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33 results on '"Hsu, Wei-Chi"'

1. PD41-05 MIR-299-3P INHIBITS CELL PROLIFERATION, MIGRATION, INVASION AND ANGIOGENESIS THROUGH VEGFA IN UPPER TRACT UROTHELIAL CARCINOMA

Author

Hsu, Wei-Chi, primary, Jhan, Jhen-Hao, additional, Wang, Chien-Sheng, additional, Lee, Yi-Chen, additional, Li, Wei-Ming, additional, Chang, Lin-Li, additional, Huang, A-Mei, additional, Lin, Hui-Hui, additional, Chang, Che-Wei, additional, Wu, Wen-Jeng, additional, Li, Ching-Chia, additional, and Ke, Hung-Lung, additional

Published
2024
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3. NTRK3 exhibits a pro‐oncogenic function in upper tract urothelial carcinomas

Author

Lim, Lee‐Moay, primary, Lee, Yi‐Chen, additional, Lin, Ting‐Wei, additional, Hong, Zi‐Xuan, additional, Hsu, Wei‐Chi, additional, Ke, Hung‐Lung, additional, Hwang, Daw‐Yang, additional, Chung, Wen‐Yu, additional, Li, Wei‐Ming, additional, Lin, Hui‐Hui, additional, Kuo, Hung‐Tien, additional, and Huang, A‐Mei, additional

Published
2024
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6. NTRK3exhibits a pro‐oncogenic function in upper tract urothelial carcinomas

Author

Lim, Lee‐Moay, Lee, Yi‐Chen, Lin, Ting‐Wei, Hong, Zi‐Xuan, Hsu, Wei‐Chi, Ke, Hung‐Lung, Hwang, Daw‐Yang, Chung, Wen‐Yu, Li, Wei‐Ming, Lin, Hui‐Hui, Kuo, Hung‐Tien, and Huang, A‐Mei

Abstract

Neurotrophic receptor tyrosine kinase 3 (NTRK3) has pleiotropic functions: it acts not only as an oncogene in breast and gastric cancers but also as a dependence receptor in tumor suppressor genes in colon cancer and neuroblastomas. However, the role of NTRK3 in upper tract urothelial carcinoma (UTUC) is not well documented. This study investigated the association between NTRK3 expression and outcomes in UTUC patients and validated the results in tests on UTUC cell lines. A total of 118 UTUC cancer tissue samples were examined to evaluate the expression of NTRK3. Survival curves were generated using Kaplan–Meier estimates, and Cox regression models were used for investigating survival outcomes. Higher NTRK3 expression was correlated with worse progression‐free survival, cancer‐specific survival, and overall survival. Moreover, the results of an Ingenuity Pathway Analysis suggested that NTRK3 may interact with the PI3K‐AKT‐mTOR signaling pathway to promote cancer. NTRK3 downregulation in BFTC909 cells through shRNA reduced cellular migration, invasion, and activity in the AKT‐mTOR pathway. Furthermore, the overexpression of NTRK3 in UM‐UC‐14 cells promoted AKT‐mTOR pathway activity, cellular migration, and cell invasion. From these observations, we concluded that NTRK3 may contribute to aggressive behaviors in UTUC by facilitating cell migration and invasion through its interaction with the AKT‐mTOR pathway and the expression of NTRK3 is a potential predictor of clinical outcomes in cases of UTUC.

Published
2024
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7. MicroRNA‐145‐5p suppresses cell proliferation, migration, and invasion in upper tract urothelial carcinoma by targeting 5‐aminoimidazole‐4‐carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

Author

Luo, Hao‐Lun, primary, Lee, Yi‐Chen, additional, Chang, Yin‐Lun, additional, Hsu, Wei‐Chi, additional, Wu, Yen‐Ting, additional, Jhan, Jhen‐Hao, additional, Lin, Hui‐Hui, additional, Wu, Yi‐Ru, additional, Ke, Hung‐Lung, additional, and Liu, Hui‐Ying, additional

Published
2023
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9. MicroRNA‐299‐3p inhibits cell proliferation, motility, invasion and angiogenesis via VEGFA in upper tract urothelial carcinoma.

