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6. Proceedings of the 14th annual conference of INEBRIA

Author

Holloway, A.S., Ferguson, J., Landale, S., Cariola, L., Newbury-Birch, D., Flynn, A., Knight, J.R., Sherritt, L., Harris, S.K., O’Donnell, A.J., Kaner, E., Hanratty, B., Loree, A.M., Yonkers, K.A., Ondersma, S.J., Gilstead-Hayden, K., Martino, S., Adam, A., Schwartz, R.P., Wu, L.-T., Subramaniam, G., Sharma, G., McNeely, J., Berman, A.H., Kolaas, K., Petersén, E., Bendtsen, P., Hedman, E., Linderoth, C., Müssener, U., Sinadinovic, K., Spak, F., Gremyr, I., Thurang, A., Mitchell, A.M., Finnell, D., Savage, C.L., Mahmoud, K.F., Riordan, B.C., Conner, T.S., Flett, J.A.M., Scarf, D., McRee, B., Vendetti, J., Gallucci, K.S., Robaina, K., Clark, B.J., Jones, J., Reed, K.D., Hodapp, R.M., Douglas, I., Burnham, E.L., Aagaard, L., Cook, P.F, Harris, B.R., Yu, J., Wolff, M., Rogers, M., Barbosa, C., Wedehase, B.J., Dunlap, L.J., Mitchell, S.G., Dusek, K.A., Gryczynski, J., Kirk, A.S., Oros, M.T., Hosler, C., O’Grady, K.E., Brown, B.S., Angus, C., Sherborne, S., Gillespie, D., Meier, P., Brennan, A., de Vargas, D., Soares, J., Castelblanco, D., Doran, K.M., Wittman, I., Shelley, D., Rotrosen, J., Gelberg, L., Edelman, E.J., Maisto, S.A., Hansen, N.B., Cutter, C.J., Deng, Y., Dziura, J., Fiellin, L.E., O’Connor, P.G., Bedimo, R., Gibert, C., Marconi, V.C., Rimland, D., Rodriguez-Barradas, M.C., Simberkoff, M.S., Justice, A.C., Bryant, K.J., Fiellin, D.A., Giles, E.L., Coulton, S., Deluca, P., Drummond, C., Howel, D., McColl, E., McGovern, R., Scott, S., Stamp, E., Sumnall, H., Vale, L., Alabani, V., Atkinson, A., Boniface, S., Frankham, J., Gilvarry, E., Hendrie, N., Howe, N., McGeechan, G.J., Ramsey, A., Stanley, G., Clephane, J., Gardiner, D., Holmes, J., Martin, N., Shevills, C., Soutar, M., Chi, F.W., Weisner, C., Ross, T.B., Mertens, J., Sterling, S.A., Shorter, G.W., Heather, N., Bray, J., Cohen, H.A., McPherson, T.L., Adam, C., López-Pelayo, H., Gual, A., Segura-Garcia, L., Colom, J., Ornelas, I.J., Doyle, S., Donovan, D., Duran, B., Torres, V., Gaume, J., Grazioli, V., Fortini, C., Paroz, S., Bertholet, N., Daeppen, J.