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1. The impact of low-mode symmetry on inertial fusion energy output in the burning plasma state.

Author

Ralph, J, Ross, J, Zylstra, A, Kritcher, A, Robey, H, Young, C, Hurricane, O, Pak, A, Callahan, D, Baker, K, Casey, D, Döppner, T, Divol, L, Hohenberger, M, Pape, S, Patel, P, Tommasini, R, Ali, S, Amendt, P, Atherton, L, Bachmann, B, Bailey, D, Benedetti, L, Berzak Hopkins, L, Betti, R, Bhandarkar, S, Biener, J, Bionta, R, Birge, N, Bond, E, Bradley, D, Braun, T, Briggs, T, Bruhn, M, Celliers, P, Chang, B, Chapman, T, Chen, H, Choate, C, Christopherson, A, Clark, D, Crippen, J, Dewald, E, Dittrich, T, Edwards, M, Farmer, W, Field, J, Fittinghoff, D, Frenje, J, Gaffney, J, Gatu Johnson, M, Glenzer, S, Grim, G, Haan, S, Hahn, K, Hall, G, Hammel, B, Harte, J, Hartouni, E, Heebner, J, Hernandez, V, Herrmann, H, Herrmann, M, Hinkel, D, Ho, D, Holder, J, Hsing, W, Huang, H, Humbird, K, Izumi, N, Jarrott, L, Jeet, J, Jones, O, Kerbel, G, Kerr, S, Khan, S, Kilkenny, J, Kim, Y, Geppert-Kleinrath, H, Geppert-Kleinrath, V, Kong, C, Koning, J, Kroll, J, Kruse, M, Kustowski, B, Landen, O, Langer, S, Larson, D, Lemos, N, Lindl, J, Ma, T, MacDonald, M, MacGowan, B, Mackinnon, A, MacLaren, S, MacPhee, A, Marinak, M, Mariscal, D, Marley, E, and Masse, L

Abstract

Indirect Drive Inertial Confinement Fusion Experiments on the National Ignition Facility (NIF) have achieved a burning plasma state with neutron yields exceeding 170 kJ, roughly 3 times the prior record and a necessary stage for igniting plasmas. The results are achieved despite multiple sources of degradations that lead to high variability in performance. Results shown here, for the first time, include an empirical correction factor for mode-2 asymmetry in the burning plasma regime in addition to previously determined corrections for radiative mix and mode-1. Analysis shows that including these three corrections alone accounts for the measured fusion performance variability in the two highest performing experimental campaigns on the NIF to within error. Here we quantify the performance sensitivity to mode-2 symmetry in the burning plasma regime and apply the results, in the form of an empirical correction to a 1D performance model. Furthermore, we find the sensitivity to mode-2 determined through a series of integrated 2D radiation hydrodynamic simulations to be consistent with the experimentally determined sensitivity only when including alpha-heating.

Published
2024

2. Experiments conducted in the burning plasma regime with inertial fusion implosions

Author

Ross, J. S., Ralph, J. E., Zylstra, A. B., Kritcher, A. L., Robey, H. F., Young, C. V., Hurricane, O. A., Callahan, D. A., Baker, K. L., Casey, D. T., Doeppner, T., Divol, L., Hohenberger, M., Pape, S. Le, Pak, A., Patel, P. K., Tommasini, R., Ali, S. J., Amendt, P. A., Atherton, L. J., Bachmann, B., Bailey, D., Benedetti, L. R., Hopkins, L. Berzak, Betti, R., Bhandarkar, S. D., Bionta, R. M., Birge, N. W., Bond, E. J., Bradley, D. K., Braun, T., Briggs, T. M., Bruhn, M. W., Celliers, P. M., Chang, B., Chapman, T., Chen, H., Choate, C., Christopherson, A. R., Clark, D. S., Crippen, J. W., Dewald, E. L., Dittrich, T. R., Edwards, M. J., Farmer, W. A., Field, J. E., Fittinghoff, D., Frenje, J., Gaffney, J., Johnson, M. Gatu, Glenzer, S. H., Grim, G. P., Haan, S., Hahn, K. D., Hall, G. N., Hammel, B. A., Harte, J., Hartouni, E., Heebner, J. E., Hernandez, V. J., Herrmann, H., Herrmann, M. C., Hinkel, D. E., Ho, D. D., Holder, J. P., Hsing, W. W., Huang, H., Humbird, K. D., Izumi, N., Jarrott, L. C., Jeet, J., Jones, O., Kerbel, G. D., Kerr, S. M., Khan, S. F., Kilkenny, J., Kim, Y., Kleinrath, H. Geppert, Kleinrath, V. Geppert, Kong, C., Koning, J. M., Kroll, J. J., Landen, O. L., Langer, S., Larson, D., Lemos, N. C., Lindl, J. D., Ma, T., MacDonald, M. J., MacGowan, B. J., Mackinnon, A. J., MacLaren, S. A., MacPhee, A. G., Marinak, M. M., Mariscal, D. A., Marley, E. V., Masse, L., Meaney, K., Meezan, N. B., Michel, P. A., Millot, M., Milovich, J. L., Moody, J. D., Moore, A. S., Morton, J. W., Murphy, T., Newman, K., Di Nicola, J. -M. G., Nikroo, A., Nora, R., Patel, M. V., Pelz, L. J., Peterson, J. L., Ping, Y., Pollock, B. B., Ratledge, M., Rice, N. G., Rinderknecht, H., Rosen, M., Rubery, M. S., Salmonson, J. D., Sater, J., Schiaffino, S., Schlossberg, D. J., Schneider, M. B., Schroeder, C. R., Scott, H. A., Sepke, S. M., Sequoia, K., Sherlock, M. W., Shin, S., Smalyuk, V. A., Spears, B. K., Springer, P. T., Stadermann, M., Stoupin, S., Strozzi, D. J., Suter, L. J., Thomas, C. A., Town, R. P. J., Tubman, E. R., Volegov, P. L., Weber, C. R., Widmann, K., Wild, C., Wilde, C. H., Van Wonterghem, B. M., Woods, D. T., Woodworth, B. N., Yamaguchi, M., Yang, S. T., and Zimmerman, G. B.

Subjects
Physics - Plasma Physics, High Energy Physics - Experiment
Abstract

An experimental program is currently underway at the National Ignition Facility (NIF) to compress deuterium and tritium (DT) fuel to densities and temperatures sufficient to achieve fusion and energy gain. The primary approach being investigated is indirect drive inertial confinement fusion (ICF), where a high-Z radiation cavity (a hohlraum) is heated by lasers, converting the incident energy into x-ray radiation which in turn drives the DT fuel filled capsule causing it to implode. Previous experiments reported DT fuel gain exceeding unity [O.A. Hurricane et al., Nature 506, 343 (2014)] and then exceeding the kinetic energy of the imploding fuel [S. Le Pape et al., Phys. Rev. Lett. 120, 245003 (2018)]. We report on recent experiments that have achieved record fusion neutron yields on NIF, greater than 100 kJ with momentary fusion powers exceeding 1PW, and have for the first time entered the burning plasma regime where fusion alpha-heating of the fuel exceeds the energy delivered to the fuel via compression. This was accomplished by increasing the size of the high-density carbon (HDC) capsule, increasing energy coupling, while controlling symmetry and implosion design parameters. Two tactics were successful in controlling the radiation flux symmetry and therefore the implosion symmetry: transferring energy between laser cones via plasma waves, and changing the shape of the hohlraum. In conducting these experiments, we controlled for known sources of degradation. Herein we show how these experiments were performed to produce record performance, and demonstrate the data fidelity leading us to conclude that these shots have entered the burning plasma regime.

