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4. COVID-19 vaccine and the risk of flares in inflammatory arthritis: a systematic literature review and meta-analysis.

Author

Hoxha, Ariela, Striani, Giovanni, Lovisotto, Marco, Simioni, Paolo, Doria, Andrea, and Ramonda, Roberta

Subjects
VACCINE trials, COVID-19, RHEUMATOID arthritis, COVID-19 vaccines, JOINT diseases
Abstract

Introduction: Coronavirus disease 2019 (COVID-19) vaccines aroused concerns about the risk of flares and adverse events in inflammatory arthritis (IA) since the vaccine clinical trials did not specifically investigate this subset of patients. Methods: A systematic literature review and meta-analysis to summarize the data on joint disease flare and adverse events following immunization (AEFI). Two researchers independently evaluated the literature on Pubmed, Scopus, and EMBASE databases from 22nd March 2020 to 30th September 2023. A random-effects model was used to pool odds ratios (OR) (with 95% CI) for the risk of joint disease flares and adverse events. Subgroup analyses were performed to evaluate the risk of disease flare between different IA and adverse events. Heterogeneity was assessed by I2 statistic. Results: A total of 9874 IA patients were included in the study: 6579 (66.6%) patients affected by RA and 3295 (33.4%) spondyloarthritis (SpA). The overall rate of flares was higher in RA vs. SpA (9.1% vs. 5.3%). However, the pooled estimated analysis showed no increased risk of joint disease flare following COVID-19 vaccination in patients affected by RA vs. SpA [OR 0.88, 95% CI: 0.77-1.00]. Furthermore, a subgroup analysis showed an increased risk of joint flares in psoriatic arthritis (PsA) patients vs. RA [OR 0.79, 95% CI: 0.68-0.93, p=0.004]. The pooled estimated analysis revealed no increased risk of AEFI in patients with RA vs. SpA [1.02, 95% CI: 0.63-1.65]. Conclusions: Our meta-analysis summarized the current evidence on joint disease flares and COVID-19 vaccine-associated AEFI in IA patients. Pooled analysis showed an increased risk of disease flares in PsA vs. RA patients. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Anti-phospholipid antibodies nephropathy is associated with an increased risk of kidney failure: a systematic literature review and meta-analysis.

Author

Hoxha, Ariela, Lovisotto, Marco, Perin, Nicola, Nalesso, Federico, Prete, Dorella Del, and Simioni, Paolo

Subjects
*PHOSPHOLIPID antibodies, *ANTICARDIOLIPIN antibodies, *RANDOM effects model, *KIDNEY failure, *ACUTE kidney failure
Abstract

Background Anti-phospholipid antibodies nephropathy (aPL-N) is a complex feature of anti-phospholipid syndrome due to microvascular lesions. Renal prognosis and predictors of outcome are not yet known. Methods We performed a systematic review of the literature (February 2006–January 2024) using the PubMed, Scopus, Cochrane Library and EMBASE databases. Two reviewers independently conducted literature screening and data extraction in a blinded, standardized manner. A random effects model was used to pool odds ratios (ORs) [with 95% confidence interval (CI)] for the primary analysis, the risk of kidney failure. Subgroup analyses were performed for clinical and laboratory features that predicted renal outcomes. Heterogeneity was assessed by I2. Results Six records involving 709 patients were included in the meta-analysis. Biopsy-proven aPL-N was found in 238/832 (28.6%) patients. Acute kidney injury (AKI) was present at diagnosis in 20/65 (30.8%), while 73/233 (31.3%) patients with aPL-N developed chronic kidney disease (CKD)/end-stage kidney disease (ESKD) at follow-up. aPL-N was associated with an increased risk of CKD/ESKD [OR 6.89 (95% CI 2.42–19.58)] and AKI [OR 2.97 (95% CI 1–4-6.29)]. Arterial hypertension and positivity for lupus anticoagulant, anti-cardiolipin antibodies and anti-β2 glycoprotein I antibodies were associated with an increased risk of developing aPL-N [OR 3.7 (95% CI 1.9–7.23), OR 4.01 (95% CI 1.88–8.53), OR 2.35 (95% CI 1.31–4.21) and OR 19.2 (95% CI 2.91–125.75), respectively]. Conclusion aPL-N is associated with poor renal outcomes. High blood pressure and aPL positivity have been identified as predictors of adverse renal outcomes. This up-to-date knowledge on renal outcomes and predictors of renal outcomes in aPL-N enables a personalized follow-up and therapeutic approach. [ABSTRACT FROM AUTHOR]