-B., Satterfield, J.M., Gregorich, S., Alvarado, N.J., Muñoz, R., Kulieva, G., Vijayaraghavan, M., Cunningham, J.A., Díaz, E., Palacio-Vieira, J., Godinho, A., Kushir, V., O’Brien, K.H.M., Aguinaldo, L.D., Sellers, C.M., Spirito, A., Chang, G., Blake-Lamb, T., LaFave, L.R.A., Thies, K.M., Pepin, A.L., Sprangers, K.E., Bradley, M., Jorgensen, S., Catano, N.A., Murray, A.R., Schachter, D., Andersen, R.M., Rey, G.N., Vahidi, M., Rico, M.W., Baumeister, S.E., Johansson, M., Sinadinovic, C., Hermansson, U., Andreasson, S., O’Grady, M.A., Kapoor, S., Akkari, C., Bernal, C., Pappacena, K., Morley, J., Auerbach, M., Neighbors, C.J., Kwon, N., Conigliaro, J., Morgenstern, J., Magill, M., Apodaca, T.R., Borsari, B., Hoadley, A., Scott Tonigan, J., Moyers, T., Fitzgerald, N.M., Schölin, L., Barticevic, N., Zuzulich, S., Poblete, F., Norambuena, P., Sacco, P., Ting, L., Beaulieu, M., Wallace, P.G., Andrews, M., Daley, K., Shenker, D., Gallagher, L., Watson, R., Weaver, T., Bruguera, P., Oliveras, C., Gavotti, C., Barrio, P., Braddick, F., Miquel, L., Suárez, M., Bruguera, C., Brown, R.L., Capell, J.W., Paul Moberg, D., Maslowsky, J., Saunders, L.A., McCormack, R.P., Scheidell, J., Gonzalez, M., Bauroth, S., Liu, W., Lindsay, D.L., Lincoln, P., Hagle, H., Wallhed Finn, S., Hammarberg, A., Andréasson, S., King, S.E., Vargo, R., Kameg, B.N., Acquavita, S.P., Van Loon, R.A., Smith, R., Brehm, B.J., Diers, T., Kim, K., Barker, A., Jones, A.L., Skinner, A.C., Hinman, A., Svikis, D.S., Thacker, C.L., Resnicow, K., Beatty, J.R., Janisse, J., Puder, K., Bakshi, A.-S., Milward, J.M., Kimergard, A., Garnett, C.V., Crane, D., Brown, J., West, R., Michie, S., Rosendahl, I., Andersson, C., Gajecki, M., Blankers, M., Donoghue, K., Lynch, E., Maconochie, I., Phillips, C., Pockett, R., Phillips, T., Patton, R., Russell, I., Strang, J., Stewart, M.T., Quinn, A.E., Brolin, M., Evans, B., Horgan, C.M., Liu, J., McCree, F., Kanovsky, D., Oberlander, T., Zhang, H., Hamlin, B., Saunders, R., Barton, M.B., Scholle, S.H., Santora, P., Bhatt, C., Ahmed, K., Hodgkin, D., Gao, W., Merrick, E.L., Drebing, C.E., Larson, M.J., Sharma, M., Petry, N.M., Saitz, R., Weisner, C.M., Young-Wolff, K.C., Lu, W.Y., Blosnich, J.R., Lehavot, K., Glass, J.E., Williams, E.C., Bensley, K.M., Chan, G., Dombrowski, J., Fortney, J., Rubinsky, A.D., Lapham, G.T., Forray, A., Olmstead, T.A., Gilstad-Hayden, K., Kershaw, T., Dillon, P., Weaver, M.F., Grekin, E.R., Ellis, J.D., and McGoron, L.

