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2. Prevalence and causes of subacute cough in Japan

Author

Ishiura, Yoshihisa, Fujimura, Masaki, Ogawa, Haruhiko, Hara, Johsuke, Shintani, Hiromoto, Hozawa, Soichiro, Atsuta, Ryo, Fukumitsu, Kensuke, Inoue, Hideki, Shioya, Takanobu, Muraki, Masato, Amemiya, Tokunao, Ohkura, Noriyuki, Oribe, Yoshitaka, Tanaka, Hiroshi, Yamada, Takechiyo, Toyoshima, Mikio, Fujimori, Katsuya, Ishizuka, Tamotsu, Kagaya, Manabu, Suzuki, Takeshi, Kita, Toshiyuki, Nishi, Koichi, Ueda, Akihito, Miyata, Yoshito, Kitada, Junya, Yamamura, Kenta, Abo, Miki, Takeda, Norihisa, Shirai, Toshihiro, Tajiri, Tomoko, Yoshihara, Shigemi, Akamatsu, Taisuke, Sawaguchi, Hirochiyo, Nagano, Tatsuya, Hanada, Soichiro, Masuda, Sawako, Ohmichi, Mitsuhide, Ito, Tomoki, Sagara, Hironori, Matsumoto, Hisako, and Niimi, Akio

Published
2025
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3. Prevalence and causes of chronic cough in Japan

Author

Ishiura, Yoshihisa, Fujimura, Masaki, Ogawa, Haruhiko, Hara, Johsuke, Shintani, Hiromoto, Hozawa, Soichiro, Atsuta, Ryo, Fukumitsu, Kensuke, Inoue, Hideki, Shioya, Takanobu, Muraki, Masato, Amemiya, Tokunao, Ohkura, Noriyuki, Oribe, Yoshitaka, Tanaka, Hiroshi, Yamada, Takechiyo, Toyoshima, Mikio, Fujimori, Katsuya, Ishizuka, Tamotsu, Kagaya, Manabu, Suzuki, Takeshi, Kita, Toshiyuki, Nishi, Koichi, Ueda, Akihito, Miyata, Yoshito, Kitada, Junya, Yamamura, Kenta, Abo, Miki, Takeda, Norihisa, Shirai, Toshihiro, Tajiri, Tomoko, Yoshihara, Shigemi, Akamatsu, Taisuke, Sawaguchi, Hirochiyo, Nagano, Tatsuya, Hanada, Soichiro, Masuda, Sawako, Ohmichi, Mitsuhide, Ito, Tomoki, Sagara, Hironori, Matsumoto, Hisako, and Niimi, Akio

Published
2024
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6. Japanese guidelines for adult asthma 2020

Author

Nakamura, Yoichi, Tamaoki, Jun, Nagase, Hiroyuki, Yamaguchi, Masao, Horiguchi, Takahiko, Hozawa, Soichiro, Ichinose, Masakazu, Iwanaga, Takashi, Kondo, Rieko, Nagata, Makoto, Yokoyama, Akihito, and Tohda, Yuji

Published
2020
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7. A Retrospective Claims Database Study to Clarify Treatment Reality of Asthma Patients Before and After Referral to a Specialist

Author

Hozawa,Soichiro, Ono,Keita, Makita,Naoyuki, Uchimura,Hitomi, Arita,Yoshifumi, Hirai,Takehiro, Tashiro,Naoki, Hozawa,Soichiro, Ono,Keita, Makita,Naoyuki, Uchimura,Hitomi, Arita,Yoshifumi, Hirai,Takehiro, and Tashiro,Naoki

Abstract

Soichiro Hozawa,1 Keita Ono,2 Naoyuki Makita,3 Hitomi Uchimura,3 Yoshifumi Arita,3 Takehiro Hirai,2 Naoki Tashiro3 1Hiroshima Allergy and Respiratory Clinic, Hiroshima, Japan; 2AstraZeneca K.K., Tokyo, Japan; 3AstraZeneca K.K., Osaka, JapanCorrespondence: Soichiro Hozawa, Hiroshima Allergy and Respiratory Clinic, 6F, 1-9-28 Hikari-machi, Higashi-ku, Hiroshima, 732-0052, Japan, Tel +81-82-568-1167, Fax +81-82-568-1239, Email hozawa@vesta.ocn.ne.jpPurpose: Japanese guidelines recommend that patients with uncontrolled asthma be referred by non-specialists to specialists (allergists and/or pulmonologists). This study investigated the reality of clinical practice in asthma patients referred to specialists in Japan.Patients and Methods: This was a retrospective, observational cohort study of asthma patients in a health insurance claim database (Cross Fact) referred from facilities with non-specialists to those with specialists from January 2016 to December 2018. The referred asthma patients were defined as patients with ≥ 4 inhaled corticosteroid (ICS)-containing prescriptions during a 1-year baseline period, with an asthma diagnosis, and who had visited a facility with specialists. Asthma exacerbation, maintenance treatment, laboratory tests, and medical procedures before and after referral were analyzed.Results: Data for 2135 patients were extracted, of which 420 with referral codes were analyzed. The proportion of patients with asthma exacerbations was 50.2% (95% confidence interval [CI]: 45.4– 55.1%) before referral and 37.4% (95% CI: 32.7– 42.2%) after, a significant decrease (P< 0.001; McNemar test). The proportions of patients prescribed ICS alone, long-acting beta-agonists (LABA), and ICS/LABA were lower after referral than before, but the proportions of patients prescribed long-acting muscarinic antagonists (LAMA), ICS/LABA/LAMA, and biologics increased after referral. More asthma-related laboratory tests were performed after referral, and spirometry inc