Published
2024
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8. The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus

Author

Giacomelli, Roberto, Afeltra, Antonella, Bartoloni, Elena, Berardicurti, Onorina, Bombardieri, Michele, Bortoluzzi, Alessandra, Carubbi, Francesco, Caso, Francesco, Cervera, Ricard, Ciccia, Francesco, Cipriani, Paola, Coloma-Bazán, Emmanuel, Conti, Fabrizio, Costa, Luisa, D’Angelo, Salvatore, Distler, Oliver, Feist, Eugen, Foulquier, Nathan, Gabini, Marco, Gerber, Vanessa, Gerli, Roberto, Grembiale, Rosa Daniela, Guggino, Giuliana, Hoxha, Ariela, Iagnocco, Annamaria, Jordan, Suzana, Kahaleh, Bashar, Lauper, Kim, Liakouli, Vasiliki, Lubrano, Ennio, Margiotta, Domenico, Naty, Saverio, Navarini, Luca, Perosa, Federico, Perricone, Carlo, Perricone, Roberto, Prete, Marcella, Pers, Jacques-Olivier, Pitzalis, Costantino, Priori, Roberta, Rivellese, Felice, Ruffatti, Amelia, Ruscitti, Piero, Scarpa, Raffaele, Shoenfeld, Yehuda, Triolo, Giovanni, and Tzioufas, Athanasios

Published
2021
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10. Management of pregnancy in autoimmune rheumatic diseases: maternal disease course, gestational and neonatal outcomes and use of medications in the prospective Italian P-RHEUM.it study

