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342 results on '"Howden, Erin J."'

6. Characterizing the influence of cardiorespiratory fitness on left atrial size and function in the general population

Author

Spencer, Luke, primary, Wright, Leah, additional, Foulkes, Stephen J., additional, Rowe, Stephanie J., additional, Dillon, Hayley T., additional, Climie, Rachel, additional, Bigaran, Ashley, additional, Janssens, Kristel, additional, Mitchell, Amy, additional, Wallace, Imogen, additional, Lindqvist, Anniina, additional, Burnham, Lauren, additional, Prior, David L., additional, Howden, Erin J., additional, and La Gerche, Andre, additional

Published
2024
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10. Reversing the Cardiac Effects of Sedentary Aging in Middle Age—A Randomized Controlled Trial

Author

Howden, Erin J, Sarma, Satyam, Lawley, Justin S, Opondo, Mildred, Cornwell, William, Stoller, Douglas, Urey, Marcus A, Adams-Huet, Beverley, and Levine, Benjamin D

Subjects
Clinical Trials and Supportive Activities, Heart Disease, Clinical Research, Aging, Prevention, Cardiovascular, Age Factors, Cardiac Catheterization, Cardiorespiratory Fitness, Echocardiography, Three-Dimensional, Female, Heart Failure, High-Intensity Interval Training, Humans, Male, Middle Aged, Myocardial Contraction, Oxygen Consumption, Prospective Studies, Protective Factors, Risk Factors, Risk Reduction Behavior, Sedentary Behavior, Texas, Time Factors, Treatment Outcome, Ventricular Dysfunction, Left, Ventricular Function, Left, Ventricular Remodeling, catheterization, diastole, exercise, humans, monitoring, physiological, prevention & control, ventricular function, ventricular remodeling, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

BackgroundPoor fitness in middle age is a risk factor for heart failure, particularly heart failure with a preserved ejection fraction. The development of heart failure with a preserved ejection fraction is likely mediated through increased left ventricular (LV) stiffness, a consequence of sedentary aging. In a prospective, parallel group, randomized controlled trial, we examined the effect of 2 years of supervised high-intensity exercise training on LV stiffness.MethodsSixty-one (48% male) healthy, sedentary, middle-aged participants (53±5 years) were randomly assigned to either 2 years of exercise training (n=34) or attention control (control; n=27). Right heart catheterization and 3-dimensional echocardiography were performed with preload manipulations to define LV end-diastolic pressure-volume relationships and Frank-Starling curves. LV stiffness was calculated by curve fit of the diastolic pressure-volume curve. Maximal oxygen uptake (Vo2max) was measured to quantify changes in fitness.ResultsFifty-three participants completed the study. Adherence to prescribed exercise sessions was 88±11%. Vo2max increased by 18% (exercise training: pre 29.0±4.8 to post 34.4±6.4; control: pre 29.5±5.3 to post 28.7±5.4, group×time P

Published
2018

17. Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study

Author

Williams, Camilla J., Li, Zhixiu, Harvey, Nicholas, Lea, Rodney A., Gurd, Brendon J., Bonafiglia, Jacob T., Papadimitriou, Ioannis, Jacques, Macsue, Croci, Ilaria, Stensvold, Dorthe, Wisloff, Ulrik, Taylor, Jenna L., Gajanand, Trishan, Cox, Emily R., Ramos, Joyce S., Fassett, Robert G., Little, Jonathan P., Francois, Monique E., Hearon, Jr, Christopher M., Sarma, Satyam, Janssen, Sylvan L. J. E., Van Craenenbroeck, Emeline M., Beckers, Paul, Cornelissen, Véronique A., Howden, Erin J., Keating, Shelley E., Yan, Xu, Bishop, David J., Bye, Anja, Haupt, Larisa M., Griffiths, Lyn R., Ashton, Kevin J., Brown, Matthew A., Torquati, Luciana, Eynon, Nir, and Coombes, Jeff S.

