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4 results on '"Hsin-Yin Chiang"'

1. Optimizing and Predicting Antidepressant Efficacy in Patients with Major Depressive Disorder Using Multi-Omics Analysis and the Opade AI Prediction Tools

Author

Giulio Corrivetti, Francesco Monaco, Annarita Vignapiano, Alessandra Marenna, Kaia Palm, Salvador Fernández-Arroyo, Eva Frigola-Capell, Volker Leen, Oihane Ibarrola, Burak Amil, Mattia Marco Caruson, Lorenzo Chiariotti, Maria Alejandra Palacios-Ariza, Pieter J. Hoekstra, Hsin-Yin Chiang, Alexandru Floareș, Andrea Fagiolini, and Alessio Fasano

Subjects
major depressive disorders, microbiome, metabolomic, transcriptomics, inflammation, genetics, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

According to the World Health Organization (WHO), major depressive disorder (MDD) is the fourth leading cause of disability worldwide and the second most common disease after cardiovascular events. Approximately 280 million people live with MDD, with incidence varying by age and gender (female to male ratio of approximately 2:1). Although a variety of antidepressants are available for the different forms of MDD, there is still a high degree of individual variability in response and tolerability. Given the complexity and clinical heterogeneity of these disorders, a shift from “canonical treatment” to personalized medicine with improved patient stratification is needed. OPADE is a non-profit study that researches biomarkers in MDD to tailor personalized drug treatments, integrating genetics, epigenetics, microbiome, immune response, and clinical data for analysis. A total of 350 patients between 14 and 50 years will be recruited in 6 Countries (Italy, Colombia, Spain, The Netherlands, Turkey) for 24 months. Real-time electroencephalogram (EEG) and patient cognitive assessment will be correlated with biological sample analysis. A patient empowerment tool will be deployed to ensure patient commitment and to translate patient stories into data. The resulting data will be used to train the artificial intelligence/machine learning (AI/ML) predictive tool.

Published
2024
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3. In situ film characterization of thermally treated microstructured conducting polymer films

Author

Matthias A. Ruderer, Peter Müller-Buschbaum, Shuai Guo, Robert Meier, Jan Perlich, Volker Körstgens, and Hsin-Yin Chiang

Subjects
Conductive polymer, chemistry.chemical_classification, Materials science, Polymers and Plastics, Thermal treatment, Polymer, Condensed Matter Physics, chemistry, Ellipsometry, Polymer chemistry, Materials Chemistry, Grazing-incidence small-angle scattering, Crystallite, Physical and Theoretical Chemistry, Thin film, Composite material, Glass transition
Abstract

Based on a low-cost fabrication routine microstructured conducting polymer films of poly (dioctylfluorene-co-benzothiadiazole) (F8BT) are prepared without any heat treatment or vacuum steps. The influence of thermal annealing at temperatures below the glass transition temperature of F8BT on such microstructured channel structures is investigated. In the applied structuring routine, a F8BT film is spin coated on a channel-type hard master structure and afterwards floated on a flat support. Thereby, the properties of the final polymeric structures, for example channel width and height, can be tuned by simply varying the polymer concentration in solution and using the same master structure. With in situ grazing incidence small angle X-ray scattering and imaging ellipsometry the installed channel structure and the influence of thermal treatment are probed. A complex interplay between a macroscopic polymer flow (reduced channel heights) and a molecular rearrangement (formation of mesoscopic crystallites) takes place during thermal annealing. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2012

Published
2012

4. Solvent-Induced Morphology in Polymer-Based Systems for Organic Photovoltaics

Author

Peter Müller-Buschbaum, Matthias A. Ruderer, Jan Perlich, J. Wiedersich, Volker Körstgens, Hsin-Yin Chiang, Shuai Guo, Robert Meier, and Stephan V. Roth

Subjects
Materials science, Photoluminescence, Organic solar cell, business.industry, Scattering, Annealing (metallurgy), Condensed Matter Physics, Electronic, Optical and Magnetic Materials, law.invention, Biomaterials, X-ray reflectivity, Optics, Chemical engineering, law, Electrochemistry, Grazing-incidence small-angle scattering, Crystallization, Thin film, business
Abstract

Studies on the influence of four different solvents on the morphology and photovoltaic performance of bulk-heterojunction films made of poly(3-hexylthiophene) (P3HT) and [6,6]-phenyl-C61 butyric acid methyl ester (PCBM) via spin-coating for photovoltaic applications are reported. Solvent-dependent PCBM cluster formation and P3HT crystallization during thermal annealing are investigated with optical microscopy and grazing-incidence wide-angle X-ray scattering (GIWAXS) and are found to be insufficient to explain the differences in device performance. A combination of atomic force microscopy (AFM), X-ray reflectivity (XRR), and grazing-incidence small-angle X-ray scattering (GISAXS) investigations results in detailed knowledge of the inner film morphology of P3HT:PCBM films. Vertical and lateral phase separation occurs during spin-coating and annealing, depending on the solvent used. The findings are summarized in schematics and compared with the IV characteristics. The main influence on the photovoltaic performance arises from the vertical material composition and the existence of lateral phase separation fitting to the exciton diffusion length. Absorption and photoluminescence measurements complement the structural analysis.

Published
2011

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