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492 results on '"Hu, Yu-Wen"'

13. The potential of integrating stereotactic ablative radiotherapy techniques with hyperfractionation for lung cancer.

Author

Chiou, Chi‐Chuan, Wu, Yuan‐Hung, Huang, Pin‐I, Lan, Keng‐Li, Chen, Yi‐Wei, Kang, Yu‐Mei, Chou, Lin‐Shan, and Hu, Yu‐Wen

Subjects
BIOLOGICAL models, PHARMACEUTICAL arithmetic, RESEARCH funding, STATISTICAL sampling, RADIOSURGERY, TREATMENT effectiveness, DESCRIPTIVE statistics, MANN Whitney U Test, LUNGS, LUNG tumors, RADIATION doses, COMPARATIVE studies
Abstract

Background: Limited literature exists on the feasibility and effectiveness of integrating stereotactic ablative radiotherapy (SABR) techniques with hyperfractionated regimens for patients with lung cancer. This study aims to assess whether the SABR technique with hyperfractionation can potentially reduce lung toxicity. Methods: We utilized the linear‐quadratic model to find the optimal fraction to maximize the tumor biological equivalent dose (BED) to normal‐tissue BED ratio. Validation was performed by comparing the SABR plans with 50 Gy/5 fractions and hyperfractionationed plans with 88.8 Gy/74 fractions with the same tumor BED and planning criteria for 10 patients with early‐stage lung cancer. Mean lung BED, Lyman–Kutcher–Burman (LKB) normal tissue complication probability (NTCP), critical volume (CV) criteria (volume below BED of 22.92 and 25.65 Gy, and mean BED for lowest 1000 and 1500 cc) and the percentage of the lung receiving 20Gy or more (V20) were compared using the Wilcoxon signed‐rank test. Results: The transition point occurs when the tumor‐to‐normal tissue ratio (TNR) of the physical dose equals the TNR of α/β in the BED dose‐volume histogram of the lung. Compared with the hypofractionated regimen, the hyperfractionated regimen is superior in the dose range above but inferior below the transition point. The hyperfractionated regimen showed a lower mean lung BED (6.40 Gy vs. 7.73 Gy) and NTCP (3.50% vs. 4.21%), with inferior results concerning CV criteria and higher V20 (7.37% vs. 7.03%) in comparison with the hypofractionated regimen (p < 0.01 for all). Conclusions: The hyperfractionated regimen has an advantage in the high‐dose region of the lung but a disadvantage in the low‐dose region. Further research is needed to determine the superiority between hypo‐ and hyperfractionation. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Feasibility estimation of injected hydrodissection before definitive radiotherapy of pancreatic adenocarcinoma

Author

Wu, Yuan-Hung, primary, Shen, Shu-Huei, additional, Wang, Yen-Po, additional, Chang, Nai-Wen, additional, Lee, Pei-Chang, additional, Li, Chung-Pin, additional, Lan, Keng-Li, additional, Shiau, Cheng-Yin, additional, Hu, Yu-Wen, additional, Huang, Pin-I, additional, Hsu, Chen-Xiong, additional, Yen, Sang-Hue, additional, and Hsu, Shih-Ming, additional

Published
2024
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19. Review of cavity optomechanical cooling

Author

Liu, Yong-Chun, Hu, Yu-Wen, Wong, Chee Wei, and Xiao, Yun-Feng

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Optics
Abstract

Quantum manipulation of macroscopic mechanical systems is of great interest in both fundamental physics and applications ranging from high-precision metrology to quantum information processing. A crucial goal is to cool the mechanical system to its quantum ground state. In this review, we focus on the cavity optomechanical cooling, which exploits the cavity enhanced interaction between optical field and mechanical motion to reduce the thermal noise. Recent remarkable theoretical and experimental efforts in this field have taken a major step forward in preparing the motional quantum ground state of mesoscopic mechanical systems. This review first describes the quantum theory of cavity optomechanical cooling, including quantum noise approach and covariance approach; then the up-to-date experimental progresses are introduced. Finally, new cooling approaches are discussed along the directions of cooling in the strong coupling regime and cooling beyond the resolved sideband limit., Comment: Invited review paper, 32 pages, 10 figures

Published
2014
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21. Secondary Primary Malignancy Risk in Patients With Cervical Cancer in Taiwan

Author

Teng, Chung-Jen, Huon, Leh-Kiong, Hu, Yu-Wen, Yeh, Chiu-Mei, Chao, Yee, Yang, Muh-Hwa, Chen, Tzeng-Ji, Hung, Yi-Ping, and Liu, Chia-Jen

Subjects
Patient Safety, Health Services, Cervical Cancer, Cancer, Clinical Research, Adult, Aged, Antineoplastic Agents, Carboplatin, Comorbidity, Female, Fluorouracil, Humans, Middle Aged, Neoplasms, Second Primary, Radiotherapy, Registries, Taiwan, Uterine Cervical Neoplasms, Young Adult, Clinical Sciences, Arthritis & Rheumatology
Abstract

To evaluate the risk of secondary primary malignancy (SPM) in patients with cervical cancer using a nationwide population-based dataset.Patients newly diagnosed with cervical cancer between 1997 and 2011 were identified using Taiwan's National Health Insurance database. Patients with antecedent malignancies were excluded. Standardized incidence ratios (SIRs) for SPM were calculated by comparing with the cancer incidence in the general population. Risk factors for cancer development were analyzed using Cox proportional hazard models.During the 14-year study period (follow-up of 223,062 person-years), 2004 cancers developed in 35,175 patients with cervical cancer. The SIR for all cancers was 1.56 (95% confidence interval, 1.50-1.63, P 10, 5 to 10, 1 to 5, and