Author

Andreoli, L, Gerardi, M, Gerosa, M, Rozza, D, Crisafulli, F, Erra, R, Lini, D, Trespidi, L, Padovan, M, Ruffilli, F, Serale, F, Cuomo, G, Raffeiner, B, Semeraro, P, Tani, C, Chimenti, M, Conigliaro, P, Hoxha, A, Nalli, C, Fredi, M, Lazzaroni, M, Filippini, M, Taglietti, M, Franceschini, F, Zatti, S, Loardi, C, Orabona, R, Ramazzotto, F, Zanardini, C, Fontana, G, Gozzoli, G, Barison, C, Bizioli, P, Caporali, R, Carrea, G, Ossola, M, Maranini, B, Silvagni, E, Govoni, M, Morano, D, Verteramo, R, Doria, A, Del Ross, T, Favaro, M, Calligaro, A, Tonello, M, Larosa, M, Zen, M, Zambon, A, Mosca, M, Zucchi, D, Elefante, E, Gori, S, Iannone, F, Anelli, M, Lavista, M, Abbruzzese, A, Fasano, C, D'Angelo, S, Cutro, M, Picerno, V, Carbone, T, Padula, A, Rovere-Querini, P, Canti, V, De Lorenzo, R, Cavallo, L, Ramoni, V, Montecucco, C, Codullo, V, Milanesi, A, Pazzola, G, Comitini, G, Marvisi, C, Salvarani, C, Epis, O, Benedetti, S, Di Raimondo, G, Gagliardi, C, Lomater, C, Crepaldi, G, Bellis, E, Bellisai, F, Garcia Gonzalez, E, Pata, A, Zerbinati, M, Urban, M, Mattioli, I, Iuliano, A, Sebastiani, G, Brucato, A, Bizzi, E, Cutolo, M, Santo, L, Tonetta, S, Landolfi, G, Carrara, G, Bortoluzzi, A, Scirè, C, Tincani, A, Andreoli, Laura, Gerardi, Maria Chiara, Gerosa, Maria, Rozza, Davide, Crisafulli, Francesca, Erra, Roberta, Lini, Daniele, Trespidi, Laura, Padovan, Melissa, Ruffilli, Francesca, Serale, Francesca, Cuomo, Giovanna, Raffeiner, Bernd, Semeraro, Paolo, Tani, Chiara, Chimenti, Maria Sole, Conigliaro, Paola, Hoxha, Ariela, Nalli, Cecilia, Fredi, Micaela, Lazzaroni, Maria Grazia, Filippini, Matteo, Taglietti, Marco, Franceschini, Franco, Zatti, Sonia, Loardi, Chiara, Orabona, Rossana, Ramazzotto, Francesca, Zanardini, Cristina, Fontana, Giulia, Gozzoli, Giorgia, Barison, Claudia, Bizioli, Paola, Caporali, Roberto Felice, Carrea, Giulia, Ossola, Manuela Wally, Maranini, Beatrice, Silvagni, Ettore, Govoni, Marcello, Morano, Danila, Verteramo, Rosita, Doria, Andrea, Del Ross, Teresa, Favaro, Maria, Calligaro, Antonia, Tonello, Marta, Larosa, Maddalena, Zen, Margherita, Zambon, Alessandra, Mosca, Marta, Zucchi, Dina, Elefante, Elena, Gori, Sabrina, Iannone, Florenzo, Anelli, Maria Grazia, Lavista, Marlea, Abbruzzese, Anna, Fasano, Carlo Giuseppe, D'Angelo, Salvatore, Cutro, Maria Stefania, Picerno, Valentina, Carbone, Teresa, Padula, Angela Anna, Rovere-Querini, Patrizia, Canti, Valentina, De Lorenzo, Rebecca, Cavallo, Ludovica, Ramoni, Véronique, Montecucco, Carlomaurizio, Codullo, Veronica, Milanesi, Alessandra, Pazzola, Giulia, Comitini, Giuseppina, Marvisi, Chiara, Salvarani, Carlo, Epis, Oscar Massimiliano, Benedetti, Sara, Di Raimondo, Giuseppina, Gagliardi, Clizia, Lomater, Claudia, Crepaldi, Gloria, Bellis, Elisa, Bellisai, Francesca, Garcia Gonzalez, Estrella, Pata, Anna Paola, Zerbinati, Martina, Urban, Maria Letizia, Mattioli, Irene, Iuliano, Annamaria, Sebastiani, Giandomenico, Brucato, Antonio Luca, Bizzi, Emanuele, Cutolo, Maurizio, Santo, Leonardo, Tonetta, Sara, Landolfi, Gianpiero, Carrara, Greta, Bortoluzzi, Alessandra, Scirè, Carlo Alberto, Tincani, Angela, Andreoli, L, Gerardi, M, Gerosa, M, Rozza, D, Crisafulli, F, Erra, R, Lini, D, Trespidi, L, Padovan, M, Ruffilli, F, Serale, F, Cuomo, G, Raffeiner, B, Semeraro, P, Tani, C, Chimenti, M, Conigliaro, P, Hoxha, A, Nalli, C, Fredi, M, Lazzaroni, M, Filippini, M, Taglietti, M, Franceschini, F, Zatti, S, Loardi, C, Orabona, R, Ramazzotto, F, Zanardini, C, Fontana, G, Gozzoli, G, Barison, C, Bizioli, P, Caporali, R, Carrea, G, Ossola, M, Maranini, B, Silvagni, E, Govoni, M, Morano, D, Verteramo, R, Doria, A, Del Ross, T, Favaro, M, Calligaro, A, Tonello, M, Larosa, M, Zen, M, Zambon, A, Mosca, M, Zucchi, D, Elefante, E, Gori, S, Iannone, F, Anelli, M, Lavista, M, Abbruzzese, A, Fasano, C, D'Angelo, S, Cutro, M, Picerno, V, Carbone, T, Padula, A, Rovere-Querini, P, Canti, V, De Lorenzo, R, Cavallo, L, Ramoni, V, Montecucco, C, Codullo, V, Milanesi, A, Pazzola, G, Comitini, G, Marvisi, C, Salvarani, C, Epis, O, Benedetti, S, Di Raimondo, G, Gagliardi, C, Lomater, C, Crepaldi, G, Bellis, E, Bellisai, F, Garcia Gonzalez, E, Pata, A, Zerbinati, M, Urban, M, Mattioli, I, Iuliano, A, Sebastiani, G, Brucato, A, Bizzi, E, Cutolo, M, Santo, L, Tonetta, S, Landolfi, G, Carrara, G, Bortoluzzi, A, Scirè, C, Tincani, A, Andreoli, Laura, Gerardi, Maria Chiara, Gerosa, Maria, Rozza, Davide, Crisafulli, Francesca, Erra, Roberta, Lini, Daniele, Trespidi, Laura, Padovan, Melissa, Ruffilli, Francesca, Serale, Francesca, Cuomo, Giovanna, Raffeiner, Bernd, Semeraro, Paolo, Tani, Chiara, Chimenti, Maria Sole, Conigliaro, Paola, Hoxha, Ariela, Nalli, Cecilia, Fredi, Micaela, Lazzaroni, Maria Grazia, Filippini, Matteo, Taglietti, Marco, Franceschini, Franco, Zatti, Sonia, Loardi, Chiara, Orabona, Rossana, Ramazzotto, Francesca, Zanardini, Cristina, Fontana, Giulia, Gozzoli, Giorgia, Barison, Claudia, Bizioli, Paola, Caporali, Roberto Felice, Carrea, Giulia, Ossola, Manuela Wally, Maranini, Beatrice, Silvagni, Ettore, Govoni, Marcello, Morano, Danila, Verteramo, Rosita, Doria, Andrea, Del Ross, Teresa, Favaro, Maria, Calligaro, Antonia, Tonello, Marta, Larosa, Maddalena, Zen, Margherita, Zambon, Alessandra, Mosca, Marta, Zucchi, Dina, Elefante, Elena, Gori, Sabrina, Iannone, Florenzo, Anelli, Maria Grazia, Lavista, Marlea, Abbruzzese, Anna, Fasano, Carlo Giuseppe, D'Angelo, Salvatore, Cutro, Maria Stefania, Picerno, Valentina, Carbone, Teresa, Padula, Angela Anna, Rovere-Querini, Patrizia, Canti, Valentina, De Lorenzo, Rebecca, Cavallo, Ludovica, Ramoni, Véronique, Montecucco, Carlomaurizio, Codullo, Veronica, Milanesi, Alessandra, Pazzola, Giulia, Comitini, Giuseppina, Marvisi, Chiara, Salvarani, Carlo, Epis, Oscar Massimiliano, Benedetti, Sara, Di Raimondo, Giuseppina, Gagliardi, Clizia, Lomater, Claudia, Crepaldi, Gloria, Bellis, Elisa, Bellisai, Francesca, Garcia Gonzalez, Estrella, Pata, Anna Paola, Zerbinati, Martina, Urban, Maria Letizia, Mattioli, Irene, Iuliano, Annamaria, Sebastiani, Giandomenico, Brucato, Antonio Luca, Bizzi, Emanuele, Cutolo, Maurizio, Santo, Leonardo, Tonetta, Sara, Landolfi, Gianpiero, Carrara, Greta, Bortoluzzi, Alessandra, Scirè, Carlo Alberto, and Tincani, Angela

