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141 results on '"Hozawa, Jiro"'

3. Expression of glutathione S-transferase-pi in human squamous cell carcinomas of the pharynx and larynx: loss after radiation therapy

Author

Tanita, Jiro, Tsuchida, Shigeki, Hozawa, Jiro, and Sato, Kiyomi

Subjects
Glutathione transferase -- Physiological aspects, Squamous cell carcinoma -- Care and treatment, Head and neck cancer -- Radiotherapy, Tumor markers -- Physiological aspects, Health
Abstract

Background and Methods. The expression of the placental form of glutathione S-transferase (GST-[Pi]) in human squamous cell carcinomas of the pharynx and larynx was investigated immunohistochemically before and after radiation therapy. Results. Before the treatment, 47 of 71 carcinoma specimens (66.2%) demonstrated positive reactions, GST-[Pi] being diffusely stained throughout the tumor lesions. Positive rates for moderately and well differentiated carcinomas were 69.7% and 88.0%, respectively, with both of these values being significantly higher than that for poorly differentiated carcinomas (15.4%, P < 0.01). Thus, GST-[Pi] expression seems to be related to the degree of differentiation. Although several tumors exhibiting GST-[Pi] staining did not respond to radiation therapy, most cases responded positively and no relation was apparent in the 41 cases of squamous cell carcinoma studied between response to radiation therapy and previous GST-[Pi] staining. After irradiation of 1000 to 7000 cGy, however, most carcinoma specimens exhibited negative GST-[Pi] staining, regardless of response to radiation therapy. Conclusions. The results suggest that although GST-[Pi] expression is not directly involved in determining sensitivity to radiation, GST-[Pi] expression can be influenced by exogenous agents. The loss or decrease of GST-[Pi] after irradiation is in clear contrast to the enhanced expression observed in many cancer cell lines resistant to chemotherapy.

Published
1993

8. Kabuki Make-up Syndrome; A Case Report.

Author

Tominaga, Takeshi, primary, Hozawa, Jiro, additional, Shinkawa, Hideichi, additional, Ivhijo, Hiroaki, additional, Tazawa, Masayuki, additional, Saito, Shin-ichi, additional, and Fujita, Takeshi, additional

Published
1993
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34. Chronic sinusitis and woodworking as risk factors for cancer of the maxillary sinus in Northeast Japan.

Author

Shimizu, Hiroyuki, Hisamichi, Shigeru, Hozawa, Jiro, Saito, Hisaki, Murai, Kazuo, Hirata, Hideto, Takasaka, Tomonori, Togawa, Kiyoshi, Konno, Akiyoshi, Kimura, Yo, Kikuchi, Akira, Ohkouchi, Yukio, and Ohtani, Iwao

Abstract

In the period 1983 to 1985, 66 patients presented to six Japanese university hospitals with squamous cell carcinoma of the maxillary sinus. Using self-administered questionnaires, a case-control study was conducted to examine history of nasal diseases, occupational exposures, and other possible risk factors for this disease. For each patient, two controls were selected from the general population, matched to the patient by sex, age (± 5 years), and district of residence. A history of chronic sinusitis was associated with a 2.3-fold increase in risk ( p = 0.05). A high relative risk was also observed in males with an occupational history of woodworking or joinery, particularly when these jobs involved sanding or lathing practices (RR = 7.5, p = 0.02). No association between cigarette smoking and maxillary sinus cancer was observed in this study and no evidence was found that indoor air pollution in the home is involved in cancer development. [ABSTRACT FROM AUTHOR]

Published
1989
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35. Repair pattern of the reticular lamina of the organ of corti in human ears.

Author

Watanuki, Kozo, Sato, Yoshiki, Hozawa, Jiro, and Kawamoto, Kazutomo

Abstract

The repair pattern of the reticular lamina of the organ of Corti was studied in the cochleae of human ears. The inner ears were obtained at autopsy from the individuals who had no evidence of auditory or vestibular disorders or therapy with ototoxic drugs: After a loss of outer or inner hair cells, the framework of the reticular lamina was distorted but no gaps were detected. The supporting cells were hypertrophied but no reparative proliferation of the supporting cells was found in the organ of Corti., Defects due to the collapse of outer hair cells of the first row were filled in mainly by the hypertrophied heads of the outer pillar cells., Defects due to the collapse of outer hair cells of the second, third and fourth row were filled in mainly by the hypertrophied phalanges of Deiters' cells of the first, second and third row respectively., The space due to inner hair cell loss was filled in by the nearest inner supporting cells which were hypertrophied and extended toward the space., The distortion of the reticular lamina and the aging degeneration were regarded as two possible causes for the total loss of the organ of Corti near the end of the first turn. [ABSTRACT FROM AUTHOR]

Published
1977
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48. Practica Oto-Rhino-Laryngologica

Author

Hozawa, Jiro, primary, Kamata, Shigeki, additional, Takagi, Akiko, additional, Nakamura, Kiyozumi, additional, Ishida, Takashi, additional, Kimura, Noriko, additional, and Ishikawa, Kaoru, additional

Published
1982
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