Author

Wang, Chien‐Shen, Lee, Yi‐Chen, Jhan, Jhen‐Hao, Li, Wei‐Ming, Chang, Lin‐Li, Huang, A‐Mei, Lin, Hui‐Hui, Wu, Yi‐Ru, Hsu, Wei‐Chi, and Ke, Hung‐Lung

Abstract

Background: Upper tract urothelial carcinoma (UTUC) is a rare tumor with extraordinarily different features between Eastern and Western countries. Vascular endothelial growth factor‐A (VEGFA) was originally identified as a secreted signaling protein and regulator of vascular development and cancer progression. In this study, we aimed to elucidate the molecular mechanisms underlying the regulation of VEGFA by microRNA in UTUC. Methods: VEGFA expression was evaluated by immunohistochemistry in 140 human UTUC tissue samples. Next, we assessed the regulatory relationship between VEGFA and miR‐299‐3p by real‐time PCR, western blotting, ELISA and dual‐luciferase reporter assays using two UTUC cell lines. The role of miR‐299‐3p/VEGFA in cell proliferation, motility, invasion, and tube formation was analyzed in vitro. Results: High VEGFA expression was significantly associated with tumor stage, grade, distant metastasis and cancer‐related death and correlated with poor progression‐free and cancer‐specific survival. VEGFA knockdown repressed proliferation, migration, invasion and angiogenesis in UTUC cell lines. miR‐299‐3p significantly reduced VEGFA protein expression and miR‐299‐3p overexpression inhibited VEGFA mRNA and protein expression by directly targeting its 3′‐UTR. Functional studies indicated that VEGFA overexpression reversed the miR‐299‐3p‐mediated suppression of tumor cell proliferation, migration, invasion and angiogenesis. In addition, miR‐299‐3p/VEGFA suppressed cellular functions in UTUC by modulating the expression of P18 and cyclin E2. Conclusions: Our findings suggest that miR‐299‐3p possibly suppresses UTUC cell proliferation, motility, invasion and angiogenesis via VEGFA. VEGFA may act as a prognostic predictor, and both VEGFA and miR‐299‐3p could be potential therapeutic targets for UTUC. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Solar concentrator constructed with a circular prism array

Author

Huang, Jia-hong, Fei, Wun-Ciang, Hsu, Wei-Chi, and Tsai, Jui-che

Subjects
Solar collectors -- Design and construction, Solar collectors -- Equipment and supplies, Engineering design -- Methods, Prisms -- Usage, Astronomy, Physics
Abstract

We present a novel idea to construct a solar concentrator with a circular prism array. FRED ray tracing software is used to evaluate our proposed structure in which the incident light rays are deflected by total internal reflection and the optical energy is concentrated and collected at the center. The light rays to be collected travel within the disk once they enter the module, saving the space that is reserved for ray propagation in other concentrators. Simulations for both single-wavelength and broadband light are performed. Our device can be used alone or serve as a secondary concentrator when combined with another solar-energy focusing module. For the proposed concentrator, an optical efficiency of 90% (single wavelength, 0.87 [micro]m) is achieved under normal incidence and with antireflection coating, and a high geometric concentration ratio of 93 is reached. When combined with a Fresnel lens, which is used as a primary concentrator, the overall efficiency and concentration ratio can reach 92% (single wavelength, 0.87 [micro]m) and 837, respectively. OCIS codes: 350.6050, 080.0080.

