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Abstract Background Differentiated thyroid cancer (DTC) affects thousands of lives worldwide each year. Typically, DTC is a treatable disease with a good prognosis. Yet, some patients are subjected to partial or total thyroidectomy and radioiodine therapy to prevent local disease recurrence and metastasis. Unfortunately, thyroidectomy and/or radioiodine therapy often worsen(s) quality of life and might be unnecessary in indolent DTC cases. On the other hand, the lack of biomarkers indicating a potential metastatic thyroid cancer imposes an additional challenge to managing and treating patients with this disease. Aim The presented clinical setting highlights the unmet need for a precise molecular diagnosis of DTC and potential metastatic disease, which should dictate appropriate therapy. Materials and methods In this article, we present a differential multi‐omics model approach, including metabolomics, genomics, and bioinformatic models, to distinguish normal glands from thyroid tumours. Additionally, we are proposing biomarkers that could indicate potential metastatic diseases in papillary thyroid cancer (PTC), a sub‐class of DTC. Results Normal and tumour thyroid tissue from DTC patients had a distinct yet well‐defined metabolic profile with high levels of anabolic metabolites and/or other metabolites associated with the energy maintenance of tumour cells. The consistency of the DTC metabolic profile allowed us to build a bioinformatic classification model capable of clearly distinguishing normal from tumor thyroid tissues, which might help diagnose thyroid cancer. Moreover, based on PTC patient samples, our data suggest that elevated nuclear and mitochondrial DNA mutational burden, intra‐tumour heterogeneity, shortened telomere length, and altered metabolic profile reflect the potential for metastatic disease. Discussion Altogether, this work indicates that a differential and integrated multi‐omics approach might improve DTC management, perhaps preventing unnecessary thyroid gland removal and/or radioiodine therapy. Conclusions Well‐designed, prospective translational clinical trials will ultimately show the value of this integrated multi‐omics approach and early diagnosis of DTC and potential metastatic PTC.

Abstract Dielectric tunability is widely used in numerous electronic devices, including wavelet filters, lens antennae, and varactors. However, a dielectric device often has only one tunable dielectric constant range, confining the integration of a multi‐frequency electronic circuit. Herein, a new kind of dielectric tunable textured BaTi0.99Fe0.01O3−δ ceramics with micro‐twin boundaries is proposed for the dual‐channel controllable dielectric constants. The relative tunability with the acceptable figure of merit is as large as 76% in the crossover channel, which is superior to that of the most state‐of‐the‐art BaxSr1 −xTiO3 counterparts. This new design strategy offers the possibility of dual‐channel filters in one dielectric device controlled by external electric fields. The required external electric field is moderate with the help of reversible micro twins, which is confirmed by first‐principles studies. The static magnetic field interference on the dielectric constant is also evaluated, showing the frequency stability of dielectric tunability in a range between 5k and 1 m Hz.

The development of synthetic host-guest systems for stimuli-responsive molecular recognition in water is challenging. Here, the authors report a pair of water-soluble naphthotubes with a pH-responsive cavity for which switchable bifunctional recognition in water is achieved.

Single crystals of 2-methylbenzimidazolium perchlorate were prepared for the first time with a slow evaporation method from an aqueous solution of a mixture of 2-methylbenzimidazole (MBI) crystals and perchloric acid HClO4. The crystal structure was determined by single crystal X-ray diffraction (XRD) and confirmed by XRD of powder. Angle-resolved polarized Raman and Fourier-transform infrared (FTIR) absorption spectra of crystals consist of lines caused by molecular vibrations in MBI molecule and ClO4− tetrahedron in the region ν = 200–3500 cm−1 and lattice vibrations in the region of 0–200 cm−1. Both XRD and Raman spectroscopy show a protonation of MBI molecule in the crystal. An analysis of ultraviolet-visible (UV-Vis) absorption spectra gives an estimation of an optical gap Eg~3.9 eV in the crystals studied. Photoluminescence spectra of MBI-perchlorate crystals consist of a number of overlapping bands with the main maximum at Ephoton ≅ 2.0 eV. Thermogravimetry-differential scanning calorimetry (TG-DSC) revealed the presence of two first-order phase transitions with different temperature hysteresis at temperatures above room temperature. The higher temperature transition corresponds to the melting temperature. Both phase transitions are accompanied by a strong increase in the permittivity and conductivity, especially during melting, which is similar to the effect of an ionic liquid.

