23 results on '"Hsiao-Yu Lee"'
Search Results
2. A real-world analysis of the effectiveness, resource use, and costs associated with ventricular tachycardia catheter ablation in Japanese patients aged ≤75 years
- Author
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Kyoko Soejima, Akiko Ueda, Mami Ogiri, Yoko Ichishima, HyeJin Park, and Stephanie Hsiao Yu Lee
- Subjects
General Earth and Planetary Sciences ,General Environmental Science - Published
- 2022
3. Quantitative video-based gait pattern analysis for hemiparkinsonian rats.
- Author
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Hsiao-Yu Lee, Tsung-Hsun Hsieh, Jen-I Liang, Ming-Long Yeh, and Jia-Jin J. Chen
- Published
- 2012
- Full Text
- View/download PDF
4. Image analysis system for acquiring three-dimensional contour of foot arch during balanced standing.
- Author
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Chi-Hsuan Lin, Jia-Jin J. Chen, Chi-Hsun Wu, Hsiao-Yu Lee, and Yuh-Hwan Liu
- Published
- 2004
- Full Text
- View/download PDF
5. Development of a virtual reality environment for somatosensory and perceptual stimulation in the balance assessment of children.
- Author
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Hsiao-Yu Lee, Rong-Ju Cherng, and Chi-Hsuan Lin
- Published
- 2004
- Full Text
- View/download PDF
6. Measurement of Interhemispheric Correlation Coefficient in Rodent Model of Middle Cerebral Artery Occlusion Using Near Infrared Spectroscopy
- Author
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Jia Jin Jason Chen, Yueh-Jen Chung, Wen-Chen Shao, Chun-Wei Wu, Chun-Man Yuen, and Hsiao-Yu Lee
- Subjects
medicine.medical_specialty ,Hemodynamics ,Infarction ,Rodentia ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Neuroimaging ,Interhemispheric correlation ,Internal medicine ,medicine ,Animals ,0501 psychology and cognitive sciences ,Middle cerebral artery occlusion ,Stroke ,Spectroscopy, Near-Infrared ,business.industry ,05 social sciences ,Near-infrared spectroscopy ,technology, industry, and agriculture ,Rodent model ,Infarction, Middle Cerebral Artery ,equipment and supplies ,medicine.disease ,Prognosis ,Rats ,Oxygen ,Disease Models, Animal ,Cerebrovascular Circulation ,Cardiology ,business ,030217 neurology & neurosurgery - Abstract
Near-infrared spectroscopy (NIRS) is a noninvasive brain imaging technique that measures hemodynamics by determining the optical properties of tissue. Clinical potential of NIRS for monitoring cerebral hemodynamics in cerebrovascular diseases, such as stroke, has been studied. However, inconsistencies in measurements among studies, which are believed to be partly due to anatomical variance and diversity in disease presentation, limit the clinical feasibility of NIRS for stroke monitoring. In the present study, bihemispheric frequency-domain NIRS measurements on middle cerebral artery occlusion rats were performed. The discrepancy in interhemispheric synchronicity in hemodynamic oscillation appeared during the early reperfusion stage is related to the size of infarct that developed three days later. These NIRS parameters may have the potential to be early prognostic biomarkers for long-term stroke monitoring in the future translational investigation.
