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1. Magnetic equilibrium design for the SMART tokamak

Author: Doyle, S.J., Lopez-Aires, D., Mancini, A., Agredano-Torres, M., Garcia-Sanchez, J.L., Segado-Fernandez, J., Ayllon-Guerola, J., Garcia-Muñoz, M., Viezzer, E., Soria-Hoyo, C., Garcia-Lopez, J., Cunningham, G., Buxton, P.F., Gryaznevich, M.P., Hwang, Y.S., and Chung, K.J.
Published: 2021
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2. DNA Methylation of Imprinted Genes in Mexican-American Newborn Children with Prenatal Phthalate Exposure

Author: Tindula, G, Murphy, S, Grenier, C, Huang, Z, Huen, K, Escudero-Fung, M, Bradman, A, Eskenazi, B, Hoyo, C, and Holland, N
Subjects: Environmental Sciences, Biological Sciences, Medical and Health Sciences, Toxicology
Published: 2017

3. Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Author: Choudhary, P., Monasso, G.S., Karhunen, V., Ronkainen, J., Mancano, G., Howe, C.G., Niu, Z., Zeng, X., Guan, W., Dou, J., Feinberg, J.I., Mordaunt, C., Pesce, G., Baïz, N., Alfano, R., Martens, D.S., Wang, C., Isaevska, E., Keikkala, E., Mustaniemi, S., Thio, C.H.L., Fraszczyk, E., Tobi, E.W., Starling, A.P., Cosin-Tomas, M., Urquiza, J., Röder, Stefan, Hoang, T.T., Page, C., Jima, D.D., House, J.S., Maguire, R.L., Ott, R., Pawlow, X., Sirignano, L., Zillich, L., Malmberg, A., Rauschert, S., Melton, P., Gong, T., Karlsson, R., Fore, R., Perng, W., Laubach, Z.M., Czamara, D., Sharp, G., Breton, C.V., Schisterman, E., Yeung, E., Mumford, S.L., Fallin, M.D., LaSalle, J.M., Schmidt, R.J., Bakulski, K.M., Annesi-Maesano, I., Heude, B., Nawrot, T.S., Plusquin, M., Ghantous, A., Herceg, Z., Nisticò, L., Vafeiadi, M., Kogevinas, M., Vääräsmäki, M., Kajantie, E., Snieder, H., Corpeleijn, E., Steegers-Theunissen, R.P.M., Yang, I.V., Dabelea, D., Fossati, S., Zenclussen, Ana Claudia, Herberth, Gunda, Magnus, M., Håberg, S.E., London, S.J., Munthe-Kaas, M.C., Murphy, S.K., Hoyo, C., Ziegler, A.-G., Hummel, S., Witt, S.H., Streit, F., Frank, J., Räikkönen, K., Lahti, J., Huang, R.-C., Almqvist, C., Hivert, M.-F., Jaddoe, V.W.V., Järvelin, M.-R., Kantomaa, M., Felix, J.F., Sebert, S., Choudhary, P., Monasso, G.S., Karhunen, V., Ronkainen, J., Mancano, G., Howe, C.G., Niu, Z., Zeng, X., Guan, W., Dou, J., Feinberg, J.I., Mordaunt, C., Pesce, G., Baïz, N., Alfano, R., Martens, D.S., Wang, C., Isaevska, E., Keikkala, E., Mustaniemi, S., Thio, C.H.L., Fraszczyk, E., Tobi, E.W., Starling, A.P., Cosin-Tomas, M., Urquiza, J., Röder, Stefan, Hoang, T.T., Page, C., Jima, D.D., House, J.S., Maguire, R.L., Ott, R., Pawlow, X., Sirignano, L., Zillich, L., Malmberg, A., Rauschert, S., Melton, P., Gong, T., Karlsson, R., Fore, R., Perng, W., Laubach, Z.M., Czamara, D., Sharp, G., Breton, C.V., Schisterman, E., Yeung, E., Mumford, S.L., Fallin, M.D., LaSalle, J.M., Schmidt, R.J., Bakulski, K.M., Annesi-Maesano, I., Heude, B., Nawrot, T.S., Plusquin, M., Ghantous, A., Herceg, Z., Nisticò, L., Vafeiadi, M., Kogevinas, M., Vääräsmäki, M., Kajantie, E., Snieder, H., Corpeleijn, E., Steegers-Theunissen, R.P.M., Yang, I.V., Dabelea, D., Fossati, S., Zenclussen, Ana Claudia, Herberth, Gunda, Magnus, M., Håberg, S.E., London, S.J., Munthe-Kaas, M.C., Murphy, S.K., Hoyo, C., Ziegler, A.-G., Hummel, S., Witt, S.H., Streit, F., Frank, J., Räikkönen, K., Lahti, J., Huang, R.-C., Almqvist, C., Hivert, M.-F., Jaddoe, V.W.V., Järvelin, M.-R., Kantomaa, M., Felix, J.F., and Sebert, S.
Abstract: Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health.
Published: 2023

4. Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Author: Kadalayil, L., Alam, M., White, C.H., Ghantous, A., Walton, E., Gruzieva, O., Merid, S.K., Kumar, A., Roy, R., Solomon, O., Huen, K., Eskenazi, B., Rzehak, P., Grote, V., Langhendries, J.-P., Verduci, E., Ferre, N., Gruszfeld, D., Gao, L., Guan, W., Zeng, X., Schisterman, E.F., Dou, J., Bakulski, K.M., Feinberg, J.I., Soomro, M.H., Pesce, G., Baiz, N., Isaevska, E., Plusquin, M., Vafeiadi, M., Roumeliotaki, T., Langie, S.A.S., Standaert, A., Allard, C., Perron, P., Bouchard, L., van Meel, E.R., Felix, J.F., Jaddoe, V.W.V., Yousefi, P.D., Ramlau‑Hansen, C.H., Relton, C.L., Tobi, E.W., Starling, A.P., Yang, I.V., Llambrich, M., Santorelli, G., Lepeule, J., Salas, L.A., Bustamante, M., Ewart, S.L., Zhang, H., Karmaus, W., Röder, Stefan, Zenclussen, Ana Claudia, Jin, J., Nystad, W., Page, C.M., Magnus, M., Jima, D.D., Hoyo, C., Maguire, R.L., Kvist, T., Czamara, D., Räikkönen, K., Gong, T., Ullemar, V., Rifas‐Shiman, S.L., Oken, E., Almqvist, C., Karlsson, R., Lahti, J., Murphy, S.K., Håberg, S.E., London, S., Herberth, Gunda, Arshad, H., Sunyer, J., Grazuleviciene, R., Dabelea, D., Steegers‑Theunissen, R.P.M., Nohr, E.A., Sørensen, T.I.A., Duijts, L., Hivert, M.-F., Nelen, V., Popovic, M., Kogevinas, M., Nawrot, T.S., Herceg, Z., Annesi-Maesano, I., Fallin, M.D., Yeung, E., Breton, C.V., Koletzko, B., Holland, N., Melén, E., Sharp, G.C., Silver, M.J., Kadalayil, L., Alam, M., White, C.H., Ghantous, A., Walton, E., Gruzieva, O., Merid, S.K., Kumar, A., Roy, R., Solomon, O., Huen, K., Eskenazi, B., Rzehak, P., Grote, V., Langhendries, J.-P., Verduci, E., Ferre, N., Gruszfeld, D., Gao, L., Guan, W., Zeng, X., Schisterman, E.F., Dou, J., Bakulski, K.M., Feinberg, J.I., Soomro, M.H., Pesce, G., Baiz, N., Isaevska, E., Plusquin, M., Vafeiadi, M., Roumeliotaki, T., Langie, S.A.S., Standaert, A., Allard, C., Perron, P., Bouchard, L., van Meel, E.R., Felix, J.F., Jaddoe, V.W.V., Yousefi, P.D., Ramlau‑Hansen, C.H., Relton, C.L., Tobi, E.W., Starling, A.P., Yang, I.V., Llambrich, M., Santorelli, G., Lepeule, J., Salas, L.A., Bustamante, M., Ewart, S.L., Zhang, H., Karmaus, W., Röder, Stefan, Zenclussen, Ana Claudia, Jin, J., Nystad, W., Page, C.M., Magnus, M., Jima, D.D., Hoyo, C., Maguire, R.L., Kvist, T., Czamara, D., Räikkönen, K., Gong, T., Ullemar, V., Rifas‐Shiman, S.L., Oken, E., Almqvist, C., Karlsson, R., Lahti, J., Murphy, S.K., Håberg, S.E., London, S., Herberth, Gunda, Arshad, H., Sunyer, J., Grazuleviciene, R., Dabelea, D., Steegers‑Theunissen, R.P.M., Nohr, E.A., Sørensen, T.I.A., Duijts, L., Hivert, M.-F., Nelen, V., Popovic, M., Kogevinas, M., Nawrot, T.S., Herceg, Z., Annesi-Maesano, I., Fallin, M.D., Yeung, E., Breton, C.V., Koletzko, B., Holland, N., Melén, E., Sharp, G.C., and Silver, M.J.
Abstract: BackgroundSeasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the associations between birth season and lifelong phenotypes remains unclear.MethodsWe carried out epigenome-wide meta-analyses within the Pregnancy And Childhood Epigenetic Consortium to identify associations of DNAm with birth season, both at differentially methylated probes (DMPs) and regions (DMRs). Associations were examined at two time points: at birth (21 cohorts, N = 9358) and in children aged 1–11 years (12 cohorts, N = 3610). We conducted meta-analyses to assess the impact of latitude on birth season-specific associations at both time points.ResultsWe identified associations between birth season and DNAm (False Discovery Rate-adjusted p values < 0.05) at two CpGs at birth (winter-born) and four in the childhood (summer-born) analyses when compared to children born in autumn. Furthermore, we identified twenty-six differentially methylated regions (DMR) at birth (winter-born: 8, spring-born: 15, summer-born: 3) and thirty-two in childhood (winter-born: 12, spring and summer: 10 each) meta-analyses with few overlapping DMRs between the birth seasons or the two time points. The DMRs were associated with genes of known functions in tumorigenesis, psychiatric/neurological disorders, inflammation, or immunity, amongst others. Latitude-stratified meta-analyses [higher (≥ 50°N), lower (< 50°N, northern hemisphere only)] revealed differences in associations between birth season and DNAm by birth latitude. DMR analysis implicated genes with previously reported links to schizophrenia (LAX1), skin disorders (PSORS1C, LTB4R), and airway inflammation including asthma (LTB4R), present only at birth in the higher latitudes (≥ 50°N).ConclusiosIn this large epigenome-wide meta-analysis study, we provide eviden
Published: 2023

5. Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Author: Universitat Rovira i Virgili, Kadalayil, L; Alam, MZ; White, CH; Ghantous, A; Walton, E; Gruzieva, O; Merid, SK; Kumar, A; Roy, RP; Solomon, O; Huen, K; Eskenazi, B; Rzehak, P; Grote, V; Langhendries, JP; Verduci, E; Ferre, N; Gruszfeld, D; Gao, L; Guan, WH; Zeng, XH; Schisterman, EF; Dou, JF; Bakulski, KM; Feinberg, JI; Soomro, MH; Pesce, G; Baiz, N; Isaevska, E; Plusquin, M; Vafeiadi, M; Roumeliotaki, T; Langie, SAS; Standaert, A; Allard, C; Perron, P; Bouchard, L; van Meel, ER; Felix, JF; Jaddoe, VWV; Yousefi, PD; Ramlau-Hansen, CH; Relton, CL; Tobi, EW; Starling, AP; Yang, IV; Llambrich, M; Santorelli, G; Lepeule, J; Salas, LA; Bustamante, M; Ewart, SL; Zhang, HM; Karmaus, W; Röder, S; Zenclussen, AC; Jin, JP; Nystad, W; Page, CM; Magnus, M; Jima, DD; Hoyo, C; Maguire, RL; Kvist, T; Czamara, D; Räikkönen, K; Gong, T; Ullemar, V; Rifas-Shiman, SL; Oken, E; Almqvist, C; Karlsson, R; Lahti, J; Murphy, SK; Håberg, SE; London, S; Herberth, G; Arshad, H; Sunyer, J; Grazuleviciene, R; Dabelea, D; Steegers-Theunissen, RPM; Nohr, EA; Sorensen, TIA; Duijts, L; Hivert, MF; Nelen, V; Popovic, M; Kogevinas, M; Nawrot, TS; Herceg, Z; Annesi-Maesano, I; Fallin, MD; Yeung, EDA; Breton, CV; Koletzko, B; Holland, N; Wiemels, JL; Melén, E; Sharp, GC; Silver, MJ; Rezwan, F; Holloway, JW, Universitat Rovira i Virgili, and Kadalayil, L; Alam, MZ; White, CH; Ghantous, A; Walton, E; Gruzieva, O; Merid, SK; Kumar, A; Roy, RP; Solomon, O; Huen, K; Eskenazi, B; Rzehak, P; Grote, V; Langhendries, JP; Verduci, E; Ferre, N; Gruszfeld, D; Gao, L; Guan, WH; Zeng, XH; Schisterman, EF; Dou, JF; Bakulski, KM; Feinberg, JI; Soomro, MH; Pesce, G; Baiz, N; Isaevska, E; Plusquin, M; Vafeiadi, M; Roumeliotaki, T; Langie, SAS; Standaert, A; Allard, C; Perron, P; Bouchard, L; van Meel, ER; Felix, JF; Jaddoe, VWV; Yousefi, PD; Ramlau-Hansen, CH; Relton, CL; Tobi, EW; Starling, AP; Yang, IV; Llambrich, M; Santorelli, G; Lepeule, J; Salas, LA; Bustamante, M; Ewart, SL; Zhang, HM; Karmaus, W; Röder, S; Zenclussen, AC; Jin, JP; Nystad, W; Page, CM; Magnus, M; Jima, DD; Hoyo, C; Maguire, RL; Kvist, T; Czamara, D; Räikkönen, K; Gong, T; Ullemar, V; Rifas-Shiman, SL; Oken, E; Almqvist, C; Karlsson, R; Lahti, J; Murphy, SK; Håberg, SE; London, S; Herberth, G; Arshad, H; Sunyer, J; Grazuleviciene, R; Dabelea, D; Steegers-Theunissen, RPM; Nohr, EA; Sorensen, TIA; Duijts, L; Hivert, MF; Nelen, V; Popovic, M; Kogevinas, M; Nawrot, TS; Herceg, Z; Annesi-Maesano, I; Fallin, MD; Yeung, EDA; Breton, CV; Koletzko, B; Holland, N; Wiemels, JL; Melén, E; Sharp, GC; Silver, MJ; Rezwan, F; Holloway, JW
Abstract: Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the associations between birth season and lifelong phenotypes remains unclear.We carried out epigenome-wide meta-analyses within the Pregnancy And Childhood Epigenetic Consortium to identify associations of DNAm with birth season, both at differentially methylated probes (DMPs) and regions (DMRs). Associations were examined at two time points: at birth (21 cohorts, N = 9358) and in children aged 1-11 years (12 cohorts, N = 3610). We conducted meta-analyses to assess the impact of latitude on birth season-specific associations at both time points.We identified associations between birth season and DNAm (False Discovery Rate-adjusted p values < 0.05) at two CpGs at birth (winter-born) and four in the childhood (summer-born) analyses when compared to children born in autumn. Furthermore, we identified twenty-six differentially methylated regions (DMR) at birth (winter-born: 8, spring-born: 15, summer-born: 3) and thirty-two in childhood (winter-born: 12, spring and summer: 10 each) meta-analyses with few overlapping DMRs between the birth seasons or the two time points. The DMRs were associated with genes of known functions in tumorigenesis, psychiatric/neurological disorders, inflammation, or immunity, amongst others. Latitude-stratified meta-analyses [higher (≥ 50°N), lower (< 50°N, northern hemisphere only)] revealed differences in associations between birth season and DNAm by birth latitude. DMR analysis implicated genes with previously reported links to schizophrenia (LAX1), skin disorders (PSORS1C, LTB4R), and airway inflammation inclu
Published: 2023

6. Synthesis of a nanosilica supported CO2 sorbent in a fluidized bed reactor

Author: Soria-Hoyo, C., Valverde, J.M., van Ommen, J.R., Sánchez-Jiménez, P.E., Pérez-Maqueda, L.A., and Sayagués, M.J.
Published: 2015
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7. Interplay of gestational parent exposure to ambient air pollution and diet characteristics on preterm birth

Author: Rappazzo, K.M., Hoyo, C., Jardel, H., and Martin, C.L.
Abstract: Background: Despite many efforts, preterm birth (PTB) is poorly understood and remains a major public health problem in the United States. Toxicological work suggests gestational parent (GP) diet may modify the effect of ambient pollutants on birth outcomes. We assessed risk of PTB in humans in relation to fine particulate matter (PM2.5), ozone (O3), and nitrogen dioxide (NO2) and variation by diet. Methods: 684 GP-singleton infant pairs in the Newborn Epigenetics Study prospective birth cohort were attributed ambient air pollutant exposures for each trimester based on residence. Total energy intake, percent of energy intake from saturated fat, and percent of energy intake from total fat were dichotomized at the 75th percentile. >We used log binomial regressions to estimate risk ratios (RR (95%CI)) for PTB by pollutant interquartile ranges, adjusting for GP age, pre-pregnancy body mass index, GP race/ethnicity, GP education, season of conception, household income, and each diet factor. We assessed departure from additivity using interaction contrast ratios (ICRs). We addressed missing covariate data with multiple imputation. Results: Point estimates suggest that O3 may be inversely associated with PTB when exposure occurs in trimester 2 (min RR: 0.77, 95% CI: 0.39, 1.49), but may be harmful when exposure occurs in trimester 3 (max RR: 1.51, 95% CI: 0.62, 3.64). Additionally, PM2.5 may be inversely associated with PTB when considered with total fat and saturated fat in trimester 2. Imprecise ICRs suggest departure from additivity (evidence of modification) with some pollutant-diet combinations. Conclusions: While confidence intervals are wide, we observed potential modification of pollutant associations by dietary factors. It is imperative that large cohorts collect the required data to examine this topic, as more power is necessary to investigate the nuances suggested by this work.
Published: 2023
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8. Disparities in Cervical Cancer Incidence and Mortality

Author: Maguire, R.L., primary, Vidal, A.C., additional, Murphy, S.K., additional, and Hoyo, C., additional
Published: 2017
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9. Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation.

Author: Solomon, O, Huen, K, Yousefi, P, Küpers, LK, González, JR, Suderman, M, Reese, SE, Page, CM, Gruzieva, O, Rzehak, P, Gao, L, Bakulski, KM, Novoloaca, A, Allard, C, Pappa, I, Llambrich, M, Vives, M, Jima, DD, Kvist, T, Baccarelli, A, White, C, Rezwan, FI, Sharp, GC, Tindula, G, Bergström, A, Grote, V, Dou, JF, Isaevska, E, Magnus, MC, Corpeleijn, E, Perron, P, Jaddoe, VWV, Nohr, EA, Maitre, L, Foraster, M, Hoyo, C, Håberg, SE, Lahti, J, DeMeo, DL, Zhang, H, Karmaus, W, Kull, I, Koletzko, B, Feinberg, JI, Gagliardi, L, Bouchard, L, Ramlau-Hansen, CH, Tiemeier, H, Santorelli, G, Maguire, RL, Czamara, D, Litonjua, AA, Langhendries, J-P, Plusquin, M, Lepeule, J, Binder, EB, Verduci, E, Dwyer, T, Carracedo, Á, Ferre, N, Eskenazi, B, Kogevinas, M, Nawrot, TS, Munthe-Kaas, MC, Herceg, Z, Relton, C, Melén, E, Gruszfeld, D, Breton, C, Fallin, MD, Ghantous, A, Nystad, W, Heude, B, Snieder, H, Hivert, M-F, Felix, JF, Sørensen, TIA, Bustamante, M, Murphy, SK, Raikkönen, K, Oken, E, Holloway, JW, Arshad, SH, London, SJ, Holland, N, Solomon, O, Huen, K, Yousefi, P, Küpers, LK, González, JR, Suderman, M, Reese, SE, Page, CM, Gruzieva, O, Rzehak, P, Gao, L, Bakulski, KM, Novoloaca, A, Allard, C, Pappa, I, Llambrich, M, Vives, M, Jima, DD, Kvist, T, Baccarelli, A, White, C, Rezwan, FI, Sharp, GC, Tindula, G, Bergström, A, Grote, V, Dou, JF, Isaevska, E, Magnus, MC, Corpeleijn, E, Perron, P, Jaddoe, VWV, Nohr, EA, Maitre, L, Foraster, M, Hoyo, C, Håberg, SE, Lahti, J, DeMeo, DL, Zhang, H, Karmaus, W, Kull, I, Koletzko, B, Feinberg, JI, Gagliardi, L, Bouchard, L, Ramlau-Hansen, CH, Tiemeier, H, Santorelli, G, Maguire, RL, Czamara, D, Litonjua, AA, Langhendries, J-P, Plusquin, M, Lepeule, J, Binder, EB, Verduci, E, Dwyer, T, Carracedo, Á, Ferre, N, Eskenazi, B, Kogevinas, M, Nawrot, TS, Munthe-Kaas, MC, Herceg, Z, Relton, C, Melén, E, Gruszfeld, D, Breton, C, Fallin, MD, Ghantous, A, Nystad, W, Heude, B, Snieder, H, Hivert, M-F, Felix, JF, Sørensen, TIA, Bustamante, M, Murphy, SK, Raikkönen, K, Oken, E, Holloway, JW, Arshad, SH, London, SJ, and Holland, N
Abstract: BACKGROUND: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits. METHODS: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5-10 years from 8 cohorts (n = 4268). RESULTS: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10-7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10-6) in older children and had methylation differences in the same direction. CONCLUSIONS: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes.
Published: 2022

10. Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Author: Universitat Rovira i Virgili, Solomon, O; Huen, K; Yousefi, P; Küpers, LK; González, JR; Suderman, M; Reese, SE; Page, CM; Gruzieva, O; Rzehak, P; Gao, L; Bakulski, KM; Novoloaca, A; Allard, C; Pappa, I; Llambrich, M; Vives, M; Jima, DD; Kvist, T; Baccarelli, A; White, C; Rezwan, FI; Sharp, GC; Tindula, G; Bergström, A; Grote, V; Dou, JF; Isaevska, E; Magnus, MC; Corpeleijn, E; Perron, P; Jaddoe, VWV; Nohr, EA; Maitre, L; Foraster, M; Hoyo, C; Håberg, SE; Lahti, J; DeMeo, DL; Zhang, HM; Karmaus, W; Kull, I; Koletzko, B; Feinberg, JI; Gagliardi, L; Bouchard, L; Ramlau-Hansen, CH; Tiemeier, H; Santorelli, G; Maguire, RL; Czamara, D; Litonjua, AA; Langhendries, JP; Plusquin, M; Lepeule, J; Binder, EB; Verduci, E; Dwyer, T; Carracedo, A; Ferre, N; Eskenazi, B; Kogevinas, M; Nawrot, TS; Munthe-Kaas, MC; Herceg, Z; Relton, C; Melén, E; Gruszfeld, D; Breton, C; Fallin, MD; Ghantous, A; Nystad, W; Heude, B; Snieder, H; Hivert, MF; Felix, JF; Sorensen, TIA; Bustamante, M; Murphy, SK; Raikkönen, K; Oken, E; Holloway, JW; Arshad, SH; London, SJ; Holland, N, Universitat Rovira i Virgili, and Solomon, O; Huen, K; Yousefi, P; Küpers, LK; González, JR; Suderman, M; Reese, SE; Page, CM; Gruzieva, O; Rzehak, P; Gao, L; Bakulski, KM; Novoloaca, A; Allard, C; Pappa, I; Llambrich, M; Vives, M; Jima, DD; Kvist, T; Baccarelli, A; White, C; Rezwan, FI; Sharp, GC; Tindula, G; Bergström, A; Grote, V; Dou, JF; Isaevska, E; Magnus, MC; Corpeleijn, E; Perron, P; Jaddoe, VWV; Nohr, EA; Maitre, L; Foraster, M; Hoyo, C; Håberg, SE; Lahti, J; DeMeo, DL; Zhang, HM; Karmaus, W; Kull, I; Koletzko, B; Feinberg, JI; Gagliardi, L; Bouchard, L; Ramlau-Hansen, CH; Tiemeier, H; Santorelli, G; Maguire, RL; Czamara, D; Litonjua, AA; Langhendries, JP; Plusquin, M; Lepeule, J; Binder, EB; Verduci, E; Dwyer, T; Carracedo, A; Ferre, N; Eskenazi, B; Kogevinas, M; Nawrot, TS; Munthe-Kaas, MC; Herceg, Z; Relton, C; Melén, E; Gruszfeld, D; Breton, C; Fallin, MD; Ghantous, A; Nystad, W; Heude, B; Snieder, H; Hivert, MF; Felix, JF; Sorensen, TIA; Bustamante, M; Murphy, SK; Raikkönen, K; Oken, E; Holloway, JW; Arshad, SH; London, SJ; Holland, N
Abstract: Background: Among children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits. Methods: We performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5–10 years from 8 cohorts (n = 4268). Results: In newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p < 1.3 × 10−7) after adjusting for white blood cell proportions and batch. Most of those sites had lower methylation levels in males than in females. Of the differentially methylated CpG sites identified in newborn blood, 68% (31,727) met look-up level significance (p < 1.1 × 10−6) in older children and had methylation differences in the same direction. Conclusions: This is a large-scale meta-analysis examining sex differences in DNA methylation in newborns and older children. Expanding upon previous studies, we replicated previous findings and identified additional autosomal sites with sex-specific differences in DNA methylation. Differentially methylated sites were enriched in genes involved in cancer, psychiatric disorders, and cardiovascular phenotypes.
Published: 2022

11. CHAPTER SIX: Disparities in Cervical Cancer Incidence and Mortality: Can Epigenetics Contribute to Eliminating Disparities?