Published
2010

18. High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma

Author

Wu, Yi‐Ru, primary, Lee, Yi‐Chen, additional, Li, Wei‐Ming, additional, Hsu, Wei‐Chi, additional, Lin, Hui‐Hui, additional, Chang, Lin‐Li, additional, Huang, A‐Mei, additional, Jhan, Jhen‐Hao, additional, Wu, Wen‐Jeng, additional, Li, Ching‐Chia, additional, Lee, Hsiang‐Ying, additional, Yeh, Hsin‐Chih, additional, and Ke, Hung‐Lung, additional

Published
2021
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22. The prognostic value of CSN6 expression in upper tract urothelial carcinomas

Author

Jhan, Jhen‐Hao, primary, Lee, Yi‐Chen, additional, Li, Wei‐Ming, additional, Chang, Lin‐Li, additional, Hsu, Wei‐Chi, additional, Lin, Hui‐Hui, additional, Liang, Peir‐In, additional, Hsu, Ya‐Ling, additional, Wu, Wen‐Jeng, additional, Lee, Hsiang‐Ying, additional, Li, Ching‐Chia, additional, Yeh, Hsin‐Chih, additional, and Ke, Hung‐Lung, additional

Published
2019
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23. Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma

Author

Ke, Hung-Lung, primary, Li, Wei-Ming, additional, Lin, Hui-Hui, additional, Hsu, Wei-Chi, additional, Hsu, Ya-Ling, additional, Chang, Lin-Li, additional, Huang, Chun-Nung, additional, Li, Ching-Chia, additional, Chang, Hsin-Ping, additional, Yeh, Hsin-Chih, additional, Li, Chien-Feng, additional, and Wu, Wen-Jeng, additional

Published
2017
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25. MiR‐193b Mediates CEBPD‐Induced Cisplatin Sensitization Through Targeting ETS1 and Cyclin D1 in Human Urothelial Carcinoma Cells

Author

Lin, Siao‐Ren, primary, Yeh, Hsin‐Chih, additional, Wang, Wei‐Jan, additional, Ke, Hung‐Lung, additional, Lin, Hui‐Hui, additional, Hsu, Wei‐Chi, additional, Chao, Shih‐Yi, additional, Hour, Tzyh‐Chyuan, additional, Wu, Wen‐Jeng, additional, Pu, Yeong‐Shiau, additional, and Huang, A‐Mei, additional

Published
2016
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33. Mechanical and electrical properties of ZrO2 (3Y) doped with RENbO4 (RE = Yb, Er, Y, Dy, YNd, Sm, Nd)

Author

Yeh, Tsung-Her, Hsu, Wei-Chi, and Chou, Chen-Chia

Abstract

Mechanical and electrical properties of specimens of ZrO2 (3Y) doped with RENbO4 (RE?=?Yb, Er, Y, Dy, YNd, Sm, Nd) were investigated using micro-indentation and impedance spectroscopy in this work. The results show that ZrO2 (3Y) doped with RENbO4 (RE?=?Yb, Er, Y, Dy) possess outstanding mechanical properties, and specimens with RENbO4 (RE?=?Y, Nd, Sm) exhibit increasing amount of the monoclinic phase after fabrication, but still show fairly good mechanical bebavior compared to those of 3Y-TZP and 8YSZ, indicating that mechanical properties can be correlated with the phase transformation behavior modified by ionic radius of dopants. The total conductivity of 5 mol%RENbO4-doped ZrO2 (3Y) comprises the intragrain conductivity and grain boundary (GB). The intragrain conductivity of 5 mol%RENbO4-doped ZrO2 (3Y) are lower than 3Y-TZP and 8YSZ. The addition of RENbO4 to ZrO2 (3Y) increases average binding energy and activation energy, and reduces the amount of oxygen vacancies. The results imply that a specific doping content in zirconia which contributes a maximum content of non-interfering oxygen vacancies, the average radius of doping ions close to that of Zr4+ and average binding energy as smaller as possible help to achieve the highest conductivity of zirconia. The conditions deviate from those possessing the best mechanical properties, suggesting that to obtain an appropriate electrolyte in the application of a solid oxide fuel cell, mechanical properties and electrical properties of zirconia need to be compromised.

Published
2005

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