Abstract

Objectives To investigate pregnancy outcomes in women with autoimmune rheumatic diseases (ARD) in the Italian prospective cohort study P-RHEUM.it. Methods Pregnant women with different ARD were enrolled for up to 20 gestational weeks in 29 Rheumatology Centres for 5 years (2018-2023). Maternal and infant information were collected in a web-based database. Results We analysed 866 pregnancies in 851 patients (systemic lupus erythematosus was the most represented disease, 19.6%). Maternal disease flares were observed in 135 (15.6%) pregnancies. 53 (6.1%) pregnancies were induced by assisted reproduction techniques, 61 (7%) ended in miscarriage and 11 (1.3%) underwent elective termination. Obstetrical complications occurred in 261 (30.1%) pregnancies, including 2.3% pre-eclampsia. Two cases of congenital heart block were observed out of 157 pregnancies (1.3%) with anti-Ro/SSA. Regarding treatments, 244 (28.2%) pregnancies were treated with glucocorticoids, 388 (44.8%) with hydroxychloroquine, 85 (9.8%) with conventional synthetic disease-modifying anti-rheumatic drugs and 122 (14.1%) with biological disease-modifying anti-rheumatic drugs. Live births were 794 (91.7%), mostly at term (84.9%); four perinatal deaths (0.5%) occurred. Among 790 newborns, 31 (3.9%) were small-for-gestational-age and 169 (21.4%) had perinatal complications. Exclusive maternal breast feeding was received by 404 (46.7%) neonates. The Edinburgh Postnatal Depression Scale was compiled by 414 women (52.4%); 89 (21.5%) scored positive for emotional distress. Conclusions Multiple factors including preconception counselling and treat-to-target with pregnancy-compatible medications may have contributed to mitigate disease-related risk factors, yielding limited disease flares, good pregnancy outcomes and frequency of complications which were similar to the Italian general obstetric population. Disease-specific issues need to be further addressed to plan preventative measures.