Author: Maguire, R. L., Vidal, A. C., Murphy, S. K., and Hoyo, C.
Published: 2017
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12. Factors Associated with African Americans’ Enrollment in a National Cancer Genetics Registry

Author: Skinner, C.S., Schildkraut, J.M., Calingaert, B., Hoyo, C., Crankshaw, S.S., Fish, L., Susswein, L., Jasper, C., and Reid, L.
Published: 2008

13. PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer

Author: Vidal, A. C., Henry, N. M., Murphy, S. K., Oneko, O., Nye, M., Bartlett, J. A., Overcash, F., Huang, Z., Wang, F., Mlay, P., Obure, J., Smith, J., Vasquez, B., Swai, B., Hernandez, B., and Hoyo, C.
Published: 2014
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14. Dependence on plasma shape and plasma fueling for small edge-localized mode regimes in TCV and ASDEX Upgrade

Author: Labit, B, Eich, T, Harrer, G, Wolfrum, E, Bernert, M, Dunne, M, Frassinetti, L, Hennequin, P, Maurizio, R, Merle, A, Meyer, H, Saarelma, S, Sheikh, U, Adamek, J, Agostini, M, Aguiam, D, Akers, R, Albanese, R, Albert, C, Alessi, E, Ambrosino, R, Andr be, Y, Angioni, C, Apruzzese, G, Aradi, M, Arnichand, H, Auriemma, F, Avdeeva, G, Ayllon-Guerola, J, Bagnato, F, Bandaru, V, Barnes, M, Barrera-Orte, L, Bettini, P, Bilato, R, Biletskyi, O, Bilkova, P, Bin, W, Blanchard, P, Blanken, T, Bobkov, V, Bock, A, Boeyaert, D, Bogar, K, Bogar, O, Bohm, P, Bolzonella, T, Bombarda, F, Boncagni, L, Bouquey, F, Bowman, C, Brezinsek, S, Brida, D, Brunetti, D, Bucalossi, J, Buchanan, J, Buermans, J, Bufferand, H, Buller, S, Buratti, P, Burckhart, A, Calabr, G, Calacci, L, Camenen, Y, Cannas, B, Cano Megias, P, Carnevale, D, Carpanese, F, Carr, M, Carralero, D, Carraro, L, Casolari, A, Cathey, A, Causa, F, Cavedon, M, Cecconello, M, Ceccuzzi, S, Cerovsky, J, Chapman, S, Chmielewski, P, Choi, D, Cianfarani, C, Ciraolo, G, Coda, S, Coelho, R, Colas, L, Colette, D, Cordaro, L, Cordella, F, Costea, S, Coster, D, Cruz Zabala, D, Cseh, G, Czarnecka, A, Cziegler, I, D'Arcangelo, O, Dal Molin, A, David, P, De Carolis, G, De Oliveira, H, Decker, J, Dejarnac, R, Delogu, R, Den Harder, N, Dimitrova, M, Dolizy, F, Dominguez-Palacios Duran, J, Douai, D, Drenik, A, Dreval, M, Dudson, B, Dunai, D, Duval, B, Dux, R, Elmore, S, Embreus, O, Erds, B, Fable, E, Faitsch, M, Fanni, A, Farnik, M, Faust, I, Faustin, J, Fedorczak, N, Felici, F, Feng, S, Feng, X, Ferreira, J, Ferr, G, Fevrier, O, Ficker, O, Figini, L, Figueiredo, A, Fil, A, Fontana, M, Francesco, M, Fuchs, C, Futatani, S, Gabellieri, L, Gadariya, D, Gahle, D, Galassi, D, Galazka, K, Galdon-Quiroga, J, Galeani, S, Gallart, D, Gallo, A, Galperti, C, Garavaglia, S, Garcia, J, Garcia-Lopez, J, Garcia-Mu oz, M, Garzotti, L, Gath, J, Geiger, B, Giacomelli, L, Giannone, L, Gibson, S, Gil, L, Giovannozzi, E, Giruzzi, G, Gobbin, M, 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Loschiavo, V, Lunt, T, Macusova, E, Madsen, J, Maggiora, R, Maljaars, B, Manas, P, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Marchenko, V, Marchetto, C, Mariani, A, Marini, C, Markovic, T, Marrelli, L, Martin, P, Martin Solis, J, Martitsch, A, Mastrostefano, S, Matos, F, Matthews, G, Mayoral, M, Mazon, D, Mazzotta, C, Mc Carthy, P, Mcclements, K, Mcdermott, R, Mcmillan, B, Meineri, C, Menkovski, V, Meshcheriakov, D, Messmer, M, Micheletti, D, Milanesio, D, Militello, F, Miron, I, Mlynar, J, Moiseenko, V, Molina Cabrera, P, Morales, J, Moret, J, Moro, A, Moulton, D, Nabais, F, Naulin, V, Naydenkova, D, Nem, R, Nespoli, F, Newton, S, Nielsen, A, Nielsen, S, Nikolaeva, V, Nocente, M, Nowak, S, Oberkofler, M, Ochoukov, R, Ollus, P, Olsen, J, Omotani, J, Ongena, J, Orain, F, Orsitto, F, Paccagnella, R, Palha, A, Panaccione, L, Panek, R, Panjan, M, Papp, G, Paradela Perez, I, Parra, F, Passeri, M, Pau, A, Pautasso, G, Pavlichenko, R, Perek, A, Pericoli Radolfini, V, Pesamosca, F, 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F., Wolfrum E., Bernert M., Dunne M. G., Frassinetti L., Hennequin P., Maurizio R., Merle A., Meyer H., Saarelma S., Sheikh U., Adamek J., Agostini M., Aguiam D., Akers R., Albanese R., Albert C., Alessi E., Ambrosino R., Andr be Y., Angioni C., Apruzzese G., Aradi M., Arnichand H., Auriemma F., Avdeeva G., Ayllon-Guerola J. M., Bagnato F., Bandaru V. K., Barnes M., Barrera-Orte L., Bettini P., Bilato R., Biletskyi O., Bilkova P., Bin W., Blanchard P., Blanken T., Bobkov V., Bock A., Boeyaert D., Bogar K., Bogar O., Bohm P., Bolzonella T., Bombarda F., Boncagni L., Bouquey F., Bowman C., Brezinsek S., Brida D., Brunetti D., Bucalossi J., Buchanan J., Buermans J., Bufferand H., Buller S., Buratti P., Burckhart A., Calabr G., Calacci L., Camenen Y., Cannas B., Cano Megias P., Carnevale D., Carpanese F., Carr M., Carralero D., Carraro L., Casolari A., Cathey A., Causa F., Cavedon M., Cecconello M., Ceccuzzi S., Cerovsky J., Chapman S., Chmielewski P., Choi D., Cianfarani C., Ciraolo G., Coda S., Coelho R., Colas L., Colette D., Cordaro L., Cordella F., Costea S., Coster D., Cruz Zabala D. J., Cseh G., Czarnecka A., Cziegler I., D'Arcangelo O., Dal Molin A., David P., De Carolis G., De Oliveira H., Decker J., Dejarnac R., Delogu R., Den Harder N., Dimitrova M., Dolizy F., Dominguez-Palacios Duran J. 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T., Walkden N., Wauters T., Weiland M., Weinzettl V., Wensing M., Wiesen S., Wiesenberger M., Wilkie G., Willensdorfer M., Wischmeier M., Wu K., Xiang L., Zagorski R., Zaloga D., Zanca P., Zaplotnik R., Zebrowski J., Zhang W., Zisis A., Zoletnik S., Zuin M., Labit, B, Eich, T, Harrer, G, Wolfrum, E, Bernert, M, Dunne, M, Frassinetti, L, Hennequin, P, Maurizio, R, Merle, A, Meyer, H, Saarelma, S, Sheikh, U, Adamek, J, Agostini, M, Aguiam, D, Akers, R, Albanese, R, Albert, C, Alessi, E, Ambrosino, R, Andr be, Y, Angioni, C, Apruzzese, G, Aradi, M, Arnichand, H, Auriemma, F, Avdeeva, G, Ayllon-Guerola, J, Bagnato, F, Bandaru, V, Barnes, M, Barrera-Orte, L, Bettini, P, Bilato, R, Biletskyi, O, Bilkova, P, Bin, W, Blanchard, P, Blanken, T, Bobkov, V, Bock, A, Boeyaert, D, Bogar, K, Bogar, O, Bohm, P, Bolzonella, T, Bombarda, F, Boncagni, L, Bouquey, F, Bowman, C, Brezinsek, S, Brida, D, Brunetti, D, Bucalossi, J, Buchanan, J, Buermans, J, Bufferand, H, Buller, S, Buratti, P, Burckhart, A, 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Galdon-Quiroga, J, Galeani, S, Gallart, D, Gallo, A, Galperti, C, Garavaglia, S, Garcia, J, Garcia-Lopez, J, Garcia-Mu oz, M, Garzotti, L, Gath, J, Geiger, B, Giacomelli, L, Giannone, L, Gibson, S, Gil, L, Giovannozzi, E, Giruzzi, G, Gobbin, M, Gonzalez-Martin, J, Goodman, T, Gorini, G, Gospodarczyk, M, Granucci, G, Grekov, D, Grenfell, G, Griener, M, Groth, M, Grover, O, Gruca, M, Gude, A, Guimarais, L, Gyergyek, T, Hacek, P, Hakola, A, Ham, C, Happel, T, Harrison, J, Havranek, A, Hawke, J, Henderson, S, Hesslow, L, Hitzler, F, Hnat, B, Hobirk, J, Hoelzl, M, Hogeweij, D, Hopf, C, Hoppe, M, Horacek, J, Hron, M, Huang, Z, Iantchenko, A, Iglesias, D, Igochine, V, Innocente, P, Ionita-Schrittwieser, C, Isliker, H, Ivanova-Stanik, I, Jacobsen, A, Jakubowski, M, Janky, F, Jardin, A, Jaulmes, F, Jensen, T, Jonsson, T, Kallenbach, A, Kappatou, A, Karpushov, A, Kasilov, S, Kazakov, Y, Kazantzidis, P, Keeling, D, Kelemen, M, Kendl, A, Kernbichler, W, Kirk, A, Kocsis, G, Komm, M, Kong, M, Korovin, V, Koubiti, M, Kovacic, J, Krawczyk, N, Krieger, K, Kripner, L, Krivska, A, Kudlacek, O, Kulyk, Y, Kurki-Suonio, T, Kwiatkowski, R, Laggner, F, Laguardia, L, Lahtinen, A, Lang, P, Likonen, J, Lipschultz, B, Liu, F, Lombroni, R, Lorenzini, R, Loschiavo, V, Lunt, T, Macusova, E, Madsen, J, Maggiora, R, Maljaars, B, Manas, P, Mantica, P, Mantsinen, M, Manz, P, Maraschek, M, Marchenko, V, Marchetto, C, Mariani, A, Marini, C, Markovic, T, Marrelli, L, Martin, P, Martin Solis, J, Martitsch, A, Mastrostefano, S, Matos, F, Matthews, G, Mayoral, M, Mazon, D, Mazzotta, C, Mc Carthy, P, Mcclements, K, Mcdermott, R, Mcmillan, B, Meineri, C, Menkovski, V, Meshcheriakov, D, Messmer, M, Micheletti, D, Milanesio, D, Militello, F, Miron, I, Mlynar, J, Moiseenko, V, Molina Cabrera, P, Morales, J, Moret, J, Moro, A, Moulton, D, Nabais, F, Naulin, V, Naydenkova, D, Nem, R, Nespoli, F, Newton, S, Nielsen, A, Nielsen, S, Nikolaeva, V, Nocente, M, Nowak, S, Oberkofler, M, Ochoukov, R, Ollus, P, Olsen, J, Omotani, J, Ongena, J, Orain, F, Orsitto, F, Paccagnella, R, Palha, A, Panaccione, L, Panek, R, Panjan, M, Papp, G, Paradela Perez, I, Parra, F, Passeri, M, Pau, A, Pautasso, G, Pavlichenko, R, Perek, A, Pericoli Radolfini, V, Pesamosca, F, Peterka, M, Petrzilka, V, Piergotti, V, Pigatto, L, Piovesan, P, Piron, C, Piron, L, Plyusnin, V, Pokol, G, Poli, E, Poloskei, P, Popov, T, Popovic, Z, Por, G, Porte, L, Pucella, G, Puiatti, M, Putterich, T, Rabinski, M, Juul Rasmussen, J, Rasmussen, J, Ratta, G, Ratynskaia, S, Ravensbergen, T, Refy, D, Reich, M, Reimerdes, H, Reimold, F, Reiser, D, Reux, C, Reznik, S, Ricci, D, Rispoli, N, Rivero-Rodriguez, J, Rocchi, G, Rodriguez-Ramos, M, Romano, A, Rosato, J, Rubinacci, G, Rubino, G, Ryan, D, Salewski, M, Salmi, A, Samaddar, D, Sanchis-Sanchez, L, Santos, J, Sarkimaki, K, Sassano, M, Sauter, O, Scannell, R, Scheffer, M, Schneider, B, Schneider, P, Schrittwieser, R, Schubert, M, Seidl, J, Seliunin, E, Sharapov, S, Sheeba, R, Sias, G, Sieglin, B, Silva, C, Sipila, S, Smith, S, Snicker, A, Solano, E, Hansen, S, Soria-Hoyo, C, Sorokovoy, E, Sozzi, C, Sperduti, A, Spizzo, G, Spolaore, M, Stejner, M, Stipani, L, Stober, J, Strand, P, Sun, H, Suttrop, W, Sytnykov, D, Szepesi, T, Tal, B, Tala, T, Tardini, G, Tardocchi, M, Teplukhina, A, Terranova, D, Testa, D, Theiler, C, Thoren, E, Thornton, A, Tilia, B, Tolias, P, Tomes, M, Toscano-Jimenez, M, Tsironis, C, Tsui, C, Tudisco, O, Urban, J, Valisa, M, Vallar, M, Vallejos Olivares, P, Valovic, M, Van Vugt, D, Vanovac, B, Varje, J, Varju, J, Varoutis, S, Vartanian, S, Vasilovici, O, Vega, J, Verdoolaege, G, Verhaegh, K, Vermare, L, Vianello, N, Vicente, J, Viezzer, E, Villone, F, Voitsekhovitch, I, Voltolina, D, Vondracek, P, Vu, N, Walkden, N, Wauters, T, Weiland, M, Weinzettl, V, Wensing, M, Wiesen, S, Wiesenberger, M, Wilkie, G, Willensdorfer, M, Wischmeier, M, Wu, K, Xiang, L, Zagorski, R, Zaloga, D, Zanca, P, Zaplotnik, R, Zebrowski, J, Zhang, W, Zisis, A, Zoletnik, S, Zuin, M, Labit B., Eich T., Harrer G. F., Wolfrum E., Bernert M., Dunne M. G., Frassinetti L., Hennequin P., Maurizio R., Merle A., Meyer H., Saarelma S., Sheikh U., Adamek J., Agostini M., Aguiam D., Akers R., Albanese R., Albert C., Alessi E., Ambrosino R., Andr be Y., Angioni C., Apruzzese G., Aradi M., Arnichand H., Auriemma F., Avdeeva G., Ayllon-Guerola J. M., Bagnato F., Bandaru V. K., Barnes M., Barrera-Orte L., Bettini P., Bilato R., Biletskyi O., Bilkova P., Bin W., Blanchard P., Blanken T., Bobkov V., Bock A., Boeyaert D., Bogar K., Bogar O., Bohm P., Bolzonella T., Bombarda F., Boncagni L., Bouquey F., Bowman C., Brezinsek S., Brida D., Brunetti D., Bucalossi J., Buchanan J., Buermans J., Bufferand H., Buller S., Buratti P., Burckhart A., Calabr G., Calacci L., Camenen Y., Cannas B., Cano Megias P., Carnevale D., Carpanese F., Carr M., Carralero D., Carraro L., Casolari A., Cathey A., Causa F., Cavedon M., Cecconello M., Ceccuzzi S., Cerovsky J., Chapman S., Chmielewski P., Choi D., Cianfarani C., Ciraolo G., Coda S., Coelho R., Colas L., Colette D., Cordaro L., Cordella F., Costea S., Coster D., Cruz Zabala D. J., Cseh G., Czarnecka A., Cziegler I., D'Arcangelo O., Dal Molin A., David P., De Carolis G., De Oliveira H., Decker J., Dejarnac R., Delogu R., Den Harder N., Dimitrova M., Dolizy F., Dominguez-Palacios Duran J. J., Douai D., Drenik A., Dreval M., Dudson B., Dunai D., Duval B. P., Dux R., Elmore S., Embreus O., Erds B., Fable E., Faitsch M., Fanni A., Farnik M., Faust I., Faustin J., Fedorczak N., Felici F., Feng S., Feng X., Ferreira J., Ferr G., Fevrier O., Ficker O., Figini L., Figueiredo A., Fil A., Fontana M., Francesco M., Fuchs C., Futatani S., Gabellieri L., Gadariya D., Gahle D., Galassi D., Galazka K., Galdon-Quiroga J., Galeani S., Gallart D., Gallo A., Galperti C., Garavaglia S., Garcia J., Garcia-Lopez J., Garcia-Mu oz M., Garzotti L., Gath J., Geiger B., Giacomelli L., Giannone L., Gibson S., Gil L., Giovannozzi E., Giruzzi G., Gobbin M., Gonzalez-Martin J., Goodman T. P., Gorini G., Gospodarczyk M., GRANUCCI, GUSTAVO, Grekov D., Grenfell G., Griener M., Groth M., Grover O., Gruca M., Gude A., Guimarais L., Gyergyek T., Hacek P., Hakola A., Ham C., Happel T., Harrison J., Havranek A., Hawke J., Henderson S., Hesslow L., Hitzler F., Hnat B., Hobirk J., Hoelzl M., Hogeweij D., Hopf C., Hoppe M., Horacek J., Hron M., Huang Z., Iantchenko A., Iglesias D., Igochine V., Innocente P., Ionita-Schrittwieser C., Isliker H., Ivanova-Stanik I., Jacobsen A., Jakubowski M., Janky F., Jardin A., Jaulmes F., Jensen T., Jonsson T., Kallenbach A., Kappatou A., Karpushov A., Kasilov S., Kazakov Y., Kazantzidis P. V., Keeling D., Kelemen M., Kendl A., Kernbichler W., Kirk A., Kocsis G., Komm M., Kong M., Korovin V., Koubiti M., Kovacic J., Krawczyk N., Krieger K., Kripner L., Krivska A., Kudlacek O., Kulyk Y., Kurki-Suonio T., Kwiatkowski R., Laggner F., Laguardia L., Lahtinen A., Lang P., Likonen J., Lipschultz B., Liu F., Lombroni R., Lorenzini R., Loschiavo V. P., Lunt T., MacUsova E., Madsen J., Maggiora R., Maljaars B., Manas P., Mantica P., Mantsinen M. J., Manz P., Maraschek M., Marchenko V., Marchetto C., MARIANI, ALBERTO, Marini C., Markovic T., Marrelli L., Martin P., Martin Solis J. R., Martitsch A., Mastrostefano S., Matos F., Matthews G., Mayoral M. -L., Mazon D., Mazzotta C., Mc Carthy P., McClements K., McDermott R., McMillan B., Meineri C., Menkovski V., Meshcheriakov D., Messmer M., Micheletti D., Milanesio D., Militello F., Miron I. G., Mlynar J., Moiseenko V., Molina Cabrera P. A., Morales J., Moret J. -M., Moro A., Moulton D., Nabais F., Naulin V., Naydenkova D., Nem R. D., Nespoli F., Newton S., Nielsen A. H., Nielsen S. K., Nikolaeva V., Nocente M., Nowak S., Oberkofler M., Ochoukov R., Ollus P., Olsen J., Omotani J., Ongena J., Orain F., Orsitto F. P., Paccagnella R., Palha A., Panaccione L., Panek R., Panjan M., Papp G., Paradela Perez I., Parra F., Passeri M., Pau A., Pautasso G., Pavlichenko R., Perek A., Pericoli Radolfini V., Pesamosca F., Peterka M., Petrzilka V., Piergotti V., Pigatto L., Piovesan P., Piron C., Piron L., Plyusnin V., Pokol G., Poli E., Poloskei P., Popov T., Popovic Z., Por G., Porte L., Pucella G., Puiatti M. E., Putterich T., Rabinski M., Juul Rasmussen J., Rasmussen J., Ratta G. A., Ratynskaia S., Ravensbergen T., Refy D., Reich M., Reimerdes H., Reimold F., Reiser D., Reux C., Reznik S., Ricci D., Rispoli N., Rivero-Rodriguez J. F., Rocchi G., Rodriguez-Ramos M., Romano A., Rosato J., Rubinacci G., Rubino G., Ryan D. A., Salewski M., Salmi A., Samaddar D., Sanchis-Sanchez L., Santos J., Sarkimaki K., Sassano M., Sauter O., Scannell R., Scheffer M., Schneider B. S., Schneider P., Schrittwieser R., Schubert M., Seidl J., Seliunin E., Sharapov S., Sheeba R. R., Sias G., Sieglin B., Silva C., Sipila S., Smith S., Snicker A., Solano E. R., Hansen S. K., Soria-Hoyo C., Sorokovoy E., Sozzi C., Sperduti A., Spizzo G., Spolaore M., Stejner M., Stipani L., Stober J., Strand P., Sun H., Suttrop W., Sytnykov D., Szepesi T., Tal B., Tala T., Tardini G., Tardocchi M., Teplukhina A., Terranova D., Testa D., Theiler C., Thoren E., Thornton A., Tilia B., Tolias P., Tomes M., Toscano-Jimenez M., Tsironis C., Tsui C., Tudisco O., Urban J., Valisa M., Vallar M., Vallejos Olivares P., Valovic M., Van Vugt D., Vanovac B., Varje J., Varju J., Varoutis S., Vartanian S., Vasilovici O., Vega J., Verdoolaege G., Verhaegh K., Vermare L., Vianello N., Vicente J., Viezzer E., Villone F., Voitsekhovitch I., Voltolina D., Vondracek P., Vu N. M. T., Walkden N., Wauters T., Weiland M., Weinzettl V., Wensing M., Wiesen S., Wiesenberger M., Wilkie G., Willensdorfer M., Wischmeier M., Wu K., Xiang L., Zagorski R., Zaloga D., Zanca P., Zaplotnik R., Zebrowski J., Zhang W., Zisis A., Zoletnik S., and Zuin M.
Abstract: Within the EUROfusion MST1 work package, a series of experiments has been conducted on AUG and TCV devices to disentangle the role of plasma fueling and plasma shape for the onset of small ELM regimes. On both devices, small ELM regimes with high confinement are achieved if and only if two conditions are fulfilled at the same time. Firstly, the plasma density at the separatrix must be large enough (ne,sep/nG ∼ 0.3), leading to a pressure profile flattening at the separatrix, which stabilizes type-I ELMs. Secondly, the magnetic configuration has to be close to a double null (DN), leading to a reduction of the magnetic shear in the extreme vicinity of the separatrix. As a consequence, its stabilizing effect on ballooning modes is weakened.
Published: 2019