Published
2024

10. Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

Author

Yañez, Anahí, Fernández, Marcelo, Tolcachier, Alberto, Belloni, Juan, Taborda, Jorge, De Salvo, Maria, Maspero, Jorge, Victorio, Carlos, Navarta, Miguel Chirino, Grilli, Monica, Rodríguez, Pablo, Otaola, María, Cambursano, Víctor, Malamud, Patricia, Stok, Ana, Arce, German, Roza, Osiris, Scherbovsky, Fernando, Elias, Pedro, Saez, Maria Salazan, Peters, Matthew, Phillips, Martin, Upham, John, Gibson, Peter, Thien, Francis, Douglass, Jo, Thomas, Paul, Bardin, Philip, Sajkov, Dimitar, Hew, Mark, Langton, David, Pez, Andreia, Fritscher, Carlos, Hetzel, Jorge, Mattos, Waldo, Stelmach, Rafael, Antila, Martti, Fernandes, Ana Luisa, Metev, Hristo, Ivanov, Yavor, Bogdanova, Aneliya, Markova, Ana Dancheva, Peneva, Marinka, Veselinova, Rumyana, Petkova, Tatyana, Petrova, Vanushka, Shopova, Elena, Ivanova, Yuliya, Yotsova, Rumyana, Kirkova, Ginka, Petrova, Galina, Dachev, Svetoslav, Sotirova, Kostadinka, Stoyanova, Mariyana, Yakov, Oleg, Ilieva-Fartunova, Vanya, Lemiere, Catherine, Laviolette, Michel, Yang, William, FitzGerald, J Mark, Pek, Bonavuth, Killorn, William Patrick, Poirier, Claude, Chouinard, Guy, Melenka, Lyle, Leigh, Richard, Nair, Parameswaran, Dorscheid, Delbert, Martin, James, Pavie, Juana, Rosenblut, Andres, Cartagena, Claudia, Quilodran, Carlos, Muñoz, Silvia, Malkusova, Ivana, Veverka, Josef, Holub, Stanislav, Mares, Jaroslav, Kozel, Radovan, Kopecka, Daniela, Zindr, Vladimir, Cerva, Pavel, Chanez, Pascal, Bourdin, Arnaud, Devouassoux, Gilles, Taille, Camille, De Blay, Frédéric, Goupil, Francois, Leroyer, Christophe, Gourcerol, Delphine, Didi, Toufik, Didier, Alain, Garcia, Gilles, Bonniaud, Philippe, Vasram, Riazate Rossanaly, Lommatzsch, Marek, Harnest, Ulf, Linnhoff, Anneliese, Keller, Claus, Hoheisel, Gerhard, Förster, Karin, Schultz, Thomas, Schenkenberger, Isabelle, Kirschner, Joachim, Schmoller, Tibor, Zielen, Stefan, Kornmann, Marc, Beck, Ekkehard, Volgmann, Lutz, Dichmann, Rolf, Overlack, Axel, Winkler, Jörg, Mikloweit, Petra, Ballenberger, Sabine, Rolke, Mathias, Korn, Stephanie, Pabel, Helmut, Hoffmann, Martin, Feimer, Jan, Rabe, Klaus, Deckelmann, Regina, Welte, Tobias, Ohbayashi, Hiroyuki, Hozawa, Soichiro, Shimoda, Terufumi, Yoshida, Makoto, Nagakura, Toshikazu, Kamei, Tadashi, Sano, Yasuyuki, Kagami, Shinichiro, Takahashi, Hisaho, Haida, Michiko, Kimura, Goro, Nakamura, Hiroyuki, To, Yasuo, Shinkai, Masaharu, Shimokawaji, Tadasuke, Kudo, Makoto, Shijyubo, Noriharu, Tochigi, Takao, Kato, Motokazu, Tanaka, Akihiko, Gon, Yasuhiro, Sasaki, Norihisa, Ohdaira, Tetsuro, Omori, Chiharu, Takahashi, Toshiki, Takeuchi, Satomi, Nakajima, Kiyotaka, Makita, Hironi, Kaneko, Masahiro, Furuta, Kenjiro, Taniguchi, Masami, Inobe, Yoshito, Miki, Hiroshi, Nakamura, Yoichi, Miyazawa, Naoki, Yano, Shuichi, Iijima, Masayuki, Yamato, Tsuyoshi, Diaz, Javier, Matsuno, Alberto, Felix, Efrain, Guerreros, Alfredo, Daly, Alejandro, Rodriguez Chariarse, Fernando, Salazar, Danilo, Castro, Socorro, Chavez, William, Estrella, Rolando, Aquino, Teresita, Atienza, Tito, Samoro, Ronnie, Isidro, Marie Grace Dawn, Kuna, Piotr, Antczak, Adam, Bednarek, Michał, Mądra-Rogacka, Danuta, Hofman, Teresa, Jutel, Marek, Pisarczyk-Bogacka, Ewa, Kot, Agata, Mróz, Robert, Czupryńska-Borkowska, Małgorzata, Żurowska-Gębala, Małgorzata, Dyczek, Andrzej, Jasieniak-Pinis, Grażyna, Wojnowski, Piotr, Trębas-Pietraś, Ewa, Dobryniewska, Małgorzata, Stobiecki, Marcin, Tarnowska-Matusiak, Marzenna, Magner, Alina, Kolczyński, Andrzej, Kachel, Tomasz, Bartuzi, Zbigniew, Majorek-Olechowska, Bernadetta, Śliwiński, Paweł, Balicka, Violetta, Hajoł, Elżbieta, Stachera, Jacek, Rachel, Marta, Michnar, Marek, Tałałaj, Jarosław, Springer, Ewa, Napora, Piotr, Grzelewski, Tomasz, Bijata-Bronisz, Renata, Świderska, Anna, Mincewicz, Grzegorz, Sankowski, Zbigniew, Fijołek, Tomasz, Kwaśniewski, Artur, Jerzyńska, Joanna, Cygler, Jerzy, Olesiejuk, Ryszard, Von Steiner, Iwona, Machowiak, Wojciech, Filipek, Krzysztof, Piskorz, Piotr, Uhryn, Ewa, Nittner-Marszalska, Marita, Rybicka-Liszewska, Elżbieta, Bodzenta-Łukaszyk, Anna, Chełmińska, Marta, Krupa-Borek, Izabella, Skucha, Wojciech, Płoszczuk, Anna, Mihaescu, Traian, Petrui, Ioan Dorin, Savu, Angelica, Apti, Ghiulten, Toma, Claudia, Trailescu, Ana, Sokurenko, Sergei, Trofimov, Vasiliy, Leshchenko, Igor, Shaporova, Natalia, Ilyashevich, Inna, Stitsenko, Irina, Vizel, Alexander, Ilkovich, Yulia, Tikhanov, Dmitrii, Goncharova, Svetlana, Ezhov, Andrey, Ignatova, Galina, Izmozherova, Nadezhda, Berdnikova, Nadezhda, Goryachkina, Ludmila, Popova, Veronika, Bolieva, Laura, Rebrov, Andrey, Nosov, Vladimir, Magnitskaya, Olga, Nedogoda, Sergey, Abrosimov, Vladimir, Molotkov, Artem, Reshedko, Galina, Smirnov, Mikhail, Osipenko, Marina, Pavlysh, Elena, Myasoedova, Svetlana, Lenskaya, Liudmila, Chistyakov, Valery, Vishneva, Elena, Uon, Liliya, Zateyschikova, Anna, Laleko, Svetlana, Pak, Tatiana, Bruning, Axel, Naidoo, Visvakuren, Reddy, Jeevren, Van Zyl Smit, Richard, Park, Hae-Sim, Cho, Young Joo, Cho, Sang-Heon, Lee, Sang Haak, Lee, Byung Jae, Kim, Ju Sang, Cho, You Sook, Park, Choon-Sik, Kim, Mi-Kyeong, Koh, Young-Il, Kim, Joo-Hee, Lee, Sook Young, Lee, Sang Pyo, Park, Jung Won, Yoo, Kwang Ha, Yoon, Hyoungkyu, Lee, Jaechun, Hur, Gyu-Young, Lee, Soo Keol, Kim, HeeKyoo, Ramos Barbón, David, Laffond Yges, Elena, Martínez Moragón, Eva, Arias Guillen, Miguel, Saura Vinuesa, Alberto, Sánchez-Toril López, Fernando, Velasco Garrido, José Luis, García-Cosio Piqueras, Borja, Pérez de Llano, Luis, Valero Santiago, Antonio Luis, Rubio, Myriam Calle, Bjermer, Leif, Lundbäck, Bo, Gemicioglu, Bilun, Bavbek, Sevim, Ediger, Dane, Erdinc, Munevver, Hanta, Ismail, Nayci, Sibel, Arinc, Sibel, Iashyna, Liudmyla, Mostovoy, Yuriy, Ostrovskyy, Mykola, Kuryk, Lesia, Lemko, Ivan, Ospanova, Tetyana, Moskalenko, Liubov, Korzh, Oleksii, Blazhko, Viktor, Krakhmalova, Olena, Romaniuk, Liliia, Dytyatkovs'ka, Yevgeniya, Yakovenko, Oleh, Gavrysyuk, Volodymyr, Burhan, Hassan, Saralaya, Dinesh, Scott, Stephen, Morice, Alyn, Jackson-Voyzey, Ewart, Win, Thida, Nasser, Shuab, Harrison, Richard, Chaudhuri, Rekha, Nordstrom, Monica, De, Pradip, Masoli, Matthew, Mansur, Adel, Gunstone, Anthony, Niven, Robert, Harrison, Timothy, Babu, Suresh, Bhuchar, Subodh, Kureishy, Shahrukh, Zwetchkenbaum, John, Kaplan, Lawrence, Bleecker, Eugene, Reyes, Santiago, Fakih, Faisal, Heuer, Marvin, Klein, Ryan, Marcus, Michael, Hussain, Iftikhar, Tanus, Tonny, Raissy, Hengameh, Alpizar, Sady, Rodriguez, Hector, Gleich, Gerald, Bridges, Tracy, Pouzar, Joe, Steven, Gary, Matz, Jonathan, Krstevska, Shana, Ziworitin, Dama, Kaplan, Adolfo, Sublett, James, DeAngelo, James, Darter, Amy, Agaiby, John, Hagan, John, Davis, Enrique, Siri, Dareen, Mcevoy, Charlene, Dharma, Chrisette, Karimjee, Najmuddin, Kelsen, Steven, Frade, Manuel, Silverthorn, Amy, Kline, Joel, Averill, Francis, Ruiz, Jose, Robinette, Emory, Shaikh, Zeeshan, Aguilar, Carlos, Nish, William, Alvarez, German, Ismail, Younus, Parikh, Purvi, Leong, Mila, Murphy, Dennis, Garcia, Francisco, Goldsobel, Alan, Blanco, Antonio, Campbell, Edward, Perez, Guido, Chupp, Geoffrey, Bates, Toby, Perez, Vandely, Wenzel, Sally, Shenoy, Kartik, Katial, Rohit, Bernstein, David, Parikh, Neil, Sims, William, Ferguson, Gary, Pham, David, George, Anu, Beasley, Richard, Perez, Gilberto, Garver, Robert, Garcia-Portela, Miriam, Wong, Stephen, Soong, Weily, Guillot, Richard, Hudes, Golda, Arif, Ahmed, Binker, Josefa, Villareal, Manuel, Ziegner, Ulrike, Ojile, Joseph, Goswami, Sanjeev, Piniella, Carlos, Segal, Ilia, Zafra, Heidi, Lee, Mitchell, Tarpay, Martha, Panuto, John, Merchant, Rajan, Springsteen, Peter, Scialla, Timothy, Shapero, Paul, Allen, Karen, Moss, Mark, Cruz, Humberto, Rumbyrt, Jeffrey, Boyd, Amy, Nathan, Robert, Bernstein, Jonathan, Jacobs, Joshua, Ginchansky, Elliot, Johnston, Janice, Baxter, Barbara, Johnson II, Thomas, Apaliski, Stephen, Corder, Clinton, Fuentes, David, Diaz, Joseph, Ngo, Chau, Le, Lan, Busse, William W, Bleecker, Eugene R, Ferguson, Gary T, Barker, Peter, Sproule, Stephanie, Olsson, Richard F, Martin, Ubaldo J, and Goldman, Mitchell