- Published
- 2020
7. Development of Innovative Feedback Device for Swallowing Therapy
- Author
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Jia Jin Jason Chen, Chih-Ming Li, Hsiao-Yu Lee, Shang-Heng Hsieh, Tyng-Guey Wang, and Hsueh-Pei Wang
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030506 rehabilitation ,medicine.medical_specialty ,business.industry ,Biomedical Engineering ,Healthy subjects ,General Medicine ,Aspiration pneumonia ,medicine.disease ,Dysphagia ,Clinical trial ,03 medical and health sciences ,0302 clinical medicine ,Swallowing ,Statistical significance ,Swallowing evaluation ,Physical therapy ,Medicine ,Swallowing therapy ,medicine.symptom ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
Dysphagia, which results from various disorders, may increase the risk of aspiration pneumonia, dehydration, and malnutrition. The aim of this study was to develop an innovative evaluation and treatment system for swallowing therapy using virtual reality (VR) feedback and electrical stimulation (ES), and to make an initial evaluation of its potential. In this system, the activation of the submental muscle and acceleration of laryngeal movement are used as the evaluation and feedback information. Twenty-one patients with chronic dysphagia for an average of 26.3 months were recruited for the VR feedback study. Each participant underwent 16 treatment sessions. After therapy, the Functional Oral Intake Scale results changed from 3.3 ± 1.5 to 5.0 ± 1.6 with statistical significance (p = 0.000). Thirteen healthy subjects were enrolled in the ES study. ES was applied for more than 2 s while the subjects were swallowing. With and without ES, swallowing triggering times were 456.17 ± 106.92 and 552.13 ± 105.97 ms, respectively. These differences were statistically significant (p = 0.04). Accelerations of laryngeal movement were 0.23 ± 0.1 g (g = 9.8 m/s2) and 0.20 ± 0.08 g, respectively, with a significant statistical difference (p = 0.033). The feasibility of a prototype that combines swallowing evaluation, VR feedback therapy, and synchronized ES is demonstrated for further clinical trials. Further comprehensive clinical studies are needed to verify the clinical efficacy of the device.
- Published
- 2016
8. Inhibition of Advanced Glycation End Products Formation Attenuates Cardiac Electrical and Mechanical Remodeling and Vulnerability to Tachyarrhythmias in Diabetic Rats
- Author
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Yung-Hsin Yeh, Hsiao-Yu Lee, Wei-Jan Chen, Yu-Shien Ko, Gwo-Jyh Chang, and Jong-Hwei S. Pang
- Subjects
0301 basic medicine ,Cardiac function curve ,Blood Glucose ,Glycation End Products, Advanced ,Male ,medicine.medical_specialty ,Cardiomyopathy ,Action Potentials ,Sudden death ,Guanidines ,Diabetes Mellitus, Experimental ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,Organ Culture Techniques ,Glycation ,Diabetes mellitus ,Diabetic cardiomyopathy ,Internal medicine ,Tachycardia ,medicine ,Myocyte ,Animals ,Myocytes, Cardiac ,Enzyme Inhibitors ,Cells, Cultured ,Pharmacology ,Ventricular Remodeling ,business.industry ,medicine.disease ,Rats ,030104 developmental biology ,Endocrinology ,cardiovascular system ,Ventricular pressure ,Molecular Medicine ,business ,030217 neurology & neurosurgery - Abstract
Diabetic patients with cardiomyopathy show a higher incidence of arrhythmias and sudden death. Chronic hyperglycemia induces the formation of advanced glycation end products (AGEs), which contribute to the pathogenesis of diabetic cardiomyopathy. This study investigated whether inhibition of AGEs formation by aminoguanidine (AG) could prevent cardiac electromechanical and arrhythmogenic remodeling in diabetes mellitus. Streptozotocin-induced diabetic rats received AG (100 mg/kg daily, i.p.) or vehicle (normal saline, i.p.) for 5 weeks. The rats underwent hemodynamic recording to evaluate cardiac function, and heart preparations were used to determine the electrical, mechanical, and biochemical functions. In vitro high glucose-induced AGEs formation, reactive oxygen species (ROS) generation, and action potential changes were examined in HL-1 atrial cells. AG treatment improved the diabetes-induced depression in left ventricular pressure and the relaxation rate, and normalized the prolongation of QTc intervals in anesthetized rats. AG reduced the vulnerabilities to atrial and ventricular tachyarrhythmias in perfused diabetic hearts. AG normalized the prolonged action potential duration in diabetic atrial and ventricular muscles, which was correlated with the restoration of both transient outward (Ito) and steady-state outward (ISS) K+ current densities in cardiomyocytes. The abnormal kinetics of Ca2+ transients and contraction were reversed in cardiomyocytes from AG-treated diabetic rats, along with parallel preservation of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2a) expression. Furthermore, ex vivo and in vitro studies showed AG attenuated AGEs and ROS formation. Thus, long-term administration of AG ameliorated cardiac electromechanical remodeling and arrhythmogenicity in diabetic rats and may present an effective strategy for the prevention of diabetes-associated arrhythmias.