15. Newborns of obese parents have altered DNA methylation patterns at imprinted genes

Author: Soubry, A, Murphy, S K, Wang, F, Huang, Z, Vidal, A C, Fuemmeler, B F, Kurtzberg, J, Murtha, A, Jirtle, R L, Schildkraut, J M, and Hoyo, C
Published: 2015
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16. A PIC based procedure for the integration of multiple time scale problems in gas discharge physics

Author: Soria-Hoyo, C., Pontiga, F., and Castellanos, A.
Published: 2009
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17. Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis

Author: Monangi, N. (Nagendra), Xu, H. (Huan), Khanam, R. (Rasheda), Khan, W. (Waqasuddin), Deb, S. (Saikat), Pervin, J. (Jesmin), Price, J. T. (Joan T.), Kennedy, S. H. (Stephen H.), Al Mahmud, A. (Abdullah), Fan, Y. (Yuemei), Le, T. Q. (Thanh Q.), Care, A. (Angharad), Landero, J. A. (Julio A.), Combs, G. F. (Gerald F.), Belling, E. (Elizabeth), Chappell, J. (Joanne), Kong, F. (Fansheng), Lacher, C. (Criag), Ahmed, S. (Salahuddin), Chowdhury, N. H. (Nabidul Haque), Rahman, S. (Sayedur), Kabir, F. (Furqan), Nisar, I. (Imran), Hotwani, A. (Aneeta), Mehmood, U. (Usma), Nizar, A. (Ambreen), Khalid, J. (Javairia), Dhingra, U. (Usha), Dutta, A. (Arup), Ali, S. (Said), Aftab, F. (Fahad), Juma, M. H. (Mohammed Hamad), Rahman, M. (Monjur), Vwalika, B. (Bellington), Musonda, P. (Patrick), Ahmed, T. (Tahmeed), Islam, M. M. (Md Munirul), Ashorn, U. (Ulla), Maleta, K. (Kenneth), Hallman, M. (Mikko), Goodfellow, L. (Laura), Gupta, J. K. (Juhi K.), Alfirevic, A. (Ana), Murphy, S. (Susan), Rand, L. (Larry), Ryckman, K. K. (Kelli K.), Murray, J. C. (Jeffrey C.), Bahl, R. (Rajiv), Litch, J. A. (James A.), Baruch-Gravett, C. (Courtney), Alfirevic, Z. (Zarko), Ashorn, P. (Per), Baqui, A. (Abdullah), Hirst, J. (Jane), Hoyo, C. (Cathrine), Jehan, F. (Fyezah), Jelliffe-Pawlowski, L. L. (Laura L.), Rahman, A. (Anisur), Roth, D. E. (Daniel E.), Sazawal, S. (Sunil), Stringer, J. (Jeffrey), Zhang, G. (Ge), Muglia, L. (Louis), Monangi, N. (Nagendra), Xu, H. (Huan), Khanam, R. (Rasheda), Khan, W. (Waqasuddin), Deb, S. (Saikat), Pervin, J. (Jesmin), Price, J. T. (Joan T.), Kennedy, S. H. (Stephen H.), Al Mahmud, A. (Abdullah), Fan, Y. (Yuemei), Le, T. Q. (Thanh Q.), Care, A. (Angharad), Landero, J. A. (Julio A.), Combs, G. F. (Gerald F.), Belling, E. (Elizabeth), Chappell, J. (Joanne), Kong, F. (Fansheng), Lacher, C. (Criag), Ahmed, S. (Salahuddin), Chowdhury, N. H. (Nabidul Haque), Rahman, S. (Sayedur), Kabir, F. (Furqan), Nisar, I. (Imran), Hotwani, A. (Aneeta), Mehmood, U. (Usma), Nizar, A. (Ambreen), Khalid, J. (Javairia), Dhingra, U. (Usha), Dutta, A. (Arup), Ali, S. (Said), Aftab, F. (Fahad), Juma, M. H. (Mohammed Hamad), Rahman, M. (Monjur), Vwalika, B. (Bellington), Musonda, P. (Patrick), Ahmed, T. (Tahmeed), Islam, M. M. (Md Munirul), Ashorn, U. (Ulla), Maleta, K. (Kenneth), Hallman, M. (Mikko), Goodfellow, L. (Laura), Gupta, J. K. (Juhi K.), Alfirevic, A. (Ana), Murphy, S. (Susan), Rand, L. (Larry), Ryckman, K. K. (Kelli K.), Murray, J. C. (Jeffrey C.), Bahl, R. (Rajiv), Litch, J. A. (James A.), Baruch-Gravett, C. (Courtney), Alfirevic, Z. (Zarko), Ashorn, P. (Per), Baqui, A. (Abdullah), Hirst, J. (Jane), Hoyo, C. (Cathrine), Jehan, F. (Fyezah), Jelliffe-Pawlowski, L. L. (Laura L.), Rahman, A. (Anisur), Roth, D. E. (Daniel E.), Sazawal, S. (Sunil), Stringer, J. (Jeffrey), Zhang, G. (Ge), and Muglia, L. (Louis)
Abstract: Background: Selenium (Se), an essential trace mineral, has been implicated in preterm birth (PTB). We aimed to determine the association of maternal Se concentrations during pregnancy with PTB risk and gestational duration in a large number of samples collected from diverse populations. Methods: Gestational duration data and maternal plasma or serum samples of 9946 singleton live births were obtained from 17 geographically diverse study cohorts. Maternal Se concentrations were determined by inductively coupled plasma mass spectrometry analysis. The associations between maternal Se with PTB and gestational duration were analysed using logistic and linear regressions. The results were then combined using fixed-effect and random-effect meta-analysis. Findings: In all study samples, the Se concentrations followed a normal distribution with a mean of 93.8 ng/mL (SD: 28.5 ng/mL) but varied substantially across different sites. The fixed-effect meta-analysis across the 17 cohorts showed that Se was significantly associated with PTB and gestational duration with effect size estimates of an OR=0.95 (95% CI: 0.9 to 1.00) for PTB and 0.66 days (95% CI: 0.38 to 0.94) longer gestation per 15 ng/mL increase in Se concentration. However, there was a substantial heterogeneity among study cohorts and the random-effect meta-analysis did not achieve statistical significance. The largest effect sizes were observed in UK (Liverpool) cohort, and most significant associations were observed in samples from Malawi. Interpretation: While our study observed statistically significant associations between maternal Se concentration and PTB at some sites, this did not generalise across the entire cohort. Whether population-specific factors explain the heterogeneity of our findings warrants further investigation. Further evidence is needed to understand the biologic pathways, clinical efficacy and safety, before changes to antenatal nutritional recommendations for Se supplementation are c
Published: 2021

18. Ca y cas, las formas reducidas de casa que el español estándar no quiso

Author: Garrido, Blanca, Moral del Hoyo, Carmen, Raab, Matthias, Garrido, B ( Blanca ), Moral del Hoyo, C ( Carmen ), Raab, M ( Matthias ), De Benito Moreno, Carlota; https://orcid.org/0000-0001-9112-5471, Garrido, Blanca, Moral del Hoyo, Carmen, Raab, Matthias, Garrido, B ( Blanca ), Moral del Hoyo, C ( Carmen ), Raab, M ( Matthias ), and De Benito Moreno, Carlota; https://orcid.org/0000-0001-9112-5471
Abstract: Este volumen colectivo recoge una selección de trabajos presentados en la sección sobre "Variación diatópica y morfosintaxis en la historia del español", que se celebró en el XXII Congreso de la Asociación Alemana de Hispanistas en Berlín. En ellos, se ofrecen diferentes enfoques teóricos y metodológicos para el estudio de la morfosintaxis dialectal histórica, se aportan nuevos datos y materiales para la dialectología histórica, y se analiza la variación morfosintáctica y fenómenos de cambio lingüístico del español desde un punto de vista dialectal. El objeto de estudio de los trabajos compilados es diverso: construcciones locativas y cuantificativas, diferentes aspectos del ámbito de la morfología nominal y verbal o la variación dialectal en autores y textos. Las aportaciones, en definitiva, pretenden impulsar el estudio diacrónico de la dialectología, que tradicionalmente no ha recibido la misma atención que la geografía lingüística sincrónica. Temática:Lingüística histórica, Morfología, Sintaxis, Variedades del español
Published: 2021

19. Experimental study of conductivity of suspensions of silica particles in propanol and toluene-ethanol mixture

Author: Medrano, M., Soria-Hoyo, C., and Perez, A.T.
Subjects: Silica -- Properties, Electrical conductivity -- Measurement, Dielectrics -- Properties, Suspensions (Chemistry) -- Electric properties, Ionic liquids -- Properties, Propanols -- Properties, Toluene -- Properties, Alcohol -- Properties, Alcohol, Denatured -- Properties, Business, Electronics, Electronics and electrical industries
Abstract: Two sets of silica particles have been synthesized and dispersed in both 1-propanol and toluene-ethanol mixture. The conductivity of the suspensions has been measured as a function of their concentration, by means of a device and experimental procedure developed by the authors. It has been observed that the conductivity increases linearly with the solid fraction for values smaller than 5%. Additionally, the water content has also been measured, to evaluate its effect on the conductivity of suspensions. Index Terms Conductivity measurement, dielectric liquids, interface phenomena, ions, particle charging, colloidal dispersions.
Published: 2009

20. Physico-chemical study of selected surfactant-clay mineral systems

Author: del Hoyo, C., Dorado, C., Rodríguez-Cruz, M. S., and Sánchez-Martín, M. J.
Published: 2008
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21. DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

Author: Vehmeijer, F.O.L. (Florianne O.L.), Küpers, A.M. (Marlijn), Sharp, G.C. (Gemma C.), Salas, L.A. (Lucas A.), Lent, S. (Samantha), Jima, D.D. (Dereje D.), Tindula, G. (Gwen), Reese, S.E. (Sarah E.), Qi, C. (Cancan), Gruzieva, O. (Olena), Page, C. (Christian), Rezwan, F.I. (Faisal I.), Melton, P.E. (Philip E.), Nohr, C. (Christian), Escaramís, G. (Geòrgia), Rzehak, P. (Peter), Heiskala, A. (Anni), Gong, T. (Tong), Tuominen, S.T. (Samuli T.), Gao, L. (Lu), Ross, J.P. (Jason P.), Starling, A.P. (Anne P.), Holloway, J.W. (John W.), Yousefi, P. (Paul), Aasvang, G.M. (Gunn Marit), Beilin, L.J. (Lawrence), Bergström, A. (Anna), Binder, E.B. (Elisabeth), Chatzi, L. (Leda), Corpeleijn, E. (Eva), Czamara, D. (Darina), Eskenazi, B. (B.), Ewart, S. (Susan), Ferre, N. (Natalia), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Håberg, S.E. (Siri E), Hoyo, C. (Cathrine), Huen, K. (Karen), Karlsson, R. (Robert), Kull, C.A. (Christian), Langhendries, J.P. (Jean Paul), Lepeule, J. (Johanna), Magnus, M.C. (Maria C.), Maguire, R.L. (Rachel L.), Molloy, P.L. (Peter L.), Poppelaars-Monnereau, C. (Claire), Mori, T.A. (Trevor A.), Oken, E. (Emily), Räikkönen, K. (Katri), Rifas-Shiman, S.L. (Sheryl), Ruiz-Arenas, C. (Carlos), Sebert, S. (Sylvain), Ullemar, V. (Vilhelmina), Verduci, E. (Elvira), Vonk, J.M. (Judith), Xu, C.-J. (Cheng-Jian), Yang, I.V. (Ivana V.), Zhang, H. (Hongmei), Zhang, W. (Weiming), Karmaus, W. (Wilfried), Dabelea, D. (Dana), Muhlhausler, B.S. (Beverly S.), Breton, C. (Carrie), Lahti, J. (Jari), Almqvist, C. (Catarina), Jarvelin, M.-R. (Marjo-Riitta), Koletzko, B. (Berthold), Vrijheid, M. (Martine), Sørensen, T.I.A. (Thorkild), Huang, R.-C. (Rae-Chi), Arshad, S.H. (Syed), Nystad, W. (Wenche), Melén, E. (Erik), Koppelman, G.H. (Gerard), London, S.J. (Stephanie J.), Holland, N. (Nina), Bustamante, M. (Mariona), Murphy, S.K. (Susan K.), Hivert, M.-F. (Marie-France), Baccarelli, A.A. (Andrea), Relton, C.L. (Caroline), Snieder, H. (Harold), Jaddoe, V.W.V. (Vincent), Felix, J.F. (Janine), Vehmeijer, F.O.L. (Florianne O.L.), Küpers, A.M. (Marlijn), Sharp, G.C. (Gemma C.), Salas, L.A. (Lucas A.), Lent, S. (Samantha), Jima, D.D. (Dereje D.), Tindula, G. (Gwen), Reese, S.E. (Sarah E.), Qi, C. (Cancan), Gruzieva, O. (Olena), Page, C. (Christian), Rezwan, F.I. (Faisal I.), Melton, P.E. (Philip E.), Nohr, C. (Christian), Escaramís, G. (Geòrgia), Rzehak, P. (Peter), Heiskala, A. (Anni), Gong, T. (Tong), Tuominen, S.T. (Samuli T.), Gao, L. (Lu), Ross, J.P. (Jason P.), Starling, A.P. (Anne P.), Holloway, J.W. (John W.), Yousefi, P. (Paul), Aasvang, G.M. (Gunn Marit), Beilin, L.J. (Lawrence), Bergström, A. (Anna), Binder, E.B. (Elisabeth), Chatzi, L. (Leda), Corpeleijn, E. (Eva), Czamara, D. (Darina), Eskenazi, B. (B.), Ewart, S. (Susan), Ferre, N. (Natalia), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Håberg, S.E. (Siri E), Hoyo, C. (Cathrine), Huen, K. (Karen), Karlsson, R. (Robert), Kull, C.A. (Christian), Langhendries, J.P. (Jean Paul), Lepeule, J. (Johanna), Magnus, M.C. (Maria C.), Maguire, R.L. (Rachel L.), Molloy, P.L. (Peter L.), Poppelaars-Monnereau, C. (Claire), Mori, T.A. (Trevor A.), Oken, E. (Emily), Räikkönen, K. (Katri), Rifas-Shiman, S.L. (Sheryl), Ruiz-Arenas, C. (Carlos), Sebert, S. (Sylvain), Ullemar, V. (Vilhelmina), Verduci, E. (Elvira), Vonk, J.M. (Judith), Xu, C.-J. (Cheng-Jian), Yang, I.V. (Ivana V.), Zhang, H. (Hongmei), Zhang, W. (Weiming), Karmaus, W. (Wilfried), Dabelea, D. (Dana), Muhlhausler, B.S. (Beverly S.), Breton, C. (Carrie), Lahti, J. (Jari), Almqvist, C. (Catarina), Jarvelin, M.-R. (Marjo-Riitta), Koletzko, B. (Berthold), Vrijheid, M. (Martine), Sørensen, T.I.A. (Thorkild), Huang, R.-C. (Rae-Chi), Arshad, S.H. (Syed), Nystad, W. (Wenche), Melén, E. (Erik), Koppelman, G.H. (Gerard), London, S.J. (Stephanie J.), Holland, N. (Nina), Bustamante, M. (Mariona), Murphy, S.K. (Susan K.), Hivert, M.-F. (Marie-France), Baccarelli, A.A. (Andrea), Relton, C.L. (Caroline), Snieder, H. (Harold), Jaddoe, V.W.V. (Vincent), and Felix, J.F. (Janine)
Abstract: Background: DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods: We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results: DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × 10−7, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × 10−4; adolescence Penrichment = 2.10 × 10−7). Conclusions: There were only minimal associations of DNA methylation with childhood and adolescent BMI.
Published: 2020
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22. DNA methylation and body mass index from birth to adolescence:meta-analyses of epigenome-wide association studies

Author: Vehmeijer, F. O. (Florianne O. L.), Kuepers, L. K. (Leanne K.), Sharp, G. C. (Gemma C.), Salas, L. A. (Lucas A.), Lent, S. (Samantha), Jima, D. D. (Dereje D.), Tindula, G. (Gwen), Reese, S. (Sarah), Qi, C. (Cancan), Gruzieva, O. (Olena), Page, C. (Christian), Rezwan, F. I. (Faisal, I), Melton, P. E. (Philip E.), Nohr, E. (Ellen), Escaramis, G. (Georgia), Rzehak, P. (Peter), Heiskala, A. (Anni), Gong, T. (Tong), Tuominen, S. T. (Samuli T.), Gao, L. (Lu), Ross, J. P. (Jason P.), Starling, A. P. (Anne P.), Holloway, J. W. (John W.), Yousefi, P. (Paul), Aasvang, G. M. (Gunn Marit), Beilin, L. J. (Lawrence J.), Bergstrom, A. (Anna), Binder, E. (Elisabeth), Chatzi, L. (Leda), Corpeleijn, E. (Eva), Czamara, D. (Darina), Eskenazi, B. (Brenda), Ewart, S. (Susan), Ferre, N. (Natalia), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Haberg, S. E. (Siri E.), Hoyo, C. (Cathrine), Huen, K. (Karen), Karlsson, R. (Robert), Kull, I. (Inger), Langhendries, J.-P. (Jean-Paul), Lepeule, J. (Johanna), Magnus, M. C. (Maria C.), Maguire, R. L. (Rachel L.), Molloy, P. L. (Peter L.), Monnereau, C. (Claire), Mori, T. A. (Trevor A.), Oken, E. (Emily), Raikkonen, K. (Katri), Rifas-Shiman, S. (Sheryl), Ruiz-Arenas, C. (Carlos), Sebert, S. (Sylvain), Ullemar, V. (Vilhelmina), Verduci, E. (Elvira), Vonk, J. M. (Judith M.), Xu, C.-j. (Cheng-jian), Yang, I. V. (Ivana, V), Zhang, H. (Hongmei), Zhang, W. (Weiming), Karmaus, W. (Wilfried), Dabelea, D. (Dana), Muhlhausler, B. S. (Beverly S.), Breton, C. V. (Carrie, V), Lahti, J. (Jari), Almqvist, C. (Catarina), Jarvelin, M.-R. (Marjo-Riitta), Koletzko, B. (Berthold), Vrijheid, M. (Martine), Sorensen, T. I. (Thorkild I. A.), Huang, R.-C. (Rae-Chi), Arshad, S. H. (Syed Hasan), Nystad, W. (Wenche), Melen, E. (Erik), Koppelman, G. H. (Gerard H.), London, S. J. (Stephanie J.), Holland, N. (Nina), Bustamante, M. (Mariona), Murphy, S. K. (Susan K.), Hivert, M.-F. (Marie-France), Baccarelli, A. (Andrea), Relton, C. L. (Caroline L.), Snieder, H. (Harold), Jaddoe, V. W. (Vincent W. V.), Felix, J. F. (Janine F.), Vehmeijer, F. O. (Florianne O. L.), Kuepers, L. K. (Leanne K.), Sharp, G. C. (Gemma C.), Salas, L. A. (Lucas A.), Lent, S. (Samantha), Jima, D. D. (Dereje D.), Tindula, G. (Gwen), Reese, S. (Sarah), Qi, C. (Cancan), Gruzieva, O. (Olena), Page, C. (Christian), Rezwan, F. I. (Faisal, I), Melton, P. E. (Philip E.), Nohr, E. (Ellen), Escaramis, G. (Georgia), Rzehak, P. (Peter), Heiskala, A. (Anni), Gong, T. (Tong), Tuominen, S. T. (Samuli T.), Gao, L. (Lu), Ross, J. P. (Jason P.), Starling, A. P. (Anne P.), Holloway, J. W. (John W.), Yousefi, P. (Paul), Aasvang, G. M. (Gunn Marit), Beilin, L. J. (Lawrence J.), Bergstrom, A. (Anna), Binder, E. (Elisabeth), Chatzi, L. (Leda), Corpeleijn, E. (Eva), Czamara, D. (Darina), Eskenazi, B. (Brenda), Ewart, S. (Susan), Ferre, N. (Natalia), Grote, V. (Veit), Gruszfeld, D. (Dariusz), Haberg, S. E. (Siri E.), Hoyo, C. (Cathrine), Huen, K. (Karen), Karlsson, R. (Robert), Kull, I. (Inger), Langhendries, J.-P. (Jean-Paul), Lepeule, J. (Johanna), Magnus, M. C. (Maria C.), Maguire, R. L. (Rachel L.), Molloy, P. L. (Peter L.), Monnereau, C. (Claire), Mori, T. A. (Trevor A.), Oken, E. (Emily), Raikkonen, K. (Katri), Rifas-Shiman, S. (Sheryl), Ruiz-Arenas, C. (Carlos), Sebert, S. (Sylvain), Ullemar, V. (Vilhelmina), Verduci, E. (Elvira), Vonk, J. M. (Judith M.), Xu, C.-j. (Cheng-jian), Yang, I. V. (Ivana, V), Zhang, H. (Hongmei), Zhang, W. (Weiming), Karmaus, W. (Wilfried), Dabelea, D. (Dana), Muhlhausler, B. S. (Beverly S.), Breton, C. V. (Carrie, V), Lahti, J. (Jari), Almqvist, C. (Catarina), Jarvelin, M.-R. (Marjo-Riitta), Koletzko, B. (Berthold), Vrijheid, M. (Martine), Sorensen, T. I. (Thorkild I. A.), Huang, R.-C. (Rae-Chi), Arshad, S. H. (Syed Hasan), Nystad, W. (Wenche), Melen, E. (Erik), Koppelman, G. H. (Gerard H.), London, S. J. (Stephanie J.), Holland, N. (Nina), Bustamante, M. (Mariona), Murphy, S. K. (Susan K.), Hivert, M.-F. (Marie-France), Baccarelli, A. (Andrea), Relton, C. L. (Caroline L.), Snieder, H. (Harold), Jaddoe, V. W. (Vincent W. V.), and Felix, J. F. (Janine F.)
Abstract: Background: DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods: We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results: DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × 10⁻⁷, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × 10⁻⁴; adolescence Penrichment = 2.10 × 10⁻⁷). Conclusions: There were only minimal associations of DNA methylation with childhood and adol
Published: 2020

23. Association between DNA methylation and ADHD symptoms from birth to school age: a prospective meta-analysis

Author: Neumann, Alexander, Walton, E, Alemany, S, Cecil, Charlotte, González, JR, Jima, DD, Lahti, J, Tuominen, ST, Barker, ED, Binder, E, Caramaschi, D, Carracedo, Á, Czamara, D, Evandt, J, Felix, Janine, Fuemmeler, BF, Gutzkow, KB, Hoyo, C, Julvez, J, Kajantie, E, Laivuori, H, Maguire, R, Maitre, L, Murphy, SK, Murcia, M, Villa, PM, Sharp, G, Sunyer, J, Raikkönen, K, Bakermans-Kranenburg, M, van IJzendoorn, M, Guxens Junyent, Monica, Relton, CL, Tiemeier, Henning, Neumann, Alexander, Walton, E, Alemany, S, Cecil, Charlotte, González, JR, Jima, DD, Lahti, J, Tuominen, ST, Barker, ED, Binder, E, Caramaschi, D, Carracedo, Á, Czamara, D, Evandt, J, Felix, Janine, Fuemmeler, BF, Gutzkow, KB, Hoyo, C, Julvez, J, Kajantie, E, Laivuori, H, Maguire, R, Maitre, L, Murphy, SK, Murcia, M, Villa, PM, Sharp, G, Sunyer, J, Raikkönen, K, Bakermans-Kranenburg, M, van IJzendoorn, M, Guxens Junyent, Monica, Relton, CL, and Tiemeier, Henning
Published: 2020

24. DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

Author: Vehmeijer, Florianne, Küpers, LK, Sharp, GC, Salas, LA, Lent, S, Jima, DD, Tindula, G, Reese, S, Qi, C, Gruzieva, O, Page, C, Rezwan, FI, Melton, PE, Nohr, E, Escaramís, G, Rzehak, P, Heiskala, A, Gong, T, Tuominen, ST, Gao, L, Ross, JP, Starling, AP, Holloway, JW, Yousefi, P, Aasvang, GM, Beilin, LJ, Bergström, A, Binder, E, Chatzi, L, Corpeleijn, E, Czamara, D, Eskenazi, B, Ewart, S, Ferre, N, Grote, V, Gruszfeld, D, Håberg, SE, Hoyo, C, Huen, K, Karlsson, R, Kull, I, Langhendries, J P, Lepeule, J, Magnus, MC, Maguire, RL, Molloy, PL, Monnereau, Claire, Mori, TA, Oken, E, Räikkönen, K, Rifas-Shiman, S, Ruiz-Arenas, C, Sebert, S, Ullemar, V, Verduci, E, Vonk, JM, Xu, CJ, Yang, IV, Zhang, H, Zhang, W, Karmaus, W, Dabelea, D, Muhlhausler, BS, Breton, CV, Lahti, J, Almqvist, C, Jarvelin, M R R, Koletzko, B, Vrijheid, M, Sørensen, TIA, Huang, RC, Arshad, SH, Nystad, W, Melén, E, Koppelman, GH, London, SJ, Holland, N, Bustamante, M, Murphy, SK, Hivert, MF, Baccarelli, A, Relton, CL, Snieder, H, Jaddoe, Vincent, Felix, Janine, Vehmeijer, Florianne, Küpers, LK, Sharp, GC, Salas, LA, Lent, S, Jima, DD, Tindula, G, Reese, S, Qi, C, Gruzieva, O, Page, C, Rezwan, FI, Melton, PE, Nohr, E, Escaramís, G, Rzehak, P, Heiskala, A, Gong, T, Tuominen, ST, Gao, L, Ross, JP, Starling, AP, Holloway, JW, Yousefi, P, Aasvang, GM, Beilin, LJ, Bergström, A, Binder, E, Chatzi, L, Corpeleijn, E, Czamara, D, Eskenazi, B, Ewart, S, Ferre, N, Grote, V, Gruszfeld, D, Håberg, SE, Hoyo, C, Huen, K, Karlsson, R, Kull, I, Langhendries, J P, Lepeule, J, Magnus, MC, Maguire, RL, Molloy, PL, Monnereau, Claire, Mori, TA, Oken, E, Räikkönen, K, Rifas-Shiman, S, Ruiz-Arenas, C, Sebert, S, Ullemar, V, Verduci, E, Vonk, JM, Xu, CJ, Yang, IV, Zhang, H, Zhang, W, Karmaus, W, Dabelea, D, Muhlhausler, BS, Breton, CV, Lahti, J, Almqvist, C, Jarvelin, M R R, Koletzko, B, Vrijheid, M, Sørensen, TIA, Huang, RC, Arshad, SH, Nystad, W, Melén, E, Koppelman, GH, London, SJ, Holland, N, Bustamante, M, Murphy, SK, Hivert, MF, Baccarelli, A, Relton, CL, Snieder, H, Jaddoe, Vincent, and Felix, Janine
Published: 2020

25. DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

Author: Universitat Rovira i Virgili, Vehmeijer FOL; Küpers LK; Sharp GC; Salas LA; Lent S; Jima DD; Tindula G; Reese S; Qi C; Gruzieva O; Page C; Rezwan FI; Melton PE; Nohr E; Escaramís G; Rzehak P; Heiskala A; Gong T; Tuominen ST; Gao L; Ross JP; Starling AP; Holloway JW; Yousefi P; Aasvang GM; Beilin LJ; Bergström A; Binder E; Chatzi L; Corpeleijn E; Czamara D; Eskenazi B; Ewart S; Ferre N; Grote V; Gruszfeld D; Håberg SE; Hoyo C; Huen K; Karlsson R, Universitat Rovira i Virgili, and Vehmeijer FOL; Küpers LK; Sharp GC; Salas LA; Lent S; Jima DD; Tindula G; Reese S; Qi C; Gruzieva O; Page C; Rezwan FI; Melton PE; Nohr E; Escaramís G; Rzehak P; Heiskala A; Gong T; Tuominen ST; Gao L; Ross JP; Starling AP; Holloway JW; Yousefi P; Aasvang GM; Beilin LJ; Bergström A; Binder E; Chatzi L; Corpeleijn E; Czamara D; Eskenazi B; Ewart S; Ferre N; Grote V; Gruszfeld D; Håberg SE; Hoyo C; Huen K; Karlsson R
Abstract: © 2020, The Author(s). Background: DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods: We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results: DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P < 1.06 × 10−7, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously ide
Published: 2020

26. Layered double hydroxides and human health: An overview

Author: Del Hoyo, C.
Published: 2007
Full Text: View/download PDF

27. Association of birth mode of delivery with infant faecal microbiota, potential pathobionts, and short chain fatty acids: a longitudinal study over the first year of life

Author: Mueller, NT, primary, Differding, MK, additional, Østbye, T, additional, Hoyo, C, additional, and Benjamin‐Neelon, SE, additional
Published: 2021
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28. OPEN: Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring

Author: Vidal, A C, Murphy, S K, Murtha, A P, Schildkraut, J M, Soubry, A, Huang, Z, Neelon, S EB, Fuemmeler, B, Iversen, E, Wang, F, Kurtzberg, J, Jirtle, R L, and Hoyo, C
Published: 2013
Full Text: View/download PDF

29. Epigenome-wide meta-analysis of DNA methylation and childhood asthma

Author: Reese, S. E. (Sarah E.), Xu, C.-J. (Cheng-Jian), den Dekker, H. T. (Herman T.), Lee, M. K. (Mi Kyeong), Sikdar, S. (Sinjini), Ruiz-Arenas, C. (Carlos), Merid, S. K. (Simon K.), Rezwan, F. I. (Faisal I.), Page, C. M. (Christian M.), Ullemar, V. (Vilhelmina), Melton, P. E. (Phillip E.), Oh, S. S. (Sam S.), Yang, I. V. (Ivana V.), Burrows, K. (Kimberley), Söderhäll, C. (Cilla), Jima, D. D. (Dereje D.), Gao, L. (Lu), Arathimos, R. (Ryan), Küpers, L. K. (Leanne K.), Wielscher, M. (Matthias), Rzehak, P. (Peter), Lahti, J. (Jari), Laprise, C. (Catherine), Madore, A.-M. (Anne-Marie), Ward, J. (James), Bennett, B. D. (Brian D.), Wang, T. (Tianyuan), Bell, D. A. (Douglas A.), T. B. (The BIOS consortium), Vonk, J. M. (Judith M.), Håberg, S. E. (Siri E.), Zhao, S. (Shanshan), Karlsson, R. (Robert), Hollams, E. (Elysia), Hu, D. (Donglei), Richards, A. J. (Adam J.), Bergström, A. (Anna), Sharp, G. C. (Gemma C.), Felix, J. F. (Janine F.), Bustamante, M. (Mariona), Gruzieva, O. (Olena), Maguire, R. L. (Rachel L.), Gilliland, F. (Frank), Baïz, N. (Nour), Nohr, E. A. (Ellen A.), Corpeleijn, E. (Eva), Sebert, S. (Sylvain), Karmaus, W. (Wilfried), Grote, V. (Veit), Kajantie, E. (Eero), Magnus, M. C. (Maria C.), Örtqvist, A. K. (Anne K.), Eng, C. (Celeste), Liu, A. H. (Andrew H.), Kull, I. (Inger), Jaddoe, V. W. (Vincent W.V.), Sunyer, J. (Jordi), Kere, J. (Juha), Hoyo, C. (Cathrine), Annesi-Maesano, I. (Isabella), Arshad, S. H. (Syed Hasan), Koletzko, B. (Berthold), Brunekreef, B. (Bert), Binder, E. B. (Elisabeth B.), Räikkönen, K. (Katri), Reischl, E. (Eva), Holloway, J. W. (John W.), Järvelin, M.-R. (Marjo-Riitta), Snieder, H. (Harold), Kazmi, N. (Nabila), Breton, C. V. (Carrie V.), Murphy, S. K. (Susan K.), Pershagen, G. (Göran), Anto, J. M. (Josep Maria), Relton, C. L. (Caroline L.), Schwartz, D. A. (David A.), Burchard, E. G. (Esteban G.), Huang, R.-C. (Rae-Chi), Nystad, W. (Wenche), Almqvist, C. (Catarina), Henderson, A. J. (A. John), Melén, E. (Erik), Duijts, L. (Liesbeth), Koppelman, G. H. (Gerard H.), and London, S. J. (Stephanie J.)
Subjects: epigenetics, newborn, methylation, asthma, drug development, childhood
Abstract: Background: Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. Objective: We sought to identify differential DNA methylation in newborns and children related to childhood asthma. Methods: Within the Pregnancy And Childhood Epigenetics consortium, we performed epigenome-wide meta-analyses of school-age asthma in relation to CpG methylation (Illumina450K) in blood measured either in newborns, in prospective analyses, or cross-sectionally in school-aged children. We also identified differentially methylated regions. Results: In newborns (8 cohorts, 668 cases), 9 CpGs (and 35 regions) were differentially methylated (epigenome-wide significance, false discovery rate < 0.05) in relation to asthma development. In a cross-sectional meta-analysis of asthma and methylation in children (9 cohorts, 631 cases), we identified 179 CpGs (false discovery rate < 0.05) and 36 differentially methylated regions. In replication studies of methylation in other tissues, most of the 179 CpGs discovered in blood replicated, despite smaller sample sizes, in studies of nasal respiratory epithelium or eosinophils. Pathway analyses highlighted enrichment for asthma-relevant immune processes and overlap in pathways enriched both in newborns and children. Gene expression correlated with methylation at most loci. Functional annotation supports a regulatory effect on gene expression at many asthma-associated CpGs. Several implicated genes are targets for approved or experimental drugs, including IL5RA and KCNH2. Conclusion: Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age. Cross-sectional associations in children can reflect both risk for and effects of disease. Asthma-related differential methylation in blood in children was substantially replicated in eosinophils and respiratory epithelium.
Published: 2019

30. Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study

Author: Collier, D., Skaar, D., Hoyo, C., McCullough, L.E., Murphy, S.K., Martin, C.L., Cowley, M., Gowdy, K.M., Maguire, R.L., Park, S.S., Fuemmeler, B., Relton, C.L., Sharp, G.C., and Jima, D.
Abstract: Pre-pregnancy obesity is an established risk factor for adverse sex-specific cardiometabolic health in offspring. Epigenetic alterations, such as in DNA methylation (DNAm), are a hypothesized link; however, sex-specific epigenomic targets remain unclear. Leveraging data from the Newborn Epigenetics Study (NEST) cohort, linear regression models were used to identify CpG sites in cord blood leukocytes associated with pre-pregnancy obesity in 187 mother-female and 173 mother-male offsprings. DNAm in cord blood was measured using the Illumina HumanMethylation450k BeadChip. Replication analysis was conducted among the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Associations between pre-pregnancy obesity-associated CpG sites and offspring BMI z-score (BMIz) and blood pressure (BP) percentiles at 4–5-years of age were also examined. Maternal pre-pregnacy obesity was associated with 876 CpGs in female and 293 CpGs in male offspring (false discovery rate
Published: 2019
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31. Selective oxidation of methanol on V2O5 and V2O5−MoO3 supported on montrmorillonite

Author: Pesheva, Y., Abadzhjieva, N., Vrachnou, E., Kovanis, Y., Rives, V., del Hoyo, C., and Klissurski, D.
Published: 1994
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32. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Author: Küpers, LK, Monnereau, C, Sharp, GC, Yousefi, P, Salas, LA, Ghantous, A, Page, CM, Reese, SE, Wilcox, AJ, Czamara, D, Starling, AP, Novoloaca, A, Lent, S, Roy, R, Hoyo, C, Breton, CV, Allard, C, Just, AC, Bakulski, KM, Holloway, JW, Everson, TM, Xu, C-J, Huang, R-C, van der Plaat, DA, Wielscher, M, Merid, SK, Ullemar, V, Rezwan, FI, Lahti, J, van Dongen, J, Langie, SAS, Richardson, TG, Magnus, MC, Nohr, EA, Xu, Z, Duijts, L, Zhao, S, Zhang, W, Plusquin, M, DeMeo, DL, Solomon, O, Heimovaara, JH, Jima, DD, Gao, L, Bustamante, M, Perron, P, Wright, RO, Hertz-Picciotto, I, Zhang, H, Karagas, MR, Gehring, U, Marsit, CJ, Beilin, LJ, Vonk, JM, Jarvelin, M-R, Bergström, A, Örtqvist, AK, Ewart, S, Villa, PM, Moore, SE, Willemsen, G, Standaert, ARL, Håberg, SE, Sørensen, TIA, Taylor, JA, Räikkönen, K, Yang, IV, Kechris, K, Nawrot, TS, Silver, MJ, Gong, YY, Richiardi, L, Kogevinas, M, Litonjua, AA, Eskenazi, B, Huen, K, Mbarek, H, Maguire, RL, Dwyer, T, Vrijheid, M, Bouchard, L, Baccarelli, AA, Croen, LA, Karmaus, W, Anderson, D, de Vries, M, Sebert, S, Kere, J, Karlsson, R, Arshad, SH, Hämäläinen, E, Routledge, MN, Boomsma, DI, Feinberg, AP, Newschaffer, CJ, Govarts, E, Moisse, M, Fallin, MD, Melén, E, Prentice, AM, Kajantie, E, Almqvist, C, Oken, E, Dabelea, D, Boezen, HM, Melton, PE, Wright, RJ, Koppelman, GH, Trevisi, L, Hivert, M-F, Sunyer, J, Munthe-Kaas, MC, Murphy, SK, Corpeleijn, E, Wiemels, J, Holland, N, Herceg, Z, Binder, EB, Davey Smith, G, Jaddoe, VWV, Lie, RT, Nystad, W, London, SJ, Lawlor, DA, Relton, CL, Snieder, H, Felix, JF, Küpers, LK, Monnereau, C, Sharp, GC, Yousefi, P, Salas, LA, Ghantous, A, Page, CM, Reese, SE, Wilcox, AJ, Czamara, D, Starling, AP, Novoloaca, A, Lent, S, Roy, R, Hoyo, C, Breton, CV, Allard, C, Just, AC, Bakulski, KM, Holloway, JW, Everson, TM, Xu, C-J, Huang, R-C, van der Plaat, DA, Wielscher, M, Merid, SK, Ullemar, V, Rezwan, FI, Lahti, J, van Dongen, J, Langie, SAS, Richardson, TG, Magnus, MC, Nohr, EA, Xu, Z, Duijts, L, Zhao, S, Zhang, W, Plusquin, M, DeMeo, DL, Solomon, O, Heimovaara, JH, Jima, DD, Gao, L, Bustamante, M, Perron, P, Wright, RO, Hertz-Picciotto, I, Zhang, H, Karagas, MR, Gehring, U, Marsit, CJ, Beilin, LJ, Vonk, JM, Jarvelin, M-R, Bergström, A, Örtqvist, AK, Ewart, S, Villa, PM, Moore, SE, Willemsen, G, Standaert, ARL, Håberg, SE, Sørensen, TIA, Taylor, JA, Räikkönen, K, Yang, IV, Kechris, K, Nawrot, TS, Silver, MJ, Gong, YY, Richiardi, L, Kogevinas, M, Litonjua, AA, Eskenazi, B, Huen, K, Mbarek, H, Maguire, RL, Dwyer, T, Vrijheid, M, Bouchard, L, Baccarelli, AA, Croen, LA, Karmaus, W, Anderson, D, de Vries, M, Sebert, S, Kere, J, Karlsson, R, Arshad, SH, Hämäläinen, E, Routledge, MN, Boomsma, DI, Feinberg, AP, Newschaffer, CJ, Govarts, E, Moisse, M, Fallin, MD, Melén, E, Prentice, AM, Kajantie, E, Almqvist, C, Oken, E, Dabelea, D, Boezen, HM, Melton, PE, Wright, RJ, Koppelman, GH, Trevisi, L, Hivert, M-F, Sunyer, J, Munthe-Kaas, MC, Murphy, SK, Corpeleijn, E, Wiemels, J, Holland, N, Herceg, Z, Binder, EB, Davey Smith, G, Jaddoe, VWV, Lie, RT, Nystad, W, London, SJ, Lawlor, DA, Relton, CL, Snieder, H, and Felix, JF
Abstract: Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10-7). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10-74) and BMI in pregnancy (3/914, p = 1.13x10-3), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.
Published: 2019

33. Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women

Author: Grant, DJ, Manichaikul, A, Alberg, AJ, Bandera, E, Barnholtz-Sloan, J, Bondy, M, Cote, ML, Funkhouser, E, Moorman, PG, Peres, LC, Peters, ES, Schwartz, AG, Terry, PD, Wang, X-Q, Keku, TO, Hoyo, C, Berchuck, A, Sandler, DP, Taylor, JA, O'Brien, KM, Edwards, DRV, Edwards, TL, Beeghly-Fadiel, A, Wentzensen, N, Pearce, CL, Wu, AH, Whittemore, AS, McGuire, V, Sieh, W, Rothstein, JH, Modugno, F, Ness, R, Moysich, K, Rossing, MA, Doherty, JA, Sellers, TA, Permuth-Way, JB, Monteiro, AN, Levine, DA, Setiawan, VW, Haiman, CA, LeMarchand, L, Wilkens, LR, Karlan, BY, Menon, U, Ramus, S, Gayther, S, Gentry-Maharaj, A, Terry, KL, Cramer, DW, Goode, EL, Larson, MC, Kaufmann, SH, Cannioto, R, Odunsi, K, Etter, JL, Huang, R-Y, Bernardini, MQ, Tone, AA, May, T, Goodman, MT, Thompson, PJ, Carney, ME, Tworoger, SS, Poole, EM, Lambrechts, D, Vergote, I, Vanderstichele, A, Van Nieuwenhuysen, E, Anton-Culver, H, Ziogas, A, Brenton, JD, Bjorge, L, Salvensen, HB, Kiemeney, LA, Massuger, LFAG, Pejovic, T, Bruegl, A, Moffitt, M, Cook, L, Le, ND, Brooks-Wilson, A, Kelemen, LE, Pharoah, PDP, Song, H, Campbell, I, Eccles, D, DeFazio, A, Kennedy, CJ, Schildkraut, JM, Grant, DJ, Manichaikul, A, Alberg, AJ, Bandera, E, Barnholtz-Sloan, J, Bondy, M, Cote, ML, Funkhouser, E, Moorman, PG, Peres, LC, Peters, ES, Schwartz, AG, Terry, PD, Wang, X-Q, Keku, TO, Hoyo, C, Berchuck, A, Sandler, DP, Taylor, JA, O'Brien, KM, Edwards, DRV, Edwards, TL, Beeghly-Fadiel, A, Wentzensen, N, Pearce, CL, Wu, AH, Whittemore, AS, McGuire, V, Sieh, W, Rothstein, JH, Modugno, F, Ness, R, Moysich, K, Rossing, MA, Doherty, JA, Sellers, TA, Permuth-Way, JB, Monteiro, AN, Levine, DA, Setiawan, VW, Haiman, CA, LeMarchand, L, Wilkens, LR, Karlan, BY, Menon, U, Ramus, S, Gayther, S, Gentry-Maharaj, A, Terry, KL, Cramer, DW, Goode, EL, Larson, MC, Kaufmann, SH, Cannioto, R, Odunsi, K, Etter, JL, Huang, R-Y, Bernardini, MQ, Tone, AA, May, T, Goodman, MT, Thompson, PJ, Carney, ME, Tworoger, SS, Poole, EM, Lambrechts, D, Vergote, I, Vanderstichele, A, Van Nieuwenhuysen, E, Anton-Culver, H, Ziogas, A, Brenton, JD, Bjorge, L, Salvensen, HB, Kiemeney, LA, Massuger, LFAG, Pejovic, T, Bruegl, A, Moffitt, M, Cook, L, Le, ND, Brooks-Wilson, A, Kelemen, LE, Pharoah, PDP, Song, H, Campbell, I, Eccles, D, DeFazio, A, Kennedy, CJ, and Schildkraut, JM
Abstract: An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom-designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high-grade serous (HGSOC), and 1,235 controls. All subjects are of African ancestry (AA). Logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (CI). We further evaluated statistical significance of selected SNPs using the Bayesian False Discovery Probability (BFDP). A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 1.2 × 10-6 , BFDP = 0.02); and an association with HGSOC was identified in the EGFR region for the SNP rs114972508 (per allele OR = 2.3, 95% CI = 1.6-3.4, P = 1.6 × 10-5 , BFDP = 0.29) and in the UGT2A1/2 region again for rs1017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 2.3 × 10-5 , BFDP = 0.23). Genetic variants in the EGFR and UGT2A1/2 may increase susceptibility of EOC in AA women. Future studies to validate these findings are warranted. Alterations in EGFR and UGT2A1/2 could perturb enzyme efficacy, proliferation in ovaries, impact and mark susceptibility to EOC.
Published: 2019

34. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Author: Kupers, L. K. (Leanne K.), Monnereau, C. (Claire), Sharp, G. C. (Gemma C.), Yousefi, P. (Paul), Salas, L. A. (Lucas A.), Ghantous, A. (Akram), Page, C. M. (Christian M.), Reese, S. E. (Sarah E.), Wilcox, A. J. (Allen J.), Czamara, D. (Darina), Starling, A. P. (Anne P.), Novoloaca, A. (Alexei), Lent, S. (Samantha), Roy, R. (Ritu), Hoyo, C. (Cathrine), Breton, C. V. (Carrie, V), Allard, C. (Catherine), Just, A. C. (Allan C.), Bakulski, K. M. (Kelly M.), Holloway, J. W. (John W.), Everson, T. M. (Todd M.), Xu, C.-J. (Cheng-Jian), Huang, R.-C. (Rae-Chi), van der Plaat, D. A. (Diana A.), Wielscher, M. (Matthias), Merid, S. K. (Simon Kebede), Ullemar, V. (Vilhelmina), Rezwan, F. I. (Faisal, I), Lahti, J. (Jari), van Dongen, J. (Jenny), Langie, S. A. (Sabine A. S.), Richardson, T. G. (Tom G.), Magnus, M. C. (Maria C.), Nohr, E. A. (Ellen A.), Xu, Z. (Zongli), Duijts, L. (Liesbeth), Zhao, S. (Shanshan), Zhang, W. (Weiming), Plusquin, M. (Michelle), DeMeo, D. L. (Dawn L.), Solomon, O. (Olivia), Heimovaara, J. H. (Joosje H.), Jima, D. D. (Dereje D.), Gao, L. (Lu), Bustamante, M. (Mariona), Perron, P. (Patrice), Wright, R. O. (Robert O.), Hertz-Picciotto, I. (Irva), Zhang, H. (Hongmei), Karagas, M. R. (Margaret R.), Gehring, U. (Ulrike), Marsit, C. J. (Carmen J.), Beilin, L. J. (Lawrence J.), Vonk, J. M. (Judith M.), Jarvelin, M.-R. (Marjo-Riitta), Bergstrom, A. (Anna), Ortqvist, A. K. (Anne K.), Ewart, S. (Susan), Villa, P. M. (Pia M.), Moore, S. E. (Sophie E.), Willemsen, G. (Gonneke), Standaert, A. R. (Arnout R. L.), Haberg, S. E. (Siri E.), Sorensen, T. I. (Thorkild I. A.), Taylor, J. A. (Jack A.), Raikkonen, K. (Katri), Yang, I. V. (Ivana, V), Kechris, K. (Katerina), Nawrot, T. S. (Tim S.), Silver, M. J. (Matt J.), Gong, Y. Y. (Yun Yun), Richiardi, L. (Lorenzo), Kogevinas, M. (Manolis), Litonjua, A. A. (Augusto A.), Eskenazi, B. (Brenda), Huen, K. (Karen), Mbarek, H. (Hamdi), Maguire, R. L. (Rachel L.), Dwyer, T. (Terence), Vrijheid, M. (Martine), Bouchard, L. (Luigi), Baccarelli, A. A. (Andrea A.), Croen, L. A. (Lisa A.), Karmaus, W. (Wilfried), Anderson, D. (Denise), de Vries, M. (Maaike), Sebert, S. (Sylvain), Kere, J. (Juha), Karlsson, R. (Robert), Arshad, S. H. (Syed Hasan), Hamalainen, E. (Esa), Routledge, M. N. (Michael N.), Boomsma, D. I. (Dorret, I), Feinberg, A. P. (Andrew P.), Newschaffer, C. J. (Craig J.), Govarts, E. (Eva), Moisse, M. (Matthieu), Fallin, M. D. (M. Daniele), Melen, E. (Erik), Prentice, A. M. (Andrew M.), Kajantie, E. (Eero), Almqvist, C. (Catarina), Oken, E. (Emily), Dabelea, D. (Dana), Boezen, H. M. (H. Marike), Melton, P. E. (Phillip E.), Wright, R. J. (Rosalind J.), Koppelman, G. H. (Gerard H.), Trevisi, L. (Letizia), Hivert, M.-F. (Marie-France), Sunyer, J. (Jordi), Munthe-Kaas, M. C. (Monica C.), Murphy, S. K. (Susan K.), Corpeleijn, E. (Eva), Wiemels, J. (Joseph), Holland, N. (Nina), Herceg, Z. (Zdenko), Binder, E. B. (Elisabeth B.), Smith, G. D. (George Davey), Jaddoe, V. W. (Vincent W. V.), Lie, R. T. (Rolv T.), Nystad, W. (Wenche), London, S. J. (Stephanie J.), Lawlor, D. A. (Debbie A.), Relton, C. L. (Caroline L.), Snieder, H. (Harold), Felix, J. F. (Janine F.), Kupers, L. K. (Leanne K.), Monnereau, C. (Claire), Sharp, G. C. (Gemma C.), Yousefi, P. (Paul), Salas, L. A. (Lucas A.), Ghantous, A. (Akram), Page, C. M. (Christian M.), Reese, S. E. (Sarah E.), Wilcox, A. J. (Allen J.), Czamara, D. (Darina), Starling, A. P. (Anne P.), Novoloaca, A. (Alexei), Lent, S. (Samantha), Roy, R. (Ritu), Hoyo, C. (Cathrine), Breton, C. V. (Carrie, V), Allard, C. (Catherine), Just, A. C. (Allan C.), Bakulski, K. M. (Kelly M.), Holloway, J. W. (John W.), Everson, T. M. (Todd M.), Xu, C.-J. (Cheng-Jian), Huang, R.-C. (Rae-Chi), van der Plaat, D. A. (Diana A.), Wielscher, M. (Matthias), Merid, S. K. (Simon Kebede), Ullemar, V. (Vilhelmina), Rezwan, F. I. (Faisal, I), Lahti, J. (Jari), van Dongen, J. (Jenny), Langie, S. A. (Sabine A. S.), Richardson, T. G. (Tom G.), Magnus, M. C. (Maria C.), Nohr, E. A. (Ellen A.), Xu, Z. (Zongli), Duijts, L. (Liesbeth), Zhao, S. (Shanshan), Zhang, W. (Weiming), Plusquin, M. (Michelle), DeMeo, D. L. (Dawn L.), Solomon, O. (Olivia), Heimovaara, J. H. (Joosje H.), Jima, D. D. (Dereje D.), Gao, L. (Lu), Bustamante, M. (Mariona), Perron, P. (Patrice), Wright, R. O. (Robert O.), Hertz-Picciotto, I. (Irva), Zhang, H. (Hongmei), Karagas, M. R. (Margaret R.), Gehring, U. (Ulrike), Marsit, C. J. (Carmen J.), Beilin, L. J. (Lawrence J.), Vonk, J. M. (Judith M.), Jarvelin, M.-R. (Marjo-Riitta), Bergstrom, A. (Anna), Ortqvist, A. K. (Anne K.), Ewart, S. (Susan), Villa, P. M. (Pia M.), Moore, S. E. (Sophie E.), Willemsen, G. (Gonneke), Standaert, A. R. (Arnout R. L.), Haberg, S. E. (Siri E.), Sorensen, T. I. (Thorkild I. A.), Taylor, J. A. (Jack A.), Raikkonen, K. (Katri), Yang, I. V. (Ivana, V), Kechris, K. (Katerina), Nawrot, T. S. (Tim S.), Silver, M. J. (Matt J.), Gong, Y. Y. (Yun Yun), Richiardi, L. (Lorenzo), Kogevinas, M. (Manolis), Litonjua, A. A. (Augusto A.), Eskenazi, B. (Brenda), Huen, K. (Karen), Mbarek, H. (Hamdi), Maguire, R. L. (Rachel L.), Dwyer, T. (Terence), Vrijheid, M. (Martine), Bouchard, L. (Luigi), Baccarelli, A. A. (Andrea A.), Croen, L. A. (Lisa A.), Karmaus, W. (Wilfried), Anderson, D. (Denise), de Vries, M. (Maaike), Sebert, S. (Sylvain), Kere, J. (Juha), Karlsson, R. (Robert), Arshad, S. H. (Syed Hasan), Hamalainen, E. (Esa), Routledge, M. N. (Michael N.), Boomsma, D. I. (Dorret, I), Feinberg, A. P. (Andrew P.), Newschaffer, C. J. (Craig J.), Govarts, E. (Eva), Moisse, M. (Matthieu), Fallin, M. D. (M. Daniele), Melen, E. (Erik), Prentice, A. M. (Andrew M.), Kajantie, E. (Eero), Almqvist, C. (Catarina), Oken, E. (Emily), Dabelea, D. (Dana), Boezen, H. M. (H. Marike), Melton, P. E. (Phillip E.), Wright, R. J. (Rosalind J.), Koppelman, G. H. (Gerard H.), Trevisi, L. (Letizia), Hivert, M.-F. (Marie-France), Sunyer, J. (Jordi), Munthe-Kaas, M. C. (Monica C.), Murphy, S. K. (Susan K.), Corpeleijn, E. (Eva), Wiemels, J. (Joseph), Holland, N. (Nina), Herceg, Z. (Zdenko), Binder, E. B. (Elisabeth B.), Smith, G. D. (George Davey), Jaddoe, V. W. (Vincent W. V.), Lie, R. T. (Rolv T.), Nystad, W. (Wenche), London, S. J. (Stephanie J.), Lawlor, D. A. (Debbie A.), Relton, C. L. (Caroline L.), Snieder, H. (Harold), and Felix, J. F. (Janine F.)
Abstract: Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10−7). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10−74) and BMI in pregnancy (3/914, p = 1.13x10−3), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.
Published: 2019

35. Dependence on plasma shape and plasma fueling for small edge-localized mode regimes in TCV and ASDEX Upgrade

Author: Labit, B., Eich, T., Harrer, G.F., Wolfrum, E., Bernert, M., Dunne, M.G., Frassinetti, L., Hennequin, P., Maurizio, R., Merle, A., Meyer, H., Saarelma, S., Sheikh, U., Adamek, J., Agostini, M., Aguiam, D., Akers, R., Albanese, R., Albert, C., Alessi, E., Ambrosino, R., Andrèbe, Y., Angioni, C., Apruzzese, G., Aradi, M., Arnichand, H., Auriemma, F., Avdeeva, G., Ayllon-Guerola, J.M., Bagnato, F., Bandaru, V.K., Barnes, M., Barrera-Orte, L., Bettini, P., Bilato, R., Biletskyi, O., Bilkova, P., Bin, W., Blanchard, P., Blanken, T., Bobkov, V., Bock, A., Boeyaert, D., Bogar, K., Bogar, O., Bohm, P., Bolzonella, T., Bombarda, F., Boncagni, L., Bouquey, F., Bowman, C., Brezinsek, S., Brida, D., Brunetti, D., Bucalossi, J., Buchanan, J., Buermans, J., Bufferand, H., Buller, S., Buratti, P., Burckhart, A., Calabrò, G., Calacci, L., Camenen, Y., Cannas, B., Cano Megías, P., Carnevale, D., Carpanese, F., Carr, M., Carralero, D., Carraro, L., Casolari, A., Cathey, A., Causa, F., Cavedon, M., Cecconello, M., Ceccuzzi, S., Cerovsky, J., Chapman, S., Chmielewski, P., Choi, D., Cianfarani, C., Ciraolo, G., Coda, S., Coelho, R., Colas, L., Colette, D., Cordaro, L., Cordella, F., Costea, S., Coster, D., Cruz Zabala, D.J., Cseh, G., Czarnecka, A., Cziegler, I., D’Arcangelo, O., Dal Molin, A., David, P., De Carolis, G., De Oliveira, H., Decker, J., Dejarnac, R., Delogu, R., den Harder, N., Dimitrova, M., Dolizy, F., Domínguez-Palacios Durán, J.J., Douai, D., Drenik, A., Dreval, M., Dudson, B., Dunai, D., Duval, B.P., Dux, R., Elmore, S., Embréus, O., Erdõs, B., Fable, E., Faitsch, M., Fanni, A., Farnik, M., Faust, I., Faustin, J., Fedorczak, N., Felici, F., Feng, S., Feng, X., Ferreira, J., Ferrò, G., Février, O., Ficker, O., Figini, L., Figueiredo, A., Fil, A., Fontana, M., Francesco, M., Fuchs, C., Futatani, S., Gabellieri, L., Gadariya, D., Gahle, D., Galassi, D., Gałązka, K., Galdon-Quiroga, J., Galeani, S., Gallart, D., Gallo, A., Galperti, C., Garavaglia, S., Garcia, J., Garcia-Lopez, J., Garcia-Muñoz, M., Garzotti, L., Gath, J., Geiger, B., Giacomelli, L., Giannone, L., Gibson, S., Gil, L., Giovannozzi, E., Giruzzi, G., Gobbin, M., Gonzalez-Martin, J., Goodman, T.P., Gorini, G., Gospodarczyk, M., Granucci, G., Grekov, D., Grenfell, G., Griener, M., Groth, M., Grover, O., Gruca, M., Gude, A., Guimarais, L., Gyergyek, T., Hacek, P., Hakola, A., Ham, C., Happel, T., Harrison, J., Havranek, A., Hawke, J., Henderson, S., Hesslow, L., Hitzler, F., Hnat, B., Hobirk, J., Hoelzl, M., Hogeweij, D., Hopf, C., Hoppe, M., Horacek, J., Hron, M., Huang, Z., Iantchenko, A., Iglesias, D., Igochine, V., Innocente, P., Ionita-Schrittwieser, C., Isliker, H., Ivanova-Stanik, I., Jacobsen, A., Jakubowski, M., Janky, F., Jardin, A., Jaulmes, F., Jensen, T., Jonsson, T., Kallenbach, A., Kappatou, A., Karpushov, A., Kasilov, S., Kazakov, Y., Kazantzidis, P.V., Keeling, D., Kelemen, M., Kendl, A., Kernbichler, W., Kirk, A., Kocsis, G., Komm, M., Kong, M., Korovin, V., Koubiti, M., Kovacic, J., Krawczyk, N., Krieger, K., Kripner, L., Křivská, A., Kudlacek, O., Kulyk, Y., Kurki-Suonio, T., Kwiatkowski, R., Laggner, F., Laguardia, L., Lahtinen, A., Lang, P., Likonen, J., Lipschultz, B., Liu, F., Lombroni, R., Lorenzini, R., Loschiavo, V.P., Lunt, T., Macusova, E., Madsen, J., Maggiora, R., Maljaars, B., Manas, P., Mantica, P., Mantsinen, M.J., Manz, P., Maraschek, M., Marchenko, V., Marchetto, C., Mariani, A., Marini, C., Markovic, T., Marrelli, L., Martin, P., Martín Solís, J.R., Martitsch, A., Mastrostefano, S., Matos, F., Matthews, G., Mayoral, M.-L., Mazon, D., Mazzotta, C., Mc Carthy, P., McClements, K., McDermott, R., Mcmillan, B., Meineri, C., Menkovski, V., Meshcheriakov, D., Messmer, M., Micheletti, D., Milanesio, D., Militello, F., Miron, I.G., Mlynar, J., Moiseenko, V., Molina Cabrera, P.A., Morales, J., Moret, J.-M., Moro, A., Moulton, D., Nabais, F., Naulin, V., Naydenkova, D., Nem, R.D., Nespoli, F., Newton, S., Nielsen, A.H., Nielsen, S.K., Nikolaeva, V., Nocente, M., Nowak, S., Oberkofler, M., Ochoukov, R., Ollus, P., Olsen, J., Omotani, J., Ongena, J., Orain, F., Orsitto, F.P., Paccagnella, R., Palha, A., Panaccione, L., Panek, R., Panjan, M., Papp, G., Paradela Perez, I., Parra, F., Passeri, M., Pau, A., Pautasso, G., Pavlichenko, R., Perek, A., Pericoli Radolfini, V., Pesamosca, F., Peterka, M., Petrzilka, V., Piergotti, V., Pigatto, L., Piovesan, P., Piron, C., Piron, L., Plyusnin, V., Pokol, G., Poli, E., Pölöskei, P., Popov, T., Popovic, Z., Pór, G., Porte, L., Pucella, G., Puiatti, M.E., Pütterich, T., Rabinski, M., Juul Rasmussen, J., Rasmussen, J., Rattá, G.A., Ratynskaia, S., Ravensbergen, T., Réfy, D., Reich, M., Reimerdes, H., Reimold, F., Reiser, D., Reux, C., Reznik, S., Ricci, D., Rispoli, N., Rivero-Rodriguez, J.F., Rocchi, G., Rodriguez-Ramos, M., Romano, A., Rosato, J., Rubinacci, G., Rubino, G., Ryan, D.A., Salewski, M., Salmi, A., Samaddar, D., Sanchis-Sanchez, L., Santos, J., Särkimäki, K., Sassano, M., Sauter, O., Scannell, R., Scheffer, M., Schneider, B.S., Schneider, P., Schrittwieser, R., Schubert, M., Seidl, J., Seliunin, E., Sharapov, S., Sheeba, R.R., Sias, G., Sieglin, B., Silva, C., Sipilä, S., Smith, S., Snicker, A., Solano, E.R., Hansen, S.K., Soria-Hoyo, C., Sorokovoy, E., Sozzi, C., Sperduti, A., Spizzo, G., Spolaore, M., Stejner, M., Stipani, L., Stober, J., Strand, P., Sun, H., Suttrop, W., Sytnykov, D., Szepesi, T., Tál, B., Tala, T., Tardini, G., Tardocchi, M., Teplukhina, A., Terranova, D., Testa, D., Theiler, C., Thorén, E., Thornton, A., Tilia, B., Tolias, P., Tomes, M., Toscano-Jimenez, M., Tsironis, C., Tsui, C., Tudisco, O., Urban, J., Valisa, M., Vallar, M., Vallejos Olivares, P., Valovic, M., Van Vugt, D., Vanovac, B., Varje, J., Varju, J., Varoutis, S., Vartanian, S., Vasilovici, O., Vega, J., Verdoolaege, G., Verhaegh, K., Vermare, L., Vianello, N., Vicente, J., Viezzer, E., Villone, F., Voitsekhovitch, I., Voltolina, D., Vondracek, P., Vu, N.M.T., Walkden, N., Wauters, T., Weiland, M., Weinzettl, V., Wensing, M., Wiesen, S., Wiesenberger, M., Wilkie, G., Willensdorfer, M., Wischmeier, M., Wu, K., Xiang, L., Zagorski, R., Zaloga, D., Zanca, P., Zaplotnik, R., Zebrowski, J., Zhang, W., Zisis, A., Zoletnik, S., Zuin, M., Labit, B., Eich, T., Harrer, G.F., Wolfrum, E., Bernert, M., Dunne, M.G., Frassinetti, L., Hennequin, P., Maurizio, R., Merle, A., Meyer, H., Saarelma, S., Sheikh, U., Adamek, J., Agostini, M., Aguiam, D., Akers, R., Albanese, R., Albert, C., Alessi, E., Ambrosino, R., Andrèbe, Y., Angioni, C., Apruzzese, G., Aradi, M., Arnichand, H., Auriemma, F., Avdeeva, G., Ayllon-Guerola, J.M., Bagnato, F., Bandaru, V.K., Barnes, M., Barrera-Orte, L., Bettini, P., Bilato, R., Biletskyi, O., Bilkova, P., Bin, W., Blanchard, P., Blanken, T., Bobkov, V., Bock, A., Boeyaert, D., Bogar, K., Bogar, O., Bohm, P., Bolzonella, T., Bombarda, F., Boncagni, L., Bouquey, F., Bowman, C., Brezinsek, S., Brida, D., Brunetti, D., Bucalossi, J., Buchanan, J., Buermans, J., Bufferand, H., Buller, S., Buratti, P., Burckhart, A., Calabrò, G., Calacci, L., Camenen, Y., Cannas, B., Cano Megías, P., Carnevale, D., Carpanese, F., Carr, M., Carralero, D., Carraro, L., Casolari, A., Cathey, A., Causa, F., Cavedon, M., Cecconello, M., Ceccuzzi, S., Cerovsky, J., Chapman, S., Chmielewski, P., Choi, D., Cianfarani, C., Ciraolo, G., Coda, S., Coelho, R., Colas, L., Colette, D., Cordaro, L., Cordella, F., Costea, S., Coster, D., Cruz Zabala, D.J., Cseh, G., Czarnecka, A., Cziegler, I., D’Arcangelo, O., Dal Molin, A., David, P., De Carolis, G., De Oliveira, H., Decker, J., Dejarnac, R., Delogu, R., den Harder, N., Dimitrova, M., Dolizy, F., Domínguez-Palacios Durán, J.J., Douai, D., Drenik, A., Dreval, M., Dudson, B., Dunai, D., Duval, B.P., Dux, R., Elmore, S., Embréus, O., Erdõs, B., Fable, E., Faitsch, M., Fanni, A., Farnik, M., Faust, I., Faustin, J., Fedorczak, N., Felici, F., Feng, S., Feng, X., Ferreira, J., Ferrò, G., Février, O., Ficker, O., Figini, L., Figueiredo, A., Fil, A., Fontana, M., Francesco, M., Fuchs, C., Futatani, S., Gabellieri, L., Gadariya, D., Gahle, D., Galassi, D., Gałązka, K., Galdon-Quiroga, J., Galeani, S., Gallart, D., Gallo, A., Galperti, C., Garavaglia, S., Garcia, J., Garcia-Lopez, J., Garcia-Muñoz, M., Garzotti, L., Gath, J., Geiger, B., Giacomelli, L., Giannone, L., Gibson, S., Gil, L., Giovannozzi, E., Giruzzi, G., Gobbin, M., Gonzalez-Martin, J., Goodman, T.P., Gorini, G., Gospodarczyk, M., Granucci, G., Grekov, D., Grenfell, G., Griener, M., Groth, M., Grover, O., Gruca, M., Gude, A., Guimarais, L., Gyergyek, T., Hacek, P., Hakola, A., Ham, C., Happel, T., Harrison, J., Havranek, A., Hawke, J., Henderson, S., Hesslow, L., Hitzler, F., Hnat, B., Hobirk, J., Hoelzl, M., Hogeweij, D., Hopf, C., Hoppe, M., Horacek, J., Hron, M., Huang, Z., Iantchenko, A., Iglesias, D., Igochine, V., Innocente, P., Ionita-Schrittwieser, C., Isliker, H., Ivanova-Stanik, I., Jacobsen, A., Jakubowski, M., Janky, F., Jardin, A., Jaulmes, F., Jensen, T., Jonsson, T., Kallenbach, A., Kappatou, A., Karpushov, A., Kasilov, S., Kazakov, Y., Kazantzidis, P.V., Keeling, D., Kelemen, M., Kendl, A., Kernbichler, W., Kirk, A., Kocsis, G., Komm, M., Kong, M., Korovin, V., Koubiti, M., Kovacic, J., Krawczyk, N., Krieger, K., Kripner, L., Křivská, A., Kudlacek, O., Kulyk, Y., Kurki-Suonio, T., Kwiatkowski, R., Laggner, F., Laguardia, L., Lahtinen, A., Lang, P., Likonen, J., Lipschultz, B., Liu, F., Lombroni, R., Lorenzini, R., Loschiavo, V.P., Lunt, T., Macusova, E., Madsen, J., Maggiora, R., Maljaars, B., Manas, P., Mantica, P., Mantsinen, M.J., Manz, P., Maraschek, M., Marchenko, V., Marchetto, C., Mariani, A., Marini, C., Markovic, T., Marrelli, L., Martin, P., Martín Solís, J.R., Martitsch, A., Mastrostefano, S., Matos, F., Matthews, G., Mayoral, M.-L., Mazon, D., Mazzotta, C., Mc Carthy, P., McClements, K., McDermott, R., Mcmillan, B., Meineri, C., Menkovski, V., Meshcheriakov, D., Messmer, M., Micheletti, D., Milanesio, D., Militello, F., Miron, I.G., Mlynar, J., Moiseenko, V., Molina Cabrera, P.A., Morales, J., Moret, J.-M., Moro, A., Moulton, D., Nabais, F., Naulin, V., Naydenkova, D., Nem, R.D., Nespoli, F., Newton, S., Nielsen, A.H., Nielsen, S.K., Nikolaeva, V., Nocente, M., Nowak, S., Oberkofler, M., Ochoukov, R., Ollus, P., Olsen, J., Omotani, J., Ongena, J., Orain, F., Orsitto, F.P., Paccagnella, R., Palha, A., Panaccione, L., Panek, R., Panjan, M., Papp, G., Paradela Perez, I., Parra, F., Passeri, M., Pau, A., Pautasso, G., Pavlichenko, R., Perek, A., Pericoli Radolfini, V., Pesamosca, F., Peterka, M., Petrzilka, V., Piergotti, V., Pigatto, L., Piovesan, P., Piron, C., Piron, L., Plyusnin, V., Pokol, G., Poli, E., Pölöskei, P., Popov, T., Popovic, Z., Pór, G., Porte, L., Pucella, G., Puiatti, M.E., Pütterich, T., Rabinski, M., Juul Rasmussen, J., Rasmussen, J., Rattá, G.A., Ratynskaia, S., Ravensbergen, T., Réfy, D., Reich, M., Reimerdes, H., Reimold, F., Reiser, D., Reux, C., Reznik, S., Ricci, D., Rispoli, N., Rivero-Rodriguez, J.F., Rocchi, G., Rodriguez-Ramos, M., Romano, A., Rosato, J., Rubinacci, G., Rubino, G., Ryan, D.A., Salewski, M., Salmi, A., Samaddar, D., Sanchis-Sanchez, L., Santos, J., Särkimäki, K., Sassano, M., Sauter, O., Scannell, R., Scheffer, M., Schneider, B.S., Schneider, P., Schrittwieser, R., Schubert, M., Seidl, J., Seliunin, E., Sharapov, S., Sheeba, R.R., Sias, G., Sieglin, B., Silva, C., Sipilä, S., Smith, S., Snicker, A., Solano, E.R., Hansen, S.K., Soria-Hoyo, C., Sorokovoy, E., Sozzi, C., Sperduti, A., Spizzo, G., Spolaore, M., Stejner, M., Stipani, L., Stober, J., Strand, P., Sun, H., Suttrop, W., Sytnykov, D., Szepesi, T., Tál, B., Tala, T., Tardini, G., Tardocchi, M., Teplukhina, A., Terranova, D., Testa, D., Theiler, C., Thorén, E., Thornton, A., Tilia, B., Tolias, P., Tomes, M., Toscano-Jimenez, M., Tsironis, C., Tsui, C., Tudisco, O., Urban, J., Valisa, M., Vallar, M., Vallejos Olivares, P., Valovic, M., Van Vugt, D., Vanovac, B., Varje, J., Varju, J., Varoutis, S., Vartanian, S., Vasilovici, O., Vega, J., Verdoolaege, G., Verhaegh, K., Vermare, L., Vianello, N., Vicente, J., Viezzer, E., Villone, F., Voitsekhovitch, I., Voltolina, D., Vondracek, P., Vu, N.M.T., Walkden, N., Wauters, T., Weiland, M., Weinzettl, V., Wensing, M., Wiesen, S., Wiesenberger, M., Wilkie, G., Willensdorfer, M., Wischmeier, M., Wu, K., Xiang, L., Zagorski, R., Zaloga, D., Zanca, P., Zaplotnik, R., Zebrowski, J., Zhang, W., Zisis, A., Zoletnik, S., and Zuin, M.
Abstract: Within the EUROfusion MST1 work package, a series of experiments has been conducted on AUG and TCV devices to disentangle the role of plasma fueling and plasma shape for the onset of small ELM regimes. On both devices, small ELM regimes with high confinement are achieved if and only if two conditions are fulfilled at the same time. Firstly, the plasma density at the separatrix must be large enough (ne,sep/nG ~ 0.3), leading to a pressure profile flattening at the separatrix, which stabilizes type-I ELMs. Secondly, the magnetic configuration has to be close to a double null (DN), leading to a reduction of the magnetic shear in the extreme vicinity of the separatrix. As a consequence, its stabilizing effect on ballooning modes is weakened.
Published: 2019