Published
2019
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14. Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes

Author

Matsumoto, Hisako, Kanemitsu, Yoshihiro, Nagasaki, Tadao, Tohda, Yuji, Horiguchi, Takahiko, Kita, Hideo, Kuwabara, Kazunobu, Tomii, Keisuke, Otsuka, Kojiro, Fujimura, Masaki, Ohkura, Noriyuki, Tomita, Katsuyuki, Yokoyama, Akihito, Ohnishi, Hiroshi, Nakano, Yasutaka, Oguma, Tetsuya, Hozawa, Soichiro, Izuhara, Yumi, Ito, Isao, Oguma, Tsuyoshi, Inoue, Hideki, Tajiri, Tomoko, Iwata, Toshiyuki, Ono, Junya, Ohta, Shoichiro, Hirota, Tomomitsu, Kawaguchi, Takahisa, Tamari, Mayumi, Yokoyama, Tetsuji, Tabara, Yasuharu, Matsuda, Fumihiko, Izuhara, Kenji, Niimi, Akio, and Mishima, Michiaki

Published
2017
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17. Association Between Patient Preference for Inhaler Medications and Asthma Outcomes

Author

Nakanishi, Yu, primary, Iwamoto, Hiroshi, additional, Miyamoto, Shintaro, additional, Nakao, Satoshi, additional, Higaki, Naoko, additional, Yamaguchi, Kakuhiro, additional, Sakamoto, Shinjiro, additional, Horimasu, Yasushi, additional, Masuda, Takeshi, additional, Matsumoto, Naoko, additional, Nakashima, Taku, additional, Onari, Yojiro, additional, Fujitaka, Kazunori, additional, Haruta, Yoshinori, additional, Hamada, Hironobu, additional, Hozawa, Soichiro, additional, and Hattori, Noboru, additional

Published
2022
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18. Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids

Author

Kanemitsu, Yoshihiro, Matsumoto, Hisako, Izuhara, Kenji, Tohda, Yuji, Kita, Hideo, Horiguchi, Takahiko, Kuwabara, Kazunobu, Tomii, Keisuke, Otsuka, Kojiro, Fujimura, Masaki, Ohkura, Noriyuki, Tomita, Katsuyuki, Yokoyama, Akihito, Ohnishi, Hiroshi, Nakano, Yasutaka, Oguma, Tetsuya, Hozawa, Soichiro, Nagasaki, Tadao, Ito, Isao, Oguma, Tsuyoshi, Inoue, Hideki, Tajiri, Tomoko, Iwata, Toshiyuki, Izuhara, Yumi, Ono, Junya, Ohta, Shoichiro, Tamari, Mayumi, Hirota, Tomomitsu, Yokoyama, Tetsuji, Niimi, Akio, and Mishima, Michiaki

Published
2013
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19. Prevalence of Uncontrolled Asthma despite Treatment with Medium- or High-Dose ICS/LABA Using Patient-Reported Outcomes in Japan: The KOCU (KnOwing the Controlled statUs of Asthma in Japan) Study.

