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1,056 results on '"Hu, Jiong"'

2. Hematopoietic stem cell transplantation activity in China 2022–2023. The proportions of peripheral blood for stem cell source continue to grow: a report from the Chinese Blood and Marrow Transplantation Registry Group

Author

Xu, Lan-Ping, Lu, Pei-Hua, Wu, De-Pei, Huang, He, Jiang, Er-Lie, Liu, Dai-Hong, Cao, Wei-Jie, Zhang, Xi, Fu, Yue-Wen, Li, Nai-Nong, Chen, Xin-Chuan, Zhu, Xiao-Yu, Liu, Qi-Fa, Xia, Ling-Hui, Zhang, Yi-Cheng, Xu, Ya-Jing, Li, Fu-Chun, Hu, Jiong, Liu, Si-Xi, Liu, Rong-Rong, Ma, Xiao-Di, Tang, Xiao-Wen, Luo, Yi, Zhang, Xiao-Hui, and Huang, Xiao-Jun

Published
2024
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7. A global study for acute myeloid leukemia with RARG rearrangement.

Author

Zhu, Hong-Hu, Qin, Ya-Zhen, Zhang, Zhang-Lin, Liu, Yong-Jing, Wen, Li-Jun, You, M, Zhang, Cheng, Such, Esperanza, Luo, Hong, Yuan, Hong-Jian, Zhou, Hong-Sheng, Liu, Hong-Xing, Xu, Reng, Li, Ji, Li, Jian-Hu, Hao, Jian-Ping, Jin, Jie, Yu, Liang, Zhang, Jing-Ying, Liu, Li-Ping, Zhang, Le-Ping, Huang, Rui-Bin, Shen, Shu-Hong, Gao, Su-Jun, Wang, Wei, Yan, Xiao-Jing, Zhang, Xin-You, Du, Xin, Chu, Xiao-Xia, Yu, Yan-Fang, Wang, Yi, Mi, Ying-Chang, Lu, Ying, Cai, Zhen, Su, Zhan, Taussig, David, MacMahon, Suzanne, Ball, Edward, Wang, Huan-You, Welch, John, Yin, C, Borthakur, Gautam, Sanz, Miguel, Kantarjian, Hagop, Huang, Jin-Yan, Hu, Jiong, and Chen, Su-Ning

Subjects
Humans, Leukemia, Myeloid, Acute, Leukemia, Promyelocytic, Acute, Tretinoin, HLA-DR Antigens, Arsenic Trioxide
Abstract

Acute myeloid leukemia (AML) with retinoic acid receptor γ (RARG) rearrangement has clinical, morphologic, and immunophenotypic features similar to classic acute promyelocytic leukemia. However, AML with RARG rearrangement is insensitive to alltrans retinoic acid (ATRA) and arsenic trioxide (ATO) and carries a poor prognosis. We initiated a global cooperative study to define the clinicopathological features, genomic and transcriptomic landscape, and outcomes of AML with RARG rearrangements collected from 29 study groups/institutions worldwide. Thirty-four patients with AML with RARG rearrangements were identified. Bleeding or ecchymosis was present in 18 (54.5%) patients. Morphology diagnosed as M3 and M3v accounted for 73.5% and 26.5% of the cases, respectively. Immunophenotyping showed the following characteristics: positive for CD33, CD13, and MPO but negative for CD38, CD11b, CD34, and HLA-DR. Cytogenetics showed normal karyotype in 38% and t(11;12) in 26% of patients. The partner genes of RARG were diverse and included CPSF6, NUP98, HNRNPc, HNRNPm, PML, and NPM1. WT1- and NRAS/KRAS-mutations were common comutations. None of the 34 patients responded to ATRA and/or ATO. Death within 45 days from diagnosis occurred in 10 patients (∼29%). At the last follow-up, 23 patients had died, and the estimated 2-year cumulative incidence of relapse, event-free survival, and overall survival were 68.7%, 26.7%, and 33.5%, respectively. Unsupervised hierarchical clustering using RNA sequencing data from 201 patients with AML showed that 81.8% of the RARG fusion samples clustered together, suggesting a new molecular subtype. RARG rearrangement is a novel entity of AML that confers a poor prognosis. This study is registered with the Chinese Clinical Trial Registry (ChiCTR2200055810).