- Published
- 2018
9. Quantitative video-based gait pattern analysis for hemiparkinsonian rats
- Author
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Tsung Hsun Hsieh, Hsiao Yu Lee, Jen I. Liang, Jia Jin Jason Chen, and Ming Long Yeh
- Subjects
Male ,medicine.medical_specialty ,Computer science ,Video Recording ,Biomedical Engineering ,Effect of gait parameters on energetic cost ,Hemiplegia ,Hindlimb ,Kinematics ,Physical medicine and rehabilitation ,Image Interpretation, Computer-Assisted ,Photography ,medicine ,Animals ,Rats, Wistar ,Gait ,Gait Disorders, Neurologic ,Foot ,Gait Disturbance ,Parkinson Disease ,Anatomy ,Rats ,Computer Science Applications ,Preferred walking speed ,medicine.anatomical_structure ,Gait analysis ,Ankle ,human activities - Abstract
Gait disturbances are common in the rat model of Parkinson's disease (PD) by administrating 6-hydroxydopamine. However, few studies have simultaneously assessed spatiotemporal gait indices and the kinematic information of PD rats during overground locomotion. This study utilized a simple, accurate, and reproducible method for quantifying the spatiotemporal and kinematic changes of gait patterns in hemiparkinsonian rats. A transparent walkway with a tilted mirror was set to capture underview footprints and lateral joint ankle images using a high-speed and high-resolution digital camera. The footprint images were semi-automatically processed with a threshold setting to identify the boundaries of soles and the critical points of each hindlimb for deriving the spatiotemporal and kinematic indices of gait. Following PD lesion, asymmetrical gait patterns including a significant decrease in the step/stride length and increases in the base of support and ankle joint angle were found. The increased footprint length, toe spread, and intermediary toe spread were found, indicating a compensatory gait pattern for impaired locomotor function. The temporal indices showed a significant decrease in the walking speed with increased durations of the stance/swing phase and double support time, which was more evident in the affected hindlimb. Furthermore, the ankle kinematic data showed that the joint angle decreased at the toe contact stage. We conclude that the proposed gait analysis method can be used to precisely detect locomotor function changes in PD rats, which is useful for objective assessments of investigating novel treatments for PD animal model.
- Published
- 2012
10. ELECTROENCEPHALOGRAPHIC ASSESSMENT OF HUMAN RELIABILITY ON VISUAL RESPONSE TASK
- Author
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Hsiao-Yu Lee, Shyh-Yueh Cheng, and Sheng-Bou Yen
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Biomedical Engineering ,Biophysics ,Healthy subjects ,Bioengineering ,Audiology ,Electroencephalography ,behavioral disciplines and activities ,Task (project management) ,Electrophysiology ,medicine ,Latency (engineering) ,Psychology ,psychological phenomena and processes ,Eriksen flanker task ,Reliability (statistics) ,Human reliability - Abstract
Electrophysiological correlates of human reliability in visual response tasks were investigated in 16 healthy subjects using electroencephalographic (EEG) spectral power and event-related potentials (ERP). Human reliability was first determined by calculating individual reaction accuracy in order to split the entire group into high reliability (HR) and low reliability (LR) subgroups, each with eight subjects. The EEG activities of testing subjects were measured at rest condition for 5 min, and during a modified Eriksen flanker task. Artifact-free EEG segments were used to compute the distribution of EEG at varied frequency bands as well as to detect peak and latency of ERPs of the flanker task. Our results showed that subjects with LR exhibited higher alpha band EEG power at the frontal recording site. Additionally, LR group revealed lower P300 amplitude and predominantly longer P300 latency at centro-parietal recording site than those of the HR group. These findings implied that higher alpha band EEG power at frontal and smaller amplitude, longer latency P300 component of ERP measures at centro-parietal might reveal the trait of lower reliability in healthy controls during visual tasks.