Subjects
lcsh:R5-920, lcsh:Social pathology. Social and public welfare. Criminology, lcsh:Medicine (General), Meeting Abstracts, lcsh:HV1-9960
Published
2017
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7. Antiplatelet therapy in the primary prevention of cardiovascular disease in patients with chronic obstructive pulmonary disease: a randomised controlled proof-of-concept trial

Author

Kunadian, V, Wilson, N, Stocken, DD, Ali, H, McColl, E, Burns, G, Howe, N, Fisher, A, and De Soyza, A

Abstract

The APPLE COPD-ICON2 trial is a prospective 2×2 factorial, double-blinded proof-of-concept randomised controlled trial targeting patients with chronic obstructive pulmonary disease (COPD) without prior history of cardiovascular disease. The primary goal of this trial is to investigate if treatment with antiplatelet therapy will produce the predefined cut-off of platelet inhibition measured using the Multiplate test in COPD patients. Eligible patients were randomised to aspirin plus placebo, ticagrelor plus placebo, aspirin plus ticagrelor or placebo only for 6 months. The primary outcome comprises inhibition (binary response) of arachidonic acid- (ASPI test, cut-off

Published
2019

8. Policing in partnership. Are organic police partnerships more effective than mandated police partnerships?

Author

Howe, N

Abstract

This thesis adopts a broad qualitative standpoint. It examines police involvement in partnerships before and after the implementation of the Crime and Disorder Act, 1998, legislation which mandated the police to work in partnership. A case-study of Staffordshire Police explores experiences of officers working in partnerships pre and post 1998. The research is used to provide insights into the complexity that is partnership, which has wider applicability beyond policing. The thesis examines also the concept and specific mechanisms of policing in partnership that have, in the main, been championed by successive government administrations since New Labour in the late 1990s and are now largely assumed as being an 'effective and efficient' way of working.\ud \ud The thesis identifies an important hitherto strangely underexplored fact, namely: that the foundational policy document, which framed the Crime and Disorder Act mandating police-partnerships, the Morgan Report (1991), produced zero-evidence as to the efficacy of the partnership approach it advocates. Despite being unevidenced, the Morgan Report set in motion a national framework, bureaucratization and professionalization of partnerships. Consequently, there now exists a complex web of professional clustering’s around pre-defined problems. Significantly, the research identifies, that the formality of partnership has encouraged the police to withdraw from elements of their pre-Morgan service and care functions. Equally, partnership has little or no connection to current policing strategy. More recently Police and Crime Commissioners provide a new dynamic to partnership governance and their increasing 'influence' is being felt. However, government fiscal austerity has shifted contemporary partnership discourse with evidence presented of organizations withdrawing support and re-entrenching core activity. The thesis concludes by framing a new conceptualization for assessing partnership effectiveness.

Published
2019

10. Antiplatelet therapy in the primary prevention of cardiovascular disease in patients with chronic obstructive pulmonary disease: protocol of a randomised controlled proof-of-concept trial (APPLE COPD-ICON 2)

Author

Kunadian, V, Chan, D, Ali, H, Wilkinson, N, Howe, N, McColl, E, Thornton, J, Von Wilamowitz-Moellendorff, A, Holstein, E-M, Burns, G, Fisher, A, Stocken, D, De Soyza, A, and APPLE COPD-ICON2 Trial Investigators

Abstract

Introduction: The antiplatelet therapy in the primary prevention of cardiovascular disease in patients with chronic obstructive pulmonary disease (APPLE COPD-ICON2) trial is a prospective 2×2 factorial, double-blinded proof-of-concept randomised controlled trial targeting patients with chronic obstructive pulmonary disease (COPD) at high risk of cardiovascular disease. The primary goal of this trial is to investigate if treatment with antiplatelet therapy will produce the required response in platelet function measured using the Multiplate test in patients with COPD. Methods and analysis: Patients with COPD are screened for eligibility using inclusion and exclusion criteria. Eligible patients are randomised and allocated into one of four groups to receive aspirin plus placebo, ticagrelor plus placebo, aspirin plus ticagrelor or placebo only. Markers of systemic inflammation, platelet reactivity, arterial stiffness, carotid intima-media thickness (CIMT), lung function and quality of life questionnaires are assessed. The primary outcome consists of inhibition (binary response) of aspirin and ADP-induced platelet function at 6 months. Secondary outcomes include changes in inflammatory markers, CIMT, non-invasive measures of vascular stiffness, quality of life using questionnaires (EuroQol–five dimensions–five levels of perceived problems (EQ5D-5L), St. George’s COPD questionnaire) and to record occurrence of repeat hospitalisation, angina, myocardial infarction or death from baseline to 6 months. Safety outcomes will be rates of major and minor bleeding, forced expiratory volume in 1 s, forced vital capacity and Medical Research Council dyspnoea scale. Ethics and dissemination: The study was approved by the North East-Tyne and Wear South Research Ethics Committee (15/NE/0155). Findings of the study will be presented in scientific sessions and published in peer-reviewed journals. Trial registration number: ISRCTN43245574; Pre-results.

Published
2018

14. IMISX-EP of S-PepTSt

Author

Huang, C.-Y., primary, Olieric, V., additional, Howe, N., additional, Warshamanage, R., additional, Weinert, T., additional, Panepucci, E., additional, Vogeley, L., additional, Basu, S., additional, Diederichs, K., additional, Caffrey, M., additional, and Wang, M., additional

Published
2018
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15. IMISX-EP of Hg-BacA Soaking SAD

Author

Huang, C.-Y., primary, Olieric, V., additional, Howe, N., additional, Warshamanage, R., additional, Weinert, T., additional, Panepucci, E., additional, Vogeley, L., additional, Basu, S., additional, Diederichs, K., additional, Caffrey, M., additional, and Wang, M., additional

Published
2018
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16. IMISX-EP of W-PgpB

Author

Huang, C.-Y., primary, Olieric, V., additional, Howe, N., additional, Warshamanage, R., additional, Weinert, T., additional, Panepucci, E., additional, Vogeley, L., additional, Basu, S., additional, Diederichs, K., additional, Caffrey, M., additional, and Wang, M., additional

