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Background: With its rapidly increasing incidence and prevalence, ulcerative colitis (UC) has become a major global health challenge. Recent evidence suggests that ferroptosis plays a significant role in the development of UC. However, the relationship between ferroptosis and the progression of UC needs to be extensively studied. Methods: The differentially expressed genes in UC patients were screened from the GEO database. The ferroptosis‐related genes were obtained from FErrDB and GeneCards. The UC subtypes were identified with the R package "CancerSubtype" and evaluated with consensus clustering (CC) to identify gene expression patterns in patients with UC. The key genes were detected with qRT‐PCR, Western blot, and immunohistochemistry in vitro and in vivo models. Ferroptosis was identified with western blotting on ferrotic‐associated proteins and staining on Fe2+ with commercial FerroOrange kits. Results: Dipeptidyl peptidase 4 (DPP4), also known as CD26, is a potential biomarker for ferroptosis in UC patients. Transcriptome sequencing data showed a positive correlation between decreased DPP4 expression and proinflammatory cytokines such as TNF‐α, IL‐6, and IL‐β, as well as immune cell infiltration in the colon tissues of UC patients. Furthermore, DPP4 was strongly associated with ferroptosis biomarkers, particularly in Subtype 2 of UC. Interestingly, our study also found that DPP4 expression was significantly reduced in RSL3‐treated ferroptotic intestinal epithelial cells, more so than in LPS‐treated cell models. Inhibition of DPP4 had a significant impact on the expression of ferroptotic biomarkers. Additionally, DPP4 expression was decreased in the colon tissues of DSS‐treated mice, and the ferroptosis inhibitor Ferritin‐1 effectively counteracted the effects of DSS on immune cell infiltration, colon length, and DPP4 expression. Conclusions: DPP4 can serve as a biomarker for ferroptosis in the diagnosis and management of UC. Highlights: DPP4‐mediated ferroptosis is involved in ulcerative colitisDPP4 is a novel diagnostic biomarker of ulcerative colitisFerroptosis involves intestinal epithelial cell death in ulcerative colitis [ABSTRACT FROM AUTHOR]

The article concentrates on the educational features of modern everyday communication. The materials used were texts of notices that prove the existence of a crisis in modern mass communication. The reasons of crisis phenomena in speech practice have been established and ways out of the situation have been suggested.

According to these drawbacks of traditional direct power control(DPC) in single-phase PWM rectifiers such as slow dynamic response,poor anti-interference ability and variable switching frequency, an algorithm based on outer loop adopting the feedback of capacitor energy storage and internal loop with deadbeat predictive direct power control is further given.This algorithm improves the speed of dynamic response and the ability of anti-interference with the outer loop control method based on the feedback variable of capacitor energy storage and load power feed forward. Meanwhile,the auto-regressive algorithm simplifies the controller design, and addresses the issue of delay compensation in traditional control. Combined with the space vector modulation(SVPWM) the system′s switch frequency is fixed. Furthermore, it reduces the design costs without voltage′s phase detector. Finally, the proposed control method and traditional DPC method were compared in computer simulation respectively , and the simulation result verified the validity of the proposed control method.