Published
2021

3. Design of inertial fusion implosions reaching the burning plasma regime

Author

Kritcher, A. L., Young, C. V., Robey, H. F., Weber, C. R., Zylstra, A. B., Hurricane, O. A., Callahan, D. A., Ralph, J. E., Ross, J. S., Baker, K. L., Casey, D. T., Clark, D. S., Döppner, T., Divol, L., Hohenberger, M., Hopkins, L. Berzak, Le Pape, S., Meezan, N. B., Pak, A., Patel, P. K., Tommasini, R., Ali, S. J., Amendt, P. A., Atherton, L. J., Bachmann, B., Bailey, D., Benedetti, L. R., Betti, R., Bhandarkar, S. D., Biener, J., Bionta, R. M., Birge, N. W., Bond, E. J., Bradley, D. K., Braun, T., Briggs, T. M., Bruhn, M. W., Celliers, P. M., Chang, B., Chapman, T., Chen, H., Choate, C., Christopherson, A. R., Crippen, J. W., Dewald, E. L., Dittrich, T. R., Edwards, M. J., Farmer, W. A., Field, J. E., Fittinghoff, D., Frenje, J. A., Gaffney, J. A., Johnson, M. Gatu, Glenzer, S. H., Grim, G. P., Haan, S., Hahn, K. D., Hall, G. N., Hammel, B. A., Harte, J., Hartouni, E., Heebner, J. E., Hernandez, V. J., Herrmann, H., Herrmann, M. C., Hinkel, D. E., Ho, D. D., Holder, J. P., Hsing, W. W., Huang, H., Humbird, K. D., Izumi, N., Jarrott, L. C., Jeet, J., Jones, O., Kerbel, G. D., Kerr, S. M., Khan, S. F., Kilkenny, J., Kim, Y., Geppert-Kleinrath, H., Geppert-Kleinrath, V., Kong, C., Koning, J. M., Kruse, M. K. G., Kroll, J. J., Kustowski, B., Landen, O. L., Langer, S., Larson, D., Lemos, N. C., Lindl, J. D., Ma, T., MacDonald, M. J., MacGowan, B. J., Mackinnon, A. J., MacLaren, S. A., MacPhee, A. G., Marinak, M. M., Mariscal, D. A., Marley, E. V., Masse, L., Meaney, K., Michel, P. A., Millot, M., Milovich, J. L., Moody, J. D., Moore, A. S., Morton, J. W., Murphy, T., Newman, K., Di Nicola, J.-M. G., Nikroo, A., Nora, R., Patel, M. V., Pelz, L. J., Peterson, J. L., Ping, Y., Pollock, B. B., Ratledge, M., Rice, N. G., Rinderknecht, H., Rosen, M., Rubery, M. S., Salmonson, J. D., Sater, J., Schiaffino, S., Schlossberg, D. J., Schneider, M. B., Schroeder, C. R., Scott, H. A., Sepke, S. M., Sequoia, K., Sherlock, M. W., Shin, S., Smalyuk, V. A., Spears, B. K., Springer, P. T., Stadermann, M., Stoupin, S., Strozzi, D. J., Suter, L. J., Thomas, C. A., Town, R. P. J., Trosseille, C., Tubman, E. R., Volegov, P. L., Widmann, K., Wild, C., Wilde, C. H., Van Wonterghem, B. M., Woods, D. T., Woodworth, B. N., Yamaguchi, M., Yang, S. T., and Zimmerman, G. B.

Published
2022
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4. Burning plasma achieved in inertial fusion

Author

Zylstra, A. B., Hurricane, O. A., Callahan, D. A., Kritcher, A. L., Ralph, J. E., Robey, H. F., Ross, J. S., Young, C. V., Baker, K. L., Casey, D. T., Döppner, T., Divol, L., Hohenberger, M., Le Pape, S., Pak, A., Patel, P. K., Tommasini, R., Ali, S. J., Amendt, P. A., Atherton, L. J., Bachmann, B., Bailey, D., Benedetti, L. R., Berzak Hopkins, L., Betti, R., Bhandarkar, S. D., Biener, J., Bionta, R. M., Birge, N. W., Bond, E. J., Bradley, D. K., Braun, T., Briggs, T. M., Bruhn, M. W., Celliers, P. M., Chang, B., Chapman, T., Chen, H., Choate, C., Christopherson, A. R., Clark, D. S., Crippen, J. W., Dewald, E. L., Dittrich, T. R., Edwards, M. J., Farmer, W. A., Field, J. E., Fittinghoff, D., Frenje, J., Gaffney, J., Gatu Johnson, M., Glenzer, S. H., Grim, G. P., Haan, S., Hahn, K. D., Hall, G. N., Hammel, B. A., Harte, J., Hartouni, E., Heebner, J. E., Hernandez, V. J., Herrmann, H., Herrmann, M. C., Hinkel, D. E., Ho, D. D., Holder, J. P., Hsing, W. W., Huang, H., Humbird, K. D., Izumi, N., Jarrott, L. C., Jeet, J., Jones, O., Kerbel, G. D., Kerr, S. M., Khan, S. F., Kilkenny, J., Kim, Y., Geppert Kleinrath, H., Geppert Kleinrath, V., Kong, C., Koning, J. M., Kroll, J. J., Kruse, M. K. G., Kustowski, B., Landen, O. L., Langer, S., Larson, D., Lemos, N. C., Lindl, J. D., Ma, T., MacDonald, M. J., MacGowan, B. J., Mackinnon, A. J., MacLaren, S. A., MacPhee, A. G., Marinak, M. M., Mariscal, D. A., Marley, E. V., Masse, L., Meaney, K., Meezan, N. B., Michel, P. A., Millot, M., Milovich, J. L., Moody, J. D., Moore, A. S., Morton, J. W., Murphy, T., Newman, K., Di Nicola, J.-M. G., Nikroo, A., Nora, R., Patel, M. V., Pelz, L. J., Peterson, J. L., Ping, Y., Pollock, B. B., Ratledge, M., Rice, N. G., Rinderknecht, H., Rosen, M., Rubery, M. S., Salmonson, J. D., Sater, J., Schiaffino, S., Schlossberg, D. J., Schneider, M. B., Schroeder, C. R., Scott, H. A., Sepke, S. M., Sequoia, K., Sherlock, M. W., Shin, S., Smalyuk, V. A., Spears, B. K., Springer, P. T., Stadermann, M., Stoupin, S., Strozzi, D. J., Suter, L. J., Thomas, C. A., Town, R. P. J., Tubman, E. R., Trosseille, C., Volegov, P. L., Weber, C. R., Widmann, K., Wild, C., Wilde, C. H., Van Wonterghem, B. M., Woods, D. T., Woodworth, B. N., Yamaguchi, M., Yang, S. T., and Zimmerman, G. B.

Published
2022
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5. The crucial role of diagnostics in achieving ignition on the National Ignition Facility (NIF).

Author

Kilkenny, J. D., Pak, A., Landen, O. L., Moore, A. S., Meezan, N. B., Haan, S. W., Hsing, W. W., Batha, S. H., Bradley, D. K., Gatu-Johnson, M., Mackinnon, A. J., Regan, S. P., and Smalyuk, V. A.