Author

Ohbayashi, Hiroyuki, Hozawa, Soichiro, Bertran, Alexandra, Yoshisue, Hajime, and Tanaka, Hiroshi

Subjects
*PATIENT reported outcome measures, *ASTHMA, *ASTHMATICS, *MUSCARINIC antagonists, *FOOD allergy, *ANIMAL specialists
Abstract

Introduction: Evidence on the prevalence of uncontrolled asthma upon the standard of care in Japan is scarce and inconsistent. We report the prevalence of uncontrolled asthma using the Japanese Guidelines for Asthma (JGL) 2018 and Global Initiative for Asthma (GINA) 2019 classifications in patients who are currently receiving standard-of-care treatment in a real-life setting. Methods: In this prospective, 12-week, noninterventional study, patients with asthma aged 20–75 years and continuously treated with medium- or high-dose inhaled corticosteroid (ICS)/LABA, with or without other controller(s), were assessed for their asthma control status. The demographics, clinical characteristics, treatment patterns, health care resource utilization, patient-reported outcomes (PROs), and adherence to prescribed treatments were assessed for patients classified as either controlled or uncontrolled. Results: Of 454 patients, 53.7% and 36.3% of the patients reported their asthma as uncontrolled based on the JGL and GINA criteria, respectively. Uncontrolled asthma was even higher (JGL, 75.0%; GINA, 63.5%) within the subpopulation of 52 patients receiving long-acting muscarinic antagonists (LAMAs; i.e., ICS/LABA/LAMA subpopulation). Sensitivity analysis by propensity matching identified significant odds ratios of controlled versus uncontrolled asthma for several demographics and clinical characteristics: male; sensitization to animals, fungi, or birch; comorbidities including food allergy or diabetes; and history of exacerbation were associated with the risk of uncontrolled asthma. No significant changes in PROs were observed. Conclusion: The frequency of uncontrolled asthma in the study population was high, as per JGL and GINA guidelines, despite good adherence to ICS/LABA treatment and other prescribed treatments over 12 weeks. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Association Between Patient Preference for Inhaler Medications and Asthma Outcomes

Author

Nakanishi,Yu, Iwamoto,Hiroshi, Miyamoto,Shintaro, Nakao,Satoshi, Higaki,Naoko, Yamaguchi,Kakuhiro, Sakamoto,Shinjiro, Horimasu,Yasushi, Masuda,Takeshi, Matsumoto,Naoko, Nakashima,Taku, Onari,Yojiro, Fujitaka,Kazunori, Haruta,Yoshinori, Hamada,Hironobu, Hozawa,Soichiro, Hattori,Noboru, Nakanishi,Yu, Iwamoto,Hiroshi, Miyamoto,Shintaro, Nakao,Satoshi, Higaki,Naoko, Yamaguchi,Kakuhiro, Sakamoto,Shinjiro, Horimasu,Yasushi, Masuda,Takeshi, Matsumoto,Naoko, Nakashima,Taku, Onari,Yojiro, Fujitaka,Kazunori, Haruta,Yoshinori, Hamada,Hironobu, Hozawa,Soichiro, and Hattori,Noboru

Abstract

Yu Nakanishi,1 Hiroshi Iwamoto,1 Shintaro Miyamoto,1 Satoshi Nakao,1 Naoko Higaki,1 Kakuhiro Yamaguchi,1 Shinjiro Sakamoto,1 Yasushi Horimasu,1 Takeshi Masuda,1 Naoko Matsumoto,2 Taku Nakashima,1 Yojiro Onari,3 Kazunori Fujitaka,1 Yoshinori Haruta,4 Hironobu Hamada,5 Soichiro Hozawa,6 Noboru Hattori1 1Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan; 2Department of Respiratory Medicine, Hiroshima Red Cross Hospital & Atomic-Bomb Survivors Hospital, Hiroshima, Japan; 3Department of Respiratory Medicine, Hiroshima Mazda Hospital, Hiroshima, Japan; 4Haruta Respiratory Clinic, Hiroshima, Japan; 5Department of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences Hiroshima University, Hiroshima, Japan; 6Hiroshima Allergy and Respiratory Clinic, Hiroshima, JapanCorrespondence: Hiroshi Iwamoto, Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan, Tel +81-82-257-5196, Email iwamotohiroshig@gmail.comPurpose: Asthma guidelines recommend considering the patient preference to optimize medication choices. Patient preference for inhaler medication may affect asthma outcomes, but evidence regarding this is lacking. This study investigated the associations between patient preference for inhaler medications and asthma outcomes.Patients and Methods: A multicenter questionnaire survey was conducted among 351 adult patients with asthma treated with regular inhaled corticosteroids. Agreement between patients’ preferences and current medication was evaluated using two questions: matched preference was defined as patients answering that the current inhaler medication was the most preferred treatment and they were satisfied with it. Mismatched preference was defined as when patients reported that the current inhaler medication was not the m

Published
2022

23. Assessment of serum periostin level as a predictor of requirement for intensive treatment for type-2 inflammation in asthmatics in future: A follow-up study of the KiHAC cohort

Author

Sunadome, Hironobu, Matsumoto, Hisako, Tohda, Yuji, Horiguchi, Takahiko, Kita, Hideo, Kuwabara, Kazunobu, Tomii, Keisuke, Otsuka, Kojiro, Fujimura, Masaki, Ohkura, Noriyuki, Iwanaga, Takashi, Hozawa, Soichiro, Niimi, Akio, Kanemitsu, Yoshihiro, Nagasaki, Tadao, Tashima, Noriyuki, Ishiyama, Yumi, Morimoto, Chie, Oguma, Tsuyoshi, Tajiri, Tomoko, Ito, Isao, Ono, Junya, Ohta, Shoichiro, Izuhara, Kenji, and Hirai, Toyohiro

Published
2021
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24. Using Exhaled Nitric Oxide and Serum Periostin as a Composite Marker to Identify Severe/Steroid-Insensitive Asthma

Author

Nagasaki, Tadao, Matsumoto, Hisako, Kanemitsu, Yoshihiro, Izuhara, Kenji, Tohda, Yuji, Horiguchi, Takahiko, Kita, Hideo, Tomii, Keisuke, Fujimura, Masaki, Yokoyama, Akihito, Nakano, Yasutaka, Hozawa, Soichiro, Ito, Isao, Oguma, Tsuyoshi, Izuhara, Yumi, Tajiri, Tomoko, Iwata, Toshiyuki, Ono, Junya, Ohta, Shoichiro, Yokoyama, Tetsuji, Niimi, Akio, and Mishima, Michiaki