- Published
- 2010
11. Nonacog alfa: an analysis of safety data from six prospective clinical studies in different patient populations with haemophilia B treated with different therapeutic modalities
- Author
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Frank E. Shafer, Hsiao-Yu Lee, Lynne Smith, and Pablo Rendo
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Fever ,Urticaria ,Haemophilia ,Hemophilia B ,law.invention ,Drug Hypersensitivity ,Factor IX ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Humans ,Haemophilia B ,Prospective Studies ,Prospective cohort study ,Adverse effect ,Child ,Clinical Trials as Topic ,business.industry ,Coagulants ,Hematology ,General Medicine ,medicine.disease ,Therapeutic modalities ,Recombinant Proteins ,Surgery ,Drug eruption ,Cough ,Nasopharyngitis ,Child, Preschool ,Observational study ,Female ,business - Abstract
Nonacog alfa is a recombinant factor IX (FIX) product indicated for treatment and prevention of bleeding episodes in patients with haemophilia B. This posthoc analysis evaluated the safety of nonacog alfa in key clinical studies across 15 years. Data were pooled from six prospective studies that utilized on-demand, prophylactic and preventive nonacog alfa regimens: three open-label, nonrandomized studies that assessed efficacy and safety; a bioequivalence study of original and reformulated nonacog alfa; an open-label, randomized study that compared on-demand and prophylactic treatment; and a noninterventional observational registry study that evaluated safety. Safety assessments included adverse events, serious adverse events (SAEs) and events of special interest. In total, 412 patients received nonacog alfa treatment. Adverse events occurred in 220 patients (53.4%), the most common being pyrexia (n = 63), nasopharyngitis (n = 53) and cough (n = 52). Forty-eight patients (11.7%) experienced treatment-related adverse events; the most common were hypersensitivity (n = 6), urticaria (n = 6), FIX inhibition (n = 5) and pyrexia (n = 4). Seventy-four patients (18.0%) developed SAEs. Thirty-seven events of special interest occurred in 31 (7.5%) patients. Events of special interest included allergic-type manifestations (n = 15), inhibitor development (n = 5), lack of effect (n = 8), red blood cell agglutination in tubing or syringe (n = 7), and thrombogenicity (n = 2). Six patients (1.5%) withdrew due to seven adverse events: hypersensitivity (n = 3), drug eruption, pruritic rash, urticaria and decreased therapeutic response (n = 1 each). Four patients died during the study; no deaths were related to study medication. This pooled safety analysis in haemophilia B patients confirmed the safety of nonacog alfa across various patient populations.
- Published
- 2015
12. Movement Training and Assessment with 3D Virtual Reality for Parkinson’s Disease Patient
- Author
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Zong Syuan Huang, Jia Jin Jason Chen, Chien An Chen, Kao Chang Lin, Hsiao Yu Lee, Yu Lin Wang, and Chao Chen Lo
- Subjects
medicine.medical_specialty ,Engineering ,Rehabilitation ,genetic structures ,business.industry ,medicine.medical_treatment ,Training system ,Optical flow ,Virtual reality ,Trunk ,Physical medicine and rehabilitation ,medicine ,Physical therapy ,medicine.symptom ,business ,Sensory cue ,Balance problems ,Balance (ability) - Abstract
Balance problems such as inability to maintain stability and postural transition are common in patients with Parkinson’s disease (PD). In clinical, visual cues are used as rehabilitation program in improving postural stability. Ball catching movement is considered a kind of suitable training program for PD patients because of its characteristics of eye-hand-foot coordination. Furthermore, studies have shown that optical flow could provide motion perceptions and improve movement performance of PD patients. The purpose of this study was to develop a 3D virtual reality (VR) training system for providing optical flow information during catching virtual balls under standing and one-step forward movements for subjects with PD. The armtrunk movement and trunk movement were utilized as the assessment indices of balance and postural control by inertial sensors attached on waist and bilateral of wrists. The balance training system accompanied with evaluation system demonstrated that arm-trunk control and balance on ball catching performance of PD patients could be improved with optical flow information.