Subjects
TREND analysis, SCIENTIFIC discoveries, FALSIFICATION, LASERS, LOGIC
Abstract

Well over 100 diagnostics can operate on the National Ignition Facility (NIF) as a result of several decades of development on NIF, and before that on Nova, OMEGA, and earlier LLNL lasers. A subset of these have guided the approach to achieving ignition on the NIF in 2022 [H. Abu-Shawareb et al. (Indirect Drive ICF Collaboration), Phys. Rev. Lett. 129(7), 075001 (2022)]. Achieving ignition on NIF has required many types of experiments with this core set of diagnostics, some constraining known unknowns and some revealing surprises—arguably unknown unknowns. Early design work realized that the extreme precision required for ignition on NIF would require fine-tuning by experiment, that is, measuring and adjusting known unknowns. Many examples are given where the use of the core set of ignition diagnostics in experimental arrangements called platforms demonstrated control of the key theoretical parameters defined as shape, adiabat, velocity, and mix. The direction of the adjustments to input conditions is found either by trend analysis or, in many cases, by observing from the diagnostic data the direction to make an adjustment. In addition, diagnostics have revealed some unexpected or neglected known issues, which degrade performance, or unexpected issues, unknown unknowns. Some of these factors had been previously considered, but underestimated or difficult to calculate at the time. The overall methodology can be described as a variant of Popper's falsifiability philosophy [K. Popper, The Logic of Scientific Discovery (Hutchinson, 1974)]. This paper summarizes the role of ignition diagnostics in terms of falsification or validation of theory or experimental setup as well as uncovering unexpected issues. The journey to ignition started in the seventies with a 1-µm wavelength laser producing disastrous results. Diagnostics have guided us to the recent multi-decadal goal of demonstrating ignition and burn in the laboratory. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Measurement of mix at the fuel–ablator interface in indirectly driven capsule implosions on the National Ignition Facility

Author

Hall, G. N., primary, Weber, C. R., additional, Smalyuk, V. A., additional, Landen, O. L., additional, Trosseille, C., additional, Pak, A., additional, Hartouni, E., additional, Marley, E., additional, Ebert, T., additional, Bradley, D. K., additional, Hsing, W., additional, Tommasini, R., additional, Izumi, N., additional, Pape, S. Le, additional, Divol, L., additional, Krauland, C. M., additional, Thompson, N., additional, Casco, E. R., additional, Ayers, M. J., additional, Nagel, S. R., additional, Carpenter, A. C., additional, Hurd, E. R., additional, Dayton, M. S., additional, Engelhorn, K., additional, and Holder, J. P., additional

Published
2024
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7. Time-resolved X-ray diffraction diagnostic development for the National Ignition Facility

Author

Werellapatha, K., primary, Palmer, N. E., additional, Gorman, M. G., additional, Bernier, J. V., additional, Bhandarkar, N. S., additional, Bradley, D. K., additional, Braun, D. G., additional, Bruhn, M., additional, Carpenter, A., additional, Celliers, P. M., additional, Coppari, F., additional, Dayton, M., additional, Durand, C., additional, Eggert, J. H., additional, Ferguson, B., additional, Heidl, B., additional, Heinbockel, C., additional, Heredia, R., additional, Huckins, J., additional, Hurd, E., additional, Hsing, W., additional, Krauland, C. M., additional, Lazicki, A. E., additional, Kalantar, D., additional, Kehl, J., additional, Killebrew, K., additional, Masters, N., additional, Millot, M., additional, Nagel, S. R., additional, Petre, R. B., additional, Ping, Y., additional, Polsin, D. N., additional, Singh, S., additional, Stan, C. V., additional, Swift, D., additional, Tabimina, J., additional, Thomas, A., additional, Zobrist, T., additional, and Benedetti, L. R., additional

Published
2024
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8. The Magnetized Indirect Drive Project on the National Ignition Facility

Author

Moody, J. D., Pollock, B. B., Sio, H., Strozzi, D. J., Ho, D. D.-M., Walsh, C., Kemp, G. E., Kucheyev, S. O., Kozioziemski, B., Carroll, E. G., Kroll, J., Yanagisawa, D. K., Angus, J., Bhandarkar, S. D., Bude, J. D., Divol, L., Ferguson, B., Fry, J., Hagler, L., Hartouni, E., Herrmann, M. C., Hsing, W., Holunga, D. M., Javedani, J., Johnson, A., Kalantar, D., Kohut, T., Logan, B. G., Masters, N., Nikroo, A., Orsi, N., Piston, K., Provencher, C., Rowe, A., Sater, J., Skulina, K., Stygar, W. A., Tang, V., Winters, S. E., Chittenden, J. P., Appelbe, B., Boxall, A., Crilly, A., O’Neill, S., Davies, J., Peebles, J., and Fujioka, S.

Published
2022
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9. Extended X-ray absorption fine structure of dynamically-compressed copper up to 1 terapascal

Author

Sio, H., primary, Krygier, A., additional, Braun, D. G., additional, Rudd, R. E., additional, Bonev, S. A., additional, Coppari, F., additional, Millot, M., additional, Fratanduono, D. E., additional, Bhandarkar, N., additional, Bitter, M., additional, Bradley, D. K., additional, Efthimion, P. C., additional, Eggert, J. H., additional, Gao, L., additional, Hill, K. W., additional, Hood, R., additional, Hsing, W., additional, Izumi, N., additional, Kemp, G., additional, Kozioziemski, B., additional, Landen, O. L., additional, Le Galloudec, K., additional, Lockard, T. E., additional, Mackinnon, A., additional, McNaney, J. M., additional, Ose, N., additional, Park, H.-S., additional, Remington, B. A., additional, Schneider, M. B., additional, Stoupin, S., additional, Thorn, D. B., additional, Vonhof, S., additional, Wu, C. J., additional, and Ping, Y., additional

Published
2023
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10. National Diagnostic Working Group (NDWG) for inertial confinement fusion (ICF)/high-energy density (HED) science: The whole exceeds the sum of its parts

Author

Kilkenny, J. D., primary, Hsing, W. W., additional, Batha, S. H., additional, Rochau, G. A., additional, Sangster, T. C., additional, Bell, P. M., additional, Bradley, D. K., additional, Chen, H., additional, Frenje, J. A., additional, Gatu-Johnson, M., additional, Glebov, V. Yu., additional, Leeper, R. J., additional, Mackinnon, A. J., additional, Regan, S. P., additional, Ross, J. S., additional, and Weaver, J. l., additional

Published
2023
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11. Performance scaling with an applied magnetic field in indirect-drive inertial confinement fusion implosions

Author

Sio, H., primary, Moody, J. D., additional, Pollock, B. B., additional, Strozzi, D. J., additional, Ho, D. D.-M., additional, Walsh, C. A., additional, Kemp, G. E., additional, Lahmann, B., additional, Kucheyev, S. O., additional, Kozioziemski, B., additional, Carroll, E. G., additional, Kroll, J., additional, Yanagisawa, D. K., additional, Angus, J., additional, Bachmann, B., additional, Baker, A. A., additional, Bayu Aji, L. B., additional, Bhandarkar, S. D., additional, Bude, J. D., additional, Divol, L., additional, Engwall, A. M., additional, Ferguson, B., additional, Fry, J., additional, Hagler, L., additional, Hartouni, E., additional, Herrmann, M. C., additional, Hsing, W., additional, Holunga, D. M., additional, Javedani, J., additional, Johnson, A., additional, Khan, S., additional, Kalantar, D., additional, Kohut, T., additional, Logan, B. G., additional, Masters, N., additional, Nikroo, A., additional, Izumi, N., additional, Orsi, N., additional, Piston, K., additional, Provencher, C., additional, Rowe, A., additional, Sater, J., additional, Shin, S. J., additional, Skulina, K., additional, Stygar, W. A., additional, Tang, V., additional, Winters, S. E., additional, Zimmerman, G., additional, Chittenden, J. P., additional, Appelbe, B., additional, Boxall, A., additional, Crilly, A., additional, O'Neill, S., additional, Barnak, D., additional, Davies, J., additional, Peebles, J., additional, Bae, J. H., additional, Clark, K., additional, Havre, M., additional, Mauldin, M., additional, Ratledge, M., additional, Vonhof, S., additional, Adrian, P., additional, Reichelt, B., additional, Fujioka, S., additional, and Fraenkel, M., additional

Published
2023
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12. Publisher Correction: Burning plasma achieved in inertial fusion

