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9. HMGA2 Gene rs8756 A>C Polymorphism Reduces Neuroblastoma Risk in Chinese Children: A Four-Center Case-Control Study

Author

Liu, Jiabin, Hua, Rui-Xi, Cheng, Yun, Zhu, Jinhong, Zhang, Jiao, Cheng, Jiwen, Zhou, Haixia, Xia, Huimin, Bian, Jun, and He, Jing

Subjects
neuroblastoma, HMGA2, susceptibility, Original Research, polymorphism
Abstract

Background Neuroblastoma, mainly affecting children, is a lethal malignancy arising from the developing sympathetic nervous system. The genetic etiology of neuroblastoma remains mostly obscure. High mobility group AT-hook 2 (HMGA2), an oncogenic gene, is up-regulated in many tumors. Single nucleotide polymorphisms (SNPs) often modify cancer susceptibility. However, no studies are investigating the association between HMGA2 SNPs and neuroblastoma susceptibility. Methods We conducted a four-center case-control study to evaluate the association between three HMGA2 polymorphisms (rs6581658 A>G, rs8756 A>C and rs968697 T>C) and neuroblastoma susceptibility in a Chinese population with 505 cases and 1070 controls. Logistic regression was performed to evaluate the strength of the association. Results We found that the rs8756 AC/CC genotypes were associated with a reduced neuroblastoma risk when compared to rs8756 AA genotype [Adjusted odds ratio (OR)=0.74, 95% confidence interval (CI)=0.56–0.99, P=0.039]. Carriers with 3 protective genotypes have lower neuroblastoma susceptibility than those without or with 0–2 protective genotypes. The stratified analysis revealed that the protective effects of rs8756 AC/CC genotypes were more predominant among children of age > 18 months, males, and subgroups with the tumor in the mediastinum. Furthermore, haplotype analysis uncovered that haplotype ACC significantly reduced neuroblastoma risk. Conclusion Our study indicated HMGA2 rs8756 A>C polymorphism is significantly associated with decreased neuroblastoma risk.

Published
2020

13. KRAS rs7973450 A>G increases neuroblastoma risk in Chinese children: a four-center case-control study

Author

Lin, Ao, Hua, Rui-Xi, Tang, Jue, Zhu, Jinhong, Zhang, Ruizhong, Zhou, Haixia, Zhang, Jiao, Cheng, Jiwen, Xia, Huimin, and He, Jing

Subjects
neuroblastoma, KRAS, susceptibility, Original Research, polymorphism
Abstract

Background Neuroblastoma is one of the most common extracranial solid pediatric tumors. KRAS plays an important role in regulating cell proliferation, differentiation, and apoptosis. Single nucleotide polymorphisms (SNPs) in KRAS have been shown to modify susceptibility to multiple tumors, but no specific molecular epidemiology study was reported regarding neuroblastoma. Methods We conducted a four-center case-control study to explore the association between KRAS gene polymorphisms (rs12587 G>T, rs7973450 A>G, rs7312175 G>A) and neuroblastoma susceptibility with 505 Chinese children and 1070 matched controls. Results We found that rs7973450 A>G was associated with significantly increased neuroblastoma risk [GG vs. AA: adjusted odds ratio (OR)=4.26, 95% confidence interval (CI)=1.28–14.19, P=0.018; GG vs. AA/AG: adjusted OR=4.27, 95% CI=1.28–14.24, P=0.018]. The stratified analysis further demonstrated that rs7973450 GG genotype carriers had a higher risk to develop neuroblastoma in the subgroups of males, tumor originated from the adrenal gland and clinical stages III+IV. Conclusions Overall, our results suggested that rs7973450 A>G was associated with increased neuroblastoma risk.

Published
2019

20. HMGA2 Gene rs8756 A>C Polymorphism Reduces Neuroblastoma Risk in Chinese Children: A Four-Center Case-Control Study

Author

Liu,Jiabin, Hua,Rui-Xi, Cheng,Yun, Zhu,Jinhong, Zhang,Jiao, Cheng,Jiwen, Zhou,Haixia, Xia,Huimin, Bian,Jun, He,Jing, Liu,Jiabin, Hua,Rui-Xi, Cheng,Yun, Zhu,Jinhong, Zhang,Jiao, Cheng,Jiwen, Zhou,Haixia, Xia,Huimin, Bian,Jun, and He,Jing

