, were included. The primary effectiveness endpoint was change in pain score from baseline to week 8. Participants were followed for 24 weeks after treatment. Statistical analyses included descriptive statistics and logistic regression to evaluate changes in pain score over the postprocedure follow-up period. RESULTS: A total of 66 participants (mean age, 60.8 years ± 14.3 [standard deviation]; 35 [53.0%] men) were enrolled and received cryoablation; 65 completed follow-up. Mean change in pain score from baseline to week 8 was -2.61 points (95% CI: -3.45, -1.78). Mean pain scores improved by 2 points at week 1 and reached clinically meaningful levels (more than a 2-point decrease) after week 8; scores continued to improve throughout follow-up. Quality of life improved, opioid doses were stabilized, and functional status was maintained over 6 months. Serious adverse events occurred in three participants. CONCLUSION: Cryoablation of metastatic bone tumors provided rapid and durable pain palliation, improved quality of life, and offered an alternative to opioids for pain control.Keywords: Ablation Techniques, Metastases, Pain Management, Radiation Therapy/OncologySupplemental material is available for this article.© RSNA, 2021.

Published
2021

10. Case 30-2024: A 45-Year-Old Woman with Kidney Lesions and Lytic Bone Disease.

Author

Chen, Luke Y. C., Huang, Ambrose J., Stone, John H., and Ferry, Judith A.

Subjects
*PLASMA cell diseases, *MEDICAL societies, *HIV infections, *SARCOIDOSIS, *CASTLEMAN'S disease, *SJOGREN'S syndrome
Abstract

This article presents a case study of a 45-year-old woman with kidney lesions and lytic bone disease. The patient underwent various imaging tests and reported symptoms such as fatigue and pain in the left shoulder and arm. Further evaluation and testing revealed polyclonal hypergammaglobulinemia with an elevated IgG level. The article explores potential causes for the patient's symptoms, ruling out certain diseases and suggesting a histiocytic disorder as the most likely diagnosis. Treatment options for systemic Rosai-Dorfman-Destombes disease are also discussed, with the patient in the case having a complete clinical response to cobimetinib. [Extracted from the article]

Published
2024
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41. Emergencies of the Foot

Author

Pugmire, Brian S., primary, Huang, Ambrose J., additional, Abujudeh, Hani H., additional, and Chang, Connie Y., additional

Published
2016
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