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138 results on '"Hu, Linping"'

4. Clonal phylogeny and evolution of critical cytogenetic aberrations in multiple myeloma at single-cell level by QM-FISH

Author

Yan, Yuting, Qin, Xiaoqi, Liu, Jiahui, Fan, Huishou, Yan, Wenqiang, Liu, Lanting, Du, Chenxing, Yu, Zhen, Xu, Yan, Hao, Mu, Deng, Shuhui, Sui, Weiwei, Lyu, Rui, Liu, Wei, Wang, Qi, Zou, Dehui, Hu, Linping, Wang, Jianxiang, Tai, Yu-Tzu, Anderson, Kenneth C., Zhang, Lei, Cheng, Tao, Zetterberg, Anders, Munshi, Nikhil C., Qiu, Lugui, and An, Gang

Published
2022
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5. An improved DIIS method using a versatile residual matrix to accelerate SCF starting from a crude guess.

Author

Hu, Linping, Sarwono, Yanoar Pribadi, Ding, Yonglong, He, Fang, and Zhang, Rui‐Qin

Subjects
*DENSITY matrices, *MATRIX inversion, *COMPUTATIONAL chemistry, *COMMUTATION (Electricity)
Abstract

The minimization of the commutator of the Fock and density matrices as the error matrix in the direct inversion of the iterative subspace (CDIIS) developed by Pulay is a powerful self‐consistent field (SCF) acceleration technique for the construction of optimum Fock matrix, if initiated with a fair initial guess. In this work, we present an alternative minimized error matrix to the commutator in the CDIIS, namely the residual or the gradient of the energy‐functional for a Slater determinant subject to the orthonormality constraints among orbitals, representing the search for a newly improved Fock matrix in the direction of the residual in the direct inversion of the iterative subspace (RDIIS). Implemented in the computational chemistry package GAMESS, the RDIIS is compared with the standard CDIIS and the second order SCF orbital optimization (SOSCF) for tested molecules started with a crude guess. As a result, the RDIIS stably and efficiently performs the SCF convergence acceleration. Furthermore, the RDIIS is considerably independent on the subspace size with the concentrated linear coefficients accounting proportionally for the Fock matrices close to the current iteration. [ABSTRACT FROM AUTHOR]

Published
2024
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6. CEACAM5 enriches functional human hematopoietic stem cells capable of long-term multi-lineage engraftment

Author

Ma, Kuiying, primary, Wang, Xuan, additional, Wu, Linjie, additional, Yu, Lingling, additional, Ye, Jinhui, additional, Li, Xueling, additional, Geng, Lili, additional, Shi, Zhongyu, additional, Yang, Huihui, additional, Zhang, Xijuan, additional, Zhang, Yongjian, additional, Wu, Shuchang, additional, Yuan, Pengfei, additional, Zhang, Yingchi, additional, Dong, Fang, additional, Hao, Sha, additional, Hu, Linping, additional, Wei, Wensheng, additional, Fang, Riguo, additional, and Cheng, Tao, additional

Published
2023
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10. Single-cell dissection of human hematopoietic reconstitution after allogeneic hematopoietic stem cell transplantation

Author

Huo, Yingying, primary, Wu, Linjie, additional, Pang, Aiming, additional, Li, Qing, additional, Hong, Fang, additional, Zhu, Caiying, additional, Yang, Zining, additional, Dai, Weiqian, additional, Zheng, Yawei, additional, Meng, Qianqian, additional, Sun, Jiali, additional, Ma, Shihui, additional, Hu, Linping, additional, Zhu, Ping, additional, Dong, Fang, additional, Gao, Xin, additional, Jiang, Erlie, additional, Hao, Sha, additional, and Cheng, Tao, additional

Published
2023
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12. CEACAM5 Enriches Human Hematopoietic Stem Cells and Regulates Stem Cell Repopulating Capacity

