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Your search keyword '"Hsiao, Fone-Ching"' showing total 139 results
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139 results on '"Hsiao, Fone-Ching"'

1. Association of fasting insulin and C peptide with diabetic retinopathy in Latinos with type 2 diabetes

Author

Kuo, Jane Z, Guo, Xiuqing, Klein, Ronald, Klein, Barbara E, Weinreb, Robert N, Genter, Pauline, Hsiao, Fone-Ching, Goodarzi, Mark O, Rotter, Jerome I, Chen, Yii-Der Ida, and Ipp, Eli

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Diabetes, Eye Disease and Disorders of Vision, Prevention, Metabolic and endocrine, C-Peptide, Insulin, Retinopathy, Clinical Sciences, Clinical sciences, Public health
Abstract

ObjectiveResidual insulin secretion provides important protection against the development of diabetic retinopathy in type 1 diabetes. The data to support this in type 2 diabetes are unclear. We therefore tested in type 2 diabetes whether markers of residual beta-cell function are associated with the development of diabetic retinopathy, an important microvascular complication of diabetes.DesignProspective, cross-sectional, family-based study.Participants585 Latino type 2 diabetic participants, ascertained in families via a proband either with known diabetes duration of greater than 10 years and/or with diabetic retinopathy.Outcome measuresCIRCULATING LEVELS OF FASTING INSULIN AND C PEPTIDE MEASURED AND CORRELATED TO DEGREE OF DIABETIC RETINOPATHY, ASSESSED BY DIGITAL FUNDUS PHOTOGRAPHY AND GRADED USING THE MODIFIED AIRLIE HOUSE CLASSIFICATION AND THE EARLY TREATMENT DIABETIC RETINOPATHY STUDY SCALE (RANGE: levels 10-85).ResultsFasting plasma insulin (β=-0.29; 95% CI -0.38 to -0.20; p

Published
2014

17. The Involvement of GAS6 Signaling in the Development of Obesity and Associated Inflammation

Author

Wu, Kuo-Sheng, Hung, Yi-Jen, Lee, Chien-Hsing, Hsiao, Fone-Ching, and Hsieh, Po-Shiuan

Subjects
Article Subject
Abstract

Growth arrest-specific 6 (GAS6), a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. GAS6 is highly expressed during growth arrest, followed by a sharp decrease during differentiation in adipocytes. The functions of GAS6 signaling are limited to TAM (Tyro3, Axl, and Mer) receptors and are dependent on the cell type. While many studies have focused on the role of GAS6 in inflammation and cancer, only few studies focused on its roles of GAS6 in obesity. Accordingly, the participation of GAS6 in the progression of obesity remains controversial. In this review, we summarize the results of current studies from clinical and basic research to elucidate the possible role of GAS6 signaling in obesity and associated disorders. In addition, this summary may offer a direction to develop clinical therapeutic strategies for the prevention and treatment of obesity and related complications.

Published
2015
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18. Chinese metabolic syndrome risk score

Author

Hsiao, Fone-Ching, Wu, Chung-Ze, Hsieh, Chang-Hsun, He, Chih-Tsueng, Hung, Yi-Jen, and Pei, Dee

Subjects
Metabolic syndrome X -- Risk factors, Metabolic syndrome X -- Demographic aspects, Metabolic syndrome X -- Research, Health
Published
2009

19. Umbilical myiasis in a healthy adult

Author

Hsiao, Fone-Ching, Chen, Yulong, and Chang, Li-Way

Subjects
Myiasis -- Case studies, Myiasis -- Causes of, Umbilical cord -- Diseases, Housefly -- Health aspects, Health
Published
2008

33. Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis

Author

Yang, Shun-Min, primary, Ka, Shuk-Man, additional, Wu, Hua-Lin, additional, Yeh, Yu-Chuan, additional, Kuo, Cheng-Hsiang, additional, Hua, Kuo-Feng, additional, Shi, Guey-Yueh, additional, Hung, Yi-Jen, additional, Hsiao, Fone-Ching, additional, Yang, Sung-Sen, additional, Shieh, Yi-Shing, additional, Lin, Shih-Hua, additional, Wei, Chyou-Wei, additional, Lee, Jeng-Shin, additional, Yang, Chu-Yi, additional, and Chen, Ann, additional

Published
2013
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47. Platelet count can predict metabolic syndrome in older women.

Author

Chen, Yen-Lin, Hung, Yi-Jen, He, Chih-Tsueng, Lee, Chien-Hsing, Hsiao, Fone-Ching, Pei, Dee, and Hsieh, Chang-Hsun

Subjects
PLATELET count, METABOLIC syndrome, DISEASES in older women, ANALYSIS of triglycerides, AGE factors in disease
Abstract

Platelet count (PC) has been found to be related to the metabolic syndrome (MetS). However, the role of PC on MetS remained unclear. In order to evaluate the relationship between PC and MetS components cross-sectionally and determine the optimal cutoff PCs for predicting the subsequent risk of MetS development with sex specificity, two stages included cross-sectional (stage 1) and prospective (stage 2) cohort study were conducted. Stage 1 involved 10 579 subjects aged ≥60 years, of which 7718 subjects advanced to stage 2 with a mean 3.8 year follow-up were enrolled. The MetS components and PC were determined. The PC cutoffs for higher chances of developing MetS in stage 1 were calculated using receiver operating characteristic (ROC) curve analyses. In stage 2, non-MetS subjects were classified into high-PC (HPC) and low-PC (LPC) groups according to the cutoff values from stage 1. We examined the difference of future MetS incidence and calculated the odds ratio (OR) between these two groups. In stage 1, multiple regression showed that age and triglyceride (both sexes) and waist circumstance and high-density lipoprotein cholesterol (only women) were independently correlated with PC. There was significant difference in the area under the ROC curve (AUC) only of HPC women, which exceeded the standard curve (AUC = 0.542, p < 0.001), with a cutoff PC of 223 × 103/μl. HPC women had an OR of 1.287 (95% confidence interval: 1.135-1.461) of developing MetS after 3.8 years. The Kaplan-Meier curve demonstrated a higher incidence of MetS development in HPC women. In conclusion, our results suggest that PC was associated with MetS with sex effects. Most of the MetS components were independent factors for increasing PC, and the risk for subsequent development of MetS was noted when PC >223 × 103/μl in elderly women. [ABSTRACT FROM AUTHOR]

Published
2015
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