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188 results on '"Hu, Jiyi"'

11. A protocol for a randomized trial evaluating the role of carbon‐ion radiation therapy plus camrelizumab for patients with locoregionally recurrent nasopharyngeal carcinoma.

Author

Hu, Jiyi, Huang, Qingting, Hu, Weixu, Gao, Jing, Yang, Jing, Zhang, Haojiong, Lu, Jiade Jay, and Kong, Lin

Subjects
*NASOPHARYNX cancer, *RADIOTHERAPY, *FALSE positive error, *HEAD & neck cancer, *IMMUNE checkpoint inhibitors
Abstract

Purpose: Management of locoregionally recurrent nasopharyngeal carcinoma (LR NPC) is difficult. Although carbon‐ion radiation therapy (CIRT) could substantially improve the overall survival (OS) of those patients, around 40% of the patients may still develop local failure. Further improvement of the disease control is necessary. Immunotherapy, such as immune checkpoint inhibitors (ICIs) becomes a promising antitumor treatment. The role of ICIs was proved in head and neck cancers including recurrent/metastatic NPC. Preclinical studies indicated potential synergistic effects between radiation therapy and ICIs. Therefore, we conduct a randomized phase 2 trial to evaluate the efficacy and safety of camrelizumab, an anti‐PD‐1 monoclonal antibody, along with CIRT in patients with LR NPC. Methods: Patients will be randomly assigned at 1:1 to receive either standard CIRT with 63 Gy (relatively biological effectiveness, [RBE]) in 21 fractions, or standard CIRT plus concurrent camrelizumab. Camrelizumab will be administered intravenously with a dose of 200 mg, every 2 week, for a maximum of 1 year. We estimate addition of camrelizumab will improve the 2‐year progression‐free survival (PFS) from 45% to 60%. A total of 146 patients (with a 5% lost to follow‐up rate) is required to yield a type I error of 0.2, and a power of 0.8. Results and Conclusion: The results of the trial may shed insights on the combined therapy with ICIs and CIRT. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Proton radiotherapy in the treatment of IDH-mutant diffuse gliomas: an early experience from shanghai proton and heavy ion center.

Author

Qiu, Xianxin, Gao, Jing, Hu, Jiyi, Yang, Jing, Hu, Weixu, Huang, Qingting, Zhang, Haojiong, Lu, Jiade J., and Kong, Lin

Abstract

Purpose: According to the presence or absence of isocitrate dehydrogenase (IDH) mutation, the 2021 WHO classification system bisected diffuse gliomas into IDH-mutant tumors and IDH-wildtype tumors. This study was aimed to evaluate the outcomes of proton radiotherapy treating IDH-mutant diffuse gliomas. Patients and Methods: Between May 2015 and May 2022, a total of 52 consecutive patients with IDH-mutant diffuse gliomas were treated at Shanghai Proton and Heavy Ion Center. Tumor histologies were 33 cases of astrocytoma and 19 cases of oligodendroglioma. Tumor classified by WHO grade 2, 3 and 4 were 22, 25, and 5 cases, respectively. All 22 patients with WHO grade 2 tumors and one patient with brain stem WHO grade 4 tumor were irradiated with 54GyE. The other 29 patients with WHO grade 3 and 4 tumors were irradiated with 60GyE. Temozolomide was recommended to all patients, and was eventually conducted in 50 patients. Results: The median follow-up time was 21.7 months. The 12/24-month progression-free survival (PFS) and overall survival (OS) rates for the entire cohort were 97.6%/78.4% and 100%/91.0% group. Examined by both univariate and multivariate analysis, WHO grade of tumor were of the most significant impact for both PFS and OS. No severe acute toxicity (grade 3 or above) was found. In terms of late toxicity, grade 3 radio-necrosis was developed in one case of oligodendroglioma, WHO grade 3. Conclusion: Proton radiotherapy produced a favorable outcome with acceptable adverse-effects in patients with IDH-mutant diffuse gliomas. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Additional file 4 of Identification of molecular subtypes based on inflammatory response in lower-grade glioma

Author

Lin, Wanzun, Gao, Jing, Zhang, Haojiong, Chen, Li, Qiu, Xianxin, Huang, Qingting, Hu, Jiyi, Kong, Lin, and Lu, Jiade J.

Abstract

Additional file 4. Illustration of the seven-step cancer-immunity cycle. The seven-step cancer-immunity cycle encompasses the production of tumor antigens (step 1), presentation of tumor antigen (step 2), priming, and activation (step 3), T cells transfer to tumors (step 4), immune cell infiltration into tumors (step 5), tumor cell detection by T cells (step 6), and tumor cells apoptosis (step 7).

Published
2022
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42. MOF‐Derived Porous Dodecahedron rGO‐Co3O4 for Robust Pulse Generation.

Author

Li, Xiaohui, An, Mingqi, Li, Gang, Han, Yueheng, Guo, Penglai, Chen, Enci, Hu, Jiyi, Song, Zhuoying, Lu, Hongbing, and Lu, Jiangbo

Subjects
MODE-locked lasers, OPTICAL modulators, FIBER lasers, METAL-organic frameworks, OPTICAL devices, PULSED lasers
Abstract

As a member of the porous crystalline material family, metal organic framework (MOF) materials have been widely used in the fields of photodetection, photovoltaic cells, nonlinear optical devices, supercapacitors, and biological imaging. However, few reports about robust pulsed laser based on MOF‐derived nanomaterials especially the one with unique structure have been reported till now. In this paper, porous dodecahedron rGO‐Co3O4 is synthesized by calcining the MOF template and systematically analyzed. Interestingly, the rGO‐Co3O4 is successfully prepared as a saturable absorber (SA) by using the optical deposition method and the modulation depth of the rGO‐Co3O4 SA is 8.38%. Through different dispersion management, robust pulses with 1.5 µm dissipative soliton (DS) in the frequency domain and square wave pulse (SWP) in the time domain can be obtained in the erbium‐doped fiber laser based on rGO‐Co3O4 SA. The 3‐dB bandwidth and pulse duration of the DS are 6.81 nm and 62.01 ps, respectively. The pulse tuning range of the SWP is 1.24 ns ≈ 19.14 ns. It is worth mentioning that the threshold of the SWP is 53.72 mW, and the mode‐locked laser can be self‐started at the pump power of 72.04 mW. The experimental results show that the porous dodecahedral rGO‐Co3O4 material derived from MOF can be used as an excellent nonlinear optical modulator, providing a new choice for material processing. [ABSTRACT FROM AUTHOR]

Published
2022
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