Published
2024

11. Myocardial Involvement in Catastrophic Antiphospholipid Syndrome during Pregnancy or Puerperium: A Case of a Young Breastfeeding Woman and Literature Review.

Author

Varotto, Leonardo, Spigolon, Luca, Dotto, Alberto, Leonardi, Denis, Bragantini, Giulia, Cerrito, Luca Felice, Deluca, Cristina, and Hoxha, Ariela

Subjects
CARDIAC magnetic resonance imaging, PREGNANT women, LITERATURE reviews, MYOCARDIAL infarction, CORONARY arteries, ANTIPHOSPHOLIPID syndrome
Abstract

Catastrophic Antiphospholipid Syndrome (CAPS) is a rare complication that can occur in patients with Antiphospholipid Syndrome (APS). CAPS occurs even more rarely during pregnancy/puerperium and pregnant patients, even less likely to show cardiac involvement without signs of damage on ultrasound and angiography with non-obstructive coronary arteries. We present a case of a 26-year-old breastfeeding woman, the youngest described with CAPS and acute myocardial infarction, whose diagnosis was made with cardiac magnetic resonance imaging (CMRI). A literature review of pregnant patients with similar problems was performed. There are diagnostic and therapeutic difficulties in treating these patients. CMRI demonstrated a transmural late enhancement area. A combination of therapies led to rapid clinical improvement. CMRI is an underused tool that reaffirms the pathophysiology of CAPS and leads clinicians to the possibility of a diffuse thrombotic process. CAPS involves more organs with high mortality rates. CMRI could be optimized in order to reach an early diagnosis and the most effective treatment. This study provides real-world evidence of the feasibility of MRI in a primary care setting during pregnancy/puerperium. Evidence from this study may influence future APS screening and inform policymakers regarding the use of leading MRI technology in the detection of the thrombotic process in a primary care setting. [ABSTRACT FROM AUTHOR]

Published
2024
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14. The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 1000 consecutive cases

Author

Alijotas-Reig, Jaume, Esteve-Valverde, Enrique, Ferrer-Oliveras, Raquel, Sáez-Comet, Luis, Lefkou, Elmina, Mekinian, Arsène, Belizna, Cristina, Ruffatti, Amelia, Tincani, Angela, Marozio, Luca, Espinosa, Gerard, Cervera, Ricard, Ríos-Garcés, Roberto, De Carolis, Sara, Latino, Omar, LLurba, Elisa, Chighizola, Cecilia Beatrice, Gerosa, Maria, Pengo, Vittorio, Lundelin, Krista, Rovere-Querini, Patrizia, Canti, Valentina, Mayer-Pickel, Karoline, Reshetnyak, Tatiana, Hoxha, Ariela, Tabacco, Sara, Stojanovich, Ldjumila, Gogou, Vassiliki, Varoudis, Aikaterini, Arnau, Anna, Ruiz-Hidalgo, Domingo, Trapé, Jaume, Sos, Laia, Stoppani, Carlotta, Martí-Cañamares, Anna, and Farran-Codina, Inmaculada

Published
2019
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15. Management of pregnancy in autoimmune rheumatic diseases: maternal disease course, gestational and neonatal outcomes and use of medications in the prospective Italian P-RHEUM. it study.

