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Soliton molecules were first discovered in optical systems and they have recently received reinvigorating scientific interests in physics and beyond. In this paper, we mainly study a typical model of nonlocal fifth-order KdV system. First, the model is obtained by using parity, time reversal invariance and Lax pairs. Secondly, we obtain soliton solutions by means of the bilinear method. Finally, based on the N-soliton solution, soliton molecules can be obtained via the velocity resonance mechanism. Especially, some soliton molecules have been observed successfully in the laboratory.

Full duplex communication highly improves spectrum efficiency of a wireless communication link. However, when it is applied to a cellular network, the capacity gain from this technology remains unknown. The reason is that full duplex communication changes the aggregate interference experienced by each communication link in cellular networks. In this paper, the capacity gain from full duplex communication is studied for cellular networks of 4G and beyond, where the same frequency channel is adopted in each cell. A two-layer Poisson point process (PPP) is adopted to model the network topology, and stochastic geometry is employed to derive the coverage probability and the average capacity of typical link in a cellular network. On the basis of these derived parameters, the capacity gain from full duplex communication is determined. Numerical results reveal that without mutual interference cancellation (MIC), the capacity gain is small under various power levels; with perfect MIC at base stations, the capacity gain can exceed 60%; with imperfect MIC at base stations, the capacity gain decreases quickly even with a slight drop of MIC performance.

Soliton solutions, lump solutions, breather solutions and soliton molecules are hot topics in recent years. And soliton molecules have been successfully discovered in optical experiments. In this paper, we firstly use the Hirota bilinear method to obtain the multiple solitary wave solutions of the (3+1)-dimensional Jimbo-Miwa equation. Secondly, on the basis of soliton solutions, the soliton molecule of the equation is studied by means of the velocity resonance condition, and the dynamic diagram of the specific case is given. Finally, we study the hybrid solution of the equation involving soliton, lump, breather, and soliton molecule.

In recent years, soliton molecules have received reinvigorating scientific interests in physics and other fields. Soliton molecules have been successfully found in optical experiments. In this paper, we attribute the solutions of the (3+1)-dimensional B-type Kadomtsev–Petviashvili (BKP) equation by employing the bilinear method. Based on the [Formula: see text]-soliton solutions, we establish the soliton molecules, asymmetric solitons and some novel hybrid solutions of this equation by means of the velocity resonance mechanism and the long wave limit method. Finally, we give dynamic graphs of soliton molecules, asymmetric solitons and some novel hybrid solutions.

Compared to half duplex communications, full duplex communications can significantly improve link capacity. However, in a large scale wireless network such as a wireless mesh network, the capacity gain from full duplex communications has not been fully investigated. To this end, a metric of network capacity called transmission capacity is studied in this paper for a full duplex wireless network. It captures the maximum transmission throughput in a unit area, subject to a certain outage probability. The key challenge of deriving transmission capacity is to characterize the aggregate interference of the typical link in a full duplex wireless network, which is completely different from that in a half duplex wireless network. In this paper, stochastic geometry is employed to model the network topology as a Thomas cluster point process and then the aggregate interference is characterized as a shot-noise process. Based on these models, the transmission capacity is derived. Analytical results show that under the same network density the distribution of aggregate interference in a full duplex wireless network is more dispersed than that in a half duplex wireless network. Comparisons of transmission capacity between a full duplex network and a half duplex network reveal that the capacity gain from full duplex communications is limited due to severe aggregate interference. This result implies that self-interference cancellation alone cannot ensure scalable full duplex wireless networking.

