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27 results on '"Hu, Wei-Chun"'

6. Supplementation of Lactobacillus Plantarum (TCI227) Prevented Potassium Oxonate Induced Hyperuricemia in Rats

Author

Chien, Chih-Yu, Chien, Yu-Jou, Lin, Yung-Hao, Lin, Yung-Hsiang, Chan, Shu-Ting, Hu, Wei Chun, Wu, Han-Fang, Chiang, Chi-Fu, and Hsu, Chin-Lin

Subjects
nutrition
Abstract

Hyperuricemia (HC) was one of the important risk factors for gout, arteriosclerosis, and cardiovascular disease. Animal studies have shown that Lactobacillus plantarum can improve the microbiota, immune regulation, and inhibit the uric acid production. However, it was not clear whether L. plantarum can improve HC and intestinal microbiota. We used potassium oxonate (PO) to induce HC in male SD rats, and then treated L. plantarum TCI227 in a dose dependent (HC+LD, HC+MD, HC+HD) for 4 weeks, and examined weight organs, biochemical examination of blood and urine, and analyzed the intestinal microbiota in feces by 16s rDNA sequence analysis. In this study, TCI227 improved body weight, decreased creatinine, serum uric acid, and increased urine uric acid compared to the HC group. Furthermore, TCI227 increased short-chain fatty acids (SCFAs). In fecal microbiota (family), TCI227 increased the level of Lactobacillaceae, and then decreased the level of Deferribacteres and Prevotellaceae compared to the HC group. Finally, in fecal microbiota (genus), TCI227 decreased the level of Prevotella, and then increased the level of Lactobacillus and Ruminococcus compared to the HC group. This study suggested that TCI227 can improve HC and change the compositions of the intestinal microbiota in PO induced male HC SD rats.

Published
2022

14. The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism.

Author

Lin, Yung-Kai, Chung, Yu-Ming, Yang, Hui-Ting, Lin, Yung-Hao, Lin, Yung-Hsiang, Hu, Wei-Chun, and Chiang, Chi-Fu

Subjects
PHYTOTHERAPY, THERAPEUTIC use of plant extracts, REGULATION of body weight, OBESITY, DRUG efficacy, BIOCHEMISTRY, TRIGLYCERIDES, FASTING, MEDICINAL plants, BODY weight, ACADEMIC medical centers, BLOOD sugar, RANDOMIZED controlled trials, COMPARATIVE studies, PLACEBOS, PRE-tests & post-tests, INSULIN, PHYTOCHEMICALS, FAT cells, DESCRIPTIVE statistics, WAIST circumference, PLANT extracts, STATISTICAL sampling, BODY mass index, BLOOD testing, LIPIDS, CITRUS, ANTIOBESITY agents, LONGITUDINAL method, ADIPOSE tissues, CHOLESTEROL, PHARMACODYNAMICS, EVALUATION
Abstract

The prevalence of obesity was increasing globally, with nearly half a billion of the world's population now considered to be overweight or obese. The immature poken (Citrus reticulata) was a good source of flavonoids and phenolic acids, which may exert an anti-obesity effect. However, the current efficacy in clinical trials was still unclear. Thus, the object of this study was to explore whether immature poken had an anti-obesity effect in the clinical trial. In this study, we identified nine major compounds from immature poken extract (IPE), and most compounds significantly decreased the lipid accumulation in adipocytes. In addition, 20 subjects with body mass index (BMI) ≥ 24 or body fat > 30 were recruited and randomly allocated to placebo and experimental (IPE) groups for 6 week intervention and 2 week follow-up. In comparison with the baseline results (week 0), the body weight, body fat, and waist circumference at week 6 in the IPE group were significantly decreased by 1.49 kg, 0.33%, 2.1 cm. Moreover, in blood biochemical analysis, total cholesterol (TC), triglyceride (TG), fasting blood sugar (FBS), and insulin levels at week 6 in IPE group were also decreased by 3.6, 4.6, 2.1 (mg/dL), and 2.9 (μU/mL), respectively. The finding showed that immature poken had important roles in fat metabolism by suppressing adipogenesis, and immature poken may provide new weight loss strategies for obese people. [ABSTRACT FROM AUTHOR]

Published
2022
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18. Impact of pile‐driving and offshore windfarm operational noise on fish chorusing.

Author

Siddagangaiah, Shashidhar, Chen, Chi‐Fang, Hu, Wei‐Chun, Pieretti, Nadia, Lecours, Vincent, and Risch, Denise

Subjects
OFFSHORE wind power plants, PILES & pile driving, NOISE, BAIT fishing, BIOLOGICAL fitness, UNDERWATER noise
Abstract

Offshore windfarms have recently emerged as a renewable energy solution. The effects of pile‐driving and long‐term impacts of operational noises on fish chorusing still, however, remain largely unknown. In this study, we investigated the variations of fish chorusing intensity and duration during the construction (2016) and operational phases (2017–2018) of a windfarm at the Eastern Taiwan Strait (ETS). At the ETS, two types of fish choruses (Types 1 and 2) were found to repeat over a diurnal pattern. In the 2 days after the pile driving, Type 1 chorusing showed lower intensity and longer duration, while Type 2 chorusing exhibited higher intensity and no changes in its duration. During the operational phases in 2017 and 2018, both choruses were longer in duration (2–3 h for Type 1; 0.5–1 h for Type 2). The intensity of Type 1 chorus increased by 5–10 dB, but no significant variation was recorded for Type 2. Our findings document, for the first time, different behavioral responses of two chorusing types exposed to pile‐driving and windfarm noise pressure. Fish choruses have been associated with several behavioral functions. Deviation from a regular pattern might affect fish reproductive success, cause migration, augmented predation, or physiological alterations. Because offshore windfarms installations are growing in magnitude and capacity worldwide, this study provides essential insights for policymakers and constitutes an important reference for assessing the effects of noise from pile driving and windfarms on fishes. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Noise impact assessment on Indo-Pacific Humpback Dolphin in the habitat of the East Taiwan Strait during the first two pile driving activities of demonstration offshore wind farm

Author

Chen, Chi-Fang, primary, Wang, Wei-Jay, additional, Wu, Chih-Hao, additional, Hu, Wei-Chun, additional, Chen, Nai-Chang, additional, Hwang, Wei-Shien, additional, Chou, Lien-Sian, additional, Guan, Shane, additional, Lin, Sheng-Fong, additional, and Lin, Derrick, additional

Published
2017
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