Author

Ma, Kuiying, primary, Wang, Xuan, additional, Wu, Linjie, additional, Yu, Lingling, additional, Ye, Jinhui, additional, Li, Xueling, additional, Geng, Lili, additional, Shi, Zhongyu, additional, Yang, Huihui, additional, Zhang, Xijuan, additional, Zhang, Yongjian, additional, Wu, Shuchang, additional, Yuan, Pengfei, additional, Zhang, Ying-Chi, additional, Dong, Fang, additional, Hao, Sha, additional, Wei, Wensheng, additional, Fang, Riguo, additional, Hu, Linping, additional, and Cheng, Tao, additional

Published
2023
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13. Temporal molecular program of human hematopoietic stem and progenitor cells after birth

Author

Zhang, Yawen, primary, Xie, Xiaowei, additional, Huang, Yaojing, additional, Liu, Mengyao, additional, Li, Qiaochuan, additional, Luo, Jianming, additional, He, Yunyan, additional, Yin, Xiuxiu, additional, Ma, Shihui, additional, Cao, Wenbin, additional, Chen, Shulian, additional, Peng, Jun, additional, Guo, Jiaojiao, additional, Zhou, Wen, additional, Luo, Hongbo, additional, Dong, Fang, additional, Cheng, Hui, additional, Hao, Sha, additional, Hu, Linping, additional, Zhu, Ping, additional, and Cheng, Tao, additional

Published
2022
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20. Radiation-induced bystander effects impair transplanted human hematopoietic stem cells via oxidative DNA damage

Author

Hu, Linping, primary, Yin, Xiuxiu, additional, Zhang, Yawen, additional, Pang, Aiming, additional, Xie, Xiaowei, additional, Yang, Shangda, additional, Zhu, Caiying, additional, Li, Yapu, additional, Zhang, Biao, additional, Huang, Yaojin, additional, Tian, Yunhong, additional, Wang, Mei, additional, Cao, Wenbin, additional, Chen, Shulian, additional, Zheng, Yawei, additional, Ma, Shihui, additional, Dong, Fang, additional, Hao, Sha, additional, Feng, Sizhou, additional, Ru, Yongxin, additional, Cheng, Hui, additional, Jiang, Erlie, additional, and Cheng, Tao, additional

Published
2021
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21. Single-cell transcriptomic landscape of human blood cells

Author

Xie, Xiaowei, primary, Liu, Mengyao, additional, Zhang, Yawen, additional, Wang, Bingrui, additional, Zhu, Caiying, additional, Wang, Chenchen, additional, Li, Qing, additional, Huo, Yingying, additional, Guo, Jiaojiao, additional, Xu, Changlu, additional, Hu, Linping, additional, Pang, Aiming, additional, Ma, Shihui, additional, Wang, Lina, additional, Cao, Wenbin, additional, Chen, Shulian, additional, Li, Qiuling, additional, Zhang, Sudong, additional, Zhao, Xueying, additional, Zhou, Wen, additional, Luo, Hongbo, additional, Zheng, Guoguang, additional, Jiang, Erlie, additional, Feng, Sizhou, additional, Chen, Lixiang, additional, Shi, Lihong, additional, Cheng, Hui, additional, Hao, Sha, additional, Zhu, Ping, additional, and Cheng, Tao, additional

Published
2020
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23. PDGFB-expressing mesenchymal stem cells improve human hematopoietic stem cell engraftment in immunodeficient mice

Author

Yin, Xiuxiu, primary, Hu, Linping, additional, Zhang, Yawen, additional, Zhu, Caiying, additional, Cheng, Hui, additional, Xie, Xiaowei, additional, Shi, Ming, additional, Zhu, Ping, additional, Zhao, Xueying, additional, Chen, Wanqiu, additional, Zhang, Lu, additional, Arakaki, Cameron, additional, Hao, Sha, additional, Wang, Mei, additional, Cao, Wenbin, additional, Ma, Shihui, additional, Zhang, Xiao-Bing, additional, and Cheng, Tao, additional

Published
2019
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29. Single-cell transcriptomic landscape of human blood cells.