Author

Zylstra, A. B., Hurricane, O. A., Callahan, D. A., Kritcher, A. L., Ralph, J. E., Robey, H. F., Ross, J. S., Young, C. V., Baker, K. L., Casey, D. T., Döppner, T., Divol, L., Hohenberger, M., Le Pape, S., Pak, A., Patel, P. K., Tommasini, R., Ali, S. J., Amendt, P. A., Atherton, L. J., Bachmann, B., Bailey, D., Benedetti, L. R., Berzak Hopkins, L., Betti, R., Bhandarkar, S. D., Biener, J., Bionta, R. M., Birge, N. W., Bond, E. J., Bradley, D. K., Braun, T., Briggs, T. M., Bruhn, M. W., Celliers, P. M., Chang, B., Chapman, T., Chen, H., Choate, C., Christopherson, A. R., Clark, D. S., Crippen, J. W., Dewald, E. L., Dittrich, T. R., Edwards, M. J., Farmer, W. A., Field, J. E., Fittinghoff, D., Frenje, J., Gaffney, J., Gatu Johnson, M., Glenzer, S. H., Grim, G. P., Haan, S., Hahn, K. D., Hall, G. N., Hammel, B. A., Harte, J., Hartouni, E., Heebner, J. E., Hernandez, V. J., Herrmann, H., Herrmann, M. C., Hinkel, D. E., Ho, D. D., Holder, J. P., Hsing, W. W., Huang, H., Humbird, K. D., Izumi, N., Jarrott, L. C., Jeet, J., Jones, O., Kerbel, G. D., Kerr, S. M., Khan, S. F., Kilkenny, J., Kim, Y., Geppert Kleinrath, H., Geppert Kleinrath, V., Kong, C., Koning, J. M., Kroll, J. J., Kruse, M. K. G., Kustowski, B., Landen, O. L., Langer, S., Larson, D., Lemos, N. C., Lindl, J. D., Ma, T., MacDonald, M. J., MacGowan, B. J., Mackinnon, A. J., MacLaren, S. A., MacPhee, A. G., Marinak, M. M., Mariscal, D. A., Marley, E. V., Masse, L., Meaney, K., Meezan, N. B., Michel, P. A., Millot, M., Milovich, J. L., Moody, J. D., Moore, A. S., Morton, J. W., Murphy, T., Newman, K., Di Nicola, J.-M. G., Nikroo, A., Nora, R., Patel, M. V., Pelz, L. J., Peterson, J. L., Ping, Y., Pollock, B. B., Ratledge, M., Rice, N. G., Rinderknecht, H., Rosen, M., Rubery, M. S., Salmonson, J. D., Sater, J., Schiaffino, S., Schlossberg, D. J., Schneider, M. B., Schroeder, C. R., Scott, H. A., Sepke, S. M., Sequoia, K., Sherlock, M. W., Shin, S., Smalyuk, V. A., Spears, B. K., Springer, P. T., Stadermann, M., Stoupin, S., Strozzi, D. J., Suter, L. J., Thomas, C. A., Town, R. P. J., Tubman, E. R., Trosseille, C., Volegov, P. L., Weber, C. R., Widmann, K., Wild, C., Wilde, C. H., Van Wonterghem, B. M., Woods, D. T., Woodworth, B. N., Yamaguchi, M., Yang, S. T., and Zimmerman, G. B.

Published
2022
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13. FY19 LLNL Experimental Programs at Omega

Author

Heeter, R., primary, Albert, F., additional, Ali, S., additional, Benedetti, L., additional, Candeias Lemos, N., additional, Chen, H., additional, Coppari, F., additional, Fernandez Panella, A., additional, Fratanduono, D., additional, Ginnane, M., additional, Gorman, M., additional, Hohenberger, M., additional, Jiang, S., additional, Kemp, G., additional, Khan, S., additional, King, P., additional, Krygier, A., additional, Lazicki, A., additional, Ma, T., additional, MacDonald, M., additional, Mariscal, D., additional, Marley, E., additional, Marshall, M., additional, Martinez, D., additional, Millot, M., additional, Palmer, C., additional, Park, H., additional, Park, J., additional, Perez Callejo, G., additional, Ping, Y., additional, Pollock, B., additional, Poole, P., additional, Ralph, J., additional, Saunders, A., additional, Swadling, G., additional, Tommasini, R., additional, Widmann, K., additional, Zylstra, A., additional, Landen, O., additional, Hsing, W., additional, and Wan, A., additional

Published
2019
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14. Increased Ion Temperature and Neutron Yield Observed in Magnetized Indirectly Driven D2 -Filled Capsule Implosions on the National Ignition Facility

Author

Moody, J. D., primary, Pollock, B. B., additional, Sio, H., additional, Strozzi, D. J., additional, Ho, D. D.-M., additional, Walsh, C. A., additional, Kemp, G. E., additional, Lahmann, B., additional, Kucheyev, S. O., additional, Kozioziemski, B., additional, Carroll, E. G., additional, Kroll, J., additional, Yanagisawa, D. K., additional, Angus, J., additional, Bachmann, B., additional, Bhandarkar, S. D., additional, Bude, J. D., additional, Divol, L., additional, Ferguson, B., additional, Fry, J., additional, Hagler, L., additional, Hartouni, E., additional, Herrmann, M. C., additional, Hsing, W., additional, Holunga, D. M., additional, Izumi, N., additional, Javedani, J., additional, Johnson, A., additional, Khan, S., additional, Kalantar, D., additional, Kohut, T., additional, Logan, B. G., additional, Masters, N., additional, Nikroo, A., additional, Orsi, N., additional, Piston, K., additional, Provencher, C., additional, Rowe, A., additional, Sater, J., additional, Skulina, K., additional, Stygar, W. A., additional, Tang, V., additional, Winters, S. E., additional, Zimmerman, G., additional, Adrian, P., additional, Chittenden, J. P., additional, Appelbe, B., additional, Boxall, A., additional, Crilly, A., additional, O’Neill, S., additional, Davies, J., additional, Peebles, J., additional, and Fujioka, S., additional

Published
2022
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17. FY18 LLNL Experimental Programs at Omega

Author

Heeter, R F, primary, Ali, S J, additional, Benedetti, L R, additional, Bernier, J V, additional, Chen, H, additional, Coppari, F, additional, Elgin, L, additional, Fernandez-Panella, A, additional, Gumbrell, E, additional, Hua, R, additional, Huntington, C M, additional, Jiang, S, additional, Kemp, G E, additional, Khan, S F, additional, Krygier, A, additional, Kuranz, C, additional, Lazicki, A E, additional, Lemos, N, additional, MacDonald, M J, additional, Mariscal, D, additional, Marley, E V, additional, Marshall, M C, additional, Martinez, D A, additional, McNaney, J M, additional, Millot, M A, additional, Ping, Y, additional, Pollock, B B, additional, Poole, P L, additional, Rinderknecht, H G, additional, Rubery, M, additional, Saunders, A M, additional, Smith, R F, additional, Swadling, G F, additional, Tommasini, R, additional, Widmann, K, additional, Williams, G J, additional, Landen, O L, additional, Hsing, W W, additional, and Wan, A S, additional

Published
2018
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19. FY17 LLNL Omega Experimental Programs

Author

Heeter, R., primary, Albert, F., additional, Ali, S., additional, Benstead, J., additional, Chen, H., additional, Coppari, F., additional, Doeppner, T., additional, Panella, A., additional, Fratanduono, D., additional, Gumbrell, E., additional, Hua, R., additional, Huntington, C., additional, Jarrott, L., additional, Jiang, S., additional, Krygier, A., additional, Kuranz, C., additional, Lazicki, A., additional, LePape, S., additional, Marley, E., additional, Martinez, D., additional, McNaney, J., additional, Millot, M., additional, Pak, A., additional, Ping, Y., additional, Pollock, B., additional, Poole, P., additional, Rinderknecht, H., additional, Rubery, M., additional, Saunders, A., additional, Schneider, M., additional, Smith, R., additional, Swadling, G., additional, Wehrenberg, C., additional, Landen, O., additional, Wan, A., additional, and Hsing, W., additional

Published
2017
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20. Observation of Hydrodynamic Flows in Imploding Fusion Plasmas on the National Ignition Facility