Abstract

Jiabin Liu, 1,* Rui-Xi Hua, 1, 2,* Yun Cheng, 3,* Jinhong Zhu, 1, 4 Jiao Zhang, 5 Jiwen Cheng, 6 Haixia Zhou, 7 Huimin Xia, 1 Jun Bian, 8 Jing He 1 1Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, People’s Republic of China; 2Department of Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong, People’s Republic of China; 3Department of Gynecology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, Jiangsu, People’s Republic of China; 4Department of Clinical Laboratory, Biobank, Harbin Medical University Cancer Hospital, Harbin 150040, Heilongjiang, People’s Republic of China; 5Department of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, People’s Republic of China; 6Department of Pediatric Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, People’s Republic of China; 7Department of Hematology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, People’s Republic of China; 8Department of General Surgery, Xi’an Children’s Hospital, Xi’an Jiaotong University Affiliated Children’s Hospital, Xi’an 710003, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing HeDepartment of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou 5106

Published
2020

28. KRAS rs7973450 A>G increases neuroblastoma risk in Chinese children: a four-center case-control study

Author

Lin,Ao, Hua,Rui-Xi, Tang,Jue, Zhu,Jinhong, Zhang,Ruizhong, Zhou,Haixia, Zhang,Jiao, Cheng,Jiwen, Xia,Huimin, He,Jing, Lin,Ao, Hua,Rui-Xi, Tang,Jue, Zhu,Jinhong, Zhang,Ruizhong, Zhou,Haixia, Zhang,Jiao, Cheng,Jiwen, Xia,Huimin, and He,Jing

Abstract

Ao Lin1,*, Rui-Xi Hua2,*, Jue Tang1,*, Jinhong Zhu3, Ruizhong Zhang1, Haixia Zhou4, Jiao Zhang5, Jiwen Cheng6, Huimin Xia1, Jing He1 1Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, People’s Republic of China; 2Department of Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, People’s Republic of China; 3Department of Clinical Laboratory, Biobank, Harbin Medical University Cancer Hospital, Harbin 150040, Heilongjiang, People’s Republic of China; 4Department of Hematology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, People’s Republic of China; 5Department of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, People’s Republic of China; 6Department of Pediatric Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huimin Xia; Jing HeDepartment of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou 510623, Guangdong, People’s Republic of ChinaTel +860 203 807 6001; +860 203 807 6560Fax +860 203 807 6001; +860 203 807 6560Email xia-huimin@foxmail.com; hejing198374@gmail.comBackground: Neuroblastoma is one of the most common extracranial solid pediatric tumors. KRAS plays an important role in regulating cell proliferation, differentiation, and apoptosis. Single nuc

Published
2019

33. LIN28A gene polymorphisms modify neuroblastoma susceptibility: A four‐centre case‐control study.

Author

Hua, Rui‐Xi, Zhuo, Zhenjian, Ge, Lili, Zhu, Jinhong, Yuan, Li, Chen, Chongfen, Liu, Jing, Cheng, Jiwen, Zhou, Haixia, Zhang, Jiao, Xia, Huimin, Zhang, Xianwei, and He, Jing

Subjects
SINGLE nucleotide polymorphisms, GENETIC polymorphisms, CASE-control method, GENETIC overexpression, NEUROBLASTOMA, RISK assessment, HAPLOTYPES
Abstract

Neuroblastoma ranks the most common seen solid tumour in childhood. Overexpression of LIN28A gene has been linked to the development of multiple human malignancies, but the relationship between LIN28A single nucleotide polymorphisms (SNPs) and neuroblastoma susceptibility is still under debate. Herein, we evaluated the correlation of four potentially functional LIN28A SNPs (rs3811464 G>A, rs3811463 T>C, rs34787247 G>A, and rs11247957 G>A) and neuroblastoma susceptibility in 505 neuroblastoma patients and 1070 controls from four independent hospitals in China. The correlation strengths were determined by using odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Among these SNPs, rs34787247 G>A exhibited a significant association with increased susceptibility in neuroblastoma (GA vs GG: adjusted OR = 1.30, 95% CI = 1.03‐1.64; AA vs GG: adjusted OR = 2.51, 95% CI = 1.36‐4.64, AA/GA vs GG: adjusted OR = 1.42, 95% CI = 1.12‐1.80, AA vs GG/GA: adjusted OR = 2.39, 95% CI = 1.29‐4.42). Furthermore, the combined analysis of risk genotypes revealed that subjects carrying three risk genotypes (adjusted OR = 1.64, 95% CI = 1.02‐2.63) are more inclined to develop neuroblastoma than those without risk genotype, and so do carriers of 1‐4 risk genotypes (adjusted OR = 1.26, 95% CI = 1.01‐1.56). Stratification analysis further revealed risk effect of rs3811464 G>A, rs34787247 G>A and 1‐4 risk genotypes in some subgroups. Haplotype analysis of these four SNPs yields two haplotypes significantly correlated with increased neuroblastoma susceptibility. Overall, our finding indicated that LIN28A SNPs, especially rs34787247 G>A, may increase neuroblastoma risk. [ABSTRACT FROM AUTHOR]