36. Epigenome-wide meta-analysis of DNA methylation and childhood asthma

Author: Reese, S., Xu, C., den Dekker, H., Lee, M., Sikdar, S., Ruiz-Arenas, C., Merid, S., Rezwan, F., Page, C., Ullemar, V., Melton, Phillip, Oh, S., Yang, I., Burrows, K., Söderhäll, C., Jima, D., Gao, L., Arathimos, R., Küpers, L., Wielscher, M., Rzehak, P., Lahti, J., Laprise, C., Madore, A., Ward, J., Bennett, B., Wang, T., Bell, D., Vonk, J., Håberg, S., Zhao, S., Karlsson, R., Hollams, E., Hu, D., Richards, A., Bergström, A., Sharp, G., Felix, J., Bustamante, M., Gruzieva, O., Maguire, R., Gilliland, F., Baïz, N., Nohr, E., Corpeleijn, E., Sebert, S., Karmaus, W., Grote, V., Kajantie, E., Magnus, M., Örtqvist, A., Eng, C., Liu, A., Kull, I., Jaddoe, V., Sunyer, J., Kere, J., Hoyo, C., Annesi-Maesano, I., Reese, S., Xu, C., den Dekker, H., Lee, M., Sikdar, S., Ruiz-Arenas, C., Merid, S., Rezwan, F., Page, C., Ullemar, V., Melton, Phillip, Oh, S., Yang, I., Burrows, K., Söderhäll, C., Jima, D., Gao, L., Arathimos, R., Küpers, L., Wielscher, M., Rzehak, P., Lahti, J., Laprise, C., Madore, A., Ward, J., Bennett, B., Wang, T., Bell, D., Vonk, J., Håberg, S., Zhao, S., Karlsson, R., Hollams, E., Hu, D., Richards, A., Bergström, A., Sharp, G., Felix, J., Bustamante, M., Gruzieva, O., Maguire, R., Gilliland, F., Baïz, N., Nohr, E., Corpeleijn, E., Sebert, S., Karmaus, W., Grote, V., Kajantie, E., Magnus, M., Örtqvist, A., Eng, C., Liu, A., Kull, I., Jaddoe, V., Sunyer, J., Kere, J., Hoyo, C., and Annesi-Maesano, I.
Abstract: Background: Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. Objective: We sought to identify differential DNA methylation in newborns and children related to childhood asthma. Methods: Within the Pregnancy And Childhood Epigenetics consortium, we performed epigenome-wide meta-analyses of school-age asthma in relation to CpG methylation (Illumina450K) in blood measured either in newborns, in prospective analyses, or cross-sectionally in school-aged children. We also identified differentially methylated regions. Results: In newborns (8 cohorts, 668 cases), 9 CpGs (and 35 regions) were differentially methylated (epigenome-wide significance, false discovery rate < 0.05) in relation to asthma development. In a cross-sectional meta-analysis of asthma and methylation in children (9 cohorts, 631 cases), we identified 179 CpGs (false discovery rate < 0.05) and 36 differentially methylated regions. In replication studies of methylation in other tissues, most of the 179 CpGs discovered in blood replicated, despite smaller sample sizes, in studies of nasal respiratory epithelium or eosinophils. Pathway analyses highlighted enrichment for asthma-relevant immune processes and overlap in pathways enriched both in newborns and children. Gene expression correlated with methylation at most loci. Functional annotation supports a regulatory effect on gene expression at many asthma-associated CpGs. Several implicated genes are targets for approved or experimental drugs, including IL5RA and KCNH2. Conclusion: Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age. Cross-sectional associations in children can reflect both risk for and effects of disease. Asthma-related differential methylation in blood in children was substantially replicated in eosinophils and respiratory epithelium.
Published: 2019

37. Development of syndromic STD algorithms to be used in primary health clinics in Mexico

Author: Teran, X, Swygard, H, Uribe-Zuniga, P, Hoffman, I, Kaydos, S C, Hoyo, C, Egremy, G, and Dallabetta, G
Published: 2001

38. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

Author: Felix, JF, Joubert, BR, Baccarelli, AA, Sharp, GC, Almqvist, C, Annesi-Maesano, I, Arshad, H, Baïz, N, Bakermans-Kranenburg, MJ, Bakulski, KM, Binder, EB, Bouchard, L, Breton, CV, Brunekreef, B, Brunst, KJ, Burchard, EG, Bustamante, M, Chatzi, L, Munthe-Kaas, M, Corpeleijn, E, Czamara, D, Dabelea, D, Smith, G, De Boever, P, Duijts, L, Dwyer, T, Eng, C, Eskenazi, B, Everson, TM, Falahi, F, Fallin, MD, Farchi, S, Fernandez, MF, Gao, L, Gaunt, TR, Ghantous, A, Gillman, MW, Gonseth, S, Grote, V, Gruzieva, O, Håberg, SE, Herceg, Z, Hivert, M-F, Holland, N, Holloway, JW, Hoyo, C, Hu, D, Huang, R-C, Huen, K, Järvelin, M-R, Jima, DD, Just, AC, Karagas, MR, Karlsson, R, Karmaus, W, Kechris, KJ, Kere, J, Kogevinas, M, Koletzko, B, Koppelman, GH, Küpers, LK, Ladd-Acosta, C, Lahti, J, Lambrechts, N, Langie, SAS, Lie, RT, Liu, AH, Magnus, MC, Magnus, P, Maguire, RL, Marsit, CJ, McArdle, W, Melén, E, Melton, P, Murphy, SK, Nawrot, TS, Nisticò, L, Nohr, EA, Nordlund, B, Nystad, W, Oh, SS, Oken, E, Page, CM, Perron, P, Pershagen, G, Pizzi, C, Plusquin, M, Raikkonen, K, Reese, SE, Reischl, E, Richiardi, L, Ring, S, Roy, RP, Rzehak, P, Schoeters, G, Schwartz, DA, Sebert, S, Snieder, H, Sørensen, TIA, Starling, AP, Sunyer, J, Taylor, JA, Tiemeier, H, Ullemar, V, Vafeiadi, M, Van Ijzendoorn, MH, Vonk, JM, Vriens, A, Vrijheid, M, Wang, P, Wiemels, JL, Wilcox, AJ, Wright, RJ, Xu, C-J, Xu, Z, Yang, IV, Yousefi, P, Zhang, H, Zhang, W, Zhao, S, Agha, G, Relton, CL, Jaddoe, VWV, London, SJ, Epidemiology, Erasmus MC other, Pediatrics, Child and Adolescent Psychiatry / Psychology, Psychiatry, Research Methods and Techniques, dIRAS RA-2, One Health Chemisch, Reproductive Origins of Adult Health and Disease (ROAHD), Lifestyle Medicine (LM), Groningen Research Institute for Asthma and COPD (GRIAC), Life Course Epidemiology (LCE), Department of Psychology and Logopedics, Helsinki Collegium for Advanced Studies, Medicum, University of Helsinki, and Developmental Psychology Research Group
Subjects: DNA Methylation/physiology, Epidemiology, Maternal Health, education, Embaràs, DISEASE, Environmental Pollution/analysis, Epigenesis, Genetic, Cohort Studies, Prenatal Exposure Delayed Effects/epidemiology, Folic Acid, Pregnancy, Journal Article, Humans, MATERNAL SMOKING, CORD BLOOD, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Cohort Profiles, METAANALYSIS, PRENATAL EXPOSURE, Maternal Exposure/adverse effects, EPIGENOME-WIDE ASSOCIATION, 0104 Statistics, Child Health, Infant, Newborn, DNA METHYLATION DATA, DNA Methylation, Epigenètica, BIRTH-WEIGHT, 3142 Public health care science, environmental and occupational health, Folic Acid/blood, 1117 Public Health And Health Services, Maternal Exposure, Prenatal Exposure Delayed Effects, MENDELIAN RANDOMIZATION, Epigenetics, Female, Human medicine, Environmental Pollution
Abstract: UK Medical Research Council; Wellcome Trust [102215/2/13/2, WT088806, 084762MA]; UK Biotechnology and Biological Sciences Research Council [BB/I025751/1, BB/I025263/1]; UK Medical Research Council Integrative Epidemiology Unit; University of Bristol [MC_UU_12013_1, MC_UU_12013_2, MC_UU_12013_5, MC_UU_12013_8]; United States National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK10324]; Swedish Research Council; Swedish Heart-Lung Foundation; Freemason Child House Foundation in Stockholm; MeDALL (Mechanisms of the Development of ALLergy), within the European Union [261357]; Stockholm County Council (ALF); Swedish Foundation for Strategic Research (SSF) [RBc08-0027]; Strategic Research Programme (SFO) in Epidemiology at Karolinska Institutet; Swedish Research Council Formas; Swedish Environment Protection Agency; Center for Integrative Research on Childhood Leukemia and the Environment [P01ES018172]; NIH [P50ES018172, R01ES09137, 5P30CA082103, P01 ES009605, R01 ES021369, R01ES023067, K01ES017801, R01ES022216, P30ES007048, R01ES014447, P01ES009581, R826708-01, RD831861-01, P50ES026086, R01DK068001, R01 DK100340, R01 DK076648, R01ES022934, R01HL111108, R01NR013945, R37 HD034568, UL1 TR001082, P30 DK56350]; EPA [RD83451101, RD83615901, RD 82670901, RD 83451301, 83615801-0]; UCSF Comprehensive Cancer Center Support grant [P30 CA82103]; Swiss Science National Foundation [P2LAP3_158674]; Sutter-Stottner Foundation; Commission of the European Community, specific RTD Programme 'Quality of Life and Management of Living Resources' within the 5th Framework Programme [QLRT-2001-00389, QLK1-CT-2002-30582]; 6th Framework Programme [007036]; European Union's Seventh Framework Programme (FP7), project EarlyNutrition [289346]; European Research Council Advanced grant ERC-AdG [322605 META-GROWTH]; Autism Speaks grant [260377]; Funds for Research in Respiratory Health; French Ministry of Research: IFR program; INSERM Nutrition Research Program; French Ministry of Health: Perinatality Program; French National Institute for Population Health Surveillance (INVS); Paris-Sud University; French National Institute for Health Education (INPES); Nestle; Mutuelle Generale de l'Education Nationale (MGEN); French-speaking association for the study of diabetes and metabolism (Alfediam) [2012/51290-6]; EU; European Research Council [ERC-2012-StG.310898, 268479-BREATHE]; Flemish Scientific Research Council (FWO) [N1516112 / G.0.873.11N.10]; European Community's Seventh Framework Programme FP7 project EXPOsOMICS [308610]; People Program (Marie Curie Actions) of the European Union's Seventh Framework Program FP7 under REA grant [628858]; Bijzonder Onderzoeksfonds (BOF) Hasselt University; Ministry of the Flemish Community (Department of Economics, Science and Innovation); Ministry of the Flemish Community (Department of Environment, Nature and Energy); CEFIC LRI award by the Research Foundation-Flanders (FWO); CEFIC LRI award by the Research Foundation-Flanders (FWO) [12L5216N]; Flemish Institute for Technological Research (VITO) [12L5216N]; Bill AMP; Melinda Gates Foundation Grand Challenges Exploration grant [OPP119403]; Sandler Family Foundation; American Asthma Foundation; National Institutes of Health; National Heart, Lung and Blood Institute [HL117004]; National Institute of Environmental Health Sciences [ES24844]; National Institute on Minority Health and Health Disparities [MD006902, MD009523]; National Institute of General Medical Sciences [GM007546]; Tobacco-Related Disease Research Program [24RT-0025]; Hutchison Whampoa Ltd, Hong Kong; University of Groningen; Well Baby Clinic Foundation Icare; Noordlease; Youth Health Care Drenthe; Biobanking and Biomolecular Research Infrastructure Netherlands [CP2011-19]; Erasmus Medical Center, Rotterdam; Erasmus University Rotterdam; Netherlands Organization for Health Research and Development; Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientific Research (NWO); Netherlands Consortium for Healthy Aging (NCHA) [050-060-810]; Genetic Laboratory of the Department of Internal Medicine, Erasmus MC; European Union's Horizon research and innovation programme [733206, 633595]; National Institute of Child and Human Development [R01HD068437]; Netherlands Organization for Health Research and Development [VIDI 016.136.361]; Consolidator grant from the European Research Council [ERC-2014-CoG-648916]; Netherlands' Organization for Scientific Research (NWO VICI); European Research Council ERC; Netherlands' Organization for Scientific Research (NWO Spinoza Award); Gravitation program of the Dutch Ministry of Education, Culture, and Science; Netherlands Organization for Scientific Research (NWO) [024.001.003]; Lung Foundation Netherlands [3.2.12.089]; Fonds de Recherche du Quebec en Sante (FRQ-S) [20697]; Canadian Institute of Health Reseach (CIHR) [MOP 115071]; Diabete Quebec grant; Canadian Diabetes Association operating grant [OG-3-08-2622]; American Diabetes Association Pathways Accelerator Early Investigator Award [1-15-ACE-26]; MRC Integrative Epidemiology Unit - Medical Research Council [MC_UU_12013/1-9]; National Institute of Environmental Health Sciences, National Institutes of Health [K99ES025817]; Instituto de Salud Carlos III [Red INMA G03/176, CB06/02/0041]; Spanish Ministry of Health [FIS-PI04/1436, FIS-PI08/1151]; Spanish Ministry of Health (FEDER funds) [FIS-PI11/00610, FIS-FEDER-PI06/0867, FIS-FEDER-PI03-1615]; Generalitat de Catalunya [CIRIT 1999SGR 00241]; Fundacio La Marato de TV3 [090430]; EU Commission [261357-MeDALL]; National Institute of Allergy and Infectious Diseases [N01-AI90052]; National Institutes of Health USA [R01 HL082925, R01 HL132321]; Asthma UK [364]; NIAID/NIH [R01AI091905, R01AI121226]; National Institute of Health [R01AI121226, R01 AI091905, R01HL132321]; NIH/NIEHS [N01-ES75558]; NIH/NINDS [1 UO1 NS 047537-01, 2 UO1 NS 047537-06A1]; Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [Z01-ES-49019, Z01 ES044005, ES049033, ES049032]; Norwegian Research Council/BIOBANK [221097]; Oslo University Hospital; Unger-Vetlesens foundation; Norwegian American Womens Club; INCA/Plan Cancer-EVA-INSERM, France; International Childhood Cancer Cohort Consortium (I4C); INCA/Plan Cancer-EVA-INSERM (France); IARC Postdoctoral Fellowship; EC FP7 Marie Curie Actions-People-Co-funding of regional, national and international programmes (COFUND); NIEHS [R21ES014947, R01ES016772]; NIDDK [R01DK085173]; National Institute of Environmental Health Science [P30 ES025128]; University of Oulu grant [65354]; Oulu University Hospital [2/97, 8/97]; Ministry of Health and Social Affairs [23/251/97, 160/97, 190/97]; National Institute for Health and Welfare, Helsinki [54121]; Regional Institute of Occupational Health, Oulu, Finland [50621, 54231]; EU [QLG1-CT-2000-01643, E51560]; NorFA grant [731, 20056, 30167]; Academy of Finland; NIH-NIEHS [P01 ES022832]; US EPA [RD83544201]; NIH-NIGMS [P20GM104416]; NCI [R25CA134286]; Netherlands Organization for Scientific Research and Development; Netherlands Asthma Fund; Netherlands Ministry of Spatial Planning, Housing, and the Environment; Netherlands Ministry of Health, Welfare, and Sport; MeDALL; European Union under the Health Cooperation Work Program of the 7th Framework program [261357]; Italian National Centre for Disease Prevention and Control (CCM grant); Italian Ministry of Health (art 12); Italian Ministry of Health (12bis Dl.gs.vo) [502/92]; EraNet; EVO; University of Helsinki Research Funds; Signe and Ane Gyllenberg foundation; Emil Aaltonen Foundation; Finnish Medical Foundation; Jane and Aatos Erkko Foundation; Novo Nordisk Foundation; Paivikki and Sakari Sohlberg Foundation; Sigrid Juselius Foundation; University of Helsinki; University of Western Australia (UWA); Curtin University; Raine Medical Research Foundation; UWA Faculty of Medicine, Dentistry and Health Sciences; Telethon Kids Institute; Women's and Infant's Research Foundation (KEMH); Edith Cowan University; National Health and Medical Research Council [1059711]; National Health and Medical Research Council (NHMRC) fellowship [1053384]; Australian National Health and Medical Research Council; United States National Institute of Health; Greek Ministry of Health (programme of prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece); Greek Ministry of Health ('Rhea Plus': Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health); European Union (EU) [EU FP6-2003-Food-3-NewGeneris, EU FP7 ENV.2007.1.2.2.2, 211250 ESCAPE, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7 ENV.2008.1.2.1.6, 226285 ENRIECO]; National Institutes of Health [NIH-NIMH R01MH094609, NIH-NIEHS R01ES022223, NIH-NIEHS R01ES025145]; Centers for Disease Control and Prevention [U10DD000180, U10DD000181, U10DD000182, U10DD000183, U10DD000184, U10DD000498]; Autism Speaks [7659]; Swedish Research Council through the Swedish Initiative for research on Microdata in the Social And Medical Sciences (SIMSAM) [340-2013-5867]; Stockholm County Council (ALF projects); Strategic Research Program in Epidemiology at Karolinska Institutet; Swedish Asthma and Allergy Association's Research Foundation; Stiftelsen Frimurare Barnahuset Stockholm; Norwegian Ministry of Health and Care Services; Ministry of the Flemish Community (Flemish Agency for Care and Health); University of Bristol; Ministry of Education and Research; European Union (EU) (EU FP7-HEALTH-single stage CHICOS); European Union (EU) (EU-FP7-HEALTH) [308333 HELIX]; European Union (EU) (EU FP6. STREP HiWATE); UK Medical Research Council; Wellcome Trust [102215/2/13/2, WT088806, 084762MA]; UK Biotechnology and Biological Sciences Research Council [BB/I025751/1, BB/I025263/1]; UK Medical Research Council Integrative Epidemiology Unit; University of Bristol [MC_UU_12013_1, MC_UU_12013_2, MC_UU_12013_5, MC_UU_12013_8]; United States National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK10324]; Swedish Research Council; Swedish Heart-Lung Foundation; Freemason Child House Foundation in Stockholm; MeDALL (Mechanisms of the Development of ALLergy), within the European Union [261357]; Stockholm County Council (ALF); Swedish Foundation for Strategic Research (SSF) [RBc08-0027]; Strategic Research Programme (SFO) in Epidemiology at Karolinska Institutet; Swedish Research Council Formas; Swedish Environment Protection Agency; Center for Integrative Research on Childhood Leukemia and the Environment [P01ES018172]; NIH [P50ES018172, R01ES09137, 5P30CA082103, P01 ES009605, R01 ES021369, R01ES023067, K01ES017801, R01ES022216, P30ES007048, R01ES014447, P01ES009581, R826708-01, RD831861-01, P50ES026086, R01DK068001, R01 DK100340, R01 DK076648, R01ES022934, R01HL111108, R01NR013945, R37 HD034568, UL1 TR001082, P30 DK56350]; EPA [RD83451101, RD83615901, RD 82670901, RD 83451301, 83615801-0]; UCSF Comprehensive Cancer Center Support grant [P30 CA82103]; Swiss Science National Foundation [P2LAP3_158674]; Sutter-Stottner Foundation; Commission of the European Community, specific RTD Programme 'Quality of Life and Management of Living Resources' within the 5th Framework Programme [QLRT-2001-00389, QLK1-CT-2002-30582]; 6th Framework Programme [007036]; European Union's Seventh Framework Programme (FP7), project EarlyNutrition [289346]; European Research Council Advanced grant ERC-AdG [322605 META-GROWTH]; Autism Speaks grant [260377]; Funds for Research in Respiratory Health; French Ministry of Research: IFR program; INSERM Nutrition Research Program; French Ministry of Health: Perinatality Program; French National Institute for Population Health Surveillance (INVS); Paris-Sud University; French National Institute for Health Education (INPES); Nestle; Mutuelle Generale de l'Education Nationale (MGEN); French-speaking association for the study of diabetes and metabolism (Alfediam) [2012/51290-6]; EU; European Research Council [ERC-2012-StG.310898, 268479-BREATHE]; Flemish Scientific Research Council (FWO) [N1516112 / G.0.873.11N.10]; European Community's Seventh Framework Programme FP7 project EXPOsOMICS [308610]; People Program (Marie Curie Actions) of the European Union's Seventh Framework Program FP7 under REA grant [628858]; Bijzonder Onderzoeksfonds (BOF) Hasselt University; Ministry of the Flemish Community (Department of Economics, Science and Innovation); Ministry of the Flemish Community (Department of Environment, Nature and Energy); CEFIC LRI award by the Research Foundation-Flanders (FWO); CEFIC LRI award by the Research Foundation-Flanders (FWO) [12L5216N]; Flemish Institute for Technological Research (VITO) [12L5216N]; Bill AMP; Melinda Gates Foundation Grand Challenges Exploration grant [OPP119403]; Sandler Family Foundation; American Asthma Foundation; National Institutes of Health; National Heart, Lung and Blood Institute [HL117004]; National Institute of Environmental Health Sciences [ES24844]; National Institute on Minority Health and Health Disparities [MD006902, MD009523]; National Institute of General Medical Sciences [GM007546]; Tobacco-Related Disease Research Program [24RT-0025]; Hutchison Whampoa Ltd, Hong Kong; University of Groningen; Well Baby Clinic Foundation Icare; Noordlease; Youth Health Care Drenthe; Biobanking and Biomolecular Research Infrastructure Netherlands [CP2011-19]; Erasmus Medical Center, Rotterdam; Erasmus University Rotterdam; Netherlands Organization for Health Research and Development; Netherlands Genomics Initiative (NGI)/Netherlands Organization for Scientific Research (NWO); Netherlands Consortium for Healthy Aging (NCHA) [050-060-810]; Genetic Laboratory of the Department of Internal Medicine, Erasmus MC; European Union's Horizon research and innovation programme [733206, 633595]; National Institute of Child and Human Development [R01HD068437]; Netherlands Organization for Health Research and Development [VIDI 016.136.361]; Consolidator grant from the European Research Council [ERC-2014-CoG-648916]; Netherlands' Organization for Scientific Research (NWO VICI); European Research Council ERC; Netherlands' Organization for Scientific Research (NWO Spinoza Award); Gravitation program of the Dutch Ministry of Education, Culture, and Science; Netherlands Organization for Scientific Research (NWO) [024.001.003]; Lung Foundation Netherlands [3.2.12.089]; Fonds de Recherche du Quebec en Sante (FRQ-S) [20697]; Canadian Institute of Health Reseach (CIHR) [MOP 115071]; Diabete Quebec grant; Canadian Diabetes Association operating grant [OG-3-08-2622]; American Diabetes Association Pathways Accelerator Early Investigator Award [1-15-ACE-26]; MRC Integrative Epidemiology Unit - Medical Research Council [MC_UU_12013/1-9]; National Institute of Environmental Health Sciences, National Institutes of Health [K99ES025817]; Instituto de Salud Carlos III [Red INMA G03/176, CB06/02/0041]; Spanish Ministry of Health [FIS-PI04/1436, FIS-PI08/1151]; Spanish Ministry of Health (FEDER funds) [FIS-PI11/00610, FIS-FEDER-PI06/0867, FIS-FEDER-PI03-1615]; Generalitat de Catalunya [CIRIT 1999SGR 00241]; Fundacio La Marato de TV3 [090430]; EU Commission [261357-MeDALL]; National Institute of Allergy and Infectious Diseases [N01-AI90052]; National Institutes of Health USA [R01 HL082925, R01 HL132321]; Asthma UK [364]; NIAID/NIH [R01AI091905, R01AI121226]; National Institute of Health [R01AI121226, R01 AI091905, R01HL132321]; NIH/NIEHS [N01-ES75558]; NIH/NINDS [1 UO1 NS 047537-01, 2 UO1 NS 047537-06A1]; Intramural Research Program of the NIH, National Institute of Environmental Health Sciences [Z01-ES-49019, Z01 ES044005, ES049033, ES049032]; Norwegian Research Council/BIOBANK [221097]; Oslo University Hospital; Unger-Vetlesens foundation; Norwegian American Womens Club; INCA/Plan Cancer-EVA-INSERM, France; International Childhood Cancer Cohort Consortium (I4C); INCA/Plan Cancer-EVA-INSERM (France); IARC Postdoctoral Fellowship; EC FP7 Marie Curie Actions-People-Co-funding of regional, national and international programmes (COFUND); NIEHS [R21ES014947, R01ES016772]; NIDDK [R01DK085173]; National Institute of Environmental Health Science [P30 ES025128]; University of Oulu grant [65354]; Oulu University Hospital [2/97, 8/97]; Ministry of Health and Social Affairs [23/251/97, 160/97, 190/97]; National Institute for Health and Welfare, Helsinki [54121]; Regional Institute of Occupational Health, Oulu, Finland [50621, 54231]; EU [QLG1-CT-2000-01643, E51560]; NorFA grant [731, 20056, 30167]; Academy of Finland; NIH-NIEHS [P01 ES022832]; US EPA [RD83544201]; NIH-NIGMS [P20GM104416]; NCI [R25CA134286]; Netherlands Organization for Scientific Research and Development; Netherlands Asthma Fund; Netherlands Ministry of Spatial Planning, Housing, and the Environment; Netherlands Ministry of Health, Welfare, and Sport; MeDALL; European Union under the Health Cooperation Work Program of the 7th Framework program [261357]; Italian National Centre for Disease Prevention and Control (CCM grant); Italian Ministry of Health (art 12); Italian Ministry of Health (12bis Dl.gs.vo) [502/92]; EraNet; EVO; University of Helsinki Research Funds; Signe and Ane Gyllenberg foundation; Emil Aaltonen Foundation; Finnish Medical Foundation; Jane and Aatos Erkko Foundation; Novo Nordisk Foundation; Paivikki and Sakari Sohlberg Foundation; Sigrid Juselius Foundation; University of Helsinki; University of Western Australia (UWA); Curtin University; Raine Medical Research Foundation; UWA Faculty of Medicine, Dentistry and Health Sciences; Telethon Kids Institute; Women's and Infant's Research Foundation (KEMH); Edith Cowan University; National Health and Medical Research Council [1059711]; National Health and Medical Research Council (NHMRC) fellowship [1053384]; Australian National Health and Medical Research Council; United States National Institute of Health; Greek Ministry of Health (programme of prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece); Greek Ministry of Health ('Rhea Plus': Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health); European Union (EU) [EU FP6-2003-Food-3-NewGeneris, EU FP7 ENV.2007.1.2.2.2, 211250 ESCAPE, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7 ENV.2008.1.2.1.6, 226285 ENRIECO]; National Institutes of Health [NIH-NIMH R01MH094609, NIH-NIEHS R01ES022223, NIH-NIEHS R01ES025145]; Centers for Disease Control and Prevention [U10DD000180, U10DD000181, U10DD000182, U10DD000183, U10DD000184, U10DD000498]; Autism Speaks [7659]; Swedish Research Council through the Swedish Initiative for research on Microdata in the Social And Medical Sciences (SIMSAM) [340-2013-5867]; Stockholm County Council (ALF projects); Strategic Research Program in Epidemiology at Karolinska Institutet; Swedish Asthma and Allergy Association's Research Foundation; Stiftelsen Frimurare Barnahuset Stockholm; Norwegian Ministry of Health and Care Services; Ministry of the Flemish Community (Flemish Agency for Care and Health); University of Bristol; Ministry of Education and Research; European Union (EU) (EU FP7-HEALTH-single stage CHICOS); European Union (EU) (EU-FP7-HEALTH) [308333 HELIX]; European Union (EU) (EU FP6. STREP HiWATE); [R01ES017646]; [R01ES01900]; [R01ES16443]; [USA / NIHH 2000 G DF682]; [50945]; [R01 HL095606]; [R01 HL1143396]
Published: 2018

