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6 results on '"Howlett, Cheryl"'

1. How Brexit affects the causal relationships between the UK and fourteen other developed countries in the European Union?

Author

Kuo-Hao Lee and Howlett, Cheryl

Subjects
DEVELOPED countries, EUROPEAN Union membership, GRANGER causality test, SMALL capitalization stocks, BRITISH withdrawal from the European Union, 2016-2020, LEVERAGED buyouts
Abstract

The goal of this research is to investigate the causal relationships among the Small-Cap stock market behaviors of the UK and the other fourteen developed countries in the European Union before and after the UK European Union membership referendum. The Granger causality test is used in this study via a leveraged bootstrap test developed by Hacker and Hatemi-J to examine the causalities. The data results show that six causalities are found before the referendum and the number of the causalities decrease to only three after the referendum. It suggested that the UK Small-Cap market is less affected and has less influence on the movement of the other fourteen developed countries in the European Union. This finding provides another aspect of the UK European Union membership referendum for the investor to take into consideration while building an investment portfolio. [ABSTRACT FROM AUTHOR]

Published
2021

3. Determination of N-Desmethylmethsuximide Serum Concentrations Using EnzymeMultiplied and Fluorescence Polarization Immunoassays

Author

Miles, Michael V., Howlett, Cheryl M., Tennison, Michael B., Greenwood, Robert S., and Cross, Robert E.

Abstract

Summary: N-Desmethylmethsuximide (NDM), the active metabolite of the antiepileptic agent methsuximide, has been analyzed by gas-liquid chromatography and high-performance liquid chromatography (HPLC) in the past. This study compares methods using two commercially available immunoassays for ethosuximide, the enzyme multiplied immunoassay technique (EMIT) and fluorescence polarization immunoassay (FPIA), with an HPLC method for the measurement of NDM concentrations in serum. Within-day precision studies, utilizing low therapeutic (15.0 mg/L) and toxic (45.0 mg/L) NDM concentrations (n = 20), resulted in coefficients of variation (CVs) of 4.6 and 4.2, respectively, for EMIT and 5.4 and 3.2, respectively, for FPIA. Day-to-day precision studies (n = 10) resulted in CVs of 7.6 and 5.5, respectively, for EMIT and 3.5 and 2.4, respectively, for FPIA. No interference was observed from toxic concentrations of acetaminophen, caffeine, carbamazepine, methsuximide, phenobarbital, phensuximide, phenytoin, primidone, salicylate, and valproic acid in the EMIT and FPIA procedures. There was good linear correlation between EMIT and HPLC NDM determinations of 50 patient samples (r= 0.970; y = 0.96 x + 0.03), and a similar correlation between FPIA and HPLC NDM determinations in 48 patient samples (r= 0.975; y = 0.91 x + 1.24). Using ethosuximide reagents, both EMIT and FPIA systems can be adapted to reliably measure NDM serum concentrations.

Published
1989

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