Published
2023

8. Correction: Hematopoietic stem cell transplantation activity in China 2022–2023. The proportions of peripheral blood for stem cell source continue to grow: a report from the Chinese Blood and Marrow Transplantation Registry Group

Author

Xu, Lan-Ping, Lu, Pei-Hua, Wu, De-Pei, Huang, He, Jiang, Er-Lie, Liu, Dai-Hong, Cao, Wei-Jie, Zhang, Xi, Fu, Yue-Wen, Li, Nai-Nong, Chen, Xin-Chuan, Zhu, Xiao-Yu, Liu, Qi-Fa, Xia, Ling-Hui, Zhang, Yi-Cheng, Xu, Ya-Jing, Li, Fu-Chun, Hu, Jiong, Liu, Si-Xi, Liu, Rong-Rong, Ma, Xiao-Di, Tang, Xiao-Wen, Luo, Yi, Zhang, Xiao-Hui, and Huang, Xiao-Jun

Published
2024
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21. Soybean Isoflavones Alleviate Osteoarthritis Through Modulation of the TSC1/mTORC1 Signaling Pathway to Reduce Intrachondral Angiogenesis.

Author

Zou, Yang, Wang, Zhaoyang, Shi, Hangchu, Hu, Jiong, and Hu, Weifeng

Subjects
LABORATORY rats, BONE remodeling, CELLULAR signal transduction, ANIMAL disease models, ISOFLAVONES
Abstract

Background: The incidence of osteoarthritis (OA) is increasing, yet its pathogenesis remains largely unknown. Recent studies suggest that abnormal subchondral bone remodeling plays a crucial role in OA development, highlighting a gap in clinical treatments targeting this aspect. Soybean Isoflavone (SI) has shown potential in treating OA, although its mechanisms are not fully understood. Methods: This research investigated the effects of SI on subchondral bone remodeling in an OA rat model, assessing joint damage, OARSI scores, and type H vessel formation (CD31hiEmcnhi expression). Additionally, the expression of ALP, OCN, BMP, and TSC1 was evaluated to determine involvement of the mTORC1 pathway. In vitro studies on IL-1β-induced osteoblasts further examined the impact of SI on TSC1/mTORC1 signaling and related markers. Results: SI treatment reduced joint damage and OARSI scores in the rat OA model, significantly decreasing CD31hiEmcnhi expression, indicating a reduction in type H vessel formation. SI also downregulated ALP, OCN, and BMP expression while upregulating TSC1, suggesting inhibition of the mTORC1 signaling pathway and VEGF release. In vitro, SI increased TSC1 expression and decreased mTORC1 signaling, VEGF, ALP, OCN, and BMP levels in IL-1β-induced osteoblasts. Conclusion: SI targets the TSC1/mTORC1 signaling pathway to suppress osteoblast activation and VEGF release, inhibiting type H vessel formation and slowing abnormal subchondral bone remodeling. These findings provide a novel therapeutic approach for OA by focusing on subchondral bone remodeling mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Characterization of the genomic landscape in large-scale Chinese patients with pancreatic cancer

Author

Zhang, Xiaofei, Mao, Tiebo, Zhang, Bei, Xu, Haiyan, Cui, Jiujie, Jiao, Feng, Chen, Dongqin, Wang, Yu, Hu, Jiong, Xia, Qing, Ge, Weiyu, Li, Shumin, Yue, Ming, Ma, Jingyu, Yao, Jiayu, Wang, Yongchao, Wang, Yanling, Shentu, Daiyuan, Zhang, Xiao, Chen, Shiqing, Bai, Yuezong, Wang, Yuexiang, Zhang, Xuebin, Liu, Qiang, Sun, Yongwei, Fu, Deliang, Liu, Yingbin, Xiong, Lei, and Wang, Liwei

