Search

This paper firstly proposes distributed fiber optic sensing technology based on big data technology and physics, distributed fiber optic sensing technology includes distributed fiber optic sensing technology based on interference type and distributed fiber optic sensing technology based on the scattering principle. Then investigated the demand for remote monitoring of distributed fiber optic sensing systems and the demand for large sensing networks in the Internet of Things and designed a long-distance distributed fiber optic sensing-based intelligent monitoring system. Finally, the vibration acceleration signal of the metal shell when partial discharge occurs is collected, and the high-frequency components in the vibration acceleration signal are used to diagnose and analyze the discharging faults caused by the metal particles of GIL. The results show that: when the rated current is loaded on the GIL, the main frequency distribution of the vibration acceleration signal on the surface of the metal shell is from 0 to 1 kHz, and the percentage of the signal energy in this frequency band is greater than 99% of the total energy in the range of 0 to 20 kHz. In the frequency range of 1 kHz to 20 kHz, the percentage of the signal energy in the total energy does not exceed 1%, and there is almost no high-frequency vibration acceleration signal. This study and the combination of these two technologies is a great contribution to the further development of each, but also more favorable for application in work and life.

Foamy viruses belong to the Spumaretrovirinae subfamily member of the Retroviridae family and produce nonpathogenic infection to hosts in the natural conditions. However, infections of foamy viruses can dramatically cause severe cytopathic effects in vitro. To date, the exact molecular mechanism has remained unclear which implied the tremendous importance of virus-host cell immune reactions. In this study, we found that the transactivator Tas in two foamy viruses isolated from Old World Monkey (OWM) induced obvious inhibition of cell proliferation via the upregulation of Foxo3a expression. It was mediated by the generation of ROS and the initiation of ER stress, and ultimately, the mitochondrial apoptosis pathway was triggered. Notably, PFV Tas contributed to the accumulation of G0/G1 phase cycle arrest induced by the activation of the p53 signaling pathway and the nuclear transportation of HDAC4 via upregulating PPM1E expression. Together, these results demonstrated the different survival strategies by which foamy virus can hijack host cell cytokines and regulate virus-host cell interactions.

Objective: Osteoarthritis (OA) is a degenerative joint disease. Excessive nitric oxide (NO) mediates the chondrocyte inflammatory response, apoptosis, and extracellular matrix (ECM) degradation during the occurrence and development of OA. NO in chondrocytes is mainly produced by inducible nitric oxide synthase (iNOS). The aim of this study was to design and synthesize an iNOS dimerization inhibitor and evaluate its effects on chondrocyte inflammation and articular cartilage injury in OA via in vitro and in vivo experiments.Design: The title compound 22o was designed, synthesized, and screened based on a previous study. The effects of different concentrations (5, 10, and 20 μM) of compound 22o on chondrocyte inflammatory response and ECM anabolism or catabolism were evaluated by Western blot and real-time quantitative reverse transcription-polymerase chain reaction using the rat chondrocyte model of IL-1β-induced OA. Furthermore, different doses (40 and 80 mg/kg) of compound 22o were administered by gavage to a rat OA model induced by anterior cruciate ligament transection (ACLT), and their protective effects on the articular cartilage were evaluated by histopathology and immunohistochemistry.Results: Compound 22o showed effective iNOS inhibitory activity by inhibiting the dimerization of iNOS. It inhibited the IL-1β-induced expression of cyclooxygenase-2 (COX-2) and matrix metalloproteinase 3 (MMP3) in the chondrocytes, decreased NO production, and significantly increased the expression levels of the ECM anabolic markers, aggrecan (ACAN), and collagen type II (COL2A1). Gavage with compound 22o was found to be effective in the rat OA model induced by ACLT, wherein it regulated the anabolism and catabolism and exerted a protective effect on the articular cartilage.Conclusions: Compound 22o inhibited the inflammatory response and catabolism of the chondrocytes and reduced articular cartilage injury in the rat OA model, indicating its potential as a disease-modifying OA drug.

The entrapment and release of flavor substances is a frontier topic in the field of food flavor research. This paper mainly reviews the research progress on the entrapment and release of flavor substances based on starch-based wall materials. Starch-based wall material refers to a kind of natural polymer material which uses starch or its derivatives to cover fat-soluble components through its hydrophobic cavity. This paper mainly focuses on the methods and classification of hydrolysis， physical modification and chemical modification of starch-based wall materials， molecular dynamics simulation of non-covalent interaction between starch and flavor substances， preparation and structural characterization of starch-based flavor microcapsules， starch-based flavor microcapsules release process， influencing factors， flavor release mechanism (diffusion， erosion， degradation， swelling， melting， etc.). And the application of starch-based flavor microcapsules was reviewed. In order to have a comprehensive understanding of the domestic and foreign research progress on the entrapment and release of flavor substances in starch-based wall materials，and provide certain theoretical and practical references for the development of starch-based flavor materials.

The DC speed regulating system has many difficult issues such as system parameters and PID control parameters are difficult to determine. On the basis of model for a single closed-loop DC speed regulating system, this paper puts forward a method of PID parameters self-tuning based on the step response detection and reduced order equivalent. First, detect system step response and get response parameters. Then equal it to a second order system model, and achieve optimal PID control parameters based on optimal second order system to realize of PID parameters self-tuning. The PID parameters self-tuning process of DC speed regulating system is simulated with the help of MATLAB/Simulink. The simulation results show that the method is simple and effective. The system can obtain good dynamic and static performance when the PID parameters are applied to DC speed regulating system.