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8 results on '"Huai-Yuan Xie"'

1. 7-(2,4-Dichlorophenyl)-2-methylsulfanylpyrazolo[1,5-a]pyrimidine-3-carbonitrile

Author

Li-rong Wen, Shu-wen Wang, and Huai-yuan Xie

Subjects
Crystallography, QD901-999
Abstract

In the molecule of the title compound, C14H8Cl2N4S, all the ring atoms in the pyrazolopyrimidine system are almost coplanar, the largest deviation from the mean plane being 0.027 (2) Å for a C atom. The conformation of the methylsulfanyl group is antiperiplanar, with a torsion angle of −176.7 (2)°. A weak intermolecular C—H...N hydrogen bond and a Cl...N halogen bond [Cl...N = 3.196 (5) Å] with a nearly linear N...Cl—C angle [174.2 (1)°] link the molecules into a two-dimensional assembly. Face-to-face π–π stacking, with a centroid–centroid separation of 3.557 (2) Å and an angle of 7.1 (1)° between the two planes, completes the intermolecular interactions in the solid state.

Published
2009
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3. 2-Anilino-3-benzoyl-4-(2,5-dichlorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-benzo[b]pyran

Author

Huai-Yuan Xie, Chen Ji, Ji-Hui Sun, and Li-Rong Wen

Subjects
Crystallography, QD901-999
Abstract

The title compound, C30H25Cl2NO3, was prepared by the reaction of 3-oxo-N,3-diphenylpropanethioamide, 2,5-dichlorobenzaldehyde and 5,5-dimethyl-1,3-cyclohexanedione (1:1:1) in ethanol. The cyclohexene ring adopts a half-chair conformation. The crystal structure exhibits intramolecular N—H...O and C—H...O, and intermolecular C—H...O interactions.

Published
2008
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5. Application of ortho-chloro-β-aroylthioamides in synthesis(II): an efficient one-pot, three-component synthesis of tricyclic thiochromeno[2,3-b]pyridine derivatives

Author

Ming Li, Huai-Yuan Xie, Chen Ji, and Li-Rong Wen

Subjects
Intramolecular reaction, Organic Chemistry, Condensation reaction, Meldrum's acid, Biochemistry, Chemical synthesis, Medicinal chemistry, chemistry.chemical_compound, chemistry, Cascade reaction, Nucleophilic aromatic substitution, Drug Discovery, Pyridine, Knoevenagel condensation
Abstract

Tricyclic thiochromeno[2,3-b]pyridine derivatives have been successfully synthesized in an unusual one-pot multicomponent cascade reaction from ortho-halo-β-aroylthioamides, Meldrum's acid, and aromatic aldehydes. The reaction presumably proceeds via Knoevenagel condensation–Michael addition–cyclocondensation–decarboxylation–rearrangement–intramolecular SNAr reaction sequence. High bond forming efficiency of this reaction makes it attractive for the synthesis of thiochromeno[2,3-b]pyridine derivatives in a single step operation.

Published
2009

7. ChemInform Abstract: Application of ortho-Chloro-β-aroylthioamides in Synthesis(II): An Efficient One-Pot, Three-Component Synthesis of Tricyclic Thiochromeno[2,3-b]pyridine Derivatives

Author

Li-Rong Wen, Huai-Yuan Xie, Chen Ji, and Ming Li

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, Cascade reaction, chemistry, Reaction sequence, Component (thermodynamics), Nucleophilic aromatic substitution, Pyridine, Single step, Knoevenagel condensation, General Medicine, Combinatorial chemistry, Tricyclic
Abstract

Tricyclic thiochromeno[2,3-b]pyridine derivatives have been successfully synthesized in an unusual one-pot multicomponent cascade reaction from ortho-halo-β-aroylthioamides, Meldrum's acid, and aromatic aldehydes. The reaction presumably proceeds via Knoevenagel condensation–Michael addition–cyclocondensation–decarboxylation–rearrangement–intramolecular SNAr reaction sequence. High bond forming efficiency of this reaction makes it attractive for the synthesis of thiochromeno[2,3-b]pyridine derivatives in a single step operation.

Published
2009

8. 2-Anilino-3-benzoyl-4-(2,5-dichloro-phen-yl)-7,7-dimethyl-5-oxo-5,6,7,8-tetra-hydro-4H-benzo[b]pyran

Author

Huai-Yuan Xie, Chen Ji, Li-Rong Wen, and Ji-Hui Sun

Subjects
Crystallography, Ethanol, biology, Cyclohexene, General Chemistry, Crystal structure, Condensed Matter Physics, Ring (chemistry), Bioinformatics, biology.organism_classification, Medicinal chemistry, Organic Papers, chemistry.chemical_compound, chemistry, QD901-999, Pyran, Tetra, General Materials Science
Abstract

The title compound, C30H25Cl2NO3, was prepared by the reaction of 3-oxo-N,3-diphenylpropanethioamide, 2,5-dichlorobenzaldehyde and 5,5-dimethyl-1,3-cyclohexanedione (1:1:1) in ethanol. The cyclohexene ring adopts a half-chair conformation. The crystal structure exhibits intramolecular N—H...O and C—H...O, and intermolecular C—H...O interactions.

Published
2007

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