- Published
- 2015
13. Measurement and modeling of stimulus-evoked electromyography in lengthened and shortened muscles for spinal cord injured subjects during an electrically-elicited fatigue process
- Author
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Jia Jin Jason Chen, Nan Ying Yu, Shao Hsia Chang, and Hsiao Yu Lee
- Subjects
Adult ,Male ,medicine.medical_specialty ,Knee Joint ,Fast twitch muscle ,Physiology ,Radioimmunoassay ,Biomedical Engineering ,Biophysics ,Enzyme-Linked Immunosorbent Assay ,Stimulation ,Electromyography ,Stimulus (physiology) ,Rheumatology ,Physiology (medical) ,Internal medicine ,Synovial Fluid ,Humans ,Medicine ,Immunoelectrophoresis ,Inflammation ,Shortened muscle ,medicine.diagnostic_test ,business.industry ,Arthritis ,Anatomy ,Middle Aged ,Spinal cord ,Evoked electromyography ,Motor unit ,medicine.anatomical_structure ,Cardiology ,Female ,business ,Algorithms - Abstract
This study compares the amplitude and temporal features of stimulus-evoked electromyography (EMG) of paralyzed muscle, rectus femoris (RF), in both lengthened and shortened positions of six spinal cord injured (SCI) subjects during an electrically elicited fatigue process. The torque output and evoked EMG were fitted by hyperbolic tangent functions from which their amplitude residual levels and temporal inflection times can be extracted. Furthermore, a structural EMG model of Fuglevand et al (1992 Biol. Cybern. 67 143-53) was modified to include type I (slow twitch) and type II (fast twitch) of motor unit (MU) fibers with viable parameters obtained from paralyzed muscles to observe their amplitude and temporal changes. Our results showed that the amplitude of stimulus-evoked EMG decreased earlier in the lengthened muscle with a shorter inflection time (48.53 +/- 8.7 s versus 55.13 +/- 4.03 s) than that of the shortened position during 120 s of stimulation time (p0.05). Similarly, the peak-to-peak duration (PTPd) of the evoked EMG increased faster at an earlier time to a higher asymptotical value in lengthened muscle (2.23 +/- 0.74 versus 1.77 +/- 0.54), compared to that of a shortened one (p0.05). These observations coincided with the higher rising rate and larger final value of the temporal coefficients, i.e., longer duration, in both type I and II MUs of lengthened muscles. From the observation of all parameters, the fatigue process in lengthened muscle proceeds faster than that in shortened muscle.
- Published
- 2006
14. Development of a virtual reality environment for somatosensory and perceptual stimulation in the balance assessment of children
- Author
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Chi Hsuan Lin, Hsiao Yu Lee, and Rong Ju Cherng
- Subjects
Adult ,Balance assessment ,Visual perception ,Adolescent ,business.industry ,Computer science ,Posture ,Reproducibility of Results ,Health Informatics ,Virtual reality ,Stimulus (physiology) ,Somatosensory system ,Computer Science Applications ,Postural control ,Center of pressure (terrestrial locomotion) ,Child, Preschool ,Somatosensory Disorders ,Humans ,Perceptual stimulation ,Computer vision ,Diagnosis, Computer-Assisted ,Artificial intelligence ,Child ,business ,Postural Balance - Abstract
In this study, we developed a balance assessment system in which the visual stimulus was generated by a virtual reality (VR) technique and somatosensation was obtained from a movable platform. By standing on the movable platform, the center of pressure (COP) was measured to express the subject's postural control in response to varied visual stimuli. From the COP data, a singular value decomposition technique was used to derive the sway area and direction, represented in a polar form. Our system demonstrated the feasibility of using a VR environment in postural control trials and provided more realistic somatosensory and visual inputs.
- Published
- 2004
15. Image analysis system for acquiring three-dimensional contour of foot arch during balanced standing
- Author
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Hsiao-Yu Lee, Jia-Jin Jason Chen, Yuh-Hwan Liu, Chi-Hsuan Lin, and Chi-Hsun Wu
- Subjects
Brightness ,business.product_category ,Foot ,business.industry ,media_common.quotation_subject ,3D reconstruction ,Health Informatics ,Load cell ,Computer Science Applications ,Footprint ,Image Processing, Computer-Assisted ,Contrast (vision) ,Force platform ,Computer vision ,Artificial intelligence ,Arch ,business ,Software ,Geology ,Digital camera ,media_common - Abstract
Compared to the X-ray approach, footprint analysis is a non-radiation and more viable method for clinical assessment of the medial longitudinal arch of the foot. In this study, we have designed an optical footprint acquisition system that consists of a digital camera and two pieces of glass, each with four load cells under each corner. When the subject stands on the transparent force plates, the digital camera is triggered, photographing the soles of the feet at the moment when both feet bear approximately at the same weight. A blue gel is placed between the foot and the force plate to enhance the contrast between sole and background. Based on the relationship between the brightness of the image and the thickness of the gel, the three-dimensional (3D) structure of the arch can be reconstructed which can provide more representative information than a conventional footprint image, with its low resolution and easy smearing.