Author

Andreoli, Laura, Gerardi, Maria Chiara, Gerosa, Maria, Rozza, Davide, Crisafulli, Francesca, Erra, Roberta, Lini, Daniele, Trespidi, Laura, Padovan, Melissa, Ruffilli, Francesca, Serale, Francesca, Cuomo, Giovanna, Raffeiner, Bernd, Semeraro, Paolo, Tani, Chiara, Chimenti, Maria Sole, Conigliaro, Paola, Hoxha, Ariela, Nalli, Cecilia, and Fredi, Micaela

Published
2024
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16. Rivaroxaban vs warfarin in high-risk patients with antiphospholipid syndrome

Author

Pengo, Vittorio, Denas, Gentian, Zoppellaro, Giacomo, Jose, Seena Padayattil, Hoxha, Ariela, Ruffatti, Amelia, Andreoli, Laura, Tincani, Angela, Cenci, Caterina, Prisco, Domenico, Fierro, Tiziana, Gresele, Paolo, Cafolla, Arturo, De Micheli, Valeria, Ghirarduzzi, Angelo, Tosetto, Alberto, Falanga, Anna, Martinelli, Ida, Testa, Sophie, Barcellona, Doris, Gerosa, Maria, and Banzato, Alessandra

Published
2018
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20. Corrigendum to “Low complement levels are related to poor obstetric outcomes in women with obstetric antiphospholipid syndrome. The EUROAPS Registry Study Group” [Placenta. 136 (2023 Apr 3) 29–34]

Author

Esteve-Valverde, Enrique, primary, Alijotas-Reig, Jaume, additional, Belizna, Cristina, additional, Marques-Soares, Joana, additional, Anunciacion-Llunell, Ariadna, additional, Feijóo-Massó, Carlos, additional, Sáez-Comet, Luis, additional, Mekinian, Arsene, additional, Ferrer-Oliveras, Raquel, additional, Lefkou, Elmina, additional, Morales-Pérez, Stephanie, additional, Hoxha, Ariela, additional, Tincani, Angela, additional, Nalli, Cecilia, additional, Pardos-Gea, Josep, additional, Marozio, Luca, additional, Maina, Aldo, additional, Espinosa, Gerard, additional, Cervera, Ricard, additional, De Carolis, Sara, additional, Latino, Omar, additional, Udry, Sebastian, additional, Llurba, Elisa, additional, Garrido-Gimenez, Carmen, additional, Trespidi, Laura, additional, Gerosa, Maria, additional, Chighizola, Cecilia B., additional, Rovere-Querini, Patrizia, additional, Canti, Valentina, additional, Mayer-Pickel, Karoline, additional, Tabacco, Sara, additional, Arnau, Anna, additional, and Miró-Mur, Francesc, additional

Published
2023
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22. Pertinence clinique de la détection précoce des anticorps anti-adalimumab dans la polyarthrite rhumatoïde, la spondylarthrite ankylosante et le rhumatisme psoriasique : étude multicentrique prospective

Author

Hoxha, Ariela, Calligaro, Antonia, Tonello, Marta, Ramonda, Roberta, Carletto, Antonio, Paolazzi, Giuseppe, Bortolotti, Roberto, Del Ross, Teresa, Grava, Chiara, Boaretto, Massimo, Favaro, Maria, Teghil, Vera, Ruffatti, Amelia, and Punzi, Leonardo

Published
2017
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23. Age at diagnosis influences the clinical phenotype, treatment strategies and outcomes in patients with giant cell arteritis: results from the observational GCAGE study on a large cohort of 1004 patients

Author

Monti, Sara, primary, Milanesi, Alessandra, additional, Klersy, Catherine, additional, Tomelleri, Alessandro, additional, Dagna, Lorenzo, additional, Campochiaro, Corrado, additional, Farina, Nicola, additional, Muratore, Francesco, additional, Galli, Elena, additional, Marvisi, Chiara, additional, Bond, Milena, additional, Berti, Alvise, additional, Bortolotti, Roberto, additional, Padoan, Roberto, additional, Schiavon, Franco, additional, Felicetti, Mara, additional, Nannini, Carlotta, additional, Cantini, Fabrizio, additional, Giollo, Alessandro, additional, Rossini, Maurizio, additional, Conticini, Edoardo, additional, Frediani, Bruno, additional, Conti, Fabrizio, additional, Priori, Roberta, additional, Sebastiani, Marco, additional, Cassone, Giulia, additional, Quartuccio, Luca, additional, Treppo, Elena, additional, Bettio, Silvano, additional, Hoxha, Ariela, additional, Lovisotto, Marco, additional, Emmi, Giacomo, additional, Mattioli, Irene, additional, Leccese, Pietro, additional, Caporali, Roberto, additional, Argolini, Lorenza Maria, additional, Foti, Rosario, additional, Visalli, Elisa, additional, Colaci, Michele, additional, Salvarani, Carlo, additional, and Montecucco, Carlomaurizio, additional

Published
2023
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26. The Journey Through the Pathogenesis and Treatment of Venous Thromboembolism in Inflammatory Bowel Diseases: A Narrative Review.

