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1. Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status.

Author

Maguire, Sinead, Al-Emadi, Samar, Alba, Paula, Aguiar, Mathia, Al Lawati, Talal, Alle, Gelsomina, Bermas, Bonnie, Bhana, Suleman, Branimir, Anic, Bulina, Inita, Clowse, Megan, Cogo, Karina, Colunga, Iris, Cook, Claire, Cortez, Karen, Dao, Kathryn, Gianfrancesco, Milena, Gore-Massey, Monique, Gossec, Laure, Grainger, Rebecca, Hausman, Jonathon, Hsu, Tiffany, Hyrich, Kimme, Isnardi, Carolina, Kawano, Yumeko, Kilding, Rachael, Kusevich, Daria, Lawson-Tovey, Saskia, Liew, Jean, McCarthy, Eoghan, Montgumery, Anna, Moyano, Sebastian, Nasir, Noreen, Padjen, Ivan, Papagoras, Charalampos, Patel, Naomi, Pera, Mariana, Pisoni, Cecilia, Pons-Estel, Guillermo, Quiambao, Antonio, Quintana, Rosana, Ruderman, Eric, Sattui, Sebastian, Savio, Veronica, Sciascia, Savino, Sencarova, Marieta, Morales, Rosa, Siddique, Faizah, Sirotich, Emily, Sparks, Jeffrey, Strangfeld, Anja, Sufka, Paul, Tanner, Helen, Tissera, Yohana, Wallace, Zachary, Werner, Marina, Wise, Leanna, Worthing, Angus, Zell, JoAnn, Zepa, Julija, Machado, Pedro, Yazdany, Jinoos, Robinson, Philip, and Conway, Richard

Subjects
COVID-19, patient outcomes, pregnancy, rheumatic disease, vaccination, women’s health, Pregnancy, Infant, Newborn, Female, Humans, COVID-19 Vaccines, COVID-19, COVID-19 Testing, Rheumatic Diseases, Premature Birth, Vaccination
Abstract

OBJECTIVE: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy. METHODS: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi-squared or Fishers exact test. RESULTS: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies, 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2% (n = 2). CONCLUSIONS: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy.

Published
2023

2. Development of a Prediction Model for COVID‐19 Acute Respiratory Distress Syndrome in Patients With Rheumatic Diseases: Results From the Global Rheumatology Alliance Registry

Author

Izadi, Zara, Gianfrancesco, Milena A, Aguirre, Alfredo, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson‐Tovey, Saskia, Kearsley‐Fleet, Lianne, Schaefer, Martin, Seet, Andrea M, Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Al‐Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y‐T, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Duarte‐García, Alí, Valenzuela‐Almada, Maria O, Ugarte‐Gil, Manuel F, Ribeiro, Sandra Lúcia Euzébio, de Oliveira Marinho, Adriana, de Azevedo Valadares, Lilian David, Di Giuseppe, Daniela, Hasseli, Rebecca, Richter, Jutta G, Pfeil, Alexander, Schmeiser, Tim, Isnardi, Carolina A, Torres, Alvaro A Reyes, Alle, Gelsomina, Saurit, Verónica, Zanetti, Anna, Carrara, Greta, Labreuche, Julien, Barnetche, Thomas, Herasse, Muriel, Plassart, Samira, Santos, Maria José, Rodrigues, Ana Maria, Robinson, Philip C, Machado, Pedro M, Sirotich, Emily, Liew, Jean W, Hausmann, Jonathan S, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Costello, Wendy, Wallace, Zachary S, Yazdany, Jinoos, and Registry, Global Rheumatology Alliance

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Prevention, Rare Diseases, Arthritis, Autoimmune Disease, Good Health and Well Being, Global Rheumatology Alliance Registry, Clinical sciences
Abstract

ObjectiveSome patients with rheumatic diseases might be at higher risk for coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS). We aimed to develop a prediction model for COVID-19 ARDS in this population and to create a simple risk score calculator for use in clinical settings.MethodsData were derived from the COVID-19 Global Rheumatology Alliance Registry from March 24, 2020, to May 12, 2021. Seven machine learning classifiers were trained on ARDS outcomes using 83 variables obtained at COVID-19 diagnosis. Predictive performance was assessed in a US test set and was validated in patients from four countries with independent registries using area under the curve (AUC), accuracy, sensitivity, and specificity. A simple risk score calculator was developed using a regression model incorporating the most influential predictors from the best performing classifier.ResultsThe study included 8633 patients from 74 countries, of whom 523 (6%) had ARDS. Gradient boosting had the highest mean AUC (0.78; 95% confidence interval [CI]: 0.67-0.88) and was considered the top performing classifier. Ten predictors were identified as key risk factors and were included in a regression model. The regression model that predicted ARDS with 71% (95% CI: 61%-83%) sensitivity in the test set, and with sensitivities ranging from 61% to 80% in countries with independent registries, was used to develop the risk score calculator.ConclusionWe were able to predict ARDS with good sensitivity using information readily available at COVID-19 diagnosis. The proposed risk score calculator has the potential to guide risk stratification for treatments, such as monoclonal antibodies, that have potential to reduce COVID-19 disease progression.

Published
2022

3. Factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry

Author

Yeoh, Su-Ann, Gianfrancesco, Milena, Lawson-Tovey, Saskia, Hyrich, Kimme L, Strangfeld, Anja, Gossec, Laure, Carmona, Loreto, Mateus, Elsa F, Schäfer, Martin, Richez, Christophe, Hachulla, Eric, Holmqvist, Marie, Scirè, Carlo Alberto, Lorenz, Hanns-Martin, Voll, Reinhard E, Hasseli, Rebecca, Jayatilleke, Arundathi, Hsu, Tiffany Y-T, D’Silva, Kristin M, Pimentel-Quiroz, Victor R, del Mercado, Monica Vasquez, Shinjo, Samuel Katsuyuki, dos Reis Neto, Edgard Torres, da Rocha, Laurindo Ferreira, de Oliveira e Silva Montandon, Ana Carolina, Pons-Estel, Guillermo J, Ornella, Sofía, Exeni, Maria Eugenia D'Angelo, Velozo, Edson, Jordan, Paula, Sirotich, Emily, Hausmann, Jonathan S, Liew, Jean W, Jacobsohn, Lindsay, Gore-Massy, Monique, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Wallace, Zachary, Robinson, Philip C, Yazdany, Jinoos, and Machado, Pedro M

Subjects
Aging, Autoimmune Disease, Rare Diseases, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Adult, COVID-19, COVID-19 Testing, Female, Humans, Male, Myositis, Physicians, Prednisolone, Registries, Rheumatology, Rituximab, polymyositis, dermatomyositis, outcome assessment, health care, epidemiology, COVID-19 Global Rheumatology Alliance, outcome assessment, health care, Clinical Sciences
Abstract

ObjectivesTo investigate factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy (IIM).MethodsDemographic data, clinical characteristics and COVID-19 outcome severity of adults with IIM were obtained from the COVID-19 Global Rheumatology Alliance physician-reported registry. A 3-point ordinal COVID-19 severity scale was defined: (1) no hospitalisation, (2) hospitalisation (and no death) and (3) death. ORs were estimated using multivariable ordinal logistic regression. Sensitivity analyses were performed using a 4-point ordinal scale: (1) no hospitalisation, (2) hospitalisation with no oxygen (and no death), (3) hospitalisation with oxygen/ventilation (and no death) and 4) death.ResultsOf 348 patients, 48% were not hospitalised, 39% were hospitalised (and did not die) and 13% died. Older age (OR=1.59/decade, 95% CI 1.31 to 1.91), high disease activity (OR=3.50, 95% CI 1.25 to 9.83; vs remission), ≥2 comorbidities (OR=2.63, 95% CI 1.39 to 4.98; vs none), prednisolone-equivalent dose >7.5 mg/day (OR=2.40, 95% CI 1.09 to 5.28; vs no intake) and exposure to rituximab (OR=2.71, 95% CI 1.28 to 5.72; vs conventional synthetic disease-modifying antirheumatic drugs only) were independently associated with severe COVID-19. In addition to these variables, in the sensitivity analyses, male sex (OR range: 1.65-1.83; vs female) was also significantly associated with severe outcomes, while COVID-19 diagnosis after 1 October 2020 (OR range: 0.51-0.59; vs on/before 15 June 2020) was significantly associated with less severe outcomes, but these associations were not significant in the main model (OR=1.57, 95% CI 0.95 to 2.59; and OR=0.61, 95% CI 0.37 to 1.00; respectively).ConclusionsThis is the first large registry data on outcomes of COVID-19 in people with IIM. Older age, male sex, higher comorbidity burden, high disease activity, prednisolone-equivalent dose >7.5 mg/day and rituximab exposure were associated with severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with IIM.