- Published
- 2004
16. RAPID PROTOTYPING OF WIRELESS AUGMENTATIVE AND ALTERNATIVE COMMUNICATION SYSTEM FOR SPEECH IMPAIRED SUBJECTS
- Author
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Hsiao-Yu Lee and Chao‐Min Wu
- Subjects
Engineering ,business.product_category ,business.industry ,Biomedical Engineering ,Biophysics ,Telecommunications service ,Bioengineering ,Augmentative and alternative communication ,Human–computer interaction ,Phone ,Mobile phone ,Personal computer ,Wireless ,Graphics ,Telecommunications ,business ,Pager - Abstract
Wireless telecommunications holds particular promise for people with speech impairment because it can provide convenience for communication and enhance user's mobility. However, people with speech impairments are likely to also have varied movement disorders which result in the inability to use the existing voice telephone facility. The aim of this research is to extend the current augmentative and alternative communication (AAC) system to wireless telecommunication service for speech-impaired subjects. A pocket personal computer (PPC) with wireless modules is adopted herein, that can be functioned as a portable AAC device, voice pager within a range, and mobile phone. The touch screen of PPC with designed graphics icon can be served as large buttons to activate the high-fidelity sound that is in turns sent to the wireless modules for "talking" through the phone. An AAC layout editor is used to link the pre-recorded sound to the graphics icon and to compile the icon-based graphics for each individual. In addition, levels of dynamic linkages, including script-based, category of use, semantic linkage, and frequency of use are implemented for assisting the speech impairment user to retrieve these pre-stored conversational items which can speed up the communication rate.
- Published
- 2003
17. Electrophysiological and mechanical effects of caffeic acid phenethyl ester, a novel cardioprotective agent with antiarrhythmic activity, in guinea-pig heart
- Author
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Wei-Jan Chen, Hsiao-Yu Lee, Gwo-Jyh Chang, Chi-Jen Chang, and Yung-Hsin Yeh
- Subjects
Male ,Cardiotonic Agents ,Guinea Pigs ,Myocardial Reperfusion Injury ,Pharmacology ,In Vitro Techniques ,QT interval ,Contractility ,chemistry.chemical_compound ,Guinea pig heart ,Caffeic Acids ,medicine ,Animals ,Cardioprotective Agent ,Myocytes, Cardiac ,Caffeic acid phenethyl ester ,Inward-rectifier potassium ion channel ,Arrhythmias, Cardiac ,Heart ,Papillary Muscles ,Phenylethyl Alcohol ,medicine.disease ,Myocardial Contraction ,Electrophysiological Phenomena ,Electrophysiology ,chemistry ,Biochemistry ,Ventricular fibrillation ,Anti-Arrhythmia Agents - Abstract
Caffeic acid phenethyl ester (CAPE) is an active component of propolis that exhibits cardioprotective and antiarrhythmic effects. The detailed mechanisms underlying these effects, however, are not entirely understood. The aim of this study was to elucidate the electromechanical effects of CAPE in guinea-pig cardiac preparations. Intracardiac electrograms, left ventricular (LV) pressure, and the anti-arrhythmic efficacy were determined using isolated hearts. Action potentials of papillary muscles were assessed with microelectrodes, Ca 2+ transients were measured by fluorescence, and ion fluxes were measured by patch-clamp techniques. In a perfused heart model, CAPE prolonged the atrio-ventricular conduction interval, the Wenckebach cycle length, and the refractory periods of the AV node and His–Purkinje system, while shortening the QT interval. CAPE reduced the occurrence of reperfusion-induced ventricular fibrillation and decreased LV pressure in isolated hearts. In papillary muscles, CAPE shortened the action potential duration and reduced both the maximum upstroke velocity and contractile force. In fura-2-loaded single ventricular myocytes, CAPE decreased cell shortening and the Ca 2+ transient amplitude. Patch-clamp experiments revealed that CAPE produced a use-dependent decrease in L-type Ca 2+ current ( I Ca,L ) ( IC 50 =1.1 μM) and Na + current ( I Na ) ( IC 50 =0.43 μM), caused a negative-shift of the voltage-dependent inactivation and a delay of recovery from inactivation. CAPE decreased the delayed outward K + current ( I K ) slightly, without affecting the inward rectifier K + current ( I K1 ). These results suggest that the preferential inhibition of Ca 2+ inward and Na + inward currents by CAPE may induce major electromechanical alterations in guinea-pig cardiac preparations, which may underlie its antiarrhythmic action.