Published
2020
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35. CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-κB-miR-21 pathways

Author

Ni, Su-Jie, primary, Zhao, Li-Qin, additional, Wang, Xiao-Feng, additional, Wu, Zhen-Hua, additional, Hua, Rui-Xi, additional, Wan, Chun-Hua, additional, Zhang, Jie-Yun, additional, Zhang, Xiao-Wei, additional, Huang, Ming-Zhu, additional, Gan, Lu, additional, Sun, Hua-Lin, additional, Dimri, Goberdhan P., additional, and Guo, Wei-Jian, additional

Published
2018
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36. Polymorphisms in the XPC gene and gastric cancer susceptibility in a Southern Chinese population

Author

He, Jing, Hua,Rui-Xi, Zhuo,Zhen-Jian, Shen,Guo-Ping, Zhu,Jinhong, Zhang,Shao-Dan, Xue,Wen-Qiong, Li,Xi-Zhao, Zhang,Pei-Fen, and Jia,Wei-Hua

Subjects
OncoTargets and Therapy
Abstract

Rui-Xi Hua,1,2,* Zhen-Jian Zhuo,3,* Guo-Ping Shen,1 Jinhong Zhu,4 Shao-Dan Zhang,1 Wen-Qiong Xue,1 Xi-Zhao Li,1 Pei-Fen Zhang,1 Jing He,1,5 Wei-Hua Jia1 1Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 2Department of Oncology, The First Affiliated Hospital of Sun Yat-sen University, 3Department of Traditional Chinese Medicine Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangdong, 4Department of Laboratory Medicine and MolecularEpidemiology Laboratory, Harbin Medical University Cancer Hospital, Heilongjiang, 5Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, GuangzhouMedical University, Guangdong, People’s Republicof China *These authors contributed equally tothiswork Abstract: Previous studies have reported that XPC gene polymorphisms may modify the individual susceptibility to gastric cancer. In this case–control study with a total of 1,142 cases and 1,173 controls, four potentially functional polymorphisms were genotyped in the XPC gene (rs2228001 A>C, rs2228000 C>T, rs2607775 C>G, and rs1870134 G>C) by Taqman assays and their associations were analyzed with the risk of gastric cancer in a Southern Chinese population. No significant association between any of XPC polymorphisms and gastric cancer risk was detected except for a borderline association with the rs2228000 CT/TT genotype (crude odds ratio =0.86, 95% confidence interval =0.73–1.02, P=0.088) when compared to the rs2228000 CCgenotype. Further stratified analysis revealed that the protective effect of rs2228000 CT/TT on the risk of gastric cancer was only significant among subjects older than 58 years. In summary, results indicated that genetic variations in XPC gene may play a weak effect on gastric cancer susceptibility in Southern Chinese population, which warrants further confirmation in larger prospective studies with different ethnic populations. Keywords: gastric cancer, XPC, polymorphism, DNA repair, genetic susceptibility

Published
2016

38. miR-134: A Human Cancer Suppressor?

Author

Pan, Jing-Yu, primary, Zhang, Feng, additional, Sun, Cheng-Cao, additional, Li, Shu-Jun, additional, Li, Guang, additional, Gong, Feng-Yun, additional, Bo, Tao, additional, He, Jing, additional, Hua, Rui-Xi, additional, Hu, Wei-Dong, additional, Yuan, Zhan-Peng, additional, Wang, Xin, additional, He, Qi-Qiang, additional, and Li, De-Jia, additional

Published
2017
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40. PRISMA—Extracapsular Dissection Versus Superficial Parotidectomy in Treatment of Benign Parotid Tumors

Author

Xie, Shang, Wang, Kan, Xu, Hui, Hua, Rui-Xi, Li, Tian-Zhu, Shan, Xiao-Feng, and Cai, Zhi-Gang

Subjects
Comparative Effectiveness Research, genetic structures, Dissection, Incidence, Sweating, Gustatory, Parotid Neoplasms, Postoperative Complications, Outcome Assessment, Health Care, Humans, Parotid Gland, Facial Nerve Diseases, Neoplasm Recurrence, Local, Systematic Review and Meta-Analysis, Research Article
Abstract

