1. Reconstructing Mayaro virus circulation in French Guiana shows frequent spillovers
- Author
-
Antoine Enfissi, Matthieu Najm, Sarah Bailly, Nathanaël Hozé, Dominique Rousset, Jessica Vanhomwegen, Jean-Claude Manuguerra, Camille Fritzell, Claude Flamand, Simon Cauchemez, Henrik Salje, Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence pour les Arbovirus - Laboratoire associé de Virologie [Cayenne, Guyane] (CNR), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Unité d'Epidémiologie, Environnement et Risques infectieux - Environment and Infectious Risks (ERI), Institut Pasteur [Paris], This study was supported by the 'European Regional Development Fund' under EPI-ARBO grant agreement (GY0008695), the 'Regional Health Agency of French Guiana', the 'National Center of Spatial Studies'. C.Fl. and C. Fr. acknowledge funding from Calmette and Yersin allocated by the 'Pasteur Institut Department of International Affairs'. N.H. and S.C. acknowledge financial support from the AXA Research Fund, the Investissement d’Avenir program, the Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases program (Grant ANR-10-LABX-62-IBEID), the Models of Infectious Disease Agent Study of the National Institute of General Medical Sciences, the INCEPTION project (PIA/ANR-16-CONV-0005), the European Union’s Horizon 2020 research and innovation programme under ZIKAlliance grant agreement No. 734548., We wish to thank Mirdad Kazanji (Institut Pasteur in French Guiana), Félix Djossou (Cayenne hospital center), Sandrine Fernandes-Pellerin (Institut Pasteur - CRT), and Léna Berthelot, Séverine Matheus, Laetitia Bremand, Bhety Labeau, David Moua, and Marine Rangon from the Arbovirus National Reference Center for their valuable contribution in the laboratory analyses. We thank Juliette Paireau and Quirine ten Bosch for insightful discussions., ANR-10-LABX-62-IBEID,IBEID,Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases'(2010), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l’étude de l’Emergence des Pathologies au Travers des Individus et des populatiONs(2016), European Project: 734548,ZIKAlliance(2016), University of Cambridge [UK] (CAM), Centre National de Référence pour les Arbovirus - Laboratoire de Virologie [Cayenne, Guyane française] (CNR - laboratoire associé), Réseau International des Instituts Pasteur (RIIP), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Hozé, Nathanaël [0000-0002-3977-8966], Salje, Henrik [0000-0003-3626-4254], Rousset, Dominique [0000-0002-1473-3147], Manuguerra, Jean-Claude [0000-0002-5202-6531], Flamand, Claude [0000-0002-8064-445X], and Apollo - University of Cambridge Repository
- Subjects
Male ,0301 basic medicine ,Statistical methods ,Epidemiology ,[SDV]Life Sciences [q-bio] ,viruses ,General Physics and Astronomy ,Rural Health ,Antibodies, Viral ,medicine.disease_cause ,Communicable Diseases, Emerging ,Viral infection ,MESH: Cross Reactions ,13/1 ,Seroepidemiologic Studies ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,MESH: Arboviruses ,MESH: Child ,MESH: Communicable Diseases, Emerging ,692/308/174 ,Chikungunya ,[MATH]Mathematics [math] ,Child ,MESH: Alphavirus Infections ,lcsh:Science ,MESH: Immunoglobulin G ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,Multidisciplinary ,MESH: Middle Aged ,article ,virus diseases ,Middle Aged ,631/114/2415 ,MESH: Infant ,French Guiana ,3. Good health ,[STAT]Statistics [stat] ,Geography ,MESH: Young Adult ,Child, Preschool ,Epidemiological Monitoring ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Female ,Sylvatic cycle ,Chikungunya virus ,Adult ,Adolescent ,Science ,030106 microbiology ,Cross Reactions ,Arbovirus ,General Biochemistry, Genetics and Molecular Biology ,Virus ,Young Adult ,03 medical and health sciences ,MESH: Cross-Sectional Studies ,692/699/255/2514 ,Environmental health ,MESH: French Guiana ,medicine ,Humans ,Natural reservoir ,Viral immunology ,MESH: Adolescent ,MESH: Seroepidemiologic Studies ,MESH: Humans ,Alphavirus Infections ,MESH: Child, Preschool ,Infant ,[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,MESH: Adult ,MESH: Chikungunya virus ,General Chemistry ,MESH: Rural Health ,biochemical phenomena, metabolism, and nutrition ,medicine.disease ,MESH: Male ,Cross-Sectional Studies ,030104 developmental biology ,Immunoglobulin G ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,lcsh:Q ,MESH: Epidemiological Monitoring ,MESH: Female ,Arboviruses ,MESH: Antibodies, Viral - Abstract
Characterizing the circulation of Mayaro virus (MAYV), an emerging arbovirus threat, is essential for risk assessment but challenging due to cross-reactivity with other alphaviruses such as chikungunya virus (CHIKV). Here, we develop an analytical framework to jointly assess MAYV epidemiology and the extent of cross-reactivity with CHIKV from serological data collected throughout French Guiana (N = 2697). We find strong evidence of an important sylvatic cycle for MAYV with most infections occurring near the natural reservoir in rural areas and in individuals more likely to go to the forest (i.e., adult males) and with seroprevalences of up to 18% in some areas. These findings highlight the need to strengthen MAYV surveillance in the region and showcase how modeling can improve interpretation of cross-reacting assays., Mayaro virus (MAYV) is an emerging arbovirus, but cross-reactivity with other alphaviruses makes analysis of its epidemiology difficult. Here, the authors develop an analytical framework to assess MAYV epidemiology and find evidence for an important sylvatic cycle and seroprevalences of up to 18% in some areas of French Guiana.
- Published
- 2020
- Full Text
- View/download PDF