Published
2022

4. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study

Author

Izadi, Zara, Gianfrancesco, Milena A, Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Ja, Clairissa, Taylor, Tiffany, Shidara, Kie, Danila, Maria I, Wysham, Katherine D, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Al-Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y-T, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Duarte-García, Alí, Valenzuela-Almada, Maria O, Ugarte-Gil, Manuel F, Ljung, Lotta, Scirè, Carlo A, Carrara, Greta, Hachulla, Eric, Richez, Christophe, Cacoub, Patrice, Thomas, Thierry, Santos, Maria J, Bernardes, Miguel, Hasseli, Rebecca, Regierer, Anne, Schulze-Koops, Hendrik, Müller-Ladner, Ulf, Pons-Estel, Guillermo, Tanten, Romina, Nieto, Romina E, Pisoni, Cecilia N, Tissera, Yohana S, Xavier, Ricardo, Marques, Claudia D Lopes, Pileggi, Gecilmara CS, Robinson, Philip C, Machado, Pedro M, Sirotich, Emily, Liew, Jean W, Hausmann, Jonathan S, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Gore-Massy, Monique, Wallace, Zachary S, Yazdany, Jinoos, Registry, COVID-19 Global Rheumatology Alliance, Dahou, Brahim, Gómez, Gimena, Roberts, Karen, Baez, Roberto M, Coello, Vanessa V Castro, Salinas, María J Haye, Maldonado, Federico N, Reyes, Alvaro A, Alle, Gelsomina, Ficco, Hernán Maldonado, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan A, Schmid, Maria M, Cosatti, Micaela, Gamba, Maria J, Leandro, Carlevaris, Cusa, María A, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Elkin, Maria S Gálvez, Medina, María A, Savio, Veronica, Tessel, Romina Rojas, Alamino, Rodolfo P, Werner, Marina L, Ornella, Sofía, Casalla, Luciana, de la Vega, Maria, Severina, María, García, Mercedes, and Lucero, Luciana Gonzalez

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Social Determinants of Health, Infectious Diseases, Coronaviruses, Emerging Infectious Diseases, Women's Health, Good Health and Well Being, COVID-19 Global Rheumatology Alliance Registry, Clinical sciences
Abstract

BackgroundDifferences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally.MethodsIn this observational study, we derived individual-level data on adults (aged 18-99 years) with rheumatic disease and a confirmed status of their highest COVID-19 severity level from the COVID-19 Global Rheumatology Alliance (GRA) registry, collected between March 12, 2020, and Aug 27, 2021. Environmental and societal factors were obtained from publicly available sources. The primary endpoint was mortality attributed to COVID-19. We used a multivariable logistic regression to evaluate independent associations between environmental and societal factors and death, after controlling for individual-level risk factors. We used a series of nested mixed-effects models to establish whether environmental and societal factors sufficiently explained country-level variations in death.Findings14 044 patients from 23 countries were included in the analyses. 10 178 (72·5%) individuals were female and 3866 (27·5%) were male, with a mean age of 54·4 years (SD 15·6). Air pollution (odds ratio 1·10 per 10 μg/m3 [95% CI 1·01-1·17]; p=0·0105), proportion of the population aged 65 years or older (1·19 per 1% increase [1·10-1·30]; p

Published
2022

5. Characteristics associated with poor COVID-19 outcomes in individuals with systemic lupus erythematosus: data from the COVID-19 Global Rheumatology Alliance

Author

Ugarte-Gil, Manuel Francisco, Alarcón, Graciela S, Izadi, Zara, Duarte-García, Ali, Reátegui-Sokolova, Cristina, Clarke, Ann Elaine, Wise, Leanna, Pons-Estel, Guillermo J, Santos, Maria Jose, Bernatsky, Sasha, Ribeiro, Sandra Lúcia Euzébio, Al Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y-T, Patel, Naomi J, Gilbert, Emily L, Valenzuela-Almada, Maria O, Jönsen, Andreas, Landolfi, Gianpiero, Fredi, Micaela, Goulenok, Tiphaine, Devaux, Mathilde, Mariette, Xavier, Queyrel, Viviane, Romão, Vasco C, Sequeira, Graca, Hasseli, Rebecca, Hoyer, Bimba, Voll, Reinhard E, Specker, Christof, Baez, Roberto, Castro-Coello, Vanessa, Ficco, Hernan Maldonado, Neto, Edgard Torres Reis, Ferreira, Gilda Aparecida Aparecida, Monticielo, Odirlei Andre André, Sirotich, Emily, Liew, Jean, Hausmann, Jonathan, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Costello, Wendy, Wallace, Zachary S, Jacobsohn, Lindsay, Taylor, Tiffany, Ja, Clairissa, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schäfer, Martin, Machado, Pedro M, Robinson, Philip C, Gianfrancesco, Milena, and Yazdany, Jinoos

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Infectious Diseases, Lupus, Emerging Infectious Diseases, Minority Health, Coronaviruses, Autoimmune Disease, Women's Health, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Inflammatory and immune system, Good Health and Well Being, COVID-19, Humans, Lupus Erythematosus, Systemic, Male, Prednisone, Rheumatology, Severity of Illness Index, lupus erythematosus, systemic, epidemiology, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

AimTo determine characteristics associated with more severe outcomes in a global registry of people with systemic lupus erythematosus (SLE) and COVID-19.MethodsPeople with SLE and COVID-19 reported in the COVID-19 Global Rheumatology Alliance registry from March 2020 to June 2021 were included. The ordinal outcome was defined as: (1) not hospitalised, (2) hospitalised with no oxygenation, (3) hospitalised with any ventilation or oxygenation and (4) death. A multivariable ordinal logistic regression model was constructed to assess the relationship between COVID-19 severity and demographic characteristics, comorbidities, medications and disease activity.ResultsA total of 1606 people with SLE were included. In the multivariable model, older age (OR 1.03, 95% CI 1.02 to 1.04), male sex (1.50, 1.01 to 2.23), prednisone dose (1-5 mg/day 1.86, 1.20 to 2.66, 6-9 mg/day 2.47, 1.24 to 4.86 and ≥10 mg/day 1.95, 1.27 to 2.99), no current treatment (1.80, 1.17 to 2.75), comorbidities (eg, kidney disease 3.51, 2.42 to 5.09, cardiovascular disease/hypertension 1.69, 1.25 to 2.29) and moderate or high SLE disease activity (vs remission; 1.61, 1.02 to 2.54 and 3.94, 2.11 to 7.34, respectively) were associated with more severe outcomes. In age-adjusted and sex-adjusted models, mycophenolate, rituximab and cyclophosphamide were associated with worse outcomes compared with hydroxychloroquine; outcomes were more favourable with methotrexate and belimumab.ConclusionsMore severe COVID-19 outcomes in individuals with SLE are largely driven by demographic factors, comorbidities and untreated or active SLE. Patients using glucocorticoids also experienced more severe outcomes.

Published
2022

6. Earlier vs. later time period of COVID-19 infection and emergent autoimmune signs, symptoms, and serologies

Author

Oakes, Emily G., Dillon, Eilish, Buhler, Katherine A., Guan, Hongshu, Paudel, Misti, Marks, Kathryne, Adejoorin, Ifeoluwakiisi, Yee, Jeong, Ellrodt, Jack, Tedeschi, Sara, Sparks, Jeffrey, Case, Siobhan M., Hsu, Tiffany, Solomon, Daniel H., Jonsson, A. Helena, Alexander, Roberta Vezza, Rao, Deepak A., Choi, May Y., and Costenbader, Karen H.

Published
2024
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7. How Russia, China and Iran Are Interfering in the Presidential Election

Author

Frenkel, Sheera, Hsu, Tiffany, and Myers, Steven Lee

Subjects
Presidents -- Elections, General interest, Facebook (Online social network)
Abstract

Byline: Sheera Frenkel, Tiffany Hsu and Steven Lee Myers Eight years after Russia interfered in the 2016 presidential election, foreign influence with American voters has grown more sophisticated. That could [...]