Author

Schlossberg, D. J., primary, Grim, G. P., additional, Casey, D. T., additional, Moore, A. S., additional, Nora, R., additional, Bachmann, B., additional, Benedetti, L. R., additional, Bionta, R. M., additional, Eckart, M. J., additional, Field, J. E., additional, Fittinghoff, D. N., additional, Gatu Johnson, M., additional, Geppert-Kleinrath, V., additional, Hartouni, E. P., additional, Hatarik, R., additional, Hsing, W. W., additional, Jarrott, L. C., additional, Khan, S. F., additional, Kilkenny, J. D., additional, Landen, O. L., additional, MacGowan, B. J., additional, Mackinnon, A. J., additional, Meaney, K. D., additional, Munro, D. H., additional, Nagel, S. R., additional, Pak, A., additional, Patel, P. K., additional, Spears, B. K., additional, Volegov, P. L., additional, and Young, C. V., additional

Published
2021
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21. FY16 LLNL Omega Experimental Programs

Author

Heeter, R., primary, Ali, S., additional, Benstead, J., additional, Celliers, P., additional, Coppari, F., additional, Eggert, J., additional, Erskine, D., additional, Panella, A., additional, Fratanduono, D., additional, Hua, R., additional, Huntington, C., additional, Jarrott, L., additional, Jiang, S., additional, Kraus, R., additional, Lazicki, A., additional, LePape, S., additional, Martinez, D., additional, McNaney, J., additional, Millot, M., additional, Moody, J., additional, Pak, A., additional, Park, H., additional, Ping, Y., additional, Pollock, B., additional, Rinderknecht, H., additional, Ross, J., additional, Rubery, M., additional, Sio, H., additional, Smith, R., additional, Swadling, G., additional, Wehrenberg, C., additional, Collins, G., additional, Landen, O., additional, Wan, A., additional, and Hsing, W., additional

Published
2016
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24. Developing “inverted-corona” fusion targets as high-fluence neutron sources

Author

Hohenberger, M., primary, Meezan, N. B., additional, Riedel, W. M., additional, Kabadi, N., additional, Forrest, C. J., additional, Aghaian, L., additional, Cappelli, M. A., additional, Farrell, M., additional, Glenzer, S. H., additional, Heeter, B., additional, Heredia, R., additional, Landen, O. L., additional, Mackinnon, A. J., additional, Petrasso, R., additional, Shuldberg, C. M., additional, Treffert, F., additional, and Hsing, W. W., additional

Published
2021
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25. Low mode implosion symmetry sensitivity in low gas-fill NIF cylindrical hohlraums

Author

Izumi, N., primary, Woods, D. T., additional, Meezan, N. B., additional, Moody, J. D., additional, Landen, O. L., additional, Divol, L., additional, Chen, Hui, additional, Callahan, D. A., additional, Hohenberger, M., additional, Kritcher, A. L., additional, Casey, D. T., additional, Rosen, M. D., additional, Ross, J. S., additional, Schneider, M. B., additional, Edwards, M. J., additional, and Hsing, W. W., additional

Published
2021
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26. The first target experiments on the National Ignition Facility

Author

Landen, O. L., Glenzer, S. H., Froula, D. H., Dewald, E. L., Suter, L. J., Schneider, M. B., Hinkel, D. E., Fernandez, J. C., Kline, J. L., Goldman, S. R., Braun, D. G., Celliers, P. M., Moon, S. J., Robey, H. S., Lanier, N. E., Glendinning, S. G., Blue, B. E., Wilde, B. H., Jones, O. S., Schein, J., Divol, L., Kalantar, D. H., Campbell, K. M., Holder, J. P., McDonald, J. W., Niemann, C., Mackinnon, A. J., Collins, G. W., Bradley, D. K., Eggert, J. H., Hicks, D. G., Gregori, G., Kirkwood, R. K., Young, B. K., Foster, J. M., Hansen, J. F., Perry, T. S., Munro, D. H., Baldis, H. A., Grim, G. P., Heeter, R. F., Hegelich, M. B., Montgomery, D. S., Rochau, G. A., Olson, R. E., Turner, R. E., Workman, J. B., Berger, R. L., Cohen, B. I., Kruer, W. L., Langdon, A. B., Langer, S. H., Meezan, N. B., Rose, H. A., Still, C. H., Williams, E. A., Dodd, E. S., Edwards, M. J., Monteil, M.-C., Stevenson, R. M., Thomas, B. R., Coker, R. F., Magelssen, G. R., Rosen, P. A., Stry, P. E., Woods, D., Weber, S. V., Young, P. E., Alvarez, S., Armstrong, G., Bahr, R., Bourgade, J.-L., Bower, D., Celeste, J., Chrisp, M., Compton, S., Cox, J., Constantin, C., Costa, R., Duncan, J., Ellis, A., Emig, J., Gautier, C., Greenwood, A., Griffith, R., Holdner, F., Holtmeier, G., Hargrove, D., James, T., Kamperschroer, J., Kimbrough, J., Landon, M., Lee, F. D., Malone, R., May, M., Montelongo, S., Moody, J., Ng, E., Nikitin, A., Pellinen, D., Piston, K., Poole, M., Rekow, V., Rhodes, M., Shepherd, R., Shiromizu, S., Voloshin, D., Warrick, A., Watts, P., Weber, F., Young, P., Arnold, P., Atherton, L., Bardsley, G., Bonanno, R., Borger, T., Bowers, M., Bryant, R., Buckman, S., Burkhart, S., Cooper, F., Dixit, S. N., Erbert, G., Eder, D. C., Ehrlich, R. E., Felker, B., Fornes, J., Frieders, G., Gardner, S., Gates, C., Gonzalez, M., Grace, S., Hall, T., Haynam, C. A., Heestand, G., Henesian, M. A., Hermann, M., Hermes, G., Huber, S., Jancaitis, K., Johnson, S., Kauffman, B., Kelleher, T., Kohut, T., Koniges, A. E., Labiak, T., Latray, D., Lee, A., Lund, D., Mahavandi, S., Manes, K. R., Marshall, C., McBride, J., McCarville, T., McGrew, L., Menapace, J., Mertens, E., Murray, J., Neumann, J., Newton, M., Opsahl, P., Padilla, E., Parham, T., Parrish, G., Petty, C., Polk, M., Powell, C., Reinbachs, I., Rinnert, R., Riordan, B., Ross, G., Robert, V., Tobin, M., Sailors, S., Saunders, R., Schmitt, M., Shaw, M., Singh, M., Spaeth, M., Stephens, A., Tietbohl, G., Tuck, J., Van Wonterghem, B. M., Vidal, R., Wegner, P. J., Whitman, P., Williams, K., Winward, K., Work, K., Wallace, R., Nobile, A., Bono, M., Day, B., Elliott, J., Hatch, D., Louis, H., Manzenares, R., O'Brien, D., Papin, P., Pierce, T., Rivera, G., Ruppe, J., Sandoval, D., Schmidt, D., Valdez, L., Zapata, K., MacGowan, B. J., Eckart, M. J., Hsing, W. W., Springer, P. T., Hammel, B. A., Moses, E. I., and Miller, G. H.