Published
2018
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17. IMISX-EP of Hg-BacA cocrystallization

Author

Huang, C.-Y., primary, Olieric, V., additional, Howe, N., additional, Warshamanage, R., additional, Weinert, T., additional, Panepucci, E., additional, Vogeley, L., additional, Basu, S., additional, Diederichs, K., additional, Caffrey, M., additional, and Wang, M., additional

Published
2018
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18. IMISX-EP of Se-LspA

Author

Huang, C.-Y., primary, Olieric, V., additional, Howe, N., additional, Warshamanage, R., additional, Weinert, T., additional, Panepucci, E., additional, Vogeley, L., additional, Basu, S., additional, Diederichs, K., additional, Caffrey, M., additional, and Wang, M., additional

Published
2018
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20. Structure of Undecaprenyl-Pyrophosphate Phosphatase, BacA

Author

Huang, C.-Y., primary, Olieric, V., additional, Warshamanage, R., additional, Wang, M., additional, Howe, N., additional, Ghachi, M.E.I., additional, Weichert, D., additional, Kerff, F., additional, Stansfeld, P., additional, Touze, T., additional, and Caffrey, M., additional

Published
2018
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24. Crystal structure of the first transmembrane PAP2 type phosphatidylglycerolphosphate phosphatase from Bacillus subtilis

Author

El Ghachi, M., primary, Howe, N., additional, Lampion, A., additional, Delbrassine, F., additional, Vogeley, L., additional, Caffrey, M., additional, Sauvage, E., additional, Auger, R., additional, Guiseppe, A., additional, Roure, S., additional, Perlier, S., additional, Mengin-lecreulx, D., additional, Foglino, M., additional, and Touze, T., additional

Published
2017
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34. Some Observations on the Structure of Encrusting Biofilms of Proteus mirabilis on Urethral Catheters

Author

Winters, C., Stickler, D. J., Howe, N. S., Williams, T. J., Wilkinson, N., and Buckley, C. J.

Subjects
Urology, Catheter-associated urinary tract infection, X -ray scanning microscopy, catheter encrustation, biofilms, X-ray microanalysis, Proteus mirabilis, Biomedical Engineering and Bioengineering
Abstract

A physical model of the bladder has been used to study the process of urinary catheter encrustation. Techniques have been devised for the preparation of sections through these encrustations in situ on the luminal surfaces of catheters and for mapping the distribution of calcium and magnesium in the biofilms. Transmission electron microscopy on these sections showed struvite-like crystals lying in the matrix and in direct contact with the catheter surface. Calcium phosphate ("bioapatite") was distributed throughout the film and many of these amorphous particles appear to have cells at their cores. Freeze-substituted sections of biofilms also showed electron dense materials around cell-like shapes and X-ray mapping and X-ray scanning transmission microscopy on the catheter biofilms also indicate that mineralization occurs around the bacterial cells. These observations suggest that in catheterized bladders infected by Proteus mirabilis, bacteria and crystals formed in the urine, adhere to the catheter. Further colonization and growth of the cells on the catheter and crystal surfaces produces the alkaline biofilm which provides the conditions for continued encrustation. The binding of crystals directly onto the catheter and the subsequent bacterial colonization of these crystals has implications for attempts to prevent encrustation by manufacturing catheters from biomaterials impregnated or coated with antibacterials.

Published
1995

41. Perceived non-shared environment, personality traits, family factors and developmental experiences in bulimia nervosa.

Author

Lehoux PM and Howe N

Abstract

Objective: The role of perceived non-shared environmental influences and personality traits in the risk of developing bulimia nervosa (BN) was compared in 40 women with BN and their non-eating disordered sisters.Methods: The two sisters were compared for (a) eating pathology, (b) perceived non-shared environmental factors (differential family relationships, developmental teasing, traumatic experiences), (c) personality traits (impulsivity, affective instability, narcissism), and (d) psychopathology (anxiety, depression).Results: Specific perceived non-shared risk factors (e.g. perceptions of teasing), non-specific non-shared risk factors (e.g. insecure paternal attachment) and personality traits (e.g. narcissism) distinguished women with BN from sisters. In the final logistic regression, insecure paternal attachment predicted the risk for BN, while trends were apparent for narcissism and developmental teasing after controlling for psychopathology.Conclusions: Our correlational cross-sectional design does not allow for investigation of direction of effects. However, it is an important first step in identifying possible perceived non-shared environmental influences and personality traits that may constitute vulnerability factors predisposing individuals to the development of BN. Findings are discussed in the light of existing models of risk factors for the etiology of BN. [ABSTRACT FROM AUTHOR]

Published
2007
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43. "All the sheeps are dead. He murdered them": sibling pretense, negotiation, internal state language, and relationship quality.