Published
2024

8. How Russia, China and Iran Are Interfering in the U.S. Election

Author

Frenkel, Sheera, Hsu, Tiffany, and Myers, Steven Lee

Subjects
Disinformation -- Methods -- Political aspects, Presidential elections (United States) -- Social aspects, Company public relations, General interest, News, opinion and commentary
Abstract

Eight years after Russia interfered in the 2016 presidential election, foreign influence with American voters has grown more sophisticated. That could have outsize consequences in the 2024 race. When Russia [...]

Published
2024

10. Twitter Barred Them. Then Musk Decided To Bring Them Back

Author

Conger, Kate, Hsu, Tiffany, and Krolik, Aaron

Subjects
Twitter Inc. -- Services, Information services industry -- Services, Conspiracy theories -- Social aspects, Information services -- Services, Online social networks -- Social aspects, Information services industry, General interest, News, opinion and commentary, Twitter (Online social network) -- Social aspects
Abstract

After Hurricane Helene, Representative Marjorie Taylor Greene, the hard-right conservative from Georgia, shared on X the widely debunked claim that government scientists could control the weather. ''It's ridiculous for anyone [...]

Published
2024

11. Twitter Barred Them. What Happened When Elon Musk Brought Them Back?

Author

Conger, Kate, Hsu, Tiffany, and Krolik, Aaron

Subjects
Scientists in government, Conspiracy theories, Social networks, General interest, Twitter (Online social network)
Abstract

Byline: Kate Conger, Tiffany Hsu and Aaron Krolik After Hurricane Helene, Representative Marjorie Taylor Greene, the hard-right conservative from Georgia, shared on X the widely debunked claim that government scientists [...]

Published
2024

12. Sketchy Websites Find a Haven in Iceland's Privacy Laws

Author

Myers, Steven Lee and Hsu, Tiffany

Subjects
Privacy -- Laws, regulations and rules, Domain names -- Laws, regulations and rules, Fraud -- Laws, regulations and rules, Information services industry -- Location, Web sites -- Laws, regulations and rules, Information services -- Location, Street addresses -- Laws, regulations and rules, Government regulation, Company Web site/Web page, Internet address/domain name, Privacy issue, Information services industry
Abstract

The modern office building near the harbor in Iceland's capital, Reykjavik, is best known as the home of the Icelandic Phallological Museum, which displays 320 specimens of mammal penises. To […]

Published
2024

13. Bizarre Falsehoods About Hurricanes Helene and Milton Disrupt Recovery Efforts

Author

Hsu, Tiffany and Thompson, Stuart A.

Subjects
United States. Federal Emergency Management Agency, Disinformation, Conspiracy theories, Hurricanes, Weather, General interest
Abstract

Byline: Tiffany Hsu and Stuart A. Thompson Experts warn that weather-related disinformation can rapidly escalate into real-world risks and distract from aid. Wildly improbable conspiracy theories about Hurricanes Helene and [...]

Published
2024

14. Bizarre Falsehoods Disrupt Hurricane Recovery Efforts

Author

Hsu, Tiffany and Thompson, Stuart A.

Subjects
United States. Federal Emergency Management Agency -- Powers and duties, Hurricane Milton, 2024, Hurricane Helene, 2024, Disinformation -- Forecasts and trends, Social media -- Influence, Conspiracy theories -- Forecasts and trends, Hurricanes -- Influence -- Political aspects -- United States, Market trend/market analysis, General interest, News, opinion and commentary
Abstract

Experts warn that weather-related disinformation can rapidly escalate into real-world risks and distract from aid. Wildly improbable conspiracy theories about Hurricanes Helene and Milton have spread largely unchecked on social [...]

Published
2024

15. Some of the Web's Sketchiest Sites Share an Address in Iceland

Author

Myers, Steven Lee and Hsu, Tiffany

Subjects
Company Web site/Web page, Privacy issue, Facebook (Online social network), Privacy, Fraud, Disinformation, Commercial real estate, Identity theft, Web sites
Abstract

Byline: Steven Lee Myers and Tiffany Hsu The modern office building near the harbor in Iceland's capital, Reykjavik, is best known as the home of the Icelandic Phallological Museum, which [...]

Published
2024

16. Another Hurdle in Recovery From Helene: Misinformation Is Getting in the Way

Author

Cochrane, Emily, Flavelle, Christopher, Shear, Michael D., and Hsu, Tiffany

Subjects
Search and rescue operations, Conspiracy theories, United States. Federal Emergency Management Agency, Hurricane Helene, 2024
Abstract

Byline: Emily Cochrane, Christopher Flavelle, Michael D. Shear and Tiffany Hsu In North Carolina and other states, a barrage of conspiracy theories and false claims over efforts to bring relief [...]

Published
2024

17. Disinformation Is Hampering Helene Recovery

Author

Cochrane, Emily, Flavelle, Christopher, Shear, Michael D., and Hsu, Tiffany

Subjects
Company business management, Company distribution practices, Disinformation -- Influence, Search and rescue operations -- Management, Post-disaster reconstruction -- Management, Conspiracy theories -- Influence, Disaster relief -- Distribution -- United States, Hurricane Helene, 2024
Abstract

In North Carolina and other states, a barrage of conspiracy theories and false claims over efforts to bring relief after Hurricane Helene is alarming and disheartening officials and workers. In [...]

Published
2024

18. Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study

Author

Sattui, Sebastian E, Conway, Richard, Putman, Michael S, Seet, Andrea M, Gianfrancesco, Milena A, Beins, Kaley, Hill, Catherine, Liew, David, Mackie, Sarah L, Mehta, Puja, Neill, Lorna, Gomez, Gimena, Salinas, Maria Isabel Haye, Maldonado, Federico Nicolas, Mariz, Henrique Ataide, de Sousa Studart, Samia Araujo, Araujo, Nafice Costa, Knight, Ann, Rozza, Davide, Quartuccio, Luca, Samson, Maxime, Bally, Stéphane, Maria, Alexandre TJ, Chazerain, Pascal, Hasseli, Rebecca, Müller-Ladner, Ulf, Hoyer, Bimba F, Voll, Reinhard, Torres, Rita Pinheiro, Luis, Mariana, Ribeirio, Sandra Lucia Euzebio, Al-Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y-T, D’Silva, Kristin M, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Almada, Maria Valenzuela, Duarte-García, Alí, Ugarte-Gil, Manuel, Jacobsohn, Lindsay, Izadi, Zara, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Sirotich, Emily, Hausmann, Jonathan S, Sufka, Paul, Bhana, Suleman, Liew, Jean W, Grainger, Rebecca, Machado, Pedro M, Wallace, Zachary S, Yazdany, Jinoos, Robinson, Philip C, Alliance, Global Rheumatology, Dahou, Brahim, Rath, Eva, Piette, Yves, Devinck, Mieke, Maeyaert, Bea, Ribeiro, Francinne Machado, Ribeiro, Sandra Lucia Euzebio, Pinheiro, Marcelo, Quintana, Rosana, Gómez, Gimena, Roberts, Karen, Baez, Roberto Miguel, Coello, Vanessa Castro, Salinas, María J Haye, Torres, Alvaro Andres Reyes, Alle, Gelsomina, Tanten, Romina, Ficco, Hernán Maldonado, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan Alejandro, Schmid, Maria Marcela, Cosatti, Micaela, Gamba, Maria Julieta, Leandro, Carlevaris, Cusa, María Alejandra, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Elkin, Maria Soledad Gálvez, Medina, María Alejandra, and Savio, Veronica

Subjects
Aging, Arthritis, Autoimmune Disease, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Inflammatory and immune system, Global Rheumatology Alliance
Abstract