Published
2014
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25. Exploratory research on asthma exacerbation risk factors using the Japanese claims database and machine learning: a retrospective cohort study

Author

Hozawa, Soichiro, Maeda, Shotaro, Kikuchi, Akira, and Koinuma, Masayoshi

Abstract

Objective: Analytical studies of risk factor assessment using machine learning have recently been reported. We performed an exploratory detection study of asthma exacerbation-related factors using health insurance claims data and machine learning to explore risk factors that have high generalizability and can be easily obtained in daily practice. Methods: A dataset of asthma patients during May 2014-April 2019 from the Japanese insurance claims database, MediScope® (DB) was used. Patient characteristics and disease information were extracted, and association with occurrence of asthma exacerbation was evaluated to comprehensively search for exacerbation risk factors. Asthma exacerbations were defined as the co-occurrence of emergency medical procedures, such as emergency transport and intravenous steroid injections, with asthma claims, which were recorded in the database. Results: In total, 5,844 (13.7%) subjects had exacerbations in 42,685 eligible cases from the DB. Information on approximately 3,300 diseases was subjected to a machine learning, and 25 variables were extracted as variable importance and targeted for risk assessment. As a result, sex, days without exacerbation from cohort entry date at look-back period, Charlson Comorbidity Index, allergic rhinitis, chronic sinusitis, acute airway disease (upper airway), acute airway disease (lower airways), Chronic obstructive pulmonary disease/chronic bronchitis, gastroesophageal reflux disease, and hypertension were significantly associated with exacerbation. Dyslipidemia and periodontitis were detected as associated factors of reduced exacerbation risk. Conclusions: A comprehensive analysis of claims data using machine learning showed asthma exacerbation risk factors mostly consistent with those in previous studies. Further examination in other fields is warranted. Supplemental data for this article is available online at https://doi.org/10.1080/02770903.2021.1923740 .

Published
2021
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26. Efficacy and safety of once-daily, single-inhaler fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol in Japanese patients with inadequately controlled asthma: the CAPTAIN study

Author

Nakamura, Yoichi, primary, Hozawa, Soichiro, additional, Sagara, Hironori, additional, Ohbayashi, Hiroyuki, additional, Lee, Laurie A., additional, Crawford, Jodie, additional, Tamaoki, Jun, additional, Nishi, Takanobu, additional, and Fowler, Andrew, additional

Published
2021
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28. Assessment of serum periostin level as a predictor of requirement for intensive treatment for type-2 inflammation in asthmatics in future: A follow-up study of the KiHAC cohort

Author

60887727, 50601324, 40447975, Sunadome, Hironobu, Matsumoto, Hisako, Tohda, Yuji, Horiguchi, Takahiko, Kita, Hideo, Kuwabara, Kazunobu, Tomii, Keisuke, Otsuka, Kojiro, Fujimura, Masaki, Ohkura, Noriyuki, Iwanaga, Takashi, Hozawa, Soichiro, Niimi, Akio, Kanemitsu, Yoshihiro, Nagasaki, Tadao, Tashima, Noriyuki, Ishiyama, Yumi, Morimoto, Chie, Oguma, Tsuyoshi, Tajiri, Tomoko, Ito, Isao, Ono, Junya, Ohta, Shoichiro, Izuhara, Kenji, Hirai, Toyohiro, 60887727, 50601324, 40447975, Sunadome, Hironobu, Matsumoto, Hisako, Tohda, Yuji, Horiguchi, Takahiko, Kita, Hideo, Kuwabara, Kazunobu, Tomii, Keisuke, Otsuka, Kojiro, Fujimura, Masaki, Ohkura, Noriyuki, Iwanaga, Takashi, Hozawa, Soichiro, Niimi, Akio, Kanemitsu, Yoshihiro, Nagasaki, Tadao, Tashima, Noriyuki, Ishiyama, Yumi, Morimoto, Chie, Oguma, Tsuyoshi, Tajiri, Tomoko, Ito, Isao, Ono, Junya, Ohta, Shoichiro, Izuhara, Kenji, and Hirai, Toyohiro

Published
2021

29. Safety of Once-Daily Single-Inhaler Triple Therapy with Fluticasone Furoate/Umeclidinium/Vilanterol in Japanese Patients with Asthma: A Long-Term (52-Week) Phase III Open-Label Study

Author

Hozawa,Soichiro, Ohbayashi,Hiroyuki, Tsuchiya,Michiko, Hara,Yu, Lee,Laurie A, Nakayama,Takashi, Tamaoki,Jun, Fowler,Andrew, Nishi,Takanobu, Hozawa,Soichiro, Ohbayashi,Hiroyuki, Tsuchiya,Michiko, Hara,Yu, Lee,Laurie A, Nakayama,Takashi, Tamaoki,Jun, Fowler,Andrew, and Nishi,Takanobu

Abstract

Soichiro Hozawa,1 Hiroyuki Ohbayashi,2 Michiko Tsuchiya,3 Yu Hara,4 Laurie A Lee,5 Takashi Nakayama,6 Jun Tamaoki,6 Andrew Fowler,7 Takanobu Nishi6 1Hiroshima Allergy and Respiratory Clinic, Hiroshima, Japan; 2Tohno Chuo Clinic, Gifu, Japan; 3Department of Respiratory Medicine, Rakuwakai Otowa Hospital, Kyoto, Japan; 4Department of Pulmonology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan; 5GSK, Collegeville, PA, USA; 6GSK, Tokyo, Japan; 7GSK, Brentford, Middlesex, UKCorrespondence: Takanobu NishiGlaxoSmithKline K.K., 1-8-1 Akasaka, Minato-ku, Tokyo, 107-0052, JapanTel +81-70-4135-5303Fax +81-3-4231-5974Email takanobu.2.nishi@gsk.comPurpose: The pivotal CAPTAIN study reported a favorable safety profile with once-daily inhaled corticosteroid/long-acting muscarinic antagonist/long-acting β2-agonist (ICS/LAMA/LABA) triple combination of fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) in patients with inadequately controlled asthma, some of whom were Japanese. Here, we evaluate the long-term (52 weeks) safety of FF/UMEC/VI in Japanese patients with asthma.Patients and Methods: This was a Phase III, 52-week, multicenter, non-comparator, non-randomized, open-label study (NCT03184987) in Japanese adults receiving maintenance therapy with ICS/LABA, with or without LAMA. At enrollment, patients were allocated to either FF/UMEC/VI 100/62.5/25mcg (Group 1) or 200/62.5/25mcg (Group 2). Patients in Group 1 could have their treatment stepped up to 200/62.5/25mcg at Week 24 if their Asthma Control Questionnaire (ACQ)-7 score was > 0.75. The primary endpoint was the incidence of adverse events (AEs) and serious AEs (SAEs). Secondary endpoints included vital signs, electrocardiogram measurements, and clinical laboratory tests (biochemistry, hematology, urinalysis). Efficacy was assessed as “other” endpoints.Results: A total of 111 Japanese patients were included in the intention-to-treat (ITT) population. Overall, 77 (69%) patients reported

Published
2021

34. Exploratory research on asthma exacerbation risk factors using the Japanese claims database and machine learning: a retrospective cohort study.

