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33 results on '"Hua, Zhaolin"'

7. Requirement for MyD88 Signaling in B Cells and Dendritic Cells for Germinal Center Anti-Nuclear Antibody Production in Lyn-Deficient Mice

Author

Hua, Zhaolin, Gross, Andrew J, Lamagna, Chrystelle, Ramos-Hernández, Natalia, Scapini, Patrizia, Ji, Ming, Shao, Haitao, Lowell, Clifford A, Hou, Baidong, and DeFranco, Anthony L

Subjects
Autoimmune Disease, Lupus, Kidney Disease, Development of treatments and therapeutic interventions, Aetiology, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Inflammatory and immune system, Animals, Antibodies, Antinuclear, Antigen-Antibody Complex, B-Lymphocytes, Dendritic Cells, Disease Models, Animal, Gene Deletion, Germinal Center, Humans, Immunoglobulin G, Intracellular Signaling Peptides and Proteins, Lupus Erythematosus, Systemic, Lupus Nephritis, Lymphocyte Count, Mice, Mice, Inbred C57BL, Mice, Knockout, Myeloid Differentiation Factor 88, Receptors, Antigen, T-Cell, gamma-delta, Self Tolerance, Signal Transduction, Signaling Lymphocytic Activation Molecule Associated Protein, Specific Pathogen-Free Organisms, Toll-Like Receptors, src-Family Kinases, Immunology
Abstract

The intracellular tyrosine kinase Lyn mediates inhibitory receptor function in B cells and myeloid cells, and Lyn(-/-) mice spontaneously develop an autoimmune and inflammatory disease that closely resembles human systemic lupus erythematosus. TLR-signaling pathways have been implicated in the production of anti-nuclear Abs in systemic lupus erythematosus and mouse models of it. We used a conditional allele of Myd88 to determine whether the autoimmunity of Lyn(-/-) mice is dependent on TLR/MyD88 signaling in B cells and/or in dendritic cells (DCs). The production of IgG anti-nuclear Abs, as well as the deposition of these Abs in the glomeruli of the kidneys, leading to glomerulonephritis in Lyn(-/-) mice, were completely abolished by selective deletion of Myd88 in B cells, and autoantibody production and glomerulonephritis were delayed or decreased by deletion of Myd88 in DCs. The reduced autoantibody production in mice lacking MyD88 in B cells or DCs was accompanied by a dramatic decrease in the spontaneous germinal center (GC) response, suggesting that autoantibodies in Lyn(-/-) mice may depend on GC responses. Consistent with this view, IgG anti-nuclear Abs were absent if T cells were deleted (TCRβ(-/-) TCRδ(-/-) mice) or if T cells were unable to contribute to GC responses as the result of mutation of the adaptor molecule SAP. Thus, the autoimmunity of Lyn(-/-) mice was dependent on T cells and on TLR/MyD88 signaling in B cells and in DCs, supporting a model in which DC hyperactivity combines with defects in tolerance in B cells to lead to a T cell-dependent systemic autoimmunity in Lyn(-/-) mice.

Published
2014

10. AMP-Activated Kinase Links Serotonergic Signaling to Glutamate Release for Regulation of Feeding Behavior in C. elegans

Author

Cunningham, Katherine A, Hua, Zhaolin, Srinivasan, Supriya, Liu, Jason, Lee, Brian H, Edwards, Robert H, and Ashrafi, Kaveh

Subjects
Pharmacology and Pharmaceutical Sciences, Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Behavioral and Social Science, Neurosciences, Nutrition, Basic Behavioral and Social Science, Obesity, AMP-Activated Protein Kinases, Animals, Basic Helix-Loop-Helix Transcription Factors, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cells, Cultured, Chemoreceptor Cells, Cyclic AMP-Dependent Protein Kinases, Feeding Behavior, Gastrointestinal Motility, Glutamic Acid, Hippocampus, Pharynx, Protein Serine-Threonine Kinases, Rats, Receptors, Serotonin, Serotonergic Neurons, Serotonin, Synaptic Transmission, Protein-Serine-Threonine Kinases, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism, Biochemistry and cell biology, Medical biochemistry and metabolomics
Abstract

Serotonergic regulation of feeding behavior has been studied intensively, both for an understanding of the basic neurocircuitry of energy balance in various organisms and as a therapeutic target for human obesity. However, its underlying molecular mechanisms remain poorly understood. Here, we show that neural serotonin signaling in C. elegans modulates feeding behavior through inhibition of AMP-activated kinase (AMPK) in interneurons expressing the C. elegans counterpart of human SIM1, a transcription factor associated with obesity. In turn, glutamatergic signaling links these interneurons to pharyngeal neurons implicated in feeding behavior. We show that AMPK-mediated regulation of glutamatergic release is conserved in rat hippocampal neurons. These findings reveal cellular and molecular mediators of serotonergic signaling.