Published
2022
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24. Arsenic trioxide replacing or reducing chemotherapy in consolidation therapy for acute promyelocytic leukemia (APL2012 trial)

Author

Chen, Li, Zhu, Hong-Ming, Li, Yan, Liu, Qi-Fa, Hu, Yu, Zhou, Jian-Feng, Jin, Jie, Hu, Jian-Da, Liu, Ting, Wu, De-Pei, Chen, Jie-Ping, Lai, Yong-Rong, Wang, Jian-Xiang, Li, Juan, Li, Jian-Yong, Du, Xin, Wang, Xin, Yang, Ming-Zhen, Yan, Jin-Song, Ouyang, Gui-Fang, Liu, Li, Hou, Ming, Huang, Xiao-Jun, Yan, Xiao-Jing, Xu, Dan, Li, Wei-Ming, Li, Deng-Ju, Lou, Yin-Jun, Wu, Zheng-Jun, Niu, Ting, Wang, Ying, Li, Xiao-Yang, You, Jian-Hua, Zhao, Hui-Jin, Chen, Yu, Shen, Yang, Chen, Qiu-Sheng, Chen, Yu, Li, Jian, Wang, Bing-Shun, Zhao, Wei-Li, Qing Mi, Jian-, Wang, Kan-Kan, Hu, Jiong, Chen, Zhu, Chen, Sai-Juan, and Li, Jun-Min

Published
2021

25. Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

Author

Hitzel, Juliane, Lee, Eunjee, Zhang, Yi, Bibli, Sofia Iris, Li, Xiaogang, Zukunft, Sven, Pflüger, Beatrice, Hu, Jiong, Schürmann, Christoph, Vasconez, Andrea Estefania, Oo, James A, Kratzer, Adelheid, Kumar, Sandeep, Rezende, Flávia, Josipovic, Ivana, Thomas, Dominique, Giral, Hector, Schreiber, Yannick, Geisslinger, Gerd, Fork, Christian, Yang, Xia, Sigala, Fragiska, Romanoski, Casey E, Kroll, Jens, Jo, Hanjoong, Landmesser, Ulf, Lusis, Aldons J, Namgaladze, Dmitry, Fleming, Ingrid, Leisegang, Matthias S, Zhu, Jun, and Brandes, Ralf P

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cardiovascular, Clinical Research, Aging, Heart Disease, Atherosclerosis, Genetics, Heart Disease - Coronary Heart Disease, 2.1 Biological and endogenous factors, Amino Acids, Aminohydrolases, Animals, Aorta, Bayes Theorem, Cardiovascular Diseases, Endothelial Cells, Gene Expression Regulation, Genetic Techniques, Glycine, Human Umbilical Vein Endothelial Cells, Humans, Methylenetetrahydrofolate Dehydrogenase (NADP), Multifunctional Enzymes, Multigene Family, Neovascularization, Pathologic, Nucleotides, Oxygen, Phospholipids, Probability, Purines, RNA, Small Interfering, Zebrafish
Abstract

Oxidized phospholipids (oxPAPC) induce endothelial dysfunction and atherosclerosis. Here we show that oxPAPC induce a gene network regulating serine-glycine metabolism with the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) as a causal regulator using integrative network modeling and Bayesian network analysis in human aortic endothelial cells. The cluster is activated in human plaque material and by atherogenic lipoproteins isolated from plasma of patients with coronary artery disease (CAD). Single nucleotide polymorphisms (SNPs) within the MTHFD2-controlled cluster associate with CAD. The MTHFD2-controlled cluster redirects metabolism to glycine synthesis to replenish purine nucleotides. Since endothelial cells secrete purines in response to oxPAPC, the MTHFD2-controlled response maintains endothelial ATP. Accordingly, MTHFD2-dependent glycine synthesis is a prerequisite for angiogenesis. Thus, we propose that endothelial cells undergo MTHFD2-mediated reprogramming toward serine-glycine and mitochondrial one-carbon metabolism to compensate for the loss of ATP in response to oxPAPC during atherosclerosis.