Author

Boccatonda, Andrea, Balletta, Marco, Vicari, Susanna, Hoxha, Ariela, Simioni, Paolo, and Campello, Elena

Subjects
INFLAMMATORY bowel diseases, THROMBOEMBOLISM, CROHN'S disease, ULCERATIVE colitis, PATHOGENESIS
Abstract

Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the gastrointestinal tract including Crohn's disease and ulcerative colitis, which may result in several extraintestinal complications (∼20–30% of cases), such as increased risk of venous thromboembolism (VTE). The main pathophysiological mechanism of VTE is an inflammation-induced hypercoagulable state, and recent data have shown that endothelial dysregulation due to gut and systemic inflammation may also lead to a prothrombotic state. Several prothrombotic alterations have been described, such as the activation of the coagulation system, platelet abnormalities, and dysregulation of fibrinolysis. Furthermore, the dysregulation of the gut microbiome seems to play a vital role in increasing systemic inflammation and thus inducing a procoagulant state. Our review aims to examine the main correlations between IBD and VTE, the underlying pathophysiology, and current therapeutic options. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Erratum: Clinical Delphi on aPL Negativization: Report from the APS Study Group of the Italian Society for Rheumatology (SIR-APS)

Author

Sciascia, Savino, primary, Foddai, Silvia Grazietta, primary, Alessandri, Cristiano, additional, Alunno, Alessia, additional, Andreoli, Laura, additional, Barinotti, Alice, additional, Calligaro, Antonia, additional, Canti, Valentina, additional, Carubbi, Francesco, additional, Cecchi, Irene, additional, Chighizola, Cecillia B., additional, Conti, Fabrizio, additional, Emmi, Giacomo, additional, Fioravanti, Antonella, additional, Fischetti, Fabio, additional, Franceschini, Franco, additional, Gerosa, Maria, additional, Hoxha, Ariela, additional, Larosa, Maddalena, additional, Lazzaroni, Maria-Grazia, additional, Nalli, Cecilia, additional, Pazzola, Giulia, additional, Radin, Massimo, additional, Raffeiner, Bernd, additional, Ramoni, Veronique L., additional, Rubini, Elena, additional, Sebastiani, Gian Domenico, additional, Truglia, Simona, additional, Urban, Maria Letizia, additional, Roccatello, Dario, additional, and Tincani, Angela, additional

Published
2022
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40. COVID-19 vaccination rate and safety profile in a multicentre Italian population affected by mixed cryoglobulinaemic vasculitis

Author

Vacchi, Caterina, primary, Testoni, Sofia, additional, Visentini, Marcella, additional, Zani, Roberta, additional, Lauletta, Gianfranco, additional, Gragnani, Laura, additional, Filippini, Davide, additional, Mazzaro, Cesare, additional, Fraticelli, Paolo, additional, Quartuccio, Luca, additional, Padoan, Roberto, additional, Castelnovo, Laura, additional, Zignego, Anna Linda, additional, Ferri, Clodoveo, additional, Scarpato, Salvatore, additional, Casato, Milvia, additional, Hoxha, Ariela, additional, Salvarani, Carlo, additional, Monti, Giuseppe, additional, Galli, Massimo, additional, and Sebastiani, Marco, additional

Published
2022
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41. Clinical Delphi on aPL Negativization: Report from the APS Study Group of the Italian Society for Rheumatology (SIR-APS)