- Published
- 2012
18. Comparing the effects of light alcohol consumption on human response to auditory and visual stimuli
- Author
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Song-Yen Tsai, Jin-Chuan Lee, Hsiao-Yu Lee, and Shyh-Yueh Cheng
- Subjects
Auditory perception ,Male ,medicine.medical_specialty ,Visual perception ,Alcohol Drinking ,Experimental and Cognitive Psychology ,Alcohol ,Stimulus (physiology) ,Audiology ,Placebo ,Choice Behavior ,Developmental psychology ,chemistry.chemical_compound ,Young Adult ,Orientation ,medicine ,Reaction Time ,Humans ,Pitch Perception ,Ethanol ,Dose-Response Relationship, Drug ,Sensory Systems ,Dose–response relationship ,chemistry ,Pattern Recognition, Visual ,Auditory Perception ,Visual Perception ,Psychology ,Alcohol consumption ,Color Perception ,Psychomotor Performance - Abstract
The purpose of this study is to examine the effects of various levels of alcohol consumption on human response to auditory and visual stimuli in terms of reaction time, movement time, total reaction time, and error rate. Placebo level and three low-level alcohol doses were randomly assigned to 20 male university student volunteers. 30 min. after consuming the alcohol or placebo, participants responded to either auditory or visual stimuli. Total reaction time increased significantly at the mid-low dose of alcohol (0.3 g/kg). For alcohol doses less than .5 g/kg, the change in total reaction time was confined to reaction time, i.e., the processing time between onset of stimulus and onset of movement. Effects of alcohol were significantly more pronounced in the choice-type tests. Notably, the effects of alcohol on total reaction time and error rate were significant for auditory but not visual stimuli.
- Published
- 2010
19. Time-course gait analysis of hemiparkinsonian rats following 6-hydroxydopamine lesion
- Author
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Tsung-Hsun, Hsieh, Jia-Jin J, Chen, Li-Hsien, Chen, Pei-Tzu, Chiang, and Hsiao-Yu, Lee
- Subjects
Male ,Analysis of Variance ,Time Factors ,Apomorphine ,Tyrosine 3-Monooxygenase ,Movement ,Medial Forebrain Bundle ,Videotape Recording ,Functional Laterality ,Rats ,Disease Models, Animal ,Parkinsonian Disorders ,Disease Progression ,Sympatholytics ,Animals ,Rats, Wistar ,Stereotyped Behavior ,Oxidopamine ,Gait Disorders, Neurologic ,Psychomotor Performance - Abstract
Gait disturbances similar to those of human Parkinson's disease (PD) can be observed in animals after administration of neurotoxin 6-hydroxydopamine (6-OHDA) to induce unilateral nigrostriatal dopamine depletion. However, the relationship between gait disturbances and dopamine depletion following 6-OHDA infusion has not been determined. The present study investigated the longitudinal changes of spatiotemporal gait patterns using a walkway system to acquire footprints and lateral limb images over a 6-week period following unilateral 6-OHDA injection into the medial forebrain bundle of rats. Our results indicated that hemiparkinsonian rats exhibited changes in gait patterns, as compared to normal controls, and pre-lesion levels, including a significantly decreased walking speed and step/stride length as well as an increased base of support and foot angle. The relative percentage of the gait cycle was also altered, showing an increase in the stance to swing ratio, which was more evident in the affected hindlimb. Time-course observations showed that these gait disturbances occurred as early as 4 days post-lesion and gradually increased up to 42 days post-injury. The extents of gait disturbances were compared with conventional apomorphine-induced turning behavior and akinesia bar tests, which were also apparent at 4 days post-lesion but remained relatively unchanged after 28 days. Our time-course gait analysis of a unilateral 6-OHDA rodent model provides insight into the compensatory changes of motor functions during the 6-week development of a nigrostriatal lesion, which might be useful for future objective assessment of novel treatments for human PD subjects.