Published
2018

32. Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy

Author

Hu, Jiong, Dziumbla, Sarah, Lin, Jihong, Bibli, Sofia-Iris, Zukunft, Sven, de Mos, Julian, Awwad, Khader, Frömel, Timo, Jungmann, Andreas, Devraj, Kavi, Cheng, Zhixing, Wang, Liya, Fauser, Sascha, Eberhart, Charles G, Sodhi, Akrit, Hammock, Bruce D, Liebner, Stefan, Müller, Oliver J, Glaubitz, Clemens, Hammes, Hans-Peter, Popp, Rüdiger, and Fleming, Ingrid

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Diabetes, Eye Disease and Disorders of Vision, Metabolic and endocrine, Animals, Antigens, CD, Cadherins, Capillary Permeability, Carrier Proteins, Cell Membrane, Cell Movement, Cell Survival, Diabetic Retinopathy, Disease Models, Animal, Disease Progression, Docosahexaenoic Acids, Endothelial Cells, Ependymoglial Cells, Epoxide Hydrolases, Fatty Acids, Unsaturated, Female, Humans, Intercellular Junctions, Male, Mice, Mice, Inbred C57BL, Pancreatic Elastase, Pericytes, Presenilin-1, Retina, Solubility, Vitreous Body, General Science & Technology
Abstract

Diabetic retinopathy is an important cause of blindness in adults, and is characterized by progressive loss of vascular cells and slow dissolution of inter-vascular junctions, which result in vascular leakage and retinal oedema. Later stages of the disease are characterized by inflammatory cell infiltration, tissue destruction and neovascularization. Here we identify soluble epoxide hydrolase (sEH) as a key enzyme that initiates pericyte loss and breakdown of endothelial barrier function by generating the diol 19,20-dihydroxydocosapentaenoic acid, derived from docosahexaenoic acid. The expression of sEH and the accumulation of 19,20-dihydroxydocosapentaenoic acid were increased in diabetic mouse retinas and in the retinas and vitreous humour of patients with diabetes. Mechanistically, the diol targeted the cell membrane to alter the localization of cholesterol-binding proteins, and prevented the association of presenilin 1 with N-cadherin and VE-cadherin, thereby compromising pericyte-endothelial cell interactions and inter-endothelial cell junctions. Treating diabetic mice with a specific sEH inhibitor prevented the pericyte loss and vascular permeability that are characteristic of non-proliferative diabetic retinopathy. Conversely, overexpression of sEH in the retinal Müller glial cells of non-diabetic mice resulted in similar vessel abnormalities to those seen in diabetic mice with retinopathy. Thus, increased expression of sEH is a key determinant in the pathogenesis of diabetic retinopathy, and inhibition of sEH can prevent progression of the disease.

Published
2017

33. Optimizing conditioning regimen with low-dose irradiation or busulfan enables the outcome of transplantation from a 6–7/8 HLA-matched donor comparable to that from an 8/8 HLA-matched unrelated donor in severe aplastic anemia patients under 40 years

Author

Qin, Xia, Zhu, Yi-Ping, Luo, Cheng-Juan, Zhou, Ming, Huang, Ke, Chen, Chun, Zhang, Wei-Ping, Sun, Yuan, Luo, Rong-Mu, Tang, Xiang-Feng, Yang, Ting, Song, Xian-Min, Hu, Shao-Yan, Sun, Zi-Min, Hu, Jiong, Wang, Shun-Qing, and Chen, Jing

Published
2021
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42. Amphiregulin improves ventricular remodeling after myocardial infarction by modulating autophagy and apoptosis

Author

Li, Nana, primary, Xia, Ni, additional, He, Junyi, additional, Liu, Meilin, additional, Gu, Muyang, additional, Lu, Yuzhi, additional, Yang, Haoyi, additional, Hao, Zhiheng, additional, Zha, Lingfeng, additional, Wang, Xuhong, additional, Wang, Weimin, additional, Hu, Desheng, additional, Hu, Jiong, additional, and Cheng, Xiang, additional

Published
2024
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