39. Dependence on plasma shape and plasma fueling for small edge-localized mode regimes in TCV and ASDEX Upgrade

Author: Labit, B., primary, Eich, T., additional, Harrer, G.F., additional, Wolfrum, E., additional, Bernert, M., additional, Dunne, M.G., additional, Frassinetti, L., additional, Hennequin, P., additional, Maurizio, R., additional, Merle, A., additional, Meyer, H., additional, Saarelma, S., additional, Sheikh, U., additional, Adamek, J., additional, Agostini, M., additional, Aguiam, D., additional, Akers, R., additional, Albanese, R., additional, Albert, C., additional, Alessi, E., additional, Ambrosino, R., additional, Andrèbe, Y., additional, Angioni, C., additional, Apruzzese, G., additional, Aradi, M., additional, Arnichand, H., additional, Auriemma, F., additional, Avdeeva, G., additional, Ayllon-Guerola, J.M., additional, Bagnato, F., additional, Bandaru, V.K., additional, Barnes, M., additional, Barrera-Orte, L., additional, Bettini, P., additional, Bilato, R., additional, Biletskyi, O., additional, Bilkova, P., additional, Bin, W., additional, Blanchard, P., additional, Blanken, T., additional, Bobkov, V., additional, Bock, A., additional, Boeyaert, D., additional, Bogar, K., additional, Bogar, O., additional, Bohm, P., additional, Bolzonella, T., additional, Bombarda, F., additional, Boncagni, L., additional, Bouquey, F., additional, Bowman, C., additional, Brezinsek, S., additional, Brida, D., additional, Brunetti, D., additional, Bucalossi, J., additional, Buchanan, J., additional, Buermans, J., additional, Bufferand, H., additional, Buller, S., additional, Buratti, P., additional, Burckhart, A., additional, Calabrò, G., additional, Calacci, L., additional, Camenen, Y., additional, Cannas, B., additional, Cano Megías, P., additional, Carnevale, D., additional, Carpanese, F., additional, Carr, M., additional, Carralero, D., additional, Carraro, L., additional, Casolari, A., additional, Cathey, A., additional, Causa, F., additional, Cavedon, M., additional, Cecconello, M., additional, Ceccuzzi, S., additional, Cerovsky, J., additional, Chapman, S., additional, Chmielewski, P., additional, Choi, D., additional, Cianfarani, C., additional, Ciraolo, G., additional, Coda, S., additional, Coelho, R., additional, Colas, L., additional, Colette, D., additional, Cordaro, L., additional, Cordella, F., additional, Costea, S., additional, Coster, D., additional, Cruz Zabala, D.J., additional, Cseh, G., additional, Czarnecka, A., additional, Cziegler, I., additional, D’Arcangelo, O., additional, Dal Molin, A., additional, David, P., additional, De Carolis, G., additional, De Oliveira, H., additional, Decker, J., additional, Dejarnac, R., additional, Delogu, R., additional, den Harder, N., additional, Dimitrova, M., additional, Dolizy, F., additional, Domínguez-Palacios Durán, J.J., additional, Douai, D., additional, Drenik, A., additional, Dreval, M., additional, Dudson, B., additional, Dunai, D., additional, Duval, B.P., additional, Dux, R., additional, Elmore, S., additional, Embréus, O., additional, Erdõs, B., additional, Fable, E., additional, Faitsch, M., additional, Fanni, A., additional, Farnik, M., additional, Faust, I., additional, Faustin, J., additional, Fedorczak, N., additional, Felici, F., additional, Feng, S., additional, Feng, X., additional, Ferreira, J., additional, Ferrò, G., additional, Février, O., additional, Ficker, O., additional, Figini, L., additional, Figueiredo, A., additional, Fil, A., additional, Fontana, M., additional, Francesco, M., additional, Fuchs, C., additional, Futatani, S., additional, Gabellieri, L., additional, Gadariya, D., additional, Gahle, D., additional, Galassi, D., additional, Gałązka, K., additional, Galdon-Quiroga, J., additional, Galeani, S., additional, Gallart, D., additional, Gallo, A., additional, Galperti, C., additional, Garavaglia, S., additional, Garcia, J., additional, Garcia-Lopez, J., additional, Garcia-Muñoz, M., additional, Garzotti, L., additional, Gath, J., additional, Geiger, B., additional, Giacomelli, L., additional, Giannone, L., additional, Gibson, S., additional, Gil, L., additional, Giovannozzi, E., additional, Giruzzi, G., additional, Gobbin, M., additional, Gonzalez-Martin, J., additional, Goodman, T.P., additional, Gorini, G., additional, Gospodarczyk, M., additional, Granucci, G., additional, Grekov, D., additional, Grenfell, G., additional, Griener, M., additional, Groth, M., additional, Grover, O., additional, Gruca, M., additional, Gude, A., additional, Guimarais, L., additional, Gyergyek, T., additional, Hacek, P., additional, Hakola, A., additional, Ham, C., additional, Happel, T., additional, Harrison, J., additional, Havranek, A., additional, Hawke, J., additional, Henderson, S., additional, Hesslow, L., additional, Hitzler, F., additional, Hnat, B., additional, Hobirk, J., additional, Hoelzl, M., additional, Hogeweij, D., additional, Hopf, C., additional, Hoppe, M., additional, Horacek, J., additional, Hron, M., additional, Huang, Z., additional, Iantchenko, A., additional, Iglesias, D., additional, 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additional, Lahtinen, A., additional, Lang, P., additional, Likonen, J., additional, Lipschultz, B., additional, Liu, F., additional, Lombroni, R., additional, Lorenzini, R., additional, Loschiavo, V.P., additional, Lunt, T., additional, Macusova, E., additional, Madsen, J., additional, Maggiora, R., additional, Maljaars, B., additional, Manas, P., additional, Mantica, P., additional, Mantsinen, M.J., additional, Manz, P., additional, Maraschek, M., additional, Marchenko, V., additional, Marchetto, C., additional, Mariani, A., additional, Marini, C., additional, Markovic, T., additional, Marrelli, L., additional, Martin, P., additional, Martín Solís, J.R., additional, Martitsch, A., additional, Mastrostefano, S., additional, Matos, F., additional, Matthews, G., additional, Mayoral, M.-L., additional, Mazon, D., additional, Mazzotta, C., additional, Mc Carthy, P., additional, McClements, K., additional, McDermott, R., additional, Mcmillan, B., additional, Meineri, C., additional, Menkovski, V., additional, Meshcheriakov, D., additional, Messmer, M., additional, Micheletti, D., additional, Milanesio, D., additional, Militello, F., additional, Miron, I.G., additional, Mlynar, J., additional, Moiseenko, V., additional, Molina Cabrera, P.A., additional, Morales, J., additional, Moret, J.-M., additional, Moro, A., additional, Moulton, D., additional, Nabais, F., additional, Naulin, V., additional, Naydenkova, D., additional, Nem, R.D., additional, Nespoli, F., additional, Newton, S., additional, Nielsen, A.H., additional, Nielsen, S.K., additional, Nikolaeva, V., additional, Nocente, M., additional, Nowak, S., additional, Oberkofler, M., additional, Ochoukov, R., additional, Ollus, P., additional, Olsen, J., additional, Omotani, J., additional, Ongena, J., additional, Orain, F., additional, Orsitto, F.P., additional, Paccagnella, R., additional, Palha, A., additional, Panaccione, L., additional, Panek, R., additional, Panjan, M., additional, Papp, G., additional, Paradela Perez, I., additional, Parra, F., additional, Passeri, M., additional, Pau, A., additional, Pautasso, G., additional, Pavlichenko, R., additional, Perek, A., additional, Pericoli Radolfini, V., additional, Pesamosca, F., additional, Peterka, M., additional, Petrzilka, V., additional, Piergotti, V., additional, Pigatto, L., additional, Piovesan, P., additional, Piron, C., additional, Piron, L., additional, Plyusnin, V., additional, Pokol, G., additional, Poli, E., additional, Pölöskei, P., additional, Popov, T., additional, Popovic, Z., additional, Pór, G., additional, Porte, L., additional, Pucella, G., additional, Puiatti, M.E., additional, Pütterich, T., additional, Rabinski, M., additional, Juul Rasmussen, J., additional, Rasmussen, J., additional, Rattá, G.A., additional, Ratynskaia, S., additional, Ravensbergen, T., additional, Réfy, D., additional, Reich, M., additional, Reimerdes, H., additional, Reimold, F., additional, Reiser, D., additional, Reux, C., additional, 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additional, Sozzi, C., additional, Sperduti, A., additional, Spizzo, G., additional, Spolaore, M., additional, Stejner, M., additional, Stipani, L., additional, Stober, J., additional, Strand, P., additional, Sun, H., additional, Suttrop, W., additional, Sytnykov, D., additional, Szepesi, T., additional, Tál, B., additional, Tala, T., additional, Tardini, G., additional, Tardocchi, M., additional, Teplukhina, A., additional, Terranova, D., additional, Testa, D., additional, Theiler, C., additional, Thorén, E., additional, Thornton, A., additional, Tilia, B., additional, Tolias, P., additional, Tomes, M., additional, Toscano-Jimenez, M., additional, Tsironis, C., additional, Tsui, C., additional, Tudisco, O., additional, Urban, J., additional, Valisa, M., additional, Vallar, M., additional, Vallejos Olivares, P., additional, Valovic, M., additional, Van Vugt, D., additional, Vanovac, B., additional, Varje, J., additional, Varju, J., additional, Varoutis, S., additional, Vartanian, S., 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Published: 2019
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40. The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring

Author: Soubry A, Murphy SK, Huang Z, Murtha A, Schildkraut JM, Jirtle RL, Wang F, Kurtzberg J, Demark-Wahnefried W, Forman MR, and Hoyo C
Subjects: antidepressants, depression, pregnancy, IGF2, offspring, race, Medicine, Genetics, QH426-470
Abstract: Abstract In utero exposures to environmental factors may result in persistent epigenetic modifications affecting normal development and susceptibility to chronic diseases in later life. We explored the relationship between exposure of the growing fetus to maternal depression or antidepressants and DNA methylation at two differentially methylated regions (DMRs) of the imprinted Insulin-like Growth Factor 2 (IGF2) gene. Aberrant DNA methylation at the IGF2 and neighboring H19 DMRs has been associated with deregulated IGF2 expression, childhood cancers and several chronic diseases during adulthood. Our study population is comprised of pregnant mothers and their newborns (n = 436), as part of the Newborn Epigenetics Study (NEST). A standardized questionnaire was completed and medical record data were abstracted to ascertain maternal depression and antidepressive drug use. DMR methylation levels in umbilical cord blood leukocytes were quantified using pyrosequencing. From the 436 newborns, laboratory data were obtained for 356 individuals at the IGF2 DMRs, and for 411 individuals at the H19 DMRs; about half of each group was African American or Caucasian. While overall no association between depression and methylation profiles was found, we observed a significant hypermethylation of the H19 DMRs in newborns of African American (n = 177) but not Caucasian (n = 168) mothers who reported the use of antidepressive drugs during pregnancy (β = +6.89, p = 0.01). Of note, our data reveal a race-independent association between smoking during pregnancy and methylation at the IGF2 DMR (+3.05%, p = 0.01). In conclusion, our findings suggest a race-dependent response related to maternal use of antidepressants at one of the IGF2 DMRs in the offspring.
Published: 2011
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41. Cohort profile: Pregnancy and childhood epigenetics (PACE) consortium

Author: Felix, J.F. (Janine F.), Joubert, B.R. (Bonnie), Baccarelli, A.A. (Andrea), Sharp, G.C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baïz, N. (Nour), Bakermans-Kranenburg, M.J. (Marian), Bakulski, K.M. (Kelly M.), Binder, E.B. (Elisabeth), Bouchard, L. (Luigi), Breton, C. (Carrie), Brunekreef, B. (Bert), Brunst, K.J. (Kelly J.), Burchard, E.G. (Esteban), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M.C. (Monica Cheng), Corpeleijn, W.E. (Willemijn), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G.D. (George Davey), Boever, P. (Patrick) de, Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (B.), Everson, T.M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M.D. (M. Daniele), Farchi, S. (Sara), Fernandez, M.F. (Mariana), Gao, L. (Lu), Gaunt, T.R. (Tom), Ghantous, A. (Akram), Gillman, M.W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Håberg, S.E. (Siri E), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J.W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D.D. (Dereje D.), Just, A.C. (Allan C.), Karagas, M.R. (Margaret), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K.J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G.H. (Gerard), Küpers, A.M. (Marlijn), Ladd-Acosta, C. (Christine), Lahti, J., Lambrechts, N. (Nathalie), Langie, S.A.S. (Sabine A.S.), Lie, R.T. (Rolv T.), Liu, A.H. (Andrew H.), Magnus, M.C. (Maria C.), Magnus, P. (Per), Maguire, R.L. (Rachel L.), Marsit, C.J. (Carmen J.), McArdle, W.L. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S.K. (Susan K.), Nawrot, T.S. (Tim S.), Nisticò, L. (Lorenza), Nohr, C. (Christian), Nordlund, B. (Björn), Nystad, W. (Wenche), Oh, S.S. (Sam S.), Oken, E. (Emily), Page, C.M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Göran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Räikkönen, K. (Katri), Reese, S.E. (Sarah E.), Reischl, G. (Gunilla), Richiardi, L. (Lorenzo), Ring, S.M. (Susan), Roy, R.P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D.A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sørensen, T.I.A. (Thorkild), Starling, A.P. (Anne P.), Sunyer, J. (Jordi), Taylor, J.A. (Jack A), Tiemeier, H.W. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), IJzendoorn, M.H. (Rien) van, Vonk, J.M. (Judith), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. (Joseph), Wilcox, A.J. (Allen), Wright, R.J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I.V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C.L. (Caroline), Jaddoe, V.W.V. (Vincent), London, S.J. (Stephanie J.), Felix, J.F. (Janine F.), Joubert, B.R. (Bonnie), Baccarelli, A.A. (Andrea), Sharp, G.C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baïz, N. (Nour), Bakermans-Kranenburg, M.J. (Marian), Bakulski, K.M. (Kelly M.), Binder, E.B. (Elisabeth), Bouchard, L. (Luigi), Breton, C. (Carrie), Brunekreef, B. (Bert), Brunst, K.J. (Kelly J.), Burchard, E.G. (Esteban), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M.C. (Monica Cheng), Corpeleijn, W.E. (Willemijn), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G.D. (George Davey), Boever, P. (Patrick) de, Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (B.), Everson, T.M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M.D. (M. Daniele), Farchi, S. (Sara), Fernandez, M.F. (Mariana), Gao, L. (Lu), Gaunt, T.R. (Tom), Ghantous, A. (Akram), Gillman, M.W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Håberg, S.E. (Siri E), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J.W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D.D. (Dereje D.), Just, A.C. (Allan C.), Karagas, M.R. (Margaret), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K.J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G.H. (Gerard), Küpers, A.M. (Marlijn), Ladd-Acosta, C. (Christine), Lahti, J., Lambrechts, N. (Nathalie), Langie, S.A.S. (Sabine A.S.), Lie, R.T. (Rolv T.), Liu, A.H. (Andrew H.), Magnus, M.C. (Maria C.), Magnus, P. (Per), Maguire, R.L. (Rachel L.), Marsit, C.J. (Carmen J.), McArdle, W.L. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S.K. (Susan K.), Nawrot, T.S. (Tim S.), Nisticò, L. (Lorenza), Nohr, C. (Christian), Nordlund, B. (Björn), Nystad, W. (Wenche), Oh, S.S. (Sam S.), Oken, E. (Emily), Page, C.M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Göran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Räikkönen, K. (Katri), Reese, S.E. (Sarah E.), Reischl, G. (Gunilla), Richiardi, L. (Lorenzo), Ring, S.M. (Susan), Roy, R.P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D.A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sørensen, T.I.A. (Thorkild), Starling, A.P. (Anne P.), Sunyer, J. (Jordi), Taylor, J.A. (Jack A), Tiemeier, H.W. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), IJzendoorn, M.H. (Rien) van, Vonk, J.M. (Judith), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. (Joseph), Wilcox, A.J. (Allen), Wright, R.J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I.V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C.L. (Caroline), Jaddoe, V.W.V. (Vincent), and London, S.J. (Stephanie J.)
Published: 2018
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42. Cohort profile:pregnancy and childhood epigenetics (PACE) consortium

Author: Felix, J. F. (Janine F.), Joubert, B. R. (Bonnie R.), Baccarelli, A. A. (Andrea A.), Sharp, G. C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baiz, N. (Nour), Bakermans-Kranenburg, M. J. (Marian J.), Bakulski, K. M. (Kelly M.), Binder, E. B. (Elisabeth B.), Bouchard, L. (Luigi), Breton, C. V. (Carrie V.), Brunekreef, B. (Bert), Brunst, K. J. (Kelly J.), Burchard, E. G. (Esteban G.), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M. C. (Monica Cheng), Corpeleijn, E. (Eva), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G. D. (George Davey), De Boever, P. (Patrick), Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (Brenda), Everson, T. M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M. D. (M. Daniele), Farchi, S. (Sara), Fernandez, M. F. (Mariana F.), Gao, L. (Lu), Gaunt, T. R. (Tom R.), Ghantous, A. (Akram), Gillman, M. W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Haberg, S. E. (Siri E.), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J. W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D. D. (Dereje D.), Just, A. C. (Allan C.), Karagas, M. R. (Margaret R.), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K. J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G. H. (Gerard H.), Kupers, L. K. (Leanne K.), Ladd-Acosta, C. (Christine), Lahti, J. (Jari), Lambrechts, N. (Nathalie), Langie, S. A. (Sabine A. S.), Lie, R. T. (Rolv T.), Liu, A. H. (Andrew H.), Magnus, M. C. (Maria C.), Magnus, P. (Per), Maguire, R. L. (Rachel L.), Marsit, C. J. (Carmen J.), McArdle, W. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S. K. (Susan K.), Nawrot, T. S. (Tim S.), Nistico, L. (Lorenza), Nohr, E. A. (Ellen A.), Nordlund, B. (Bjorn), Nystad, W. (Wenche), Oh, S. S. (Sam S.), Oken, E. (Emily), Page, C. M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Goran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Raikkonen, K. (Katri), Reese, S. E. (Sarah E.), Reischl, E. (Eva), Richiardi, L. (Lorenzo), Ring, S. (Susan), Roy, R. P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D. A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sorensen, T. I. (Thorkild I. A.), Starling, A. P. (Anne P.), Sunyer, J. (Jordi), ATaylor, J. (Jack), Tiemeier, H. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), Van Ijzendoorn, M. H. (Marinus H.), Vonk, J. M. (Judith M.), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. L. (Joseph L.), Wilcox, A. J. (Allen J.), Wright, R. J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I. V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C. L. (Caroline L.), Jaddoe, V. W. (Vincent W. V.), London, S. J. (Stephanie J.), Felix, J. F. (Janine F.), Joubert, B. R. (Bonnie R.), Baccarelli, A. A. (Andrea A.), Sharp, G. C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baiz, N. (Nour), Bakermans-Kranenburg, M. J. (Marian J.), Bakulski, K. M. (Kelly M.), Binder, E. B. (Elisabeth B.), Bouchard, L. (Luigi), Breton, C. V. (Carrie V.), Brunekreef, B. (Bert), Brunst, K. J. (Kelly J.), Burchard, E. G. (Esteban G.), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M. C. (Monica Cheng), Corpeleijn, E. (Eva), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G. D. (George Davey), De Boever, P. (Patrick), Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (Brenda), Everson, T. M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M. D. (M. Daniele), Farchi, S. (Sara), Fernandez, M. F. (Mariana F.), Gao, L. (Lu), Gaunt, T. R. (Tom R.), Ghantous, A. (Akram), Gillman, M. W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Haberg, S. E. (Siri E.), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J. W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D. D. (Dereje D.), Just, A. C. (Allan C.), Karagas, M. R. (Margaret R.), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K. J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G. H. (Gerard H.), Kupers, L. K. (Leanne K.), Ladd-Acosta, C. (Christine), Lahti, J. (Jari), Lambrechts, N. (Nathalie), Langie, S. A. (Sabine A. S.), Lie, R. T. (Rolv T.), Liu, A. H. (Andrew H.), Magnus, M. C. (Maria C.), Magnus, P. (Per), Maguire, R. L. (Rachel L.), Marsit, C. J. (Carmen J.), McArdle, W. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S. K. (Susan K.), Nawrot, T. S. (Tim S.), Nistico, L. (Lorenza), Nohr, E. A. (Ellen A.), Nordlund, B. (Bjorn), Nystad, W. (Wenche), Oh, S. S. (Sam S.), Oken, E. (Emily), Page, C. M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Goran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Raikkonen, K. (Katri), Reese, S. E. (Sarah E.), Reischl, E. (Eva), Richiardi, L. (Lorenzo), Ring, S. (Susan), Roy, R. P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D. A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sorensen, T. I. (Thorkild I. A.), Starling, A. P. (Anne P.), Sunyer, J. (Jordi), ATaylor, J. (Jack), Tiemeier, H. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), Van Ijzendoorn, M. H. (Marinus H.), Vonk, J. M. (Judith M.), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. L. (Joseph L.), Wilcox, A. J. (Allen J.), Wright, R. J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I. V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C. L. (Caroline L.), Jaddoe, V. W. (Vincent W. V.), and London, S. J. (Stephanie J.)
Published: 2018

43. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium

Author: Felix, Janine, Joubert, BR, Baccarelli, AA, Sharp, GC, Almqvist, C, Annesi-Maesano, I, Arshad, H, Baiz, N, Bakermans-Kranenburg, MJ, Bakulski, KM, Binder, EB, Bouchard, L, Breton, CV, Brunekreef, B, Brunst, KJ, Burchard, EG, Bustamante, M, Chatzi, L, Munthe-Kaas, MC, Corpeleijn, E, Czamara, D, Dabelea, D, Smith, GD, De Boever, P, Duijts, Liesbeth, Dwyer, T, Eng, C, Eskenazi, B, Everson, TM, Falahi, F, Fallin, MD, Farchi, S, Fernandez, MF, Gao, L, Gaunt, TR, Ghantous, A, Gillman, MW, Gonseth, S, Grote, V, Gruzieva, O, Haberg, SE, Herceg, Z, Hivert, MF, Holland, N, Holloway, JW, Hoyo, C, Hu, DL, Huang, RC, Huen, K, Jarvelin, MR, Jima, DD, Just, AC, Karagas, MR, Karlsson, R, Karmaus, W, Kechris, KJ, Kere, J, Kogevinas, M, Koletzko, B, Koppelman, GH, Kupers, LK, Ladd-Acosta, C, Lahti, J, Lambrechts, N, Langie, SAS, Lie, RT, Liu, AH, Magnus, MC, Magnus, P, Maguire, RL, Marsit, CJ, McArdle, W, Melen, E, Melton, P, Murphy, SK, Nawrot, TS, Nistico, L, Nohr, EA, Nordlund, B, Nystad, W, Oh, SS, Oken, E, Page, CM, Perron, P, Pershagen, G, Pizzi, C, Plusquin, M, Raikkonen, K, Reese, SE, Reischl, E, Richiardi, L, Ring, S, Roy, RP, Rzehak, P, Schoeters, G, Schwartz, DA, Sebert, S, Snieder, H, Sorensen, TIA, Starling, AP, Sunyer, J, Ataylor, J, Tiemeier, Henning, Ullemar, V, Vafeiadi, M, van IJzendoorn, Marinus, Vonk, JM, Vriens, A, Vrijheid, M, Wang, P, Wiemels, JL, Wilcox, AJ, Wright, RJ, Xu, CJ, Xu, ZL, Yang, IV, Yousefi, P, Zhang, HM, Zhang, WM, Zhao, SS, Agha, G, Relton, CL, Jaddoe, Vincent, London, SJ, Felix, Janine, Joubert, BR, Baccarelli, AA, Sharp, GC, Almqvist, C, Annesi-Maesano, I, Arshad, H, Baiz, N, Bakermans-Kranenburg, MJ, Bakulski, KM, Binder, EB, Bouchard, L, Breton, CV, Brunekreef, B, Brunst, KJ, Burchard, EG, Bustamante, M, Chatzi, L, Munthe-Kaas, MC, Corpeleijn, E, Czamara, D, Dabelea, D, Smith, GD, De Boever, P, Duijts, Liesbeth, Dwyer, T, Eng, C, Eskenazi, B, Everson, TM, Falahi, F, Fallin, MD, Farchi, S, Fernandez, MF, Gao, L, Gaunt, TR, Ghantous, A, Gillman, MW, Gonseth, S, Grote, V, Gruzieva, O, Haberg, SE, Herceg, Z, Hivert, MF, Holland, N, Holloway, JW, Hoyo, C, Hu, DL, Huang, RC, Huen, K, Jarvelin, MR, Jima, DD, Just, AC, Karagas, MR, Karlsson, R, Karmaus, W, Kechris, KJ, Kere, J, Kogevinas, M, Koletzko, B, Koppelman, GH, Kupers, LK, Ladd-Acosta, C, Lahti, J, Lambrechts, N, Langie, SAS, Lie, RT, Liu, AH, Magnus, MC, Magnus, P, Maguire, RL, Marsit, CJ, McArdle, W, Melen, E, Melton, P, Murphy, SK, Nawrot, TS, Nistico, L, Nohr, EA, Nordlund, B, Nystad, W, Oh, SS, Oken, E, Page, CM, Perron, P, Pershagen, G, Pizzi, C, Plusquin, M, Raikkonen, K, Reese, SE, Reischl, E, Richiardi, L, Ring, S, Roy, RP, Rzehak, P, Schoeters, G, Schwartz, DA, Sebert, S, Snieder, H, Sorensen, TIA, Starling, AP, Sunyer, J, Ataylor, J, Tiemeier, Henning, Ullemar, V, Vafeiadi, M, van IJzendoorn, Marinus, Vonk, JM, Vriens, A, Vrijheid, M, Wang, P, Wiemels, JL, Wilcox, AJ, Wright, RJ, Xu, CJ, Xu, ZL, Yang, IV, Yousefi, P, Zhang, HM, Zhang, WM, Zhao, SS, Agha, G, Relton, CL, Jaddoe, Vincent, and London, SJ
Published: 2018

44. Carbohydrate intake, glycemic index and prostate cancer risk

Author: Vidal, A. C., Williams, C. D., Allott, E. H., Howard, L. E., Grant, D. J., McPhail, M., Sourbeer, K. N., Hwa, L. P., Boffetta, P., Hoyo, C., Freedland, S. J., Vidal, A.C., Williams, C.D., Allott, E.H., Howard, L.E., Grant, D.J., McPhail, M., Sourbeer, K.N., Hwa, L.P., Boffetta, P., Hoyo, C., and Freedland, S.J.
Subjects: dietary carbohydrate - prostate cancer (PC)
Abstract: BACKGROUND. Reported associations between dietary carbohydrate and prostate cancer (PC) risk are poorly characterized by race. METHODS. We analyzed the association between carbohydrate intake, glycemic index (GI), and PC risk in a study of white (N = 262) and black (N = 168) veterans at the Durham VA Hospital. Cases were 156 men with biopsy-confirmed PC and controls (N = 274) had a PSA test but were not recommended for biopsy. Diet was assessed before biopsy with a self-administered food frequency questionnaire. Logistic regression models were used to estimate PC risk. RESULTS. In multivariable analyzes, higher carbohydrate intake, measured as percent of energy from carbohydrates, was associated with reduced PC risk (3rd vs. 1st tertile, OR = 0.41, 95% CI 0.21-0.81, P = 0.010), though this only reached significance in white men (p-trend = 0.029). GI was unrelated to PC risk among all men, but suggestively linked with reduced PC risk in white men (p-trend = 0.066) and increased PC risk in black men (p-trend = 0.172), however, the associations were not significant. Fiber intake was not associated with PC risk (all p-trends > 0.55). Higher carbohydrate intake was associated with reduced risk of high-grade (p-trend = 0.016), but not low-grade PC (p-trend = 0.593). CONCLUSION. Higher carbohydrate intake may be associated with reduced risk of overall and high-grade PC. Future larger studies are needed to confirm these findings. © 2014 Wiley Periodicals, Inc.
Published: 2015

45. Elevated metabolites of acetaminophen in cord blood of children with obesity

Author: Sorrow, P., primary, Maguire, R., additional, Murphy, S. K., additional, Belcher, S. M., additional, and Hoyo, C., additional
Published: 2018
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46. Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children

Author: Do, E. K., primary, Zucker, N. L., additional, Huang, Z. Y., additional, Schechter, J. C., additional, Kollins, S. H., additional, Maguire, R. L., additional, Murphy, S. K., additional, Hoyo, C., additional, and Fuemmeler, B. F., additional
Published: 2018
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47. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the pregnancy and childhood epigenetics (PACE) consortium

Author: Sharp, G.C. (Gemma C.), Salas, L.A. (Lucas A.), Poppelaars-Monnereau, C. (Claire), Allard, C. (Catherine), Yousefi, P. (Paul), Everson, T.M. (Todd M.), Bohlin, J. (Jon), Xu, Z. (Zongli), Huang, R.-C. (Rae-Chi), Reese, S.E. (Sarah E.), Xu, C.-J. (Cheng-Jian), Baïz, N. (Nour), Hoyo, C. (Cathrine), Agha, G. (Golareh), Roy, R. (Ritu), Holloway, J. (John), Ghantous, A. (Akram), Merid, S.K. (Simon Kebede), Bakulski, K.M. (Kelly M.), Küpers, A.M. (Marlijn), Zhang, H. (Hongmei), Richmond, R.C. (Rebecca C.), Page, C.M. (Christian M.), Duijts, L. (Liesbeth), Lie, R.T. (Rolv T.), Melton, P.E. (Phillip E.), Vonk, J.M. (Judith), Nohr, C. (Christian), Williams-DeVane, C. (ClarLynda), Huen, K. (Karen), Rifas-Shiman, S.L. (Sheryl), Ruiz-Arenas, C. (Carlos), Gonseth, S. (Semira), Rezwan, F.I. (Faisal I.), Herceg, Z. (Zdenko), Ekström, S. (Sandra), Croen, L. (Lisa), Falahi, F. (Fahimeh), Perron, P. (Patrice), Karagas, M.R. (Margaret), Quraishi, B.M. (Bilal M.), Suderman, M.J. (Matthew J.), Magnus, M.C. (Maria C.), Jaddoe, V.W.V. (Vincent), Taylor, J.A. (Jack A.), Anderson, D. (Denise), Zhao, S. (Shanshan), Smit, H.A. (Henriëtte), Josey, M.J. (Michele J.), Bradman, A. (Asa), Baccarelli, A.A. (Andrea), Bustamante, M. (Mariona), Håberg, S.E. (Siri E), Pershagen, G. (Göran), Hertz-Picciotto, I. (Irva), Newschaffer, C. (Craig), Corpeleijn, W.E. (Willemijn), Bouchard, L. (Luigi), Lawlor, D.A. (Debbie A.), Maguire, R.L. (Rachel L.), Barcellos, L.F. (Lisa), Smith, G.D. (George Davey), Eskenazi, B. (B.), Karmaus, W. (Wilfried), Marsit, C.J. (Carmen J.), Hivert, M.-F. (Marie-France), Snieder, H. (Harold), Fallin, M.D. (M. Daniele), Melén, E. (Erik), Munthe-Kaas, M.C. (Monica Cheng), Arshad, H. (Hasan), Wiemels, J. (Joseph), Annesi-Maesano, I. (Isabella), Vrijheid, M. (Martine), Oken, E. (Emily), Holland, N. (Nina), Murphy, S.K. (Susan K.), Sørensen, T.I.A. (Thorkild), Koppelman, G.H. (Gerard), Newnham, J.P. (John), Wilcox, A.J. (Allen), Nystad, W. (Wenche), London, S.J. (Stephanie J.), Felix, J.F. (Janine), Relton, C.L. (Caroline), Sharp, G.C. (Gemma C.), Salas, L.A. (Lucas A.), Poppelaars-Monnereau, C. (Claire), Allard, C. (Catherine), Yousefi, P. (Paul), Everson, T.M. (Todd M.), Bohlin, J. (Jon), Xu, Z. (Zongli), Huang, R.-C. (Rae-Chi), Reese, S.E. (Sarah E.), Xu, C.-J. (Cheng-Jian), Baïz, N. (Nour), Hoyo, C. (Cathrine), Agha, G. (Golareh), Roy, R. (Ritu), Holloway, J. (John), Ghantous, A. (Akram), Merid, S.K. (Simon Kebede), Bakulski, K.M. (Kelly M.), Küpers, A.M. (Marlijn), Zhang, H. (Hongmei), Richmond, R.C. (Rebecca C.), Page, C.M. (Christian M.), Duijts, L. (Liesbeth), Lie, R.T. (Rolv T.), Melton, P.E. (Phillip E.), Vonk, J.M. (Judith), Nohr, C. (Christian), Williams-DeVane, C. (ClarLynda), Huen, K. (Karen), Rifas-Shiman, S.L. (Sheryl), Ruiz-Arenas, C. (Carlos), Gonseth, S. (Semira), Rezwan, F.I. (Faisal I.), Herceg, Z. (Zdenko), Ekström, S. (Sandra), Croen, L. (Lisa), Falahi, F. (Fahimeh), Perron, P. (Patrice), Karagas, M.R. (Margaret), Quraishi, B.M. (Bilal M.), Suderman, M.J. (Matthew J.), Magnus, M.C. (Maria C.), Jaddoe, V.W.V. (Vincent), Taylor, J.A. (Jack A.), Anderson, D. (Denise), Zhao, S. (Shanshan), Smit, H.A. (Henriëtte), Josey, M.J. (Michele J.), Bradman, A. (Asa), Baccarelli, A.A. (Andrea), Bustamante, M. (Mariona), Håberg, S.E. (Siri E), Pershagen, G. (Göran), Hertz-Picciotto, I. (Irva), Newschaffer, C. (Craig), Corpeleijn, W.E. (Willemijn), Bouchard, L. (Luigi), Lawlor, D.A. (Debbie A.), Maguire, R.L. (Rachel L.), Barcellos, L.F. (Lisa), Smith, G.D. (George Davey), Eskenazi, B. (B.), Karmaus, W. (Wilfried), Marsit, C.J. (Carmen J.), Hivert, M.-F. (Marie-France), Snieder, H. (Harold), Fallin, M.D. (M. Daniele), Melén, E. (Erik), Munthe-Kaas, M.C. (Monica Cheng), Arshad, H. (Hasan), Wiemels, J. (Joseph), Annesi-Maesano, I. (Isabella), Vrijheid, M. (Martine), Oken, E. (Emily), Holland, N. (Nina), Murphy, S.K. (Susan K.), Sørensen, T.I.A. (Thorkild), Koppelman, G.H. (Gerard), Newnham, J.P. (John), Wilcox, A.J. (Allen), Nystad, W. (Wenche), London, S.J. (Stephanie J.), Felix, J.F. (Janine), and Relton, C.L. (Caroline)
Abstract: Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs). We attempted to infer causality by comparing the effects of maternal versus paternal BMI and incorporating genetic variation. In four additional cohorts (1,817 mother-child pairs), we meta-analysed the association between maternal BMI at the start of pregnancy and blood methylation in adolescents. In newborns, maternal BMI was associated with small (<0.2% per BMI unit (1 kg/m2), P < 1.06 × 10-7) methylation variation at 9,044 sites throughout the genome. Adjustment for estimated cell proportions greatly attenuated the number of significant CpGs to 104, including 86 sites common to the unadjusted model. At 72/86 sites, the direction of the association was the same in newborns and adolescents, suggesting persistence of signals. However, we found evidence for a6causal intrauterine effect of maternal BMI on newborn methylation at just 8/86 sites. In conclusion, this well-powered analysis identified robust associations between maternal adiposity and variations in newborn blood DNA methylation, but these small effects may be better explained by genetic or lifestyle factors than a causal intrauterine mechanism. This highlights the need for large-scale collaborative approaches and the application of causal inference techniques in epigenetic epidemiology.
Published: 2017
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48. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium

Author: Sharp, GC, Salas, LA, Monnereau, Claire, Allard, C, Yousefi, P, Everson, TM, Bohlin, J, Xu, ZL, Huang, RC, Reese, SE, Xu, CJ, Baiz, N, Hoyo, C, Agha, G, Roy, R, Holloway, JW, Ghantous, A, Merid, SK, Bakulski, KM, Kupers, LK, Zhang, HM, Richmond, Rebecca, Page, CM, Duijts, Liesbeth, Lie, RT, Melton, PE, Vonk, JM, Nohr, EA, Williams-DeVane, C, Huen, K, Rifas-Shiman, SL, Ruiz-Arenas, C, Gonseth, S, Rezwan, FI, Herceg, Z, Ekstrom, S, Croen, L, Falahi, F, Perron, P, Karagas, MR, Quraishi, BM, Suderman, M, Magnus, MC, Jaddoe, Vincent, Taylor, JA, Anderson, D, Zhao, SS, Smit, HA, Josey, MJ, Bradman, A, Baccarelli, AA, Bustamante, M, Haberg, SE, Pershagen, G, Hertz-Picciotto, I, Newschaffer, C, Corpeleijn, E, Bouchard, L, Lawlor, DA, Maguire, RL, Barcellos, LF, Smith, GD, Eskenazi, B, Karmaus, W, Marsit, CJ, Hivert, MF, Snieder, H, Fallin, MD, Melen, E, Munthe-Kaas, MC, Arshad, H, Wiemels, JL, Annesi-Maesano, I, Vrijheid, M, Oken, E, Holland, N, Murphy, SK, Sorensen, TIA, Koppelman, GH, Newnham, JP, Wilcox, AJ, Nystad, W, London, SJ, Felix, Janine, Relton, CL, Sharp, GC, Salas, LA, Monnereau, Claire, Allard, C, Yousefi, P, Everson, TM, Bohlin, J, Xu, ZL, Huang, RC, Reese, SE, Xu, CJ, Baiz, N, Hoyo, C, Agha, G, Roy, R, Holloway, JW, Ghantous, A, Merid, SK, Bakulski, KM, Kupers, LK, Zhang, HM, Richmond, Rebecca, Page, CM, Duijts, Liesbeth, Lie, RT, Melton, PE, Vonk, JM, Nohr, EA, Williams-DeVane, C, Huen, K, Rifas-Shiman, SL, Ruiz-Arenas, C, Gonseth, S, Rezwan, FI, Herceg, Z, Ekstrom, S, Croen, L, Falahi, F, Perron, P, Karagas, MR, Quraishi, BM, Suderman, M, Magnus, MC, Jaddoe, Vincent, Taylor, JA, Anderson, D, Zhao, SS, Smit, HA, Josey, MJ, Bradman, A, Baccarelli, AA, Bustamante, M, Haberg, SE, Pershagen, G, Hertz-Picciotto, I, Newschaffer, C, Corpeleijn, E, Bouchard, L, Lawlor, DA, Maguire, RL, Barcellos, LF, Smith, GD, Eskenazi, B, Karmaus, W, Marsit, CJ, Hivert, MF, Snieder, H, Fallin, MD, Melen, E, Munthe-Kaas, MC, Arshad, H, Wiemels, JL, Annesi-Maesano, I, Vrijheid, M, Oken, E, Holland, N, Murphy, SK, Sorensen, TIA, Koppelman, GH, Newnham, JP, Wilcox, AJ, Nystad, W, London, SJ, Felix, Janine, and Relton, CL
Published: 2017

49. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the pregnancy and childhood epigenetics (PACE) consortium

Author: Sharp, G., Salas, L., Monnereau, C., Allard, C., Yousefi, P., Everson, T., Bohlin, J., Xu, Z., Huang, R., Reese, S., Xu, C., Baïz, N., Hoyo, C., Agha, G., Roy, R., Holloway, J., Ghantous, A., Merid, S., Bakulski, K., Küpers, L., Zhang, H., Richmond, R., Page, C., Duijts, L., Lie, R., Melton, Phillip, Vonk, J., Nohr, E., Williams-DeVane, C., Huen, K., Rifas-Shiman, S., Ruiz-Arenas, C., Gonseth, S., Rezwan, F., Herceg, Z., Ekström, S., Croen, L., Falahi, F., Perron, P., Karagas, M., Quraishi, B., Suderman, M., Magnus, M., Jaddoe, V., Taylor, J., Anderson, D., Zhao, S., Smit, H., Josey, M., Bradman, A., Baccarelli, A., Bustamante, M., Håberg, S., Pershagen, G., Hertz-Picciotto, I., Newschaffer, C., Corpeleijn, E., Bouchard, L., Lawlor, D., Maguire, R., Barcellos, L., Smith, G., Eskenazi, B., Karmaus, W., Marsit, C., Sharp, G., Salas, L., Monnereau, C., Allard, C., Yousefi, P., Everson, T., Bohlin, J., Xu, Z., Huang, R., Reese, S., Xu, C., Baïz, N., Hoyo, C., Agha, G., Roy, R., Holloway, J., Ghantous, A., Merid, S., Bakulski, K., Küpers, L., Zhang, H., Richmond, R., Page, C., Duijts, L., Lie, R., Melton, Phillip, Vonk, J., Nohr, E., Williams-DeVane, C., Huen, K., Rifas-Shiman, S., Ruiz-Arenas, C., Gonseth, S., Rezwan, F., Herceg, Z., Ekström, S., Croen, L., Falahi, F., Perron, P., Karagas, M., Quraishi, B., Suderman, M., Magnus, M., Jaddoe, V., Taylor, J., Anderson, D., Zhao, S., Smit, H., Josey, M., Bradman, A., Baccarelli, A., Bustamante, M., Håberg, S., Pershagen, G., Hertz-Picciotto, I., Newschaffer, C., Corpeleijn, E., Bouchard, L., Lawlor, D., Maguire, R., Barcellos, L., Smith, G., Eskenazi, B., Karmaus, W., and Marsit, C.
Abstract: © The Author 2017. Published by Oxford University Press. All rights reserved. Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs). We attempted to infer causality by comparing the effects of maternal versus paternal BMI and incorporating genetic variation. In four additional cohorts (1,817 mother-child pairs), we meta-analysed the association between maternal BMI at the start of pregnancy and blood methylation in adolescents. In newborns, maternal BMI was associated with small ( < 0.2% per BMI unit (1 kg/m 2 ), P < 1.06 × 10 -7 ) methylation variation at 9,044 sites throughout the genome. Adjustment for estimated cell proportions greatly attenuated the number of significant CpGs to 104, including 86 sites common to the unadjusted model. At 72/86 sites, the direction of the association was the same in newborns and adolescents, suggesting persistence of signals. However, we found evidence for a6causal intrauterine effect of maternal BMI on newborn methylation at just 8/86 sites. In conclusion, this well-powered analysis identified robust associations between maternal adiposity and variations in newborn blood DNA methylation, but these small effects may be better explained by genetic or lifestyle factors than a causal intrauterine mechanism. This highlights the need for large-scale collaborative approaches and the application of causal inference techniques in epigenetic epidemiology.
Published: 2017

50. Maternal vitamin D, DNA methylation at imprint regulatory regions and offspring weight at birth, 1 year and 3 years

Author: Benjamin Neelon, S E, primary, White, A J, additional, Vidal, A C, additional, Schildkraut, J M, additional, Murtha, A P, additional, Murphy, S K, additional, Kullman, S W, additional, and Hoyo, C, additional
Published: 2017
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