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Background. The immunopathogenesis of psoriasis is complex, and involves alterations in the innate immunologic system Case Report: A 57-year-old female was evaluated for the presence of rapidly appearing plaques on the knees and elbows. Methods: Skin biopsies for hematoxylin and eosin examination, as well as for direct immunofluorescence and immunohistochemistry analysis were performed. Results: H&E examination demonstrated classic features of psoriasis. Direct immunofluorescence revealed positive anti-corneal antibodies with several immunoglobulins, as well as positivity to upper and deep small dermal blood vessels. Immunohistochemistry revealed an increased expression of survivin, anti-human-ribosomal protein S6-p240, Topoisomerase II ά, cyclin D1, and Bcl-2 in lesional plaques. Conclusions: The pathobiology of psoriasis seems to involve a series of molecules involved in a complex interaction between the inflammation itself, cell cycle regulation, and ectopic expression of selected molecules.

Sediment traps were used to obtain data for calculating seasonal flux patterns in foraminifera and annual sea-surface temperature ranges from those foraminiferal assemblages. Findings indicate that the patterns are representative of long-term flux patterns found in core-top assemblages, providing an analogous interpretation for environmental change drawing on fossil assemblages.

Planktonic foraminifera in the southwest Pacific Ocean suggest the sea surface temperature was warmer during the Pleistocene than the Holocene. Change was relatively rapid, suggesting global-scale mechanisms.

Author(s): Elisabeth L. Sikes (corresponding author) [1, 2]; Catherine R. Samson [2, 3]; Thomas P. Guilderson [4, 5]; William R. Howard [2] Marine radiocarbon ([sup.14] C) dates are widely used [...]

Dentists should develop a written maintenance plan for reducing the levels of nitric oxide in the office. Nitric oxide is often used to calm anxious patients. However, it can cause problems for the dentists and dental assistants who are exposed to it all day. Chronic exposure has been linked to reproductive, hematologic, neurologic, immunological, liver and kidney disorders. The National Institutes for Occupational Safety and Health recommends levels no higher than 25 parts per million when the gas is being administered. A scavenging system and well-maintained equipment can meet this objective.