- Published
- 2010
20. Development of a quantitative assessment system for correlation analysis of footprint parameters to postural control in children
- Author
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Chi-Hsuan Lin, Hsiao-Yu Lee, Ming-Dar Kuo, Hsin-Min Lee, and Jia Jin Jason Chen
- Subjects
Male ,medicine.medical_specialty ,Physiology ,Foot ,Posturography ,Biomedical Engineering ,Biophysics ,Sensory system ,Footprint ,Physical medicine and rehabilitation ,Physiology (medical) ,Child, Preschool ,Correlation analysis ,Postural Balance ,Quantitative assessment ,medicine ,Humans ,Female ,Arch ,Psychology ,Child ,Simulation ,Psychomotor Performance ,Balance (ability) - Abstract
It is known that neurological impairments impact postural stability, but few studies have observed the biomechanical influence of foot structure on balance. The aim of this study was to develop an integrated device for investigating the relationship between static balance and the foot structure, derived from a footprint image, under clinical tests of sensory interactions. Quantitative analysis of the footprint image acquired during balanced standing was developed as an indirect measure of the longitudinal arch, an important structural component of the foot. A data pool was collected from 64 children, 32 children from each of two age groups (4–5 years old versus 8–10 years old). Six common footprint parameters derived from the footprint angle or contact area were used to investigate the relationship between footprint parameters and postural stability. Postural balance ability was evaluated by analyzing sway area in posturography under visual or somatosensory confliction conditions. The footprint parameters, derived from the footprint image, inter-correlated well with each other (p < 0.01). The relationships between footprint parameters and sway area were correlated only for younger children under visually deprived (eye close) and cutaneous unreliable (standing on compliant foam) conditions. This implies that the correlations between footprint parameters and sway area are very subtle which can only be observed in unreliable visual and somatosensory conditions of younger children. In addition, younger children with a lower arch height would have a smaller sway area and better posture control which might result from more cutaneous somatosensation or a flexible biomechanical structure in low arch feet during conditioned static standing.
- Published
- 2006
21. Nonacog Alfa: Analysis Of Safety Data From 6 Prospective Clinical Studies In Different Patient Populations With Hemophilia B Treated With Different Therapeutic Modalities
- Author
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Rendo, Pablo, primary, Smith, Lynne, additional, Hsiao-Yu, Lee, additional, and Shafer, Frank E., additional
- Published
- 2013
- Full Text
- View/download PDF
22. Nonacog alfa: an analysis of safety data from six prospective clinical studies in different patient populations with haemophilia B treated with different therapeutic modalities.
- Author
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Rendo, Pablo, Smith, Lynne, Hsiao-Yu Lee, and Shafer, Frank
- Published
- 2015
- Full Text
- View/download PDF
23. COMPARING THE EFFECTS OF LIGHT ALCOHOL CONSUMPTION ON HUMAN RESPONSE TO AUDITORY AND VISUAL STIMULI.
- Author
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SHYH-YU EH CHENG, HSIAO-YU LEE, JIN-CHUAN LEE, and SONG-YEN TSAI
- Subjects
- *
ANALYSIS of variance , *COLLEGE students , *COMPUTER software , *ALCOHOL drinking , *SENSORY perception , *REACTION time , *RESEARCH funding , *SENSORY stimulation , *VISION , *DATA analysis , *RANDOMIZED controlled trials ,TRAFFIC accident risk factors - Abstract
The purpose of this study is to examine the effects of various levels of alcohol consumption on human response to auditory and visual stimuli in terms of reaction time, movement time, total reaction time, and error rate. Placebo level and three low-level alcohol doses were randomly assigned to 20 male university student volunteers. 30 min. after consuming the alcohol or placebo, participants responded to either auditory or visual stimuli. Total reaction time increased significantly at the mid-low dose of alcohol (0.3 g/kg). For alcohol doses less than .5 g/kg, the change in total reaction time was confined to reaction time, i.e., the processing time between onset of stimulus and onset of movement. Effects of alcohol were significantly more pronounced in the choice-type tests. Notably, the effects of alcohol on total reaction time and error rate were significant for auditory but not visual stimuli. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
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