Author

Xie, Xiaowei, Liu, Mengyao, Zhang, Yawen, Wang, Bingrui, Zhu, Caiying, Wang, Chenchen, Li, Qing, Huo, Yingying, Guo, Jiaojiao, Xu, Changlu, Hu, Linping, Pang, Aiming, Ma, Shihui, Wang, Lina, Cao, Wenbin, Chen, Shulian, Li, Qiuling, Zhang, Sudong, Zhao, Xueying, and Zhou, Wen

Subjects
BLOOD cells, LINCRNA, HEMATOPOIETIC stem cells, HEMATOPOIESIS, WEB portals, TRANSCRIPTION factors
Abstract

High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis. However, an elaborate and comprehensive transcriptome reference of the whole blood system is lacking. Here, we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types, including hematopoietic stem cells, progenitors and mature blood cells derived from 21 healthy donors. With high sequencing depth and coverage, we constructed a single-cell transcriptional atlas of blood cells (ABC) on the basis of both protein-coding genes and long noncoding RNAs (lncRNAs), and showed a high consistence between them. Notably, putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified. While common transcription factor regulatory networks were activated in neutrophils and monocytes, lymphoid cells dramatically changed their regulatory networks during differentiation. Furthermore, we showed a subset of nucleated erythrocytes actively expressing immune signals, suggesting the existence of erythroid precursors with immune functions. Finally, a web portal offering transcriptome browsing and blood cell type prediction has been established. Thus, our work provides a transcriptional map of human blood cells at single-cell resolution, thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Cytoplasmic p27 is a novel prognostic biomarker and oncogenic protein for nasopharyngeal carcinoma.

Author

Teng, Yaoshu, Hu, Linping, Yu, Bo, Li, Xiao, Chen, Manman, Fu, Xiao, Zhang, Jin, Gao, Yueqiu, Xu, Rujun, and Zhu, Jin

Subjects
*ONCOGENIC proteins, *NASOPHARYNX cancer, *BIOMARKERS, *CELL cycle, *PROGNOSIS, *ONCOGENES
Abstract

Cytoplasmic p27 plays an important role in regulating the cell cycle. Recent studies have revealed p27 protein translocation from the nucleus to the cytoplasm in many tumour cells. The aim of this study was to investigate the role and molecular mechanisms of cytoplasmic p27 in the progression of nasopharyngeal carcinoma (NPC) and to explore its prognostic value. We found increased cytoplasmic p27 expression by immunohistochemistry in NPC tissues, and its expression level was significantly correlated with the T classification and TNM clinical stage of NPC. The survival rate was significantly lower for NPC patients with cytoplasmic p27 immunopositivity than for NPC patients with cytoplasmic p27 immunonegativity, and cytoplasmic p27 was an independent risk factor that affected the prognosis of patients with NPC. Cytoplasmic p27 promoted the proliferation, cell cycle progression, migration, and invasion of NPC cells, increased Bim-1 and Twist1 protein levels, and decreased RhoA-GTP level. Collectively, these findings suggest that cytoplasmic relocalization of p27 is involved in the pathogenesis of NPC and is closely related to the unfavourable prognosis of patients with NPC. Therefore, cytoplasmic p27 might be a useful prognostic factor and potential therapeutic target for patients with NPC. [ABSTRACT FROM AUTHOR]

Published
2020
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35. Theoretical study on the reaction mechanism of OH radical with Z(E)-CF3CH=CHF.