BackgroundPatients with primary systemic vasculitis or polymyalgia rheumatica might be at a high risk for poor COVID-19 outcomes due to the treatments used, the potential organ damage cause by primary systemic vasculitis, and the demographic factors associated with these conditions. We therefore aimed to investigate factors associated with COVID-19 outcomes in patients with primary systemic vasculitis or polymyalgia rheumatica.MethodsIn this retrospective cohort study, adult patients (aged ≥18 years) diagnosed with COVID-19 between March 12, 2020, and April 12, 2021, who had a history of primary systemic vasculitis (antineutrophil cytoplasmic antibody [ANCA]-associated vasculitis, giant cell arteritis, Behçet's syndrome, or other vasculitis) or polymyalgia rheumatica, and were reported to the COVID-19 Global Rheumatology Alliance registry were included. To assess COVID-19 outcomes in patients, we used an ordinal COVID-19 severity scale, defined as: (1) no hospitalisation; (2) hospitalisation without supplemental oxygen; (3) hospitalisation with any supplemental oxygen or ventilation; or (4) death. Multivariable ordinal logistic regression analyses were used to estimate odds ratios (ORs), adjusting for age, sex, time period, number of comorbidities, smoking status, obesity, glucocorticoid use, disease activity, region, and medication category. Analyses were also stratified by type of rheumatic disease.FindingsOf 1202 eligible patients identified in the registry, 733 (61·0%) were women and 469 (39·0%) were men, and their mean age was 63·8 years (SD 17·1). A total of 374 (31·1%) patients had polymyalgia rheumatica, 353 (29·4%) had ANCA-associated vasculitis, 183 (15·2%) had giant cell arteritis, 112 (9·3%) had Behçet's syndrome, and 180 (15·0%) had other vasculitis. Of 1020 (84·9%) patients with outcome data, 512 (50·2%) were not hospitalised, 114 (11·2%) were hospitalised and did not receive supplemental oxygen, 239 (23·4%) were hospitalised and received ventilation or supplemental oxygen, and 155 (15·2%) died. A higher odds of poor COVID-19 outcomes were observed in patients who were older (per each additional decade of life OR 1·44 [95% CI 1·31-1·57]), were male compared with female (1·38 [1·05-1·80]), had more comorbidities (per each additional comorbidity 1·39 [1·23-1·58]), were taking 10 mg/day or more of prednisolone compared with none (2·14 [1·50-3·04]), or had moderate, or high or severe disease activity compared with those who had disease remission or low disease activity (2·12 [1·49-3·02]). Risk factors varied among different disease subtypes.InterpretationAmong patients with primary systemic vasculitis and polymyalgia rheumatica, severe COVID-19 outcomes were associated with variable and largely unmodifiable risk factors, such as age, sex, and number of comorbidities, as well as treatments, including high-dose glucocorticoids. Our results could be used to inform mitigation strategies for patients with these diseases.FundingAmerican College of Rheumatology and the European Alliance of Associations for Rheumatology.

Published
2021

19. Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry

Author

Sparks, Jeffrey A, Wallace, Zachary S, Seet, Andrea M, Gianfrancesco, Milena A, Izadi, Zara, Hyrich, Kimme L, Strangfeld, Anja, Gossec, Laure, Carmona, Loreto, Mateus, Elsa F, Lawson-Tovey, Saskia, Trupin, Laura, Rush, Stephanie, Katz, Patricia, Schmajuk, Gabriela, Jacobsohn, Lindsay, Wise, Leanna, Gilbert, Emily L, Duarte-García, Ali, Valenzuela-Almada, Maria O, Pons-Estel, Guillermo J, Isnardi, Carolina A, Berbotto, Guillermo A, Hsu, Tiffany Y-T, D’Silva, Kristin M, Patel, Naomi J, Kearsley-Fleet, Lianne, Schäfer, Martin, Ribeiro, Sandra Lúcia Euzébio, Al Emadi, Samar, Tidblad, Liselotte, Scirè, Carlo Alberto, Raffeiner, Bernd, Thomas, Thierry, Flipo, René-Marc, Avouac, Jérôme, Seror, Raphaèle, Bernardes, Miguel, Cunha, Maria Margarida, Hasseli, Rebecca, Schulze-Koops, Hendrik, Müller-Ladner, Ulf, Specker, Christof, de Souza, Viviane Angelina, da Mota, Licia Maria Henrique, Gomides, Ana Paula Monteiro, Dieudé, Philippe, Nikiphorou, Elena, Kronzer, Vanessa L, Singh, Namrata, Ugarte-Gil, Manuel F, Wallace, Beth, Akpabio, Akpabio, Thomas, Ranjeny, Bhana, Suleman, Costello, Wendy, Grainger, Rebecca, Hausmann, Jonathan S, Liew, Jean W, Sirotich, Emily, Sufka, Paul, Robinson, Philip C, Machado, Pedro M, Yazdany, Jinoos, Dahou, Brahim, Quintana, Rosana, Gómez, Gimena, Roberts, Karen, Baez, Roberto Miguel, Coello, Vanessa Castro, Salinas, María Haye, Maldonado, Federico Nicolas, Reyes, Alvaro Andres, Alle, Gelsomina, Tanten, Romina, Ficco, Hernán Maldonado, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan Alejandro, Schmid, Maria Marcela, Cosatti, Micaela, Gamba, Maria Julieta, Leandro, Carlevaris, Cusa, María Alejandra, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Elkin, Maria Soledad, Medina, María Alejandra, Savio, Veronica, Tessel, Ivana Romina, Alamino, Rodolfo Perez, Werner, Marina Laura, Ornella, Sofía, and Casalla, Luciana

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Emerging Infectious Diseases, Rheumatoid Arthritis, Autoimmune Disease, Infectious Diseases, Arthritis, Coronaviruses, 6.1 Pharmaceuticals, Inflammatory and immune system, Good Health and Well Being, Aged, Antirheumatic Agents, Arthritis, Rheumatoid, COVID-19, Female, Humans, Male, Middle Aged, Registries, SARS-CoV-2, Severity of Illness Index, COVID-19 Global Rheumatology Alliance, Covid-19, abatacept, rheumatoid arthritis, rituximab, tumour necrosis factor inhibitors, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

ObjectiveTo investigate baseline use of biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis (RA).MethodsWe analysed the COVID-19 Global Rheumatology Alliance physician registry (from 24 March 2020 to 12 April 2021). We investigated b/tsDMARD use for RA at the clinical onset of COVID-19 (baseline): abatacept (ABA), rituximab (RTX), Janus kinase inhibitors (JAKi), interleukin 6 inhibitors (IL-6i) or tumour necrosis factor inhibitors (TNFi, reference group). The ordinal COVID-19 severity outcome was (1) no hospitalisation, (2) hospitalisation without oxygen, (3) hospitalisation with oxygen/ventilation or (4) death. We used ordinal logistic regression to estimate the OR (odds of being one level higher on the ordinal outcome) for each drug class compared with TNFi, adjusting for potential baseline confounders.ResultsOf 2869 people with RA (mean age 56.7 years, 80.8% female) on b/tsDMARD at the onset of COVID-19, there were 237 on ABA, 364 on RTX, 317 on IL-6i, 563 on JAKi and 1388 on TNFi. Overall, 613 (21%) were hospitalised and 157 (5.5%) died. RTX (OR 4.15, 95% CI 3.16 to 5.44) and JAKi (OR 2.06, 95% CI 1.60 to 2.65) were each associated with worse COVID-19 severity compared with TNFi. There were no associations between ABA or IL6i and COVID-19 severity.ConclusionsPeople with RA treated with RTX or JAKi had worse COVID-19 severity than those on TNFi. The strong association of RTX and JAKi use with poor COVID-19 outcomes highlights prioritisation of risk mitigation strategies for these people.