Published
2007
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27. Optimized continuum x-ray emission from laser-generated plasma

Author

Krygier, A., primary, Kemp, G. E., additional, Coppari, F., additional, Thorn, D. B., additional, Bradley, D., additional, Do, A., additional, Eggert, J. H., additional, Hsing, W., additional, Khan, S. F., additional, Krauland, C., additional, Landen, O. L., additional, MacDonald, M. J., additional, McNaney, J. M., additional, Park, H.-S., additional, Remington, B. A., additional, Rubery, M., additional, Schneider, M. B., additional, Sio, H., additional, and Ping, Y., additional

Published
2020
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28. Erratum: “First demonstration of ARC-accelerated proton beams at the National Ignition Facility” [Physics of Plasmas 26, 043110 (2019)]

Author

Mariscal, D., primary, Ma, T., additional, Wilks, S. C., additional, Kemp, A. J., additional, Williams, G. J., additional, Michel, P., additional, Chen, H., additional, Patel, P. K., additional, Remington, B. A., additional, Bowers, M., additional, Pelz, L., additional, Hermann, M. R., additional, Hsing, W., additional, Martinez, D., additional, Sigurdsson, R., additional, Prantil, M., additional, Conder, A., additional, Lawson, J., additional, Hamamoto, M., additional, Di Nicola, P., additional, Widmayer, C., additional, Hoemoelle, D., additional, Lowe-Webb, R., additional, Herriot, S., additional, Williams, W., additional, Alessi, D., additional, Kalantar, D., additional, Zacharias, R., additional, Haefner, C., additional, Thompson, N., additional, Zobrist, T., additional, Lord, D., additional, Hash, N., additional, Pak, A., additional, Lemos, N., additional, Tabak, M., additional, McGuffey, C., additional, Kim, J., additional, Beg, F. N., additional, Wei, M. S., additional, Norreys, P., additional, Morace, A., additional, Iwata, N., additional, Sentoku, Y., additional, Neely, D., additional, Scott, G. G., additional, Flippo, K., additional, Gatu-Johnson, M., additional, and Lahmann, B., additional

Published
2020
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29. Foam-lined hohlraum, inertial confinement fusion experiments on the National Ignition Facility

Author

Moore, A. S., primary, Meezan, N. B., additional, Milovich, J., additional, Johnson, S., additional, Heredia, R., additional, Baumann, T. F., additional, Biener, M., additional, Bhandarkar, S. D., additional, Chen, H., additional, Divol, L., additional, Izumi, N., additional, Nikroo, A., additional, Baker, K., additional, Jones, O., additional, Landen, O. L., additional, Hsing, W. W., additional, Moody, J. D., additional, Thomas, C. A., additional, Lahmann, B., additional, Williams, J., additional, Alfonso, N., additional, and Schoff, M. E., additional

Published
2020
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30. Time-Resolved Fuel Density Profiles of the Stagnation Phase of Indirect-Drive Inertial Confinement Implosions

Author

Tommasini, Riccardo, primary, Landen, O. L., additional, Berzak Hopkins, L., additional, Hatchett, S. P., additional, Kalantar, D. H., additional, Hsing, W. W., additional, Alessi, D. A., additional, Ayers, S. L., additional, Bhandarkar, S. D., additional, Bowers, M. W., additional, Bradley, D. K., additional, Conder, A. D., additional, Di Nicola, J. M., additional, Di Nicola, P., additional, Divol, L., additional, Fittinghoff, D., additional, Gururangan, G., additional, Hall, G. N., additional, Hamamoto, M., additional, Hargrove, D. R., additional, Hartouni, E. P., additional, Heebner, J. E., additional, Herriot, S. I., additional, Hermann, M. R., additional, Holder, J. P., additional, Holunga, D. M., additional, Homoelle, D., additional, Iglesias, C. A., additional, Izumi, N., additional, Kemp, A. J., additional, Kohut, T., additional, Kroll, J. J., additional, LaFortune, K., additional, Lawson, J. K., additional, Lowe-Webb, R., additional, MacKinnon, A. J., additional, Martinez, D., additional, Masters, N. D., additional, Mauldin, M. P., additional, Milovich, J., additional, Nikroo, A., additional, Okui, J. K., additional, Park, J., additional, Prantil, M., additional, Pelz, L. J., additional, Schoff, M., additional, Sigurdsson, R., additional, Volegov, P. L., additional, Vonhof, S., additional, Zobrist, T. L., additional, Wallace, R. J., additional, Walters, C. F., additional, Wegner, P., additional, Widmayer, C., additional, Williams, W. H., additional, Youngblood, K., additional, Edwards, M. J., additional, and Herrmann, M. C., additional

Published
2020
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32. FY15 LLNL OMEGA Experimental Programs

Author

Heeter, R., primary, Baker, K., additional, Barrios, M., additional, Beckwith, M., additional, Casey, D., additional, Celliers, P., additional, Chen, H., additional, Coppari, F., additional, Fournier, K., additional, Fratanduono, D., additional, Frenje, J., additional, Huntington, C., additional, Kraus, R., additional, Lazicki, A., additional, Martinez, D., additional, McNaney, J., additional, Millot, M., additional, Pak, A., additional, Park, H., additional, Ping, Y., additional, Pollock, B., additional, Smith, R., additional, Wehrenberg, C., additional, Widmann, K., additional, Collins, G., additional, Landen, O., additional, Wan, A., additional, and Hsing, W., additional

Published
2015
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33. Experimental demonstration of the reduced expansion of a laser-heated surface using a low density foam layer, pertaining to advanced hohlraum designs with less wall-motion

Author

Moore, A. S., primary, Meezan, N. B., additional, Thomas, C. A., additional, Bhandarkar, S. D., additional, Divol, L., additional, Izumi, N., additional, Nikroo, A., additional, Baumann, T. F., additional, Rubery, M. S., additional, Williams, J., additional, Alfonso, N., additional, Landen, O. L., additional, Hsing, W. W., additional, and Moody, J. D., additional

Published
2020
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34. Production of relativistic electrons at subrelativistic laser intensities

Author

Williams, G. J., primary, Link, A., additional, Sherlock, M., additional, Alessi, D. A., additional, Bowers, M., additional, Conder, A., additional, Di Nicola, P., additional, Fiksel, G., additional, Fiuza, F., additional, Hamamoto, M., additional, Hermann, M. R., additional, Herriot, S., additional, Homoelle, D., additional, Hsing, W., additional, d'Humières, E., additional, Kalantar, D., additional, Kemp, A., additional, Kerr, S., additional, Kim, J., additional, LaFortune, K. N., additional, Lawson, J., additional, Lowe-Webb, R., additional, Ma, T., additional, Mariscal, D. A., additional, Martinez, D., additional, Manuel, M. J.-E., additional, Nakai, M., additional, Pelz, L., additional, Prantil, M., additional, Remington, B., additional, Sigurdsson, R., additional, Widmayer, C., additional, Williams, W., additional, Willingale, L., additional, Zacharias, R., additional, Youngblood, K., additional, and Chen, Hui, additional

Published
2020
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35. Review of hydrodynamic instability experiments in inertially confined fusion implosions on National Ignition Facility

Author

Smalyuk, V A, primary, Weber, C R, additional, Landen, O L, additional, Ali, S, additional, Bachmann, B, additional, Celliers, P M, additional, Dewald, E L, additional, Fernandez, A, additional, Hammel, B A, additional, Hall, G, additional, MacPhee, A G, additional, Pickworth, L, additional, Robey, H F, additional, Alfonso, N, additional, Baker, K L, additional, Hopkins, L F Berzak, additional, Carlson, L, additional, Casey, D T, additional, Clark, D S, additional, Crippen, J, additional, Divol, L, additional, Döppner, T, additional, Edwards, M J, additional, Farrell, M, additional, Felker, S, additional, Field, J E, additional, Haan, S W, additional, Hamza, A V, additional, Havre, M, additional, Herrmann, M C, additional, Hsing, W W, additional, Khan, S, additional, Kline, J, additional, Kroll, J J, additional, LePape, S, additional, Loomis, E, additional, MacGowan, B J, additional, Martinez, D, additional, Masse, L, additional, Mauldin, M, additional, Milovich, J L, additional, Moore, A S, additional, Nikroo, A, additional, Pak, A, additional, Patel, P K, additional, Peterson, J L, additional, Raman, K, additional, Remington, B A, additional, Rice, N, additional, Schoff, M, additional, and Stadermann, M, additional

Published
2019
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36. The National Ignition Facility (NIF) Diagnostic Set at the Completion of the National Ignition Campaign (NIC) September 2013

