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This study examines the development trajectory and current trends of three-dimensional (3D) geological modelling. In recent years, due to the rising global energy demand and the increasing frequency of regional geological disasters, significant progress has been made in this field. The purpose of this study is to clarify the potential complexity of 3D geological modelling, identify persistent challenges, and propose potential avenues for improvement. The main objectives include simplifying the modelling process, improving model accuracy, integrating different data sources, and quantitatively evaluating model parameters. This study integrates global research in this field, focusing on the latest breakthroughs and applications in mineral exploration, engineering geology, geological disaster assessment, and military geosciences. For example, unmanned aerial vehicle (UAV) tilt photography technology, multisource data fusion, 3D geological modelling method based on machine learning, etc. By identifying areas for improvement and making recommendations, this work aims to provide valuable insights to guide the future development of geological modelling toward a more comprehensive and accurate "Transparent Earth". This review underscores the global applications of 3D geological modelling, highlighting its crucial role across various sectors such as mineral exploration, the oil and gas industry, urban planning, geological hazard assessment, and geoscientific research. The review emphasizes the sector-specific importance of this technology in enhancing modelling accuracy and efficiency, optimizing resource management, driving technological innovation, and improving disaster response capabilities. These insights provide a comprehensive understanding of how 3D geological modelling can significantly impact and benefit multiple industries worldwide. [ABSTRACT FROM AUTHOR]

Background Clostridioides difficile infection (CDI) is a common healthcare-associated infection with limited treatment options. Omadacycline, an aminomethylcycline tetracycline, has potent in vitro activity against C difficile and a low propensity to cause CDI in clinical trials. We aimed to assess fecal pharmacokinetics and gut microbiome effects of oral omadacycline compared to oral vancomycin in healthy adults. Methods This was a phase 1, nonblinded, randomized clinical trial conducted in healthy volunteers aged 18–40 years. Subjects received a 10-day course of omadacycline or vancomycin. Stool samples were collected at baseline, daily during therapy, and at follow-up visits. Omadacycline and vancomycin stool concentrations were assessed, and microbiome changes were compared. Results Sixteen healthy volunteers with a mean age of 26 (standard deviation [SD], 5) years were enrolled; 62.5% were male, and participants' mean body mass index was 23.5 (SD, 4.0) kg/m2. Omadacycline was well tolerated with no safety signal differences between the 2 antibiotics. A rapid initial increase in fecal concentrations of omadacycline was observed compared to vancomycin, with maximum concentrations achieved within 48 hours. A significant difference in alpha diversity was observed following therapy in both the omadacycline and vancomycin groups (P <.05). Bacterial abundance and beta diversity analysis showed differing microbiome changes in subjects who received omadacycline versus vancomycin. Conclusions Subjects given omadacycline had high fecal concentrations with a distinct microbiome profile compared to vancomycin. Clinical Trials Registration NCT06030219. [ABSTRACT FROM AUTHOR]

To understand the sedimentary characteristics and sedimentary patterns of the Triassic Shaofanggou For- mation in the North Santai High area of the eastern Junggar Basin and clarify the constraints on reservoir development, a study on the sedimentary patterns of the Shaofanggou Formation and its control on reservoir development was carried out on the basis of sedimentology and in combination with the data such as core, thin section, grain size and conventional physical properties. The study shows that there are nine typical petrographic types developed in the Shaofanggou Formation, namely channeled interlaminated conglomerate phase, platy interlaminated conglomerate phase, massive laminated conglomerate phase, channeled interlaminated sandstone phase, platy interlaminated sandstone phase, massive laminated sandstone phase, wave-formed sand laminated sandstone phase, parallel lami- nated siltstone phase and massive laminated mudstone phase; the Shaofanggou Formation is mainly dominated by braided river delta phase, and the sedimentary microphases include 10 types such as floodplain, abovewater braided river channel, channel bar, natural dike, underwater braided river channel, interdistributary area, underwater nat- ural dike, estuary bar, prodelta mud and beach bar, among which, underwater braided river channel, estuary bar and beach bar reservoirs have the best physical properties, with average porosity of 17. 31%, 20. 66% and 21. 81%, and average permeability of 6. 89, 7. 05 and 12. 98 mD, respectively. The reservoir properties in this area are mainly controlled by sedimentation, and the high-quality reservoirs are mainly developed in underwater braided channels, estuary bar and beach bar microphase. The study can provide a theoretical basis for further fine explora- tion and development of oil and gas within the study area. [ABSTRACT FROM AUTHOR]