Benign parotid tumor is one of the most common neoplasms in head and neck region. Its therapeutic methods have been debatable topics over the past 100 years. Recently, some surgeons suggest that extracapsular dissection (ECD) instead of superficial parotidectomy (SP) for treatment of benign parotid tumor. This study aimed to compare ECD with SP in the treatment of benign parotid tumors by a meta-analysis. We searched Cochrane Library, PubMed, Embase, Ovid, and Web of Science databases on February 14, 2015 for studies that assessed clinical outcomes of SP and ECD as surgical techniques for the management of benign parotid tumors. Outcome data were evaluated by pooled risk ratio (RR) and corresponding 95% confidence interval (CI). After serious scrutiny, a total of 14 cohort studies with 3194 patients were included in this meta-analysis. The pooled RR revealed that there were no significant difference in tumor recurrence rate between ECD and SP (fixed-effect model: RR = 0.71, 95% CI = 0.40–1.27, P = 0.249; random-effect model: RR = 0.67, 95% CI = 0.38–1.23, P = 0.197). However, there were significantly lower incidences of transient facial nerve dysfunction (FND), permanent FND, and Frey's syndrome in patients of ECD group compared with SP group. ECD might be a good choice in treatment of the benign parotid tumor that were mobile, small, located in superficial lobe and without adhesion to facial nerve; ECD should be performed by the experienced surgeons with ability of dissection facial nerve, who should perform SP if tumor is found adhere to facial nerve during an operation; and a multicenter randomized control trial study is necessary to decide the optimal treatment of benign parotid tumor.

Published
2015

41. Polymorphisms in the XPC gene and gastric cancer susceptibility in a Southern Chinese population

Author

Hua,Rui-Xi, Zhuo,Zhen-Jian, Shen,Guo-Ping, Zhu,Jinhong, Zhang,Shao-Dan, Xue,Wen-Qiong, Li,Xi-Zhao, Zhang,Pei-Fen, He,Jing, Jia,Wei-Hua, Hua,Rui-Xi, Zhuo,Zhen-Jian, Shen,Guo-Ping, Zhu,Jinhong, Zhang,Shao-Dan, Xue,Wen-Qiong, Li,Xi-Zhao, Zhang,Pei-Fen, He,Jing, and Jia,Wei-Hua

Abstract

Rui-Xi Hua,1,2,* Zhen-Jian Zhuo,3,* Guo-Ping Shen,1 Jinhong Zhu,4 Shao-Dan Zhang,1 Wen-Qiong Xue,1 Xi-Zhao Li,1 Pei-Fen Zhang,1 Jing He,1,5 Wei-Hua Jia1 1Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 2Department of Oncology, The First Affiliated Hospital of Sun Yat-sen University, 3Department of Traditional Chinese Medicine Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangdong, 4Department of Laboratory Medicine and Molecular Epidemiology Laboratory, Harbin Medical University Cancer Hospital, Heilongjiang, 5Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangdong, People’s Republic of China *These authors contributed equally to this work Abstract: Previous studies have reported that XPC gene polymorphisms may modify the individual susceptibility to gastric cancer. In this case–control study with a total of 1,142 cases and 1,173 controls, four potentially functional polymorphisms were genotyped in the XPC gene (rs2228001 A>C, rs2228000 C>T, rs2607775 C>G, and rs1870134 G>C) by Taqman assays and their associations were analyzed with the risk of gastric cancer in a Southern Chinese population. No significant association between any of XPC polymorphisms and gastric cancer risk was detected except for a borderline association with the rs2228000 CT/TT genotype (crude odds ratio =0.86, 95% confidence interval =0.73–1.02, P=0.088) when compared to the rs2228000 CC genotype. Further stratified analysis revealed that the protective effect of rs2228000 CT/TT on the risk of gastric cancer was only significant among subjects older tha

Published
2016

45. Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population

Author

Qiu, Li-Xin, primary, Hua, Rui-Xi, additional, Cheng, Lei, additional, He, Jing, additional, Wang, Meng-Yun, additional, Zhou, Fei, additional, Zhu, Xiao-Dong, additional, Sun, Meng-Hong, additional, Zhou, Xiao-Yan, additional, Li, Jin, additional, Wang, Ya-Nong, additional, Yang, Ya-Jun, additional, Wang, Jiu-Cun, additional, Jin, Li, additional, Guo, Wei-Jian, additional, and Wei, Qing-Yi, additional

Published
2016
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