Author

Kilkenny, J., primary, Bell, P., additional, Bradley, D., additional, Bleuel, D., additional, Caggiano, J., additional, Dewald, E., additional, Hsing, W., additional, Kalantar, H., additional, Kauffman, R., additional, Moody, J., additional, Schneider, M., additional, Shaughnessy, D., additional, Shelton, R., additional, Yeamans, C., additional, Batha, S., additional, Grim, G., additional, Herrmann, H., additional, Merrill, F., additional, Leeper, R., additional, Sangster, T., additional, Edgell, D., additional, Glebov, V., additional, Regan, S., additional, Frenje, J., additional, Gatu-Johnson, M., additional, Petrasso, R., additional, Rindernecht, H., additional, Zylstra, A., additional, Cooper, G., additional, and Ruiz, C., additional

Published
2015
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37. FY14 LLNL OMEGA Experimental Programs

Author

Heeter, R., primary, Fournier, K., additional, Baker, K., additional, Barrios, M., additional, Bernstein, L., additional, Brown, G., additional, Celliers, P., additional, Chen, H., additional, Coppari, F., additional, Fratanduono, D., additional, Johnson, M., additional, Huntington, C., additional, Jenei, A., additional, Kraus, R., additional, Ma, T., additional, Martinez, D., additional, McNabb, D., additional, Millot, M., additional, Moore, A., additional, Nagel, S., additional, Park, H., additional, Patel, P., additional, Perez, F., additional, Ping, Y., additional, Pollock, B., additional, Ross, J., additional, Rygg, J., additional, Smith, R., additional, Zylstra, A., additional, Collins, G., additional, Landen, O., additional, Wan, A., additional, and Hsing, W., additional

Published
2014
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39. CD44-specific nanoparticles for redox-triggered reactive oxygen species production and doxorubicin release

Author

Sin Yu Wang, Fwu Long Mi, Kun Ying Lu, Cheng Wei Lin, and Hsing W. Sung

Subjects
Proton Magnetic Resonance Spectroscopy, 02 engineering and technology, 01 natural sciences, Biochemistry, Chitosan, chemistry.chemical_compound, polycyclic compounds, Disulfides, Hyaluronic Acid, Cytotoxicity, chemistry.chemical_classification, Cell Death, Penicillamine, General Medicine, 021001 nanoscience & nanotechnology, Glutathione, Hyaluronan Receptors, 0210 nano-technology, Drug carrier, Oxidation-Reduction, Fluorescein-5-isothiocyanate, Biotechnology, medicine.drug, Materials science, Cell Survival, Static Electricity, Biomedical Engineering, 010402 general chemistry, Redox, Biomaterials, Cell Line, Tumor, medicine, Humans, Doxorubicin, Particle Size, Molecular Biology, Reactive oxygen species, technology, industry, and agriculture, Hydrogen Peroxide, 0104 chemical sciences, Molecular Weight, Drug Liberation, chemistry, Cancer cell, Biophysics, Nanoparticles, Reactive Oxygen Species
Abstract

CD44-specific and redox-responsive nanoparticles were prepared by coating a bioreducible chitosan-based nanoparticles with hyaluronic acid for intracellular glutathione-triggered reactive oxygen species (ROS) production and doxorubicin (DOX) release. Chitosan (CS) was conjugated with a copper chelator, D-penicillamine (D-pen), to obtain a CS-SS-D-pen conjugate through the formation of a disulfide bond. D-pen release from the conjugate was triggered by intracellular glutathione (GSH) via reducing biologically reversible disulfide bonds. Self-assembled CS-SS-D-pen nanoparticles were prepared through ionotropic gelation with tripolyphosphate and subsequently coated with hyaluronic acid (HA). The HA-coated CS-SS-D-pen NPs were reduced by GSH to release free D-pen and trigger ROS production via a series of reactions involving Cu(II)-catalyzed D-pen oxidation and H2O2 generation. DOX was loaded into the HA-coated CS-SS-D-pen NPs by a method involving the complexation of DOX with Cu(II) ions. The Cu(II)–DOX complex-loaded NPs exhibited redox-responsive release properties which accelerated DOX release at a higher glutathione level (10 mM). Confocal fluorescence microscopy demonstrated that the Cu(II)–DOX-loaded NPs effectively delivered DOX to human colon adenocarcinoma cells (HT-29) by active targeting via HA–CD44 interactions. Intracellular ROS generated from the HA-coated CS-SS-D-pen NPs sensitized cancer cells to DOX-induced cytotoxicity. In vitro cytotoxicity assays revealed that Cu(II)–DOX-loaded NPs sensitized cells to DOX-induced cytotoxicity in CD44-overexpressing HT-29 cells compared to CD44 low-expressing HCT-15 cells. Statement of Significance In this manuscript, we develop a CD44-targetable loaded with nanoparticles Cu(II)–DOX complex. The nanoparticles exhibited redox-responsive properties, which triggered reactive oxygen species (ROS) production and accelerated DOX release. The Cu(II)–DOX-loaded nanoparticle sensitized cells to DOX-induced cytotoxicity in CD44-overexpressing HT-29 cells. To our knowledge, this is the first report showing the combination of CD44-targeting and redox-responsive property for triggering ROS production and subsequent drug release. We believe our findings would appeal to the readership of Acta Biomaterialia because the study bring new and interesting ideals in the development of specific and stimuli-responsive nanoparticles as drug carrier for cancer therapy.

Published
2016

40. FY13 LLNL OMEGA Experimental Programs

Author

Heeter, R, primary, Fournier, K, additional, Baker, K, additional, Brown, G, additional, Casey, D, additional, Celliers, P, additional, Fratanduono, D, additional, Hawreliak, J, additional, Huntington, C, additional, Lazicki, A, additional, Ma, T, additional, May, M, additional, Moore, A, additional, Pak, A, additional, Park, H, additional, Patterson, R, additional, Perez, F, additional, Ping, Y, additional, Plechaty, C, additional, Rinderknecht, H, additional, Ross, J, additional, Rygg, J, additional, Smalyuk, V, additional, Tommasini, R, additional, Wehrenberg, C, additional, Zylstra, A, additional, Collins, G, additional, Landen, O, additional, Wan, A, additional, and Hsing, W, additional

Published
2013
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41. Progress of indirect drive inertial confinement fusion in the United States

Author

Kline, J.L., primary, Batha, S.H., additional, Benedetti, L.R., additional, Bennett, D., additional, Bhandarkar, S., additional, Hopkins, L.F. Berzak, additional, Biener, J., additional, Biener, M.M., additional, Bionta, R., additional, Bond, E., additional, Bradley, D., additional, Braun, T., additional, Callahan, D.A., additional, Caggiano, J., additional, Cerjan, C., additional, Cagadas, B., additional, Clark, D., additional, Castro, C., additional, Dewald, E.L., additional, Döppner, T., additional, Divol, L., additional, Dylla-Spears, R., additional, Eckart, M., additional, Edgell, D., additional, Farrell, M., additional, Field, J., additional, Fittinghoff, D.N., additional, Gatu Johnson, M., additional, Grim, G., additional, Haan, S., additional, Haines, B.M., additional, Hamza, A.V., additional, Hartouni, EP., additional, Hatarik, R., additional, Henderson, K., additional, Herrmann, H.W., additional, Hinkel, D., additional, Ho, D., additional, Hohenberger, M., additional, Hoover, D., additional, Huang, H., additional, Hoppe, M.L., additional, Hurricane, O.A., additional, Izumi, N., additional, Johnson, S., additional, Jones, O.S., additional, Khan, S., additional, Kozioziemski, B.J., additional, Kong, C., additional, Kroll, J., additional, Kyrala, G.A., additional, LePape, S., additional, Ma, T., additional, Mackinnon, A.J., additional, MacPhee, A.G., additional, MacLaren, S., additional, Masse, L., additional, McNaney, J., additional, Meezan, N.B., additional, Merrill, J.F., additional, Milovich, J.L., additional, Moody, J., additional, Nikroo, A., additional, Pak, A., additional, Patel, P., additional, Peterson, L., additional, Piceno, E., additional, Pickworth, L., additional, Ralph, J.E., additional, Rice, N., additional, Robey, H.F., additional, Ross, J.S., additional, Rygg, J.R., additional, Sacks, M.R., additional, Salmonson, J., additional, Sayre, D., additional, Sater, J.D., additional, Schneider, M., additional, Schoff, M., additional, Sepke, S., additional, Seugling, R., additional, Smalyuk, V., additional, Spears, B., additional, Stadermann, M., additional, Stoeffl, W., additional, Strozzi, D.J., additional, Tipton, R., additional, Thomas, C., additional, Volegov, P.L., additional, Walters, C., additional, Wang, M., additional, Wilde, C., additional, Woerner, E., additional, Yeamans, C., additional, Yi, S.A., additional, Yoxall, B., additional, Zylstra, A.B., additional, Kilkenny, J., additional, Landen, O.L., additional, Hsing, W., additional, and Edwards, M.J., additional