Yong Zhou, Chengzhi Gu, Jia Li, Lianhai Zhu, Guoxiang Huang, Jie Dai, Huaiyu Huang Department of Neurology, The Second Affiliated Hospital of Nantong University, The First People’s Hospital of Nantong, Nantong, China Purpose: Parkinson’s disease (PD) is a common neurodegenerative movement disorder, but the pathogenesis remains elusive. This study was aimed to explore key genes and long noncoding RNAs (lncRNAs) associated with PD.Materials and methods: Three patients with PD and three normal controls were enrolled in the present study from July 12, 2017, to August 29, 2017. RNA sequencing and bioinformatics analysis were performed to obtain differentially expressed micro RNAs (DEmRNAs) and lncRNAs (DElncRNAs) between patients with PD and normal controls. PD-specific protein–protein interaction networks were constructed. DEmRNAs transcribed within a 100kb window upstream or downstream of DElncRNAs were searched, which were defined as cis nearby targeted DEmRNAs of DElncRNAs. Datasets GSE57475 and GSE68719 were downloaded from the Gene Expression Omnibus database, which were used to validate the expression of selected DEmRNAs.Results: A total of 857 DEmRNAs and 77 DElncRNAs were obtained between PD and normal controls. Natural killer cell-mediated cytotoxicity was a significantly enriched pathway in PD. ERBB2, HSPB1, and MYC were three hub proteins of PD-specific protein–protein interaction network. LOC105378701-TAL1, LOC102724104-CX3CR1, LOC105375056-TREML1/TREML4, LOC105379392-ANK1, and LOC101928100-KLRK1/KLRD1 interactions were identified DElncRNA nearby targeted DEmRNA pairs in PD. Gene expression results validated by GSE57475 and GSE68719 were consistent with our RNA-sequencing results, generally.Conclusion: This present study identified key genes and lncRNAs associated with PD, which will provide new clues for exploring the pathogenesis and developing potential biomarkers of PD. Keywords: RNA-sequencing, mRNA, bioinformatics analysis, protein–protein interaction network&nbsp

Objective: To detect the serum levels of D-dimer and N-terminal pro B-type natriuretic peptide (NT-pro BNP) in patients with Acute Ischemic Stroke (AIS), and to explore the risk factors of AIS. Methods: A total of 246 AIS patients treated in our hospital from January 2015 to January 2017 were selected. Meanwhile, 240 healthy subjects were selected as a control group. The D-dimer and NT-pro BNP levels of the two groups were compared. Correlations of such levels with age, gender, blood lipid, Intima-Media Thickness (IMT), fibrinogen and degree of neurological deficits were analyzed. Results: The AIS group had significantly higher levels of Triglyceride (TG), Low-Density Lipoprotein (LDL), D-dimer, NT-pro BNP and fibrinogen as well as IMT than those of the control group, but the High-Density Lipoprotein (HDL) level of the AIS group was significantly lower (P

We aimed to analyze the mutation site and frequency of catechol-O-methyltransferase (COMT) gene, to explore the relationship between COMT genotype and phenotype, and to find new pathogenic genes for paroxysmal kinesigenic dyskinesia (PKD). PKD patients who were treated from December 2011 to January 2014 were selected and subjected to genetic testing in the exon region of COMT. Two patients and one intrafamilial healthy control were subjected to exome sequencing using whole exome capture in combination with high-throughput sequencing to find candidate pathogenic gene sites. The results were verified by Sanger sequencing. A total of 11 familial PKD patients from 4 families and 9 sporadic patients without family history were included. Pathogenic c.634dupC(p.P220fsX7) mutation of COMT gene was found in 7 familial PKD patients and3 sporadic patients. Mutated COMT gene carriers suffered from PKD earlier (average age of onset: 11.61 ± 2.33 vs 16.21 ± 2.58, P = 0.001) with symmetric symptoms in most cases, while the mutation-negative group only showed unilateral symptoms (P = 0.001). The mutation-positive group also had more daily attacks (P = 0.038). Carbamazepine worked for all mutation-positive patients (10/10, 100%), but only for a part of mutation-negative patients (3/10, 30.0%). About 90000 single nucleotide polymorphisms and 2000 insertion-deletion polymorphisms were detected in each of the three samples. c.737C → T(p.T246 M) mutation of POC1B gene was a new pathogenic site for a selected family. COMT gene mutation, which was the pathogenesis of most familial PKD patients and a part of sporadic patients, predicted the response to carbamazepine. POC1B may be a novel pathogenic gene for PKD.