Published
2015

22. Secondary Primary Malignancy Risk in Patients With Ovarian Cancer in Taiwan

Author

Hung, Yi-Ping, Liu, Chia-Jen, Hu, Yu-Wen, Chen, Min-Huang, Li, Chun-Pin, Yeh, Chiu-Mei, Chiou, Tzeon-Jye, Chen, Tzeng-Ji, Yang, Muh-Hwa, and Chao, Yee

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Prevention, Ovarian Cancer, Rare Diseases, Cancer, Clinical Research, Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Comorbidity, Female, Fluorouracil, Humans, Incidence, Middle Aged, Neoplasms, Second Primary, Ovarian Neoplasms, Radiotherapy, Retrospective Studies, Risk Assessment, Taiwan, Young Adult
Abstract

To evaluate the incidence of secondary primary malignancy (SPM) in patients with ovarian cancer using a nationwide retrospective population-based dataset. Patients newly diagnosed with ovarian cancer between 1997 and 2010 were identified using Taiwan's National Health Insurance database. Patients with antecedent malignancies were excluded. Standardized incidence ratios (SIRs) for SPM were calculated and compared with the cancer incidence in the general population. Risk factors for cancer development were analyzed using Cox proportional hazard models. Effects of surgery, chemotherapy, and radiotherapy after ovarian cancer diagnosis were regarded as time-dependent variables to prevent immortal time bias. During the 14-year study period (follow-up of 56,214 person-years), 707 cancers developed in 12,127 patients with ovarian cancer. The SIR for all cancers was 2.78 (95% confidence interval 2.58-3.00). SIRs for follow-up periods of >5, 1-5, and

Published
2015

36. Old age and EGFR mutation status in inoperable early‐stage non‐small cell lung cancer patients receiving stereotactic ablative radiotherapy: A single institute experience of 71 patients in Taiwan

Author

Wu, Yuan‐Hung, primary, Kang, Yu‐Mei, additional, Hu, Yu‐Wen, additional, Lan, Keng‐Li, additional, Yen, Sang‐Hue, additional, Lai, Tzu‐Yu, additional, Lan, Tien‐Li, additional, Chen, Yuh‐Min, additional, Chiu, Chao‐Hua, additional, Luo, Yung‐Hung, additional, Chao, Heng‐sheng, additional, Chiang, Chi‐Lu, additional, Shiao, Tsu‐Hui, additional, Yang, Chao‐Neng, additional, Hsu, Wen‐Hu, additional, Wu, Yu‐Chung, additional, Hsu, Han‐Shui, additional, Hung, Jung‐Jyh, additional, Huang, Chien‐Sheng, additional, Hsu, Po‐Kuei, additional, and Chen, Yi‐Wei, additional

Published
2023
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41. Lipoprotein-Associated Phospholipase A2 Correlates with Reduced Left Ventricle Ejection Fraction in Hemodialysis Patients

Author

Chen Jun-Feng, Jin Xiao-Ping, Zhang Juan, Yang Man-Li, Liu Fan, Fu Peng, Wu Qi-Shun, Shu Yang, Si Bo-Lin, Hu Yu-Wen, and Chen Liang

Subjects
Biochemistry (medical), Clinical Biochemistry
Abstract

ObjectiveReduced left ventricular ejection fraction (LVEF) is common in hemodialysis (HD) patients. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered an important determinant of cardiovascular events. The aim of the study was to evaluate the relationship between Lp-PLA2 and LVEF in HD patients.MethodsFifty-seven HD patients with coronary heart disease were enrolled. Predialysis and postdialysis venous whole blood samples were collected. The patients were divided into preserved and reduced LVEF groups. The relationship between Lp-PLA2 and LVEF was assessed.ResultsA significant difference in C-reactive protein (CRP) and Lp-PLA2 was observed, with higher levels noted in patients with reduced LVEF (P ≤ .001). Both Lp-PLA2 and CRP were negatively correlated with LVEF in the HD patients. Only Lp-PLA2 remained associated with LVEF in multiple regression analysis.ConclusionLipoprotein-associated phospholipase A2 levels are associated with LVEF and could potentially be used to evaluate chronic heart failure with reduced LVEF in HD patients for risk stratification management.

Published
2023
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50. MoO2/Ni0.2Mo0.8N nanorods on nickel foam as a high performance electrocatalyst for efficient water oxidation.

Author

Hu, Yu-wen, Yang, Hao, and Chen, Jian

Subjects
*FOAM, *OXIDATION of water, *NANORODS, *OXYGEN evolution reactions, *NICKEL
Abstract

MoO2/Ni0.2Mo0.8N interfacial nanorods on nickel foam (MONMN-NRs) were reported as an efficient electrocatalyst for the oxygen evolution reaction (OER) in alkaline media. The optimized catalyst delivered an ultralow overpotential of 264 mV@10 mA cm−2 in 1.0 M KOH. The enhanced performance is mainly attributed to the strong electronic interaction between MoO2 and Ni0.2Mo0.8N that facilitates the OER intermediates according to theoretical analysis. [ABSTRACT FROM AUTHOR]

Published
2023
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