Immune checkpoint inhibitors (ICIs) have made great progress in the field of tumors and have become a promising direction of tumor treatment. With advancements in genomics and bioinformatics technology, it is possible to individually analyze the neoantigens produced by somatic mutations of each patient. Neoantigen load (NAL), a promising biomarker for predicting the efficacy of ICIs, has been extensively studied. This article reviews the research progress on NAL as a biomarker for predicting the anti-tumor effects of ICI. First, we provide a definition of NAL, and summarize the detection methods, and their relationship with tumor mutation burden. In addition, we describe the common genomic sources of NAL. Finally, we review the predictive value of NAL as a tumor prediction marker based on various clinical studies. This review focuses on the predictive ability of NAL’s ICI efficacy against tumors. In melanoma, lung cancer, and gynecological tumors, NAL can be considered a predictor of treatment efficacy. In contrast, the use of NAL for urinary system and liver tumors requires further research. When NAL alone is insufficient to predict efficacy, its combination with other indicators can improve prediction efficiency. Evaluating the response of predictive biomarkers before the treatment initiation is essential for guiding the clinical treatment of cancer. The predictive power of NAL has great potential; however, it needs to be based on more accurate sequencing platforms and technologies.

In recent years, immune checkpoint inhibitors (ICIs) have become the standard treatment option for tumors. With the widespread application of ICIs, immune-related adverse events (irAEs) have gradually attracted the attention of researchers. Owing to the characteristics of ICIs, irAEs can affect each organ of the human body. Thromboembolism is uncommon in cancer patients receiving ICIs, but it may affect their survival. Most thromboembolic events do not cause serious effects after early prediction and treatment, but life-threatening toxic reactions are also observed. This condition should not be ignored because of vague and atypical symptoms, which make early diagnosis more challenging. This article focuses on the high-risk factors, underlying mechanisms, incidence, and prognosis of thromboembolism in patients using ICIs and briefly describes the intervention and treatment measures. This information would allow patients to effectively manage the side effects of thromboembolism during Immune checkpoint inhibitors treatment, ensuring the efficacy of ICIs and reducing mortality.

Glycine (Gly) single crystals doped with croconic acid (CA) were grown by evaporation from aqueous solutions. Depending on the weight ratio of Gly and CA in solutions, the crystals take on a plate or pyramidal shape. Both powder and single crystal XRD analyses indicate that the crystal lattices of plates (α-Gly:CA) and pyramides (γ-Gly:CA) correspond to the lattices of pure α-Gly and γ-Gly polymorphs, respectively. Raman and FTIR spectra of Gly:CA crystals are very close to the spectra of undoped crystals, but include bands associated with CA impurity. Analysis of UV-Vis absorption spectra indicates that doping does not remarkably change bandgap value Eg~5.2 eV but results in appearance of strong absorption bands in the transparency region of pure glycine crystals, which result from local electronic transitions. Incorporation of CA molecules in Gly creates strong green photoluminescence in a wide spectral range 1.6–3.6 eV. Comparison of the optical spectra of Gly:CA and previously studied TGS:CA crystals indicates that in both cases, the modifications of the optical spectra induced by CA doping are practically identical and are related to the interaction between CA molecules located in the pores of the host Gly crystals and neighboring Gly molecules.

Triglycine sulfate (TGS) single crystals doped with croconic acid (CA) were grown by evaporation from aqueous solutions. X-ray diffraction analysis shows a slight reduction in unit cell volume in TGS:CA compared to pure TGS crystals. The polarized Raman and near-infrared absorption spectra show that the positions of most lines resulting from inter- and intramolecular vibrations are in good agreement with those in spectra of undoped TGS crystals. The inclusion of CA in TGS is confirmed by the presence of bands characteristic of CA in the infrared-Fourier transform spectra. The ultraviolet-visible absorption spectra of TGS:CA are characterized by the presence of additional absorption bands (compared to the spectra of pure TGS) located in the transparent region of pure TGS. In the photon energy region 1.6–3.6 eV, a strong “green” luminescence band is present in TGS:CA upon excitation at λ = 325 nm. The position of the emission band depends on the wavelength of the exciting light. Doping of TGS with CA causes pinning of domain walls, which is accompanied by a decrease in amplitude and frequency dispersion of the dielectric anomaly at the phase transition, a decrease in the switchable polarization and an increase in the coercive field of hysteresis loops.

Abstract Eu-doped calcium aluminate was synthesized via the low-cost self-propagating combustion synthesis (SPCS) technique, whose phase constitutions were identified as Ca9Al6O18 and Ca3Al2O6. The Ca2+ ions in Ca9Al6O18 rather than Ca3Al2O6 phase were replaced by Eu3+ ions. The product exhibits the superior luminescent property and photocatalytic activity, which may find potential applications in the display devices and environment treatments.

The title complex, [Pb(C8H5N2O2S)2]n, consists of one PbII ion located on a crystallographic twofold axis and two symmetry-related 2-amino-1,3-benzothiazole-6-carboxylate (ABTC) ligands. The central PbII ion has a (4 + 2) coordination by four O atoms of the two ABTC ligands and two weaker Pb—S bonding interactions (Pb—S secondary bonds) from S atoms of other two neighbouring ABTC ligands. These bonds link the metal ions into zigzag chains along the c axis, which, in turn, aggregate through π–π interactions [centroid–centroid distance = 3.7436 Å] between ABTC rings and N—H...O and N—H...N hydrogen bonds.