Published
2021

20. Association of Race and Ethnicity With COVID‐19 Outcomes in Rheumatic Disease: Data From the COVID‐19 Global Rheumatology Alliance Physician Registry

Author

Gianfrancesco, Milena A, Leykina, Liza A, Izadi, Zara, Taylor, Tiffany, Sparks, Jeffrey A, Harrison, Carly, Trupin, Laura, Rush, Stephanie, Schmajuk, Gabriela, Katz, Patricia, Jacobsohn, Lindsay, Hsu, Tiffany Y, D’Silva, Kristin M, Serling‐Boyd, Naomi, Wallwork, Rachel, Todd, Derrick J, Bhana, Suleman, Costello, Wendy, Grainger, Rebecca, Hausmann, Jonathan S, Liew, Jean W, Sirotich, Emily, Sufka, Paul, Wallace, Zachary S, Machado, Pedro M, Robinson, Philip C, Yazdany, Jinoos, and Alliance, the COVID‐19 Global Rheumatology

Subjects
Arthritis, Autoimmune Disease, Good Health and Well Being, Adolescent, Adult, Aged, COVID-19, Cross-Sectional Studies, Ethnicity, Female, Hospitalization, Humans, Male, Middle Aged, Odds Ratio, Racial Groups, Registries, Respiration, Artificial, Rheumatic Diseases, Rheumatology, SARS-CoV-2, United States, Young Adult, COVID-19 Global Rheumatology Alliance, Clinical Sciences, Immunology, Public Health and Health Services, Arthritis & Rheumatology
Abstract

ObjectiveRacial/ethnic minorities experience more severe outcomes of coronavirus disease 2019 (COVID-19) in the general US population. This study was undertaken to examine the association between race/ethnicity and COVID-19 hospitalization, ventilation status, and mortality in people with rheumatic disease.MethodsUS patients with rheumatic disease and COVID-19 were entered into the COVID-19 Global Rheumatology Alliance physician registry between March 24, 2020 and August 26, 2020 were included. Race/ethnicity was defined as White, African American, Latinx, Asian, or other/mixed race. Outcome measures included hospitalization, requirement for ventilatory support, and death. Multivariable regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) adjusted for age, sex, smoking status, rheumatic disease diagnosis, comorbidities, medication use prior to infection, and rheumatic disease activity.ResultsA total of 1,324 patients were included, of whom 36% were hospitalized and 6% died; 26% of hospitalized patients required mechanical ventilation. In multivariable models, African American patients (OR 2.74 [95% CI 1.90-3.95]), Latinx patients (OR 1.71 [95% CI 1.18-2.49]), and Asian patients (OR 2.69 [95% CI 1.16-6.24]) had higher odds of hospitalization compared to White patients. Latinx patients also had 3-fold increased odds of requiring ventilatory support (OR 3.25 [95% CI 1.75-6.05]). No differences in mortality based on race/ethnicity were found, though power to detect associations may have been limited.ConclusionSimilar to findings in the general US population, racial/ethnic minorities with rheumatic disease and COVID-19 had increased odds of hospitalization and ventilatory support. These results illustrate significant health disparities related to COVID-19 in people with rheumatic diseases. The rheumatology community should proactively address the needs of patients currently experiencing inequitable health outcomes during the pandemic.

Published
2021

21. Why Debunked Falsehoods About Haitian Migrants Gained Traction

Author

Hsu, Tiffany

Subjects
Disinformation, News, opinion and commentary
Abstract

The racist and inflammatory narrative spread on the backs of memes, greed, biases and news deserts. https://www.nytimes.com/by/tiffany-hsu The false narrative that Haitian immigrants in Springfield, Ohio, were https://www.nytimes.com/2024/09/10/technology/trump-dead-cats-migrants-ohio.html was quickly [...]

Published
2024

22. On YouTube, Major Brands' Ads Appear Alongside Racist Falsehoods About Haitian Immigrants

Author

Hsu, Tiffany and Thompson, Stuart A.

Subjects
Transportation equipment industry -- Officials and employees, Computer software industry -- Officials and employees, Advertising, Immigrants, Advertising executives, Mazda Motor Corp. -- Advertising -- Officials and employees
Abstract

Byline: Tiffany Hsu and Stuart A. Thompson Large organizations and brands saw their advertising dollars funneled to videos amplifying inflammatory narratives, underscoring how difficult it can be to maintain brand [...]

Published
2024

23. Brands Find Racist Videos Next to Ads

Author

Hsu, Tiffany and Thompson, Stuart A.

Subjects
Internet/Web advertising, Mass media industry -- Advertising, Internet/Web advertising -- Political aspects, Racism -- Media coverage, Hate crimes -- Media coverage, YouTube L.L.C. -- Advertising
Abstract

Large organizations and brands saw their advertising dollars funneled to videos amplifying inflammatory narratives, underscoring how difficult it can be to maintain brand safety online. On YouTube, an ad for [...]

Published
2024

24. Iran Ramps Up Fake News Threat in U.S. Election

Author

Myers, Steven Lee, Hsu, Tiffany, and Fassihi, Farnaz

Subjects
Disinformation -- Forecasts and trends, Propaganda -- Forecasts and trends, Presidential elections (United States) -- Forecasts and trends, Market trend/market analysis, General interest, News, opinion and commentary
Abstract

With a flurry of hacks and fake websites, Iran has intensified its efforts to discredit American democracy and possibly tip the race against former President Donald Trump. A website called [...]

Published
2024

25. Left Sows Misinformation of Its Own

Author

Thompson, Stuart A. and Hsu, Tiffany

Subjects
Electioneering -- Forecasts and trends, Right and left (Political science) -- Forecasts and trends, Social media -- Forecasts and trends, Political campaigns -- Forecasts and trends, Conspiracy theories -- Forecasts and trends, Market trend/market analysis, General interest, News, opinion and commentary
Abstract

America's right flank remains the chief purveyor of misinformation, but this summer's political tumult created ideal conditions for falsehoods to spread among progressives. Several elected officials, along with a top [...]

Published
2024

26. Elections Officials Battle a Deluge of Disinformation

Author

Hsu, Tiffany

Subjects
Voting-machines, Elections, Disinformation, Conspiracy theories, General interest
Abstract

Byline: Tiffany Hsu Tate Fall is overwhelmed. When she signed on to be director of elections in Cobb County, Ga., last year, she knew she'd be registering voters and recruiting [...]

Published
2024

27. Officials Battle Disinformation Deluging Voters

Author

Hsu, Tiffany

Subjects
Voting-machines, Disinformation, Conspiracy theories, General interest, News, opinion and commentary
Abstract

Tate Fall is overwhelmed. When she signed on to be director of elections in Cobb County, Ga., last year, she knew she'd be registering voters and recruiting poll workers, maybe [...]

Published
2024

28. Ad Coalition Closes After X Lawsuit Accuses It of Antitrust Violations

Author

Conger, Kate and Hsu, Tiffany

Subjects
Twitter Inc. -- Cases, Antitrust law -- Cases, Information services industry -- Cases, Commercial associations -- Organization dissolution -- Cases, Information services -- Cases, Company legal issue, Antitrust issue, Information services industry, General interest, News, opinion and commentary
Abstract

The Global Alliance for Responsible Media will dissolve after Mr. Musk accused the group of orchestrating a boycott. An influential advertising industry group said it would shut down after being [...]

Published
2024

29. Advertising Coalition Shuts Down After X, Owned by Elon Musk, Sues

Author

Conger, Kate and Hsu, Tiffany

Subjects
Advertising -- Cases, Company legal issue, News, opinion and commentary, World Federation of Advertisers -- Cases
Abstract

The Global Alliance for Responsible Media will dissolve after Mr. Musk accused the group of orchestrating a boycott. An influential advertising industry group said it would shut down after being [...]

Published
2024

30. Harris Campaign Faces a Faster, Uglier Version of the Internet

Author

Hsu, Tiffany, Thompson, Stuart A., and Myers, Steven Lee

Subjects
Electioneering, Sexism -- Political aspects, Racism -- Political aspects, Social media -- Political aspects, Political campaigns, Conspiracy theories -- Forecasts and trends, Vice-Presidents -- Political activity, Market trend/market analysis, General interest, News, opinion and commentary, Democratic Party (United States) -- Political activity
Abstract

Politicians have long faced racist and sexist attacks online. But Ms. Harris is being attacked on more platforms, with new technologies and in front of bigger audiences than Barack Obama [...]

Published
2024

31. A Volatile Election Is Intensifying Conspiracy Theories Online

Author

Myers, Steven Lee, Thompson, Stuart A., and Hsu, Tiffany

Subjects
Assassination, Presidents -- Elections, Conspiracy theories, Ex-presidents, General interest, Truth Social (Online social network)
Abstract

Byline: Steven Lee Myers, Stuart A. Thompson and Tiffany Hsu Users on X, Truth Social, Rumble and Gab have benefited from a series of major events to spread baseless falsehoods [...]

Published
2024

32. Tackling the Falsehoods About Kamala Harris

Author

Hsu, Tiffany

Subjects
Disinformation -- Political aspects, News, opinion and commentary
Abstract

The likely Democratic presidential nominee faces toxic discourse unlike anything Biden ever has. https://www.nytimes.com/by/tiffany-hsu Vice President Kamala Harris has been campaigning for president for three days. And she is already [...]

