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Your search keyword '"Hsueh, Ying-Chao"' showing total 9 results
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9 results on '"Hsueh, Ying-Chao"'

2. RNAi-based modulation of IFN-γ signaling in skin

Author

Tang, Qi, Sousa, Jacquelyn, Echeverria, Dimas, Fan, Xueli, Hsueh, Ying-Chao, Afshari, Khashayar, MeHugh, Nicholas, Cooper, David A., Vangjeli, Lorenc, Monopoli, Kathryn, Okamura, Ken, Biscans, Annabelle, Clauss, Adam, Harris, John E., and Khvorova, Anastasia

Published
2022
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3. The Development of a Skin-Targeted Interferon-Gamma-Neutralizing Bispecific Antibody for Vitiligo Treatment

Author

Hsueh, Ying-Chao

Subjects
integumentary system
Abstract

Despite the central role of IFNγ in vitiligo pathogenesis, systemic IFNγ neutralization is an impractical treatment option due to strong immunosuppression. However, most vitiligo patients present with less than 20% affected body surface area, which provides an opportunity for localized treatments that avoid systemic side effects. After identifying keratinocytes as key cells that amplify IFNγ signaling during vitiligo, I hypothesized that tethering an IFNγ neutralizing antibody to keratinocytes would limit anti-IFNγ effects to the treated skin for the localized treatment. To that end, I developed a bispecific antibody (BsAb) capable of blocking IFNγ signaling while binding to desmoglein expressed by keratinocytes. I characterized the effect of the BsAb in vitro, ex vivo, and in a mouse model of vitiligo. SPECT/CT biodistribution and serum assays after local footpad injection revealed that the BsAb had improved skin retention, faster elimination from the blood, and less systemic IFNγ inhibition than the non-tethered version. Furthermore, the BsAb conferred localized protection almost exclusively to the treated footpad during vitiligo that was not possible by local injection of the non-tethered anti-IFNγ antibody. Thus, keratinocyte-tethering proved effective while significantly diminishing off-tissue effects of IFNγ blockade, offering a new treatment strategy for localized skin diseases, including vitiligo.

Published
2022
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6. Characterization of the Antigenic Heterogeneity of Lipoarabinomannan, the Major Surface Glycolipid of Mycobacterium tuberculosis, and Complexity of Antibody Specificities toward This Antigen

Author

Choudhary, Alok, primary, Patel, Deendayal, additional, Honnen, William, additional, Lai, Zhong, additional, Prattipati, Raja Sekhar, additional, Zheng, Ruixiang Blake, additional, Hsueh, Ying-Chao, additional, Gennaro, Maria Laura, additional, Lardizabal, Alfred, additional, Restrepo, Blanca I., additional, Garcia-Viveros, Moncerrato, additional, Joe, Maju, additional, Bai, Yu, additional, Shen, Ke, additional, Sahloul, Kamar, additional, Spencer, John S., additional, Chatterjee, Delphi, additional, Broger, Tobias, additional, Lowary, Todd L., additional, and Pinter, Abraham, additional

Published
2018
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7. MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease

Author

Satishchandran, Abhishek, primary, Ambade, Aditya, additional, Rao, Sitara, additional, Hsueh, Ying-Chao, additional, Iracheta-Vellve, Arvin, additional, Tornai, David, additional, Lowe, Patrick, additional, Gyongyosi, Benedek, additional, Li, Jia, additional, Catalano, Donna, additional, Zhong, Li, additional, Kodys, Karen, additional, Xie, Jun, additional, Bala, Shashi, additional, Gao, Guangping, additional, and Szabo, Gyongyi, additional

Published
2018
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8. 655 Grainyhead-Like 2, a Novel Hepatic Transcription Factor, Promotes Alcohol-induced Liver Injury, Steatosis and Inflammation via miR-122 Down-regulation

Author

Satishchandran, Abhishek, primary, Ambade, Aditya, additional, Rao, Sitara, additional, Hsueh, Ying-Chao, additional, Gyongyosi, Benedek, additional, Lowe, Patrick, additional, Mehta, Nicita, additional, Zatsiorsky, James, additional, Iracheta-Vellve, Arvin, additional, Li, Jia, additional, Xie, Jun, additional, Zhong, Li, additional, Catalano, Donna, additional, Saha, Banishree, additional, Kodys, Karen, additional, Bala, Shashi, additional, Gao, Guangping, additional, and Szabo, Gyongyi, additional

Published
2016
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