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Herein, nanoflower-shaped Mn-doped NiO nano-enzyme composites with high catalytic performance and excellent conductivity were grown on 3D flexible carbon fiber cloth (CFC) via hydrothermal and calcination methods to construct an efficient flexible glucose-sensitive detection electrode. For electrochemical-based sensors, high conductivity is a prerequisite for reliable data acquisition. To avoid the problems associated with using insulating Nafion or paraffin binders, we adopted a strategy of directly growing Mn-doped NiO onto the electrode surface, thereby avoiding interference due to the oxidization of species present in real samples at higher redox potentials, since Ni 2+ /Ni 3+ has low redox potential. Therefore, the electrode has a linear range of 3-5166 μM for glucose detection, with a detection limit as low as 0.28 μM, showing excellent selectivity and reproducibility. The composite-modified electrode provides accurate detection results with real human serum samples, which are in full agreement with those of commercial blood glucose meters. In addition, we tested the glucose content in tea and sorghum fermentation broth at different stages, further expanding the application range of the Mn-NiO sensors. The nano-enzyme sensor fabricated herein offers a new idea for further integration into wearable flexible electronic devices for accurate glucose detection.

Herein, a three-dimensional graphene wall (GWs) and nano-Cu 2 O modified carbon fiber paper (CFP) electrode were used to develop a disposable and sensitive non-enzymatic glucose sensor. This sensing interface of GWs/Cu 2 O consists of an interlaced CFP on which intercrossed graphene walls (GWs) were vertically tethered in situ by radio frequency plasma enhanced chemical vapor deposition (RF-PECVD), and Cu 2 O nanoparticles (NPs) were evenly grew on the 3D GWs layer and skeleton through the complete thermal decomposition of copper acetate (Cu (CH 3 COO) 2 ) at high temperature. The CFP/GWs/Cu 2 O shows a large specific surface area and rich solution diffusion channels, which can expose more catalytic active sites without Nafion fixation film, thus greatly improving the electrocatalytic performance of this glucose sensor. The CFP/GWs/Cu 2 O sensor shows excellent catalytic performance to glucose with a linear detection range of 0.5 μM-5166 μM, LOD of 0.21 μM, and response time <4 s. This kind of disposable and sensitive electrode can capable of controlling uniform growth and accurate quantification, and has great development potential in the field of medical detection and the commercialization of wearable sensors., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)