Published
2024

34. First, Gunshots. Moments Later, Disinformation

Author

Hsu, Tiffany, Frenkel, Sheera, and Bensinger, Ken

Subjects
Electioneering, Disinformation -- Forecasts and trends, Social media -- Forecasts and trends, Political campaigns, Presidential candidates -- Political activity -- Crimes against, Conspiracy theories -- Forecasts and trends, Company legal issue, Market trend/market analysis, General interest, News, opinion and commentary
Abstract

Claims that President Biden and his allies ordered the attack on Donald J. Trump, or that Mr. Trump staged the attack, started quickly and spread fast across social media. Four [...]

Published
2024

35. A Struggle To Debunk Fake News

Author

Hsu, Tiffany and Thompson, Stuart A.

Subjects
Disinformation, General interest, News, opinion and commentary
Abstract

To fight disinformation in a chaotic election year, Ruth Quint, a volunteer for a nonpartisan civic group in Pennsylvania, is relying on tactics both extensively studied and frequently deployed. Many [...]

Published
2024

36. Even Disinformation Experts Don't Know How to Stop It

Author

Hsu, Tiffany and Thompson, Stuart A.

Subjects
Disinformation, General interest
Abstract

Byline: Tiffany Hsu and Stuart A. Thompson To fight disinformation in a chaotic election year, Ruth Quint, a volunteer for a nonpartisan civic group in Pennsylvania, is relying on tactics [...]

Published
2024

37. Social Media Platforms Deluged by Unsubstantiated Claims About Trump Rally

Author

Frenkel, Sheera and Hsu, Tiffany

Subjects
Disinformation, Social media, Web site management software, Ex-presidents, Web site management software, News, opinion and commentary
Abstract

Disinformation experts immediately urged caution, warning people not to jump to conclusions. Unsubstantiated claims about what took place at Saturday’s rally in Butler, Pa., immediately flooded social media after former [...]

Published
2024

38. New Tactic in China's Information War: Harassing a Critic's Child in the U.S

Author

Myers, Steven Lee and Hsu, Tiffany

Subjects
Communism -- China, Children and war, Propaganda, General interest, Facebook (Online social network)
Abstract

Byline: Steven Lee Myers and Tiffany Hsu Deng Yuwen, a prominent Chinese writer who now lives in exile in the suburbs of Philadelphia, has regularly criticized China and its authoritarian [...]

Published
2024

39. Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.

Author

Brar, Gurpreet, Farhat, Nisar A, Sukhina, Alisa, Lam, Alex K, Kim, Yong Hoon, Hsu, Tiffany, Tong, Leming, Lin, Wai Wai, Ware, Carl F, Blackman, Marcia A, Sun, Ren, and Wu, Ting-Ting

Subjects
Vaccine Related, Genetics, Emerging Infectious Diseases, Immunization, Biotechnology, Infectious Diseases, Prevention, Cancer, 3.4 Vaccines, 2.1 Biological and endogenous factors, Infection
Abstract

Vaccines based on live attenuated viruses often induce broad, multifaceted immune responses. However, they also usually sacrifice immunogenicity for attenuation. It is particularly difficult to elicit an effective vaccine for herpesviruses due to an armament of immune evasion genes and a latent phase. Here, to overcome the limitation of attenuation, we developed a rational herpesvirus vaccine in which viral immune evasion genes were deleted to enhance immunogenicity while also attaining safety. To test this vaccine strategy, we utilized murine gammaherpesvirus-68 (MHV-68) as a proof-of-concept model for the cancer-associated human γ-herpesviruses, Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus. We engineered a recombinant MHV-68 virus by targeted inactivation of viral antagonists of type I interferon (IFN-I) pathway and deletion of the latency locus responsible for persistent infection. This recombinant virus is highly attenuated with no measurable capacity for replication, latency, or persistence in immunocompetent hosts. It stimulates robust innate immunity, differentiates virus-specific memory T cells, and elicits neutralizing antibodies. A single vaccination affords durable protection that blocks the establishment of latency following challenge with the wild type MHV-68 for at least six months post-vaccination. These results provide a framework for effective vaccination against cancer-associated herpesviruses through the elimination of latency and key immune evasion mechanisms from the pathogen.