Published
2012

15. A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates

Author

Guo, Chang, primary, Peng, Yanan, additional, Lin, Lin, additional, Pan, Xiaoyan, additional, Fang, Mengqi, additional, Zhao, Yun, additional, Bao, Keyan, additional, Li, Runhan, additional, Han, Jianbao, additional, Chen, Jiaorong, additional, Song, Tian-Zhang, additional, Feng, Xiao-Li, additional, Zhou, Yahong, additional, Zhao, Gan, additional, Zhang, Leike, additional, Zheng, Yongtang, additional, Zhu, Ping, additional, Hang, Haiying, additional, Zhang, Linqi, additional, Hua, Zhaolin, additional, Deng, Hongyu, additional, and Hou, Baidong, additional

Published
2021
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18. Homeostatic regulation of T follicular helper and antibody response to particle antigens by IL-1Ra of medullary sinus macrophage origin

Author

Lin, Xinwen, primary, Twelkmeyer, Trix, additional, Zhu, Danming, additional, Zhang, Li, additional, Zhao, Yang, additional, Zhang, Chao, additional, Iwakura, Yoichiro, additional, Meng, Guangxun, additional, Hua, Zhaolin, additional, Yan, Bingyu, additional, Liu, William J., additional, Luo, Zhongguang, additional, Gong, Sitang, additional, Chen, Hairong, additional, Li, Shuran, additional, Hou, Baidong, additional, and Tang, Hong, additional

Published
2021
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23. B Cell–Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle

Author

Tian, Meijie, primary, Hua, Zhaolin, additional, Hong, Sheng, additional, Zhang, Zhimin, additional, Liu, Can, additional, Lin, Lin, additional, Chen, Jiaorong, additional, Zhang, Wei, additional, Zhou, Xuyu, additional, Zhang, Fuping, additional, DeFranco, Anthony L., additional, and Hou, Baidong, additional

Published
2018
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33. Researches for Modeling Water Quality of Tidal Rivers

Author

Hua Zhaolin, Huang Wuyang, and Chang Tsun-Tsing

Subjects
geography, Noise, geography.body_of_water, Series (mathematics), Meteorology, Estimation theory, System identification, Range (statistics), Applied mathematics, Tidal river, Water quality, Time series, Physics::Geophysics
Abstract

This paper deals with system identification by statistical method for modeling dynamically water quality of tidal rivers by using the nonstationary time series of the observations of the water quality parameters (NBOD, CBOD and DO) and the time series of the observations of the hydraulic parameters (V, Q and A). For this purpose, a difference model with time-varying coefficients is derived with the concentration of the water quality parameters as nonstationary spacetime series data. The time-varying coefficients of the model are then divided into two parts, time-varying and time-invariant, the former consists of some hydraulic parameters and the later is then used for parameter estimation. In the second part of this paper, a noise model is also derived. It is a linear time-varying model. The noise process is not wide-sense stationary. According to the measured data of hydraulic parameters of a tidal river, we analyse the time-varying part and then obtain its varying range. Further the tidal period can be decomposed into a set of subsequences according to its different phases. From each of them we can obtain a noise model which is linear time-invariant. And we then conclude that the noise process is mean value ergodic. From an analysis of the noise behavior, it is found that the time series analysis method can be used for modeling the water quality of tidal rivers. Allen’s PSS criterion is then used for choosing the model and determining the estimated parameters. This is exactly that Tamura’s NICE (Nonstationary Statistical System Identification Method for River Quality Modeling) is applied to tidal rivers. The paper further proposes a method for determining the model and modifying its parameter values Computer simulation shows that the proposed method is realizable and recommended for modeling the water quality of tidal rivers (Snangnai Huang-Pu River).

Published
1987
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