Published
2019
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42. First demonstration of ARC-accelerated proton beams at the National Ignition Facility

Author

Mariscal, D., primary, Ma, T., additional, Wilks, S. C., additional, Kemp, A. J., additional, Williams, G. J., additional, Michel, P., additional, Chen, H., additional, Patel, P. K., additional, Remington, B. A., additional, Bowers, M., additional, Pelz, L., additional, Hermann, M. R., additional, Hsing, W., additional, Martinez, D., additional, Sigurdsson, R., additional, Prantil, M., additional, Conder, A., additional, Lawson, J., additional, Hamamoto, M., additional, Di Nicola, P., additional, Widmayer, C., additional, Homoelle, D., additional, Lowe-Webb, R., additional, Herriot, S., additional, Williams, W., additional, Alessi, D., additional, Kalantar, D., additional, Zacharias, R., additional, Haefner, C., additional, Thompson, N., additional, Zobrist, T., additional, Lord, D., additional, Hash, N., additional, Pak, A., additional, Lemos, N., additional, Tabak, M., additional, McGuffey, C., additional, Kim, J., additional, Beg, F. N., additional, Wei, M. S., additional, Norreys, P., additional, Morace, A., additional, Iwata, N., additional, Sentoku, Y., additional, Neely, D., additional, Scott, G. G., additional, and Flippo, K., additional

Published
2019
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44. Development of the CD Symcap platform to study gas-shell mix in implosions at the National Ignition Facility

Author

Casey, D, primary, Smalyuk, V, additional, Tipton, R, additional, Pino, J, additional, Grim, G, additional, Remington, B, additional, Rowley, D, additional, Weber, S, additional, Barrios, M, additional, Benedetti, R, additional, Bleuel, D, additional, Bond, E, additional, Bradley, D, additional, Caggiano, J, additional, Callahan, D, additional, Cerjan, C, additional, Chen, K, additional, Edgell, D, additional, Edwards, M, additional, Fittinghoff, D, additional, Frenje, J, additional, Gatu-Johnson, M, additional, Glebov, V, additional, Glenn, S, additional, Guler, N, additional, Haan, S, additional, Hamza, A, additional, Hatarik, R, additional, Herrmann, H, additional, Hoover, D, additional, Hsing, W, additional, Izumi, N, additional, Kervin, P, additional, Khan, S, additional, Kilkenny, J, additional, Kline, J, additional, Knauer, J, additional, Kyrala, G, additional, Landen, O, additional, Ma, T, additional, MacPhee, A, additional, McNaney, J, additional, Mintz, M, additional, Moore, A, additional, Nikroo, A, additional, Pak, A, additional, Parham, T, additional, Petrasso, R, additional, Rinderknecht, H, additional, Sayre, D, additional, Schneider, M, additional, Stoeffl, W, additional, Tommasini, R, additional, Town, R, additional, Widman, K, additional, Wilson, D, additional, and Yeamans, C, additional

Published
2013
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45. FY12 LLNL OMEGA Experimental Programs

Author

Heeter, R, primary, Fournier, K, additional, Baker, K, additional, Celliers, P, additional, Fratanduono, D, additional, Hawreliak, J, additional, Kirkwood, R, additional, Kritcher, A, additional, Lazicki, A, additional, Ma, T, additional, Maddox, B, additional, Pak, A, additional, Park, H, additional, Patterson, R, additional, Perez, F, additional, Ping, Y, additional, Plechaty, C, additional, Ross, J, additional, Rygg, R, additional, Smalyuk, V, additional, Tommasini, R, additional, Wehrenberg, C, additional, Collins, G, additional, Hsing, W, additional, and Landen, O, additional

Published
2012
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46. FY11 LLNL OMEGA Experimental Programs

Author

Tommasini, R., primary, Fournier, K., additional, Celliers, P., additional, Comley, A., additional, Farley, D., additional, Hawreliak, J., additional, Heeter, B., additional, Kritcher, A., additional, Lazicki, A., additional, Ma, T., additional, Maddox, B., additional, May, M., additional, McNaney, J., additional, Pak, A., additional, Park, H., additional, Ping, Y., additional, Ross, J., additional, Rygg, R., additional, Smalyuk, V., additional, Smith, R., additional, Collins, G., additional, Hsing, W., additional, and Landen, O., additional

Published
2011
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48. A “polar contact” tent for reduced perturbation and improved performance of NIF ignition capsules

Author

Hammel, B. A., primary, Weber, C. R., additional, Stadermann, M., additional, Alday, C. L., additional, Aracne-Ruddle, C., additional, Bigelow, J. R., additional, Clark, D. S., additional, Cortez, J. P., additional, Diaz, S., additional, Döppner, T., additional, Felker, S., additional, Field, J. E., additional, Haan, S. W., additional, Havre, M. O., additional, Heinbockel, C., additional, Hinkel, D. E., additional, Hsing, W. W., additional, Johnson, S. A., additional, Nikroo, A., additional, Pickworth, L. A., additional, Ralph, J. E., additional, Robey, H. F., additional, and Smalyuk, V. A., additional

Published
2018
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49. Hydrodynamic instabilities seeded by the X-ray shadow of ICF capsule fill-tubes

Author

MacPhee, A. G., primary, Smalyuk, V. A., additional, Landen, O. L., additional, Weber, C. R., additional, Robey, H. F., additional, Alfonso, E. L., additional, Baker, K. L., additional, Berzak Hopkins, L. F., additional, Biener, J., additional, Bunn, T., additional, Casey, D. T., additional, Clark, D. S., additional, Crippen, J. W., additional, Divol, L., additional, Farrell, M., additional, Felker, S., additional, Field, J. E., additional, Hsing, W. W., additional, Kong, C., additional, Le Pape, S., additional, Martinez, D. A., additional, Michel, P., additional, Milovich, J., additional, Moore, A., additional, Nikroo, A., additional, Pickworth, L., additional, Rice, N., additional, Stadermann, M., additional, Yeamans, C., additional, and Wild, C., additional

Published
2018
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50. Development of new platforms for hydrodynamic instability and asymmetry measurements in deceleration phase of indirectly driven implosions on NIF

Author

Pickworth, L. A., primary, Hammel, B. A., additional, Smalyuk, V. A., additional, Robey, H. F., additional, Tommasini, R., additional, Benedetti, L. R., additional, Berzak Hopkins, L., additional, Bradley, D. K., additional, Dayton, M., additional, Felker, S., additional, Field, J. E., additional, Haan, S. W., additional, Haid, B., additional, Hatarik, R., additional, Hartouni, E., additional, Holunga, D., additional, Hoppe, M., additional, Izumi, N., additional, Johnson, S., additional, Khan, S., additional, Kohut, T., additional, Lahmann, B., additional, Landen, O. L., additional, LePape, S., additional, MacPhee, A. G., additional, Marley, E., additional, Meezan, N. B., additional, Milovich, J., additional, Nagel, S. R., additional, Nikroo, A., additional, Pak, A. E., additional, Petrasso, R., additional, Remington, B. A., additional, Rice, N. G., additional, Scott, H. A., additional, Springer, P. T., additional, Stadermann, M., additional, Walters, C., additional, Widmann, K., additional, and Hsing, W. W., additional

Published
2018
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