Published
2020

40. Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study

Author

Dahou, Brahim, Rath, Eva, Piette, Yves, Devinck, Mieke, Maeyaert, Bea, Machado Ribeiro, Francinne, Euzebio Ribeiro, Sandra Lucia, Pinheiro, Marcelo, Quintana, Rosana, Gómez, Gimena, Roberts, Karen, Baez, Roberto Miguel, Castro Coello, Vanessa, Haye Salinas, María J., Maldonado, Federico Nicolas, Reyes Torres, Alvaro Andres, Alle, Gelsomina, Tanten, Romina, Maldonado Ficco, Hernán, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan Alejandro, Schmid, Maria Marcela, Cosatti, Micaela, Gamba, Maria Julieta, Leandro, Carlevaris, Cusa, María Alejandra, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Gálvez Elkin, Maria Soledad, Medina, María Alejandra, Savio, Veronica, Rojas Tessel, Ivana Romina, Perez Alamino, Rodolfo, Werner, Marina Laura, Ornella, Sofía, Casalla, Luciana, de la Vega, Maria, Severina, María, García, Mercedes, Gonzalez Lucero, Luciana, Romeo, Cecilia, Moyano, Sebastián, Barbich, Tatiana, Bertoli, Ana, Baños, Andrea, Petruzzelli, Sandra, Matellan, Carla, Conti, Silvana, Lazaro, Ma. Alicia, Rodriguez Gil, Gustavo Fabián, Risueño, Fabian, Quaglia, Maria Isabel, Scafati, Julia, Cuchiaro, Natalia Lili, Rebak, Jonathan Eliseo, Pineda, Susana Isabel, Calvo, María Elena, Picco, Eugenia, Gallino Yanzi, Josefina, Maid, Pablo, Guaglianone, Debora, Morbiducci, Julieta Silvana, Porta, Sabrina, Herscovich, Natalia, Velasco Zamora, José Luis, Kisluk, Boris, Castaños Menescardi, Maria Sol, Gallo, Rosana, Martire, María Victoria, Maldini, Carla, Goizueta, Cecilia, de la Vega Fernandez, Sabrina Solange, Aeschlimann, Carolina, Subils, Gisela, Ibáñez, Sebastián, Chassin-Trubert, Anne-Marie, Dong, Lingli, Cajas, Lui, Barešic, Marko, Anic, Branimir, Culo, Melanie-Ivana, Pavelic, Tea Ahel, Kovacevic Stranski, Kristina, Karanovic, Boris, Vencovsky, Jiri, Píchová, Marta, Filkova, Maria, Hamoud, Hesham, Vassilopoulos, Dimitrios, Guzman Melgar, Gabriela Maria, So, Ho, Király, Márta, Vojdanian, Mahdi, Balbir-Gurman, Alexandra, Abutiban, Fatemah, Zepa, Julija, Bulina, Inita, Bukauskiene, Loreta, Zaueta, Beatriz, Castillo Ortiz, Angel Alejandro, Zamora Tehozol, Erick, Vega, David, Cervántes Rosete, Diana, Martín Nares, Eduardo, Rodriguez-Reyna, Tatiana Sofia, Rull Gabayet, Marina, Alpízar-Rodríguez, Deshiré, Irazoque, Fedra, Jimenez, Xochitl, Geurts-van Bon, Lenny, Zijlstra, Theo, Hoekstra, Monique, Al-Adhoubi, Nasra, Salim, Babur, Giraldo, Enrique, Salinas, Ariel, Ugarte-Gil, Manuel, Nowakowski, Jaroslaw, Al-Emadi, Samar, Conway, Richard, Flood, Rachael, McCarthy, Geraldine, Felea, Ioana, Filipescu, Ileana, Rednic, Simona, Groseanu, Laura, Tamas, Maria Magdelena, Mlynarikova, Vanda, Skamlova, Martina, Zlnay, Martin, Miceková, Dagmar, Capova, Lubica, Macejova, Zelmira, Štenová, Emoke, Raffayova, Helena, Belakova, Gabriela, Strakova, Eva, Sencarová, Marieta, Žlnayová, Sona, Anna Sabová, Anna, Spisakova, Daniela, Oetterová, Mária, Lukacova, Olga, Bakosova, Martina, Hocevar, Alojzija, de la Torre-Rubio, Natalia, Alegre Sancho, Juan José, Corteguera Coro, Montserrat, Cobeta Garcia, Juan Carlos, Torres Martin, Maria Carmen, Campos, Jose, Gomez Puerta, Jose A, Yardimci, Gozd Kubra, Akar, Servet, Icacan, Ozan Cemal, Çelik, Selda, Vasylets, Viktoriia, Yeoh, Su-Ann, Vandevelde, Claire, Dunt, Sasha, Leeder, Jane, Macphie, Elizabeth, Salerno, Rosaria, Graver, Christine, Williams, Katie, O'Reilly, Sheila, Devine, Kirsty, Tyler, Jennifer, Warner, Elizabeth, Pilcher, James, Patel, Samir, Nikiphorou, Elena, Chadwick, Laura, Jones, Caroline Mulvaney, Harrison, Beverley, Thornton, Lucy, O'Kane, Diana, Fusi, Lucia, Low, Audrey, Horton, Sarah, Jatwani, Shraddha, Baig, Sara, Bajwa, Hammad, Berglund, Vernon, Dahle, Angela, Dorman, Walter, Hargrove, Jody, Hilton, Maren, Lebedoff, Nicholas, Leonard, Susan, Morgan, Jennifer, Pfeifer, Emily, Skemp, Archibald, Wilson, Jeffrey, Wolff, Anne, Cepeda, Eduardo, D'Silva, Kristin, Hsu, Tiffany, Patel, Naomi, Sparks, Jeffrey, Todd, Derrick, Wallace, Zachary, Hare, Denise, Calabrese, Cassandra, Adams, Christopher, Khosroshahi, Arezou, Kilian, Adam, White, Douglas, Winter, Melanie, Fields, Theodore, Siegel, Caroline, Daver, Nicole, Harvey, Melissa, Kramer, Neil, Lamore, Concetta, Hogarty, Suneya, Yeter, Karen, Wise, Leanna, Siddique, Faizah, Ban, Byung, Tanner, Tamar, Ruderman, Eric, Davis, William, Quinet, Robert, Scopelitis, Evangeline, Toribio Toribio, Karen, Webb-Detiege, Tameka, Zakem, Jerald, Abbass, Khurram, Kepecs, Gilbert, Miranda, Lilliam, Guma, Michael, Haikal, Ammar, Mody, Sushama, Mueller, Daric, Jayatilleke, Arundathi, Zell, JoAnn, Bays, Alison, Dao, Kathryn, Fatemeh, Ezzati, Parks, Deborah, Karp, David, Quiceno, Guillermo, Sattui, Sebastian E, Putman, Michael S, Seet, Andrea M, Gianfrancesco, Milena A, Beins, Kaley, Hill, Catherine, Liew, David, Mackie, Sarah L, Mehta, Puja, Neill, Lorna, Gomez, Gimena, Salinas, Maria Isabel Haye, Mariz, Henrique Ataide, de Sousa Studart, Samia Araujo, Araujo, Nafice Costa, Knight, Ann, Rozza, Davide, Quartuccio, Luca, Samson, Maxime, Bally, Stéphane, Maria, Alexandre TJ, Chazerain, Pascal, Hasseli, Rebecca, Müller-Ladner, Ulf, Hoyer, Bimba F, Voll, Reinhard, Torres, Rita Pinheiro, Luis, Mariana, Ribeirio, Sandra Lucia Euzebio, Sparks, Jeffrey A, Hsu, Tiffany Y-T, D’Silva, Kristin M, Patel, Naomi J, Gilbert, Emily, Almada, Maria Valenzuela, Duarte-García, Alí, Jacobsohn, Lindsay, Izadi, Zara, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Sirotich, Emily, Hausmann, Jonathan S, Sufka, Paul, Bhana, Suleman, Liew, Jean W, Grainger, Rebecca, Machado, Pedro M, Wallace, Zachary S, Yazdany, Jinoos, and Robinson, Philip C

Published
2021
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41. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study

Author

Dahou, Brahim, Gómez, Gimena, Roberts, Karen, Baez, Roberto M, Castro Coello, Vanessa V, Haye Salinas, María J, Maldonado, Federico N, Reyes, Alvaro A, Alle, Gelsomina, Tanten, Romina, Maldonado Ficco, Hernán, Nieto, Romina, Gobbi, Carla, Tissera, Yohana, Pisoni, Cecilia, Paula, Alba, Albiero, Juan A, Schmid, Maria M, Cosatti, Micaela, Gamba, Maria J, Leandro, Carlevaris, Cusa, María A, German, Noelia, Bellomio, Veronica, Takashima, Lorena, Pera, Mariana, Cogo, Karina, Gálvez Elkin, Maria S, Medina, María A, Savio, Veronica, Rojas Tessel, Romina, Alamino, Rodolfo P, Werner, Marina L, Ornella, Sofía, Casalla, Luciana, de la Vega, Maria, Severina, María, García, Mercedes, Gonzalez Lucero, Luciana, Romeo, Cecilia, Moyano, Sebastián, Barbich, Tatiana, Bertoli, Ana, Baños, Andrea, Petruzzelli, Sandra, Matellan, Carla, Conti, Silvana, Lazaro, Maria A, Rodriguez Gil, Gustavo F, Risueño, Fabian, Quaglia, Maria I, Scafati, Julia, Cuchiaro, Natalia L, Rebak, Jonathan E, Pineda, Susana I, Calvo, María E, Picco, Eugenia, Yanzi, Josefina G, Maid, Pablo, Guaglianone, Debora, Morbiducci, Julieta S, Porta, Sabrina, Herscovich, Natalia, Velasco Zamora, José L, Kisluk, Boris, Castaños Menescardi, Maria S, Gallo, Rosana, Martire, María V, Maldini, Carla, Goizueta, Cecilia, de la Vega Fernandez, Sabrina S, Aeschlimann, Carolina, Subils, Gisela, Rath, Eva, Piette, Yves, Devinck, Mieke, Maeyaert, Bea, Machado Ribeiro, Francinne, Euzebio Ribeiro, Sandra L, Pinheiro, Marcelo, Ibáñez, Sebastián, Chassin Trubert, Anne-Marie, Dong, Lingli, Cajas, Lui, Barešić, Marko, Anić, Branimir, Ćulo, Melanie-Ivana, Pavelić, Tea A, Stranski, Kristina K, Karanovic, Boris, Vencovsky, Jiri, Píchová, Marta, Filkova, Maria, Hamoud, Hesham, Vassilopoulos, Dimitrios, Guzman Melgar, Gabriela M, So, Ho, Király, Márta, Vojdanian, Mahdi, Balbir Gurman, Alexandra, Abutiban, Fatemah, Zepa, Julija, Bulina, Inita, Bukauskiene, Loreta, Zazueta Montiel, Beatriz E, Castillo Ortiz, Angel A, Zamora Tehozol, Erick, Vega Morales, David, Cervántes Rosete, Diana, Martín Nares, Eduardo, Rodriguez Reyna, Tatiana S, Rull Gabayet, Marina, Alpízar Rodríguez, Deshiré, Irazoque, Fedra, Jimenez, Xochitl, Geurts van Bon, Lenny, Zijlstra, Theo, Hoekstra, Monique, Al Adhoubi, Nasra, Salim, Babur, Giraldo, Enrique, Salinas, Ariel, Ugarte Gil, Manuel, Nowakowski, Jarosław, Conway, Richard, Flood, Rachael, McCarthy, Geraldine, Felea, Ioana, Filipescu, Ileana, Rednic, Simona, Groseanu, Laura, Tamas, Maria M, Mlynarikova, Vanda, Skamlova, Martina, Zlnay, Martin, Mičeková, Dagmar, Capova, Lubica, Macejova, Zelmira, Šteňová, Emőke, Raffayova, Helena, Belakova, Gabriela, Strakova, Eva, Senčarová, Marieta, Žlnayová, Soňa, Sabová, Anna, Spisakova, Daniela, Oetterová, Mária, Lukacova, Olga, Bakosova, Martina, Hocevar, Alojzija, de la Torre Rubio, Natalia, Alegre Sancho, Juan J, Corteguera Coro, Montserrat, Cobeta Garcia, Juan C, Torres Martin, Maria C, Campos, Jose, Gomez Puerta, Jose A, Yardimci, Gozd K, Akar, Servet, Icacan, Ozan C, ÇELİK, Selda, Vasylets, Viktoriia, Yeoh, Su-Ann, Vandevelde, Claire, Dunt, Sasha, Leeder, Jane, Macphie, Elizabeth, Salerno, Rosaria, Graver, Christine, Williams, Katie, O'Reilly, Sheila, Devine, Kirsty, Tyler, Jennifer, Warner, Elizabeth, Pilcher, James, Patel, Samir, Nikiphorou, Elena, Chadwick, Laura, Jones, Caroline M, Harrison, Beverley, Thornton, Lucy, O'Kane, Diana, Fusi, Lucia, Low, Audrey, Horton, Sarah, Jatwani, Shraddha, Baig, Sara, Bajwa, Hammad, Berglund, Vernon, Dahle, Angela, Dorman, Walter, Hargrove, Jody, Hilton, Maren, Lebedoff, Nicholas, Leonard, Susan, Morgan, Jennifer, Pfeifer, Emily, Skemp, Archibald, Wilson, Jeffrey, Wolff, Anne, Cepeda, Eduardo, Todd, Derrick, Hare, Denise, Calabrese, Cassandra, Adams, Christopher, Khosroshahi, Arezou, Kilian, Adam, White, Douglas, Winter, Melanie, Fields, Theodore, Siegel, Caroline, Daver, Nicole, Harvey, Melissa, Kramer, Neil, Lamore, Concetta, Hogarty, Suneya, Yeter, Karen, Siddique, Faizah, Ban, Byung, Tanner, Tamar, Ruderman, Eric, Davis, William, Quinet, Robert, Scopelitis, Evangeline, Toribio, Karen, Webb Detiege, Tameka, Zakem, Jerald, Abbass, Khurram, Kepecs, Gilbert, Miranda, Lilliam, Guma, Michael, Haikal, Ammar, Mody, Sushama, Mueller, Daric, Jayatilleke, Arundathi, Zell, JoAnn, Bays, Alison, Dao, Kathryn, Ezzati, Fatemeh, Parks, Deborah, Karp, David, Quiceno, Guillermo, Izadi, Zara, Gianfrancesco, Milena A, Schmajuk, Gabriela, Jacobsohn, Lindsay, Katz, Patricia, Rush, Stephanie, Ja, Clairissa, Taylor, Tiffany, Shidara, Kie, Danila, Maria I, Wysham, Katherine D, Strangfeld, Anja, Mateus, Elsa F, Hyrich, Kimme L, Gossec, Laure, Carmona, Loreto, Lawson-Tovey, Saskia, Kearsley-Fleet, Lianne, Schaefer, Martin, Al-Emadi, Samar, Sparks, Jeffrey A, Hsu, Tiffany Y-T, Patel, Naomi J, Wise, Leanna, Gilbert, Emily, Duarte-García, Alí, Valenzuela-Almada, Maria O, Ugarte-Gil, Manuel F, Ljung, Lotta, Scirè, Carlo A, Carrara, Greta, Hachulla, Eric, Richez, Christophe, Cacoub, Patrice, Thomas, Thierry, Santos, Maria J, Bernardes, Miguel, Hasseli, Rebecca, Regierer, Anne, Schulze-Koops, Hendrik, Müller-Ladner, Ulf, Pons-Estel, Guillermo, Nieto, Romina E, Pisoni, Cecilia N, Tissera, Yohana S, Xavier, Ricardo, Lopes Marques, Claudia D, Pileggi, Gecilmara C S, Robinson, Philip C, Machado, Pedro M, Sirotich, Emily, Liew, Jean W, Hausmann, Jonathan S, Sufka, Paul, Grainger, Rebecca, Bhana, Suleman, Gore-Massy, Monique, Wallace, Zachary S, and Yazdany, Jinoos