Author

Xu, Chao, Wang, Chaoyang, Li, Bo, Hu, Linping, and Gu, Feng Long

Abstract

Understanding the atmospheric fate of hydrofluoroolefins (HFOs) is of great significance to assess their potential risk to the environment. As an important type of HFO, the comprehensive transformation mechanism and kinetics of Z(E)-CF3CH=CHF initiated by OH radicals were investigated by performing quantum chemical calculations at the CCSD(T)/aug-cc-pVTZ//MP2/cc-pVDZ level. The results show that the OH-addition pathways are the most favorable for the title reaction. The rate constants are obtained by transition state theory with Wigner tunneling correction (TST/W). The calculated total rate constants are in good agreement with the experimental data. At 298 K, the computed rate constant and lifetime of Z(E)-CF3CH=CHF are 9.66 × 10−13 (4.02 × 10−13) cm3 molecule−1 s−1 and 12.3 (29.7) days, respectively, which demonstrates that Z(E)-CF3CH=CHF is atmospherically persistent. [ABSTRACT FROM AUTHOR]

Published
2019
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37. Three-dimensional nitrogen-doped graphene supported molybdenum disulfide nanoparticles as an advanced catalyst for hydrogen evolution reaction

Author

Dong, Haifeng, Liu, Conghui, Ye, Haitao, Hu, Linping, Fugetsu, Bunshi, Dai, Wenhao, Cao, Yu, Qi, Xueqiang, Lu, Huiting, Zhang, Xueji, Dong, Haifeng, Liu, Conghui, Ye, Haitao, Hu, Linping, Fugetsu, Bunshi, Dai, Wenhao, Cao, Yu, Qi, Xueqiang, Lu, Huiting, and Zhang, Xueji

Abstract

An efficient three-dimensional (3D) hybrid material of nitrogen-doped graphene sheets (N-RGO) supporting molybdenum disulfide (MoS2) nanoparticles with high-performance electrocatalytic activity for hydrogen evolution reaction (HER) is fabricated by using a facile hydrothermal route. Comprehensive microscopic and spectroscopic characterizations confirm the resulting hybrid material possesses a 3D crumpled few-layered graphene network structure decorated with MoS2 nanoparticles. Electrochemical characterization analysis reveals that the resulting hybrid material exhibits efficient electrocatalytic activity toward HER under acidic conditions with a low onset potential of 112 mV and a small Tafel slope of 44 mV per decade. The enhanced mechanism of electrocatalytic activity has been investigated in detail by controlling the elemental composition, electrical conductance and surface morphology of the 3D hybrid as well as Density Functional Theory (DFT) calculations. This demonstrates that the abundance of exposed active sulfur edge sites in the MoS2 and nitrogen active functional moieties in N-RGO are synergistically responsible for the catalytic activity, whilst the distinguished and coherent interface in MoS 2 /N-RGO facilitates the electron transfer during electrocatalysis. Our study gives insights into the physical/chemical mechanism of enhanced HER performance in MoS2/N-RGO hybrids and illustrates how to design and construct a 3D hybrid to maximize the catalytic efficiency.

Published
2015

41. Epidermal growth factor receptor and AKT 1 gene copy numbers by multi‐gene fluorescence in situ hybridization impact on prognosis in breast cancer

Author

Li, Jiao, primary, Su, Wei, additional, Zhang, Sheng, additional, Hu, Yunhui, additional, Liu, Jingjing, additional, Zhang, Xiaobei, additional, Bai, Jingchao, additional, Yuan, Weiping, additional, Hu, Linping, additional, Cheng, Tao, additional, Zetterberg, Anders, additional, Lei, Zhenmin, additional, and Zhang, Jin, additional

Published
2015
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46. Hematopoietic Stem Cell Regeneration Enhanced by Ectopic Expression of ROS-detoxifying Enzymes in Transplant Mice

Author

Miao, Weimin, primary, XuFeng, Richard, additional, Park, Moo-Rim, additional, Gu, Haihui, additional, Hu, Linping, additional, Kang, Jin Wook, additional, Ma, Shihui, additional, Liang, Paulina H, additional, Li, Yanxin, additional, Cheng, Haizi, additional, Yu, Hui, additional, Epperly, Michael, additional, Greenberger, Joel, additional, and Cheng, Tao, additional

Published
2013
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50. Semantic-Based Test Oracles

Author

Bai, Xiaoying, primary, Hou, Kejia, additional, Lu, Hao, additional, Zhang, Yao, additional, Hu, Linping, additional, and Ye, Hong, additional

Published
2011
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