Author

Sciascia, Savino, additional, Foddai, Silvia Grazietta, additional, Alessandri, Cristiano, additional, Alunno, Alessia, additional, Andreoli, Laura, additional, Barinotti, Alice, additional, Calligaro, Antonia, additional, Canti, Valentina, additional, Carubbi, Francesco, additional, Cecchi, Irene, additional, B. Chighizola, Cecillia, additional, Conti, Fabrizio, additional, Emmi, Giacomo, additional, Fioravanti, Antonella, additional, Fischetti, Fabio, additional, Franceschini, Franco, additional, Gerosa, Maria, additional, Hoxha, Ariela, additional, Larosa, Maddalena, additional, Lazzaroni, Maria-Grazia, additional, Nalli, Cecilia, additional, Pazzola, Giulia, additional, Radin, Massimo, additional, Raffeiner, Bernd, additional, Ramoni, Veronique L., additional, Rubini, Elena, additional, Sebastiani, Gian Domenico, additional, Truglia, Simona, additional, Urban, Maria Letizia, additional, Roccatello, Dario, additional, and Tincani, Angela, additional

Published
2022
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42. Predictors of disease activity in gout: a 12-month analysis of the ATTACk (Achieving improvement in the management of crystal-induced arthritis) multicentre cohort study

Author

Lorenzin, Mariagrazia, primary, Ughi, Nicola, additional, Ariani, Alarico, additional, Raffeiner, Bernd, additional, Frallonardo, Paola, additional, Hoxha, Ariela, additional, Ortolan, Augusta, additional, Favero, Marta, additional, Parisi, Simone, additional, Bortoluzzi, Alessandra, additional, Ceccarelli, Fulvia, additional, Lucchetti, Ramona, additional, Furini, Federica, additional, Del Ross, Teresa, additional, Zanetti, Anna, additional, Carrara, Greta, additional, Scirè, Carlo Alberto, additional, Doria, Andrea, additional, and Ramonda, Roberta, additional

Published
2022
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43. Antiphospholipid antibody profile based obstetric outcomes of primary antiphospholipid syndrome: the PREGNANTS study

Author

Saccone, Gabriele, Berghella, Vincenzo, Maruotti, Giuseppe Maria, Ghi, Tullio, Rizzo, Giuseppe, Simonazzi, Giuliana, Rizzo, Nicola, Facchinetti, Fabio, Dall’Asta, Andrea, Visentin, Silvia, Sarno, Laura, Xodo, Serena, Bernabini, Dalila, Monari, Francesca, Roman, Amanda, Eke, Ahizechukwu Chigoziem, Hoxha, Ariela, Ruffatti, Amelia, Schuit, Ewoud, and Martinelli, Pasquale

Published
2017
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44. Corrigendum to: Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from EUROAPS registry

Author

Alijotas-Reig, Jaume, primary, Esteve-Valverde, Enrique, additional, Ferrer-Oliveras, Raquel, additional, Sáez-Comet, Luis, additional, Lefkou, Elmina, additional, Mekinian, Arsène, additional, Belizna, Cristina, additional, Ruffatti, Amelia, additional, Hoxha, Ariela, additional, Tincani, Angela, additional, Nalli, Cecilia, additional, Marozio, Luca, additional, Maina, Aldo, additional, Espinosa, Gerard, additional, Ríos-Garcés, Roberto, additional, Cervera, Ricard, additional, De Carolis, Sara, additional, Monteleone, Giuseppina, additional, Latino, Omar, additional, Udry, Sebastian, additional, LLurba, Elisa, additional, Garrido-Gimenez, Carmen, additional, Trespidi, Laura, additional, Gerosa, Maria, additional, Chighizola, Cecilia Beatrice, additional, Rovere-Querini, Patrizia, additional, Canti, Valentina, additional, Mayer-Pickel, Karoline, additional, Tabacco, Sara, additional, Arnau, Anna, additional, Trapé, Jaume, additional, Ruiz-Hidalgo, Domingo, additional, Sos, Laia, additional, and Farran-Codina, Inmaculada, additional

Published
2021
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50. High plasma C5a and C5b-9 levels during quiescent phases are associated to severe antiphospholipid syndrome subsets

Author

Ruffatti, Amelia, primary, Tonello, Marta, additional, Calligaro, Antonia, additional, Del Ross, Teresa, additional, Favaro, Maria, additional, Zen, Margherita, additional, Carletto, Antonio, additional, Lotti, Virginia, additional, Bertoldo, Eugenia, additional, Tedesco, Francesco, additional, Hoxha, Ariela, additional, and Biasi, Domenico, additional

Published
2021
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