Published
2021
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22. A Multifaceted Activity Program Preserves VO2peak In Adults Undergoing Allogeneic Stem Cell Transplantation For Hematological Cancer

Author

Dillon, Hayley T., primary, Saner, Nicholas J., additional, Ilsley, Tegan, additional, Kliman, David, additional, Spencer, Andrew, additional, Avery, Sharon, additional, Dunstan, David W., additional, Daly, Robin M., additional, Fraser, Steve F., additional, Owen, Neville, additional, Lynch, Brigid M., additional, Kingwell, Bronwyn A., additional, La Gerche, Andre, additional, and Howden, Erin J., additional

Published
2023
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31. Exercise for the Prevention of Anthracycline-Induced Functional Disability and Cardiac Dysfunction: The BREXIT Study

Author

Foulkes, Stephen J., primary, Howden, Erin J., additional, Haykowsky, Mark J., additional, Antill, Yoland, additional, Salim, Agus, additional, Nightingale, Sophie S., additional, Loi, Sherene, additional, Claus, Piet, additional, Janssens, Kristel, additional, Mitchell, Amy M., additional, Wright, Leah, additional, Costello, Ben T., additional, Lindqvist, Anniina, additional, Burnham, Lauren, additional, Wallace, Imogen, additional, Daly, Robin M., additional, Fraser, Steve F., additional, and La Gerche, André, additional

Published
2023
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45. Exercise for the Prevention of Anthracycline-induced Functional Disability and Cardiac Dysfunction: The BReast Cancer Randomized EXercise InTervention (BREXIT) Study.

Author

Foulkes, Stephen J., Howden, Erin J., Haykowsky, Mark J., Antill, Yoland, Salim, Agus, Nightingale, Sophie S., Loi, Sherene, Claus, Piet, Janssens, Kristel, Mitchell, Amy M., Wright, Leah, Costello, Ben T., Lindqvist, Anniina, Burnham, Lauren, Wallace, Imogen, Daly, Robin M., Fraser, Steve F., and La Gerche, André

Subjects
*VENTRICULAR ejection fraction, *GLOBAL longitudinal strain, *EXERCISE therapy, *HEART diseases, *CARDIAC magnetic resonance imaging, *BREAST cancer, *PEOPLE with disabilities, *ENDURANCE athletes
Abstract

Background: Breast cancer (BC) survivors treated with anthracycline-based chemotherapy (AC) have increased risk of functional limitation and cardiac dysfunction. We conducted a 12-month randomized controlled trial in 104 early-stage BC patients scheduled for AC to determine if 12-months of exercise training (ExT) could attenuate functional disability (primary endpoint), improve cardiorespiratory fitness (VO2peak) and prevent cardiac dysfunction. Methods: Women aged 40-75 years with stage I-III BC scheduled for AC were randomized to 3-4 days/wk of aerobic and resistance ExT for 12-months (n = 52) or usual care ([ UC ], n = 52). Functional measures were performed at baseline, 4-weeks following AC (4-months) and at 12-months comprising: 1) cardiopulmonary exercise testing to quantify VO2peak and functional disability (VO2peak ≤18.0mL/kg/min), 2) cardiac reserve (response from rest to peak exercise) quantified using exercise cardiac magnetic resonance measures to determine changes in left- and right-ventricular ejection fraction [ LVEF, RVEF ], cardiac output [ CO ], and stroke volume [ SV ]), 3) standard-of-care echocardiography-derived resting LVEF and global longitudinal strain [ GLS ], and 4) biochemistry (troponin and B-type natriuretic peptide [ BNP ]). Results: Among 104 participants randomized, greater study attrition was observed among UC participants (P=0.031) with 93 women assessed at 4-months (ExT: n=49, UC: n=44) and 87 at 12-months (ExT: n=49, UC: n=38). ExT attenuated functional disability at 4-months (OR: 0.32 [95% CI 0.11, 0.94], P=0.03), but not at 12-months (OR: 0.27, [95% CI 0.06, 1.12], P=0.07). In a per-protocol analysis, functional disability was entirely prevented at 12-months among participants adherent to ExT (ExT: 0% vs. UC: 20%, P=0.005). As compared with UC at 12-months, ExT was associated with a net +3.5 mL/kg/min improvement in VO2peak that coincided with greater CO, SV, LVEF and RVEF reserve (P<0.001 for all). There was no effect of ExT on resting measures of LV function. Post-chemotherapy troponin increased less in ExT than UC (8-fold vs. 16-fold increase, P=0.002). There were no changes in BNP in either group. Conclusions: In women with early-stage BC undergoing AC, 12-months of ExT did not attenuate functional disability but provided large and clinically meaningful benefits on VO2peak and cardiac reserve. Clinical Trial Registration: URL: https://www.anzctr.org.au/ Unique Identifier: ACTRN12617001408370. [ABSTRACT FROM AUTHOR]

Published
2023
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