Author

Howe, Nina, Petrakos, Harriet, Rinaldi, Christina M., Howe, N, Petrakos, H, and Rinaldi, C M

Subjects
CHILD development
Abstract

Pretend play enactment, negotiation, internal state language, and sibling relationship quality were examined in 40 kindergarten-aged children with either an older (M age = 7.10 years) or younger (M age = 3.6 years) sibling. Dyads were identified as engaging in frequent (n = 20) or infrequent (n = 20) pretend play. Results indicated that frequent pretend play dyads engaged in more high-level negotiation, whereas infrequent pretend dyads preferred low-level negotiation strategies. Frequent pretend dyads were more likely to use internal state language, especially during high-level negotiation. Friendly sibling relationship quality was negatively related to pretend enactment, whereas conflict was negatively associated with internal state language. Discussion focuses on the sibling relationship as a context in which to investigate the links between aspects of pretend play, sibling relationship quality, and social understanding. [ABSTRACT FROM AUTHOR]

Published
1998
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44. A portable system for measuring cutaneous thresholds for warming and cooling.

Author

Fowler, C J, Carroll, M B, Burns, D, Howe, N, and Robinson, K

Abstract

Measurement of cutaneous thermal thresholds is a valuable technique for detecting small fibre neuropathy. A robust and portable microcomputer controlled system, which separately measures thresholds for warming and cooling, is described. Thresholds at three sites have been measured; the cheek, the dorsum of the hand and the sole of the foot. Regional variability and a correlation with age have been found, indicating the sensitivity of this system. [ABSTRACT FROM AUTHOR]

Published
1987

46. Dinosaurs in the backyard.

Author

Howe, N.

Subjects
DEERFIELD (Mass.), MASSACHUSETTS, UNITED States
Abstract

Recounts the author's memories of growing up among the interesting residents, some of them Polish, in Deerfield, Mass. where a dinosaur footprint could be found in a neighbor's backyard. Elderly residents; Houses the author lived in; Weather mileposts through the years; Deerfield during the war. INSET: How historic Deerfield has been saved (so far)..

Published
1992

47. Racing through the years at Waterville Valley.

Author

Howe, N.

Subjects
*SKIING
Abstract

Discusses the racing history of the Waterville Valley (N.H.) ski resort and describes the 1991 World Cup finals. Former US ski racer Tom Corcoran, who built and still operates Waterville; Why racing is a priority at Waterville; Black and Blue Traail Smashers (BBTS), the local ski club; Victory by American skier Julie Parisien of Auburn, Me.; Italy's racer Alberto Tomba; Town Square development; Mount Tecumseh. INSET: A racer first and foremost (profile if Tom Corcoran), by N.H..

Published
1991

48. High-style freestyle.

Author

Howe, N.

Subjects
BUCHER, Jan
Abstract

Profiles freestyle skiers Jan Bucher, 33, and Donna Weinbrecht, two leaders on the US Freestyle Team. Skiing careers; Personal philosophies; World Cup freestyle tour.

Published
1990

49. Boom times in Bethel.

Author

Howe, N.

Subjects
*SKIING
Abstract

Discusses the skiing and accommodations at Sunday River (Bethel, Me.). White Heat ski run; Resort's history; New improvements; Lifts; Barker Mountain; Travel information. INSET: The ski dorm, 1990s style (Snow Cap Lodge), by N.H.;At home in....

Published
1990

50. Diann & Kristi.

Author

Howe, N.

Subjects
ROFFE, Diann
Abstract

Profiles US ski racers Diann Roffe and Kristi Terzian. Backgrounds; Training and fitness regimens; Roffe's recovery from injuries; Wins and successes. INSET: Room at the top (Austrian and Swiss women skiers), by N.H..

Published
1990

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