Published
2022
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42. From Abroad, China Targets Critic's Child

Author

Myers, Steven Lee and Hsu, Tiffany

Subjects
Authors, Chinese -- Family -- Safety and security measures -- Crimes against, Cyberbullying -- Investigations -- Political aspects, Company legal issue, General interest, News, opinion and commentary
Abstract

Deng Yuwen, a prominent Chinese writer who now lives in exile in the suburbs of Philadelphia, has regularly criticized China and its authoritarian leader, Xi Jinping. China's reaction of late [...]

Published
2024

43. How Misleading Videos Are Trailing Biden as He Battles Age Doubts

Author

Glueck, Katie, Hsu, Tiffany, and Li, Ang

Subjects
Video recordings, Ex-presidents, General interest, Republican National Committee -- Officials and employees
Abstract

Byline: Katie Glueck, Tiffany Hsu and Ang Li A flurry of recent clips, many of them edited or lacking context, laid bare a major challenge for the president as he [...]

Published
2024

44. Misleading Videos Are Trailing Biden as He Battles Age Doubts

Author

Glueck, Katie, Hsu, Tiffany, and Li, Ang

Subjects
Electioneering, Internet videos -- Political aspects, Political campaigns, Old age -- Influence, General interest, News, opinion and commentary
Abstract

A flurry of recent clips, many of them edited or lacking context, laid bare a major challenge for the president as he tries to persuade voters he has the energy [...]

Published
2024

45. An A.I.-Generated News Site Prized Clicks Over Truth

Author

Hill, Kashmir and Hsu, Tiffany

Subjects
Microsoft Corp., Computer software industry, Sexual abuse, General interest, News, opinion and commentary
Abstract

The news was featured on MSN.com: ''Prominent Irish broadcaster faces trial over alleged sexual misconduct.'' At the top of the story was a photo of Dave Fanning. But Mr. Fanning, [...]

Published
2024

46. It Looked Like a Reliable News Site. It Was an A.I. Chop Shop

Author

Hill, Kashmir and Hsu, Tiffany

Subjects
Microsoft Corp., Computer software industry, Sexual abuse, General interest
Abstract

Byline: Kashmir Hill and Tiffany Hsu The news was featured on MSN.com: 'Prominent Irish broadcaster faces trial over alleged sexual misconduct.' At the top of the story was a photo [...]

Published
2024

47. Disinformation Around E.U. Elections Is Fueled by a 'Convergence of Anger'

Author

Hsu, Tiffany

Subjects
Elections -- Political aspects, Disinformation -- Political aspects, Climatic changes -- Political aspects, General interest, News, opinion and commentary, European Union -- Political activity -- Political aspects
Abstract

False narratives and conspiracy theories about climate change, immigration and Ukraine are spreading via politicians and foreign operatives. The fury of European farmers is more than just a major issue [...]

Published
2024

48. ‘Convergence of Anger’ Drives Disinformation Around E.U. Elections

Author

Hsu, Tiffany

Subjects
Elections, Disinformation, Climatic changes, News, opinion and commentary
Abstract

False narratives and conspiracy theories about climate change, immigration and Ukraine are spreading via politicians and foreign operatives. The https://www.nytimes.com/2024/03/31/world/europe/angry-farmers-are-reshaping-europe.html of https://www.nytimes.com/2024/01/31/world/europe/spark-french-farmer-protests.html https://www.nytimes.com/2024/02/06/climate/europe-farming-protests-policy.html is more than just a major issue [...]

Published
2024

49. Europe Banned Russia's RT Network. Its Content Is Still Spreading

Author

Hsu, Tiffany and Myers, Steven Lee

Subjects
Propaganda -- Reports, General interest, European Union -- Reports
Abstract

Byline: Tiffany Hsu and Steven Lee Myers A study found that hundreds of sites, many without obvious Kremlin links, copied Russian propaganda and spread it to unsuspecting audiences ahead of [...]

Published
2024

50. Sites Host Propaganda From Russia

Author

Hsu, Tiffany and Myers, Steven Lee

Subjects
Web sites -- Investigations -- Information management, Propaganda -- Investigations, Company legal issue, Company Web site/Web page, Company systems management, General interest, News, opinion and commentary, European Union -- Elections
Abstract

A study found that hundreds of sites, many without obvious Kremlin links, copied Russian propaganda and spread it to unsuspecting audiences ahead of the E.U. election. The website calling itself [...]

Published
2024

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