Author

Hozawa, Soichiro, Maeda, Shotaro, Kikuchi, Akira, and Koinuma, Masayoshi

Subjects
*MACHINE learning, *WHEEZE, *CHRONIC obstructive pulmonary disease, *HEALTH insurance claims, *DISEASE exacerbation, *ASTHMATICS
Abstract

Objective: Analytical studies of risk factor assessment using machine learning have recently been reported. We performed an exploratory detection study of asthma exacerbation-related factors using health insurance claims data and machine learning to explore risk factors that have high generalizability and can be easily obtained in daily practice. Methods: A dataset of asthma patients during May 2014-April 2019 from the Japanese insurance claims database, MediScope® (DB) was used. Patient characteristics and disease information were extracted, and association with occurrence of asthma exacerbation was evaluated to comprehensively search for exacerbation risk factors. Asthma exacerbations were defined as the co-occurrence of emergency medical procedures, such as emergency transport and intravenous steroid injections, with asthma claims, which were recorded in the database. Results: In total, 5,844 (13.7%) subjects had exacerbations in 42,685 eligible cases from the DB. Information on approximately 3,300 diseases was subjected to a machine learning, and 25 variables were extracted as variable importance and targeted for risk assessment. As a result, sex, days without exacerbation from cohort entry date at look-back period, Charlson Comorbidity Index, allergic rhinitis, chronic sinusitis, acute airway disease (upper airway), acute airway disease (lower airways), Chronic obstructive pulmonary disease/chronic bronchitis, gastroesophageal reflux disease, and hypertension were significantly associated with exacerbation. Dyslipidemia and periodontitis were detected as associated factors of reduced exacerbation risk. Conclusions: A comprehensive analysis of claims data using machine learning showed asthma exacerbation risk factors mostly consistent with those in previous studies. Further examination in other fields is warranted. Supplemental data for this article is available online at https://doi.org/10.1080/02770903.2021.1923740. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes

Author

Nagasaki, Tadao, Matsumoto, Hisako, Kanemitsu, Yoshihiro, Izuhara, Kenji, Tohda, Yuji, Kita, Hideo, Horiguchi, Takahiko, Kuwabara, Kazunobu, Tomii, Keisuke, Otsuka, Kojiro, Fujimura, Masaki, Ohkura, Noriyuki, Tomita, Katsuyuki, Yokoyama, Akihito, Ohnishi, Hiroshi, Nakano, Yasutaka, Oguma, Tetsuya, Hozawa, Soichiro, Ito, Isao, Oguma, Tsuyoshi, Inoue, Hideki, Tajiri, Tomoko, Iwata, Toshiyuki, Izuhara, Yumi, Ono, Junya, Ohta, Shoichiro, Yokoyama, Tetsuji, Niimi, Akio, and Mishima, Michiaki

Published
2014
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43. Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial

Author

Busse, William W, primary, Bleecker, Eugene R, additional, FitzGerald, J Mark, additional, Ferguson, Gary T, additional, Barker, Peter, additional, Sproule, Stephanie, additional, Olsson, Richard F, additional, Martin, Ubaldo J, additional, Goldman, Mitchell, additional, Yañez, Anahí, additional, Fernández, Marcelo, additional, Tolcachier, Alberto, additional, Belloni, Juan, additional, Taborda, Jorge, additional, De Salvo, Maria, additional, Maspero, Jorge, additional, Victorio, Carlos, additional, Navarta, Miguel Chirino, additional, Grilli, Monica, additional, Rodríguez, Pablo, additional, Otaola, María, additional, Cambursano, Víctor, additional, Malamud, Patricia, additional, Stok, Ana, additional, Arce, German, additional, Roza, Osiris, additional, Scherbovsky, Fernando, additional, Elias, Pedro, additional, Saez, Maria Salazan, additional, Peters, Matthew, additional, Phillips, Martin, additional, Upham, John, additional, Gibson, Peter, additional, Thien, Francis, additional, Douglass, Jo, additional, Thomas, Paul, additional, Bardin, Philip, additional, Sajkov, Dimitar, additional, Hew, Mark, additional, Langton, David, additional, Pez, Andreia, additional, Fritscher, Carlos, additional, Hetzel, Jorge, additional, Mattos, Waldo, additional, Stelmach, Rafael, additional, Antila, Martti, additional, Fernandes, Ana Luisa, additional, Metev, Hristo, additional, Ivanov, Yavor, additional, Bogdanova, Aneliya, additional, Markova, Ana Dancheva, additional, Peneva, Marinka, additional, Veselinova, Rumyana, additional, Petkova, Tatyana, additional, Petrova, Vanushka, additional, Shopova, Elena, additional, Ivanova, Yuliya, additional, Yotsova, Rumyana, additional, Kirkova, Ginka, additional, Petrova, Galina, additional, Dachev, Svetoslav, additional, Sotirova, Kostadinka, additional, Stoyanova, Mariyana, additional, Yakov, Oleg, additional, Ilieva-Fartunova, Vanya, additional, Lemiere, Catherine, additional, Laviolette, Michel, additional, Yang, William, additional, Pek, Bonavuth, additional, Killorn, William Patrick, additional, Poirier, Claude, additional, Chouinard, Guy, additional, Melenka, Lyle, additional, Leigh, Richard, additional, Nair, Parameswaran, additional, Dorscheid, Delbert, additional, Martin, James, additional, Pavie, Juana, additional, Rosenblut, Andres, additional, Cartagena, Claudia, additional, Quilodran, Carlos, additional, Muñoz, Silvia, additional, Malkusova, Ivana, additional, Veverka, Josef, additional, Holub, Stanislav, additional, Mares, Jaroslav, additional, Kozel, Radovan, additional, Kopecka, Daniela, additional, Zindr, Vladimir, additional, Cerva, Pavel, additional, Chanez, Pascal, additional, Bourdin, Arnaud, additional, Devouassoux, Gilles, additional, Taille, Camille, additional, De Blay, Frédéric, additional, Goupil, Francois, additional, Leroyer, Christophe, additional, Gourcerol, Delphine, additional, Didi, Toufik, additional, Didier, Alain, additional, Garcia, Gilles, additional, Bonniaud, Philippe, additional, Vasram, Riazate Rossanaly, additional, Lommatzsch, Marek, additional, Harnest, Ulf, additional, Linnhoff, Anneliese, additional, Keller, Claus, additional, Hoheisel, Gerhard, additional, Förster, Karin, additional, Schultz, Thomas, additional, Schenkenberger, Isabelle, additional, Kirschner, Joachim, additional, Schmoller, Tibor, additional, Zielen, Stefan, additional, Kornmann, Marc, additional, Beck, Ekkehard, additional, Volgmann, Lutz, additional, Dichmann, Rolf, additional, Overlack, Axel, additional, Winkler, Jörg, additional, Mikloweit, Petra, additional, Ballenberger, Sabine, additional, Rolke, Mathias, additional, Korn, Stephanie, additional, Pabel, Helmut, additional, Hoffmann, Martin, additional, Feimer, Jan, additional, Rabe, Klaus, additional, Deckelmann, Regina, additional, Welte, Tobias, additional, Ohbayashi, Hiroyuki, additional, Hozawa, Soichiro, additional, Shimoda, Terufumi, additional, Yoshida, Makoto, additional, Nagakura, Toshikazu, additional, Kamei, Tadashi, additional, Sano, Yasuyuki, additional, Kagami, Shinichiro, additional, Takahashi, Hisaho, additional, Haida, Michiko, additional, Kimura, Goro, additional, Nakamura, Hiroyuki, additional, To, Yasuo, additional, Shinkai, Masaharu, additional, Shimokawaji, Tadasuke, additional, Kudo, Makoto, additional, Shijyubo, Noriharu, additional, Tochigi, Takao, additional, Kato, Motokazu, additional, Tanaka, Akihiko, additional, Gon, Yasuhiro, additional, Sasaki, Norihisa, additional, Ohdaira, Tetsuro, additional, Omori, Chiharu, additional, Takahashi, Toshiki, additional, Takeuchi, Satomi, additional, Nakajima, Kiyotaka, additional, Makita, Hironi, additional, Kaneko, Masahiro, additional, Furuta, Kenjiro, additional, Taniguchi, Masami, additional, Inobe, Yoshito, additional, Miki, Hiroshi, additional, Nakamura, Yoichi, additional, Miyazawa, Naoki, additional, Yano, Shuichi, additional, Iijima, Masayuki, additional, Yamato, Tsuyoshi, additional, Diaz, Javier, additional, Matsuno, Alberto, additional, Felix, Efrain, additional, Guerreros, Alfredo, additional, Daly, Alejandro, additional, Rodriguez Chariarse, Fernando, additional, Salazar, Danilo, additional, Castro, Socorro, additional, Chavez, William, additional, Estrella, Rolando, additional, Aquino, Teresita, additional, Atienza, Tito, additional, Samoro, Ronnie, additional, Isidro, Marie Grace Dawn, additional, Kuna, Piotr, additional, Antczak, Adam, additional, Bednarek, Michał, additional, Mądra-Rogacka, Danuta, additional, Hofman, Teresa, additional, Jutel, Marek, additional, Pisarczyk-Bogacka, Ewa, additional, Kot, Agata, additional, Mróz, Robert, additional, Czupryńska-Borkowska, Małgorzata, additional, Żurowska-Gębala, Małgorzata, additional, Dyczek, Andrzej, additional, Jasieniak-Pinis, Grażyna, additional, Wojnowski, Piotr, additional, Trębas-Pietraś, Ewa, additional, Dobryniewska, Małgorzata, additional, Stobiecki, Marcin, additional, Tarnowska-Matusiak, Marzenna, additional, Magner, Alina, additional, Kolczyński, Andrzej, additional, Kachel, Tomasz, additional, Bartuzi, Zbigniew, additional, Majorek-Olechowska, Bernadetta, additional, Śliwiński, Paweł, additional, Balicka, Violetta, additional, Hajoł, Elżbieta, additional, Stachera, Jacek, additional, Rachel, Marta, additional, Michnar, Marek, additional, Tałałaj, Jarosław, additional, Springer, Ewa, additional, Napora, Piotr, additional, Grzelewski, Tomasz, additional, Bijata-Bronisz, Renata, additional, Świderska, Anna, additional, Mincewicz, Grzegorz, additional, Sankowski, Zbigniew, additional, Fijołek, Tomasz, additional, Kwaśniewski, Artur, additional, Jerzyńska, Joanna, additional, Cygler, Jerzy, additional, Olesiejuk, Ryszard, additional, Von Steiner, Iwona, additional, Machowiak, Wojciech, additional, Filipek, Krzysztof, additional, Piskorz, Piotr, additional, Uhryn, Ewa, additional, Nittner-Marszalska, Marita, additional, Rybicka-Liszewska, Elżbieta, additional, Bodzenta-Łukaszyk, Anna, additional, Chełmińska, Marta, additional, Krupa-Borek, Izabella, additional, Skucha, Wojciech, additional, Płoszczuk, Anna, additional, Mihaescu, Traian, additional, Petrui, Ioan Dorin, additional, Savu, Angelica, additional, Apti, Ghiulten, additional, Toma, Claudia, additional, Trailescu, Ana, additional, Sokurenko, Sergei, additional, Trofimov, Vasiliy, additional, Leshchenko, Igor, additional, Shaporova, Natalia, additional, Ilyashevich, Inna, additional, Stitsenko, Irina, additional, Vizel, Alexander, additional, Ilkovich, Yulia, additional, Tikhanov, Dmitrii, additional, Goncharova, Svetlana, additional, Ezhov, Andrey, additional, Ignatova, Galina, additional, Izmozherova, Nadezhda, additional, Berdnikova, Nadezhda, additional, Goryachkina, Ludmila, additional, Popova, Veronika, additional, Bolieva, Laura, additional, Rebrov, Andrey, additional, Nosov, Vladimir, additional, Magnitskaya, Olga, additional, Nedogoda, Sergey, additional, Abrosimov, Vladimir, additional, Molotkov, Artem, additional, Reshedko, Galina, additional, Smirnov, Mikhail, additional, Osipenko, Marina, additional, Pavlysh, Elena, additional, Myasoedova, Svetlana, additional, Lenskaya, Liudmila, additional, Chistyakov, Valery, additional, Vishneva, Elena, additional, Uon, Liliya, additional, Zateyschikova, Anna, additional, Laleko, Svetlana, additional, Pak, Tatiana, additional, Bruning, Axel, additional, Naidoo, Visvakuren, additional, Reddy, Jeevren, additional, Van Zyl Smit, Richard, additional, Park, Hae-Sim, additional, Cho, Young Joo, additional, Cho, Sang-Heon, additional, Lee, Sang Haak, additional, Lee, Byung Jae, additional, Kim, Ju Sang, additional, Cho, You Sook, additional, Park, Choon-Sik, additional, Kim, Mi-Kyeong, additional, Koh, Young-Il, additional, Kim, Joo-Hee, additional, Lee, Sook Young, additional, Lee, Sang Pyo, additional, Park, Jung Won, additional, Yoo, Kwang Ha, additional, Yoon, Hyoungkyu, additional, Lee, Jaechun, additional, Hur, Gyu-Young, additional, Lee, Soo Keol, additional, Kim, HeeKyoo, additional, Ramos Barbón, David, additional, Laffond Yges, Elena, additional, Martínez Moragón, Eva, additional, Arias Guillen, Miguel, additional, Saura Vinuesa, Alberto, additional, Sánchez-Toril López, Fernando, additional, Velasco Garrido, José Luis, additional, García-Cosio Piqueras, Borja, additional, Pérez de Llano, Luis, additional, Valero Santiago, Antonio Luis, additional, Rubio, Myriam Calle, additional, Bjermer, Leif, additional, Lundbäck, Bo, additional, Gemicioglu, Bilun, additional, Bavbek, Sevim, additional, Ediger, Dane, additional, Erdinc, Munevver, additional, Hanta, Ismail, additional, Nayci, Sibel, additional, Arinc, Sibel, additional, Iashyna, Liudmyla, additional, Mostovoy, Yuriy, additional, Ostrovskyy, Mykola, additional, Kuryk, Lesia, additional, Lemko, Ivan, additional, Ospanova, Tetyana, additional, Moskalenko, Liubov, additional, Korzh, Oleksii, additional, Blazhko, Viktor, additional, Krakhmalova, Olena, additional, Romaniuk, Liliia, additional, Dytyatkovs'ka, Yevgeniya, additional, Yakovenko, Oleh, additional, Gavrysyuk, Volodymyr, additional, Burhan, Hassan, additional, Saralaya, Dinesh, additional, Scott, Stephen, additional, Morice, Alyn, additional, Jackson-Voyzey, Ewart, additional, Win, Thida, additional, Nasser, Shuab, additional, Harrison, Richard, additional, Chaudhuri, Rekha, additional, Nordstrom, Monica, additional, De, Pradip, additional, Masoli, Matthew, additional, Mansur, Adel, additional, Gunstone, Anthony, additional, Niven, Robert, additional, Harrison, Timothy, additional, Babu, Suresh, additional, Bhuchar, Subodh, additional, Kureishy, Shahrukh, additional, Zwetchkenbaum, John, additional, Kaplan, Lawrence, additional, Bleecker, Eugene, additional, Reyes, Santiago, additional, Fakih, Faisal, additional, Heuer, Marvin, additional, Klein, Ryan, additional, Marcus, Michael, additional, Hussain, Iftikhar, additional, Tanus, Tonny, additional, Raissy, Hengameh, additional, Alpizar, Sady, additional, Rodriguez, Hector, additional, Gleich, Gerald, additional, Bridges, Tracy, additional, Pouzar, Joe, additional, Steven, Gary, additional, Matz, Jonathan, additional, Krstevska, Shana, additional, Ziworitin, Dama, additional, Kaplan, Adolfo, additional, Sublett, James, additional, DeAngelo, James, additional, Darter, Amy, additional, Agaiby, John, additional, Hagan, John, additional, Davis, Enrique, additional, Siri, Dareen, additional, Mcevoy, Charlene, additional, Dharma, Chrisette, additional, Karimjee, Najmuddin, additional, Kelsen, Steven, additional, Frade, Manuel, additional, Silverthorn, Amy, additional, Kline, Joel, additional, Averill, Francis, additional, Ruiz, Jose, additional, Robinette, Emory, additional, Shaikh, Zeeshan, additional, Aguilar, Carlos, additional, Nish, William, additional, Alvarez, German, additional, Ismail, Younus, additional, Parikh, Purvi, additional, Leong, Mila, additional, Murphy, Dennis, additional, Garcia, Francisco, additional, Goldsobel, Alan, additional, Blanco, Antonio, additional, Campbell, Edward, additional, Perez, Guido, additional, Chupp, Geoffrey, additional, Bates, Toby, additional, Perez, Vandely, additional, Wenzel, Sally, additional, Shenoy, Kartik, additional, Katial, Rohit, additional, Bernstein, David, additional, Parikh, Neil, additional, Sims, William, additional, Ferguson, Gary, additional, Pham, David, additional, George, Anu, additional, Beasley, Richard, additional, Perez, Gilberto, additional, Garver, Robert, additional, Garcia-Portela, Miriam, additional, Wong, Stephen, additional, Soong, Weily, additional, Guillot, Richard, additional, Hudes, Golda, additional, Arif, Ahmed, additional, Binker, Josefa, additional, Villareal, Manuel, additional, Ziegner, Ulrike, additional, Ojile, Joseph, additional, Goswami, Sanjeev, additional, Piniella, Carlos, additional, Segal, Ilia, additional, Zafra, Heidi, additional, Lee, Mitchell, additional, Tarpay, Martha, additional, Panuto, John, additional, Merchant, Rajan, additional, Springsteen, Peter, additional, Scialla, Timothy, additional, Shapero, Paul, additional, Allen, Karen, additional, Moss, Mark, additional, Cruz, Humberto, additional, Rumbyrt, Jeffrey, additional, Boyd, Amy, additional, Nathan, Robert, additional, Bernstein, Jonathan, additional, Jacobs, Joshua, additional, Ginchansky, Elliot, additional, Johnston, Janice, additional, Baxter, Barbara, additional, Johnson II, Thomas, additional, Apaliski, Stephen, additional, Corder, Clinton, additional, Fuentes, David, additional, Diaz, Joseph, additional, Ngo, Chau, additional, and Le, Lan, additional

Published
2019
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44. Update: Mepolizumab treatment in patients with severe eosinophilic asthma and prior omalizumab use.

Author

Albers, Frank C., Hozawa, Soichiro, Bratton, Daniel J., Yancey, Steven W., Prazma, Charlene M., Humbert, Marc, and Liu, Mark C.

Subjects
*ASTHMA
Abstract

Keywords: asthma; asthma treatment; biologics; eosinophils EN asthma asthma treatment biologics eosinophils 942 946 5 04/23/20 20200401 NES 200401 Over the last two decades, several biologic therapies have emerged for the targeted treatment of severe asthma, defined as asthma inadequately controlled by guideline-recommended treatment with high-dose inhaled corticosteroids (ICS) and bronchodilator therapies.[1] These biologic therapies target specific mechanisms underlying differing asthma phenotypes. Omalizumab (anti-immunoglobulin E) is indicated for moderate-to-severe allergic asthma,[2] and mepolizumab (anti-interleukin-5) is indicated for severe eosinophilic asthma.[3] Although omalizumab has demonstrated efficacy in clinical studies,[4] not all patients achieve good disease control with therapy, some of these patients may also be eligible for mepolizumab treatment. Asthma, asthma treatment, biologics